Damage Associated Molecular Patterns In Human Diseases Vol 1 Vol 2

Author : Walter Gottlieb Land
Publisher : Springer Nature
Page : 629 pages
File Size : 43,8 Mb
Release : 2020-09-19
Category : Medical
ISBN : 9783030538682

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Damage-Associated Molecular Patterns in Human Diseases by Walter Gottlieb Land Pdf

This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (“SAMPs”) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses

Author : Walter Gottlieb Land
Publisher : Springer
Page : 128 pages
File Size : 49,9 Mb
Release : 2021-03-15
Category : Medical
ISBN : 3030619990

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Damage-Associated Molecular Patterns in Human Diseases Vol.1 & Vol. 2 by Walter Gottlieb Land Pdf

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

Author : Walter Gottlieb Land
Publisher : Springer Nature
Page : 708 pages
File Size : 50,8 Mb
Release : 2023-03-10
Category : Medical
ISBN : 9783031217760

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Damage-Associated Molecular Patterns in Human Diseases by Walter Gottlieb Land Pdf

The core of this three-volume book deals with damage-associated molecular patterns abbreviated “DAMPs”, which are unique molecules that save life and fight for survival of all organisms on this planet by triggering robust inflammatory/immune defense responses upon any injury, including those caused by pathogens such as viruses and bacteria. However, these molecules also have a dark side: when produced in excess upon severe insults, they can trigger serious human diseases. The three volumes present current understanding of the importance of DAMP-promoted immune responses in the etiopathogenesis of human diseases and explore how this understanding is impacting diagnosis, prognosis, and future treatment. This third volume addresses the potential of DAMPs in clinical practice, as therapeutic targets and therapeutics, by focusing on a description of antigen-related diseases, which are pathogenetically dominated by DAMPs, that is, infectious and autoimmune disorders and allograft rejection (as an undesired function of these molecules), as well as tumor rejection (as the desired function of these molecules). The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists, hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses; Damage-Associated Molecular Patterns in Human Diseases - Vol. 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets.

Author : Walter Land
Publisher : Unknown
Page : 0 pages
File Size : 48,5 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1422844924

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Damage-associated Molecular Patterns in Human Diseases by Walter Land Pdf

Author : Walter Gottlieb Land
Publisher : Springer
Page : 870 pages
File Size : 45,6 Mb
Release : 2018-10-09
Category : Medical
ISBN : 9783319786551

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Damage-Associated Molecular Patterns in Human Diseases by Walter Gottlieb Land Pdf

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

Author : Martin Heil,Massimo E. Maffei,S. Y. Seong,Walter Gottlieb Land,Hans-Joachim Anders
Publisher : Frontiers Media SA
Page : 156 pages
File Size : 48,5 Mb
Release : 2022-02-03
Category : Science
ISBN : 9782889742707

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DAMPs across the Tree of Life, Volume 1: Plants by Martin Heil,Massimo E. Maffei,S. Y. Seong,Walter Gottlieb Land,Hans-Joachim Anders Pdf

Author : S.-Y. Seong,Walter Gottlieb Land,Hans-Joachim Anders,Martin Heil,Massimo E. Maffei
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 51,5 Mb
Release : 2022-04-26
Category : Medical
ISBN : 9782889743544

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DAMPs across the Tree of Life, Volume 2: Regulated Cell Death and Immune Responses by S.-Y. Seong,Walter Gottlieb Land,Hans-Joachim Anders,Martin Heil,Massimo E. Maffei Pdf

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 43,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Richard Polin,Steven H. Abman,David H. Rowitch,William Benitz
Publisher : Elsevier Health Sciences
Page : 2555 pages
File Size : 48,7 Mb
Release : 2021-07-29
Category : Medical
ISBN : 9780323712859

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Fetal and Neonatal Physiology by Richard Polin,Steven H. Abman,David H. Rowitch,William Benitz Pdf

Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, and Developmental Biology of Lung Stem Cells, as well as significantly revised chapters on Cellular Mechanisms of Neonatal Brain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and Gastrointestinal Motility, and Physiology of Twin-Twin Transfusion. Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170+ chapters, and more than 350 global contributors. Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout. Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quick reference and review. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

Author : Katerina Dorovini-Zis
Publisher : CRC Press
Page : 394 pages
File Size : 47,9 Mb
Release : 2015-10-21
Category : Medical
ISBN : 9781498727099

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The Blood-Brain Barrier in Health and Disease, Volume Two by Katerina Dorovini-Zis Pdf

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Page : 3000 pages
File Size : 46,8 Mb
Release : 2015-04-17
Category : Medical
ISBN : 9780071802161

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Harrison's Principles of Internal Medicine 19/E (Vol.1 & Vol.2) (ebook) by Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo Pdf

The landmark guide to internal medicine— updated and streamlined for today’s students and clinicians The only place you can get ALL the great content found in the two print volumes AND the acclaimed DVD in one convenient resource! Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison’s Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the new 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the new Nineteenth Edition: Content is practically organized around two basic themes: education and clinical practice The teaching and learning sections cover foundational principles, cardinal manifestations of disease and approach to differential diagnosis; the content devoted to clinical practice focuses on disease pathogenesis and treatment NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever Outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, are available for easy download Supporting the renowned coverage are supplemental resources that reflect and assist modern medical practice: more than 1,000 full-color photographs to aid visual recognition skills, hundreds of state-of-the-art radiographs, from plain film to 3D CT to PET Scans; beautiful illustrations that bring applied anatomy and processes to life; the renowned Harrison’s patient-care algorithms, essential summary tables, and practical demonstrative videos. In addition, several digital atlases highlight noninvasive imaging, percutaneous revascularization, gastrointestinal endoscopy, diagnosis and management of vasculitis, and numerous other issues commonly encountered in clinical practice. Acclaim for Harrison’s: “Covering nearly every possible topic in the field of medicine, the book begins with a phenomenal overview of clinical medicine, discussing important topics such as global medicine, decision-making in clinical practice, the concepts of disease screening and prevention, as well as the importance of medical disorders in specific groups (e.g. women, surgical patients, end of life). The extensive chapters that follow focus on a symptom-based presentation of disease and then illness organized by organ system. Numerous tables, graphs, and figures add further clarity to the text." ...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. It is organized in a way that makes reading from beginning to end a logical journey, yet each chapter can stand alone as a quick reference on a particular topic. “ Doody’s Review Service reviewing the previous edition of Harrison’s

Author : Alan D. Lopez
Publisher : World Bank Publications
Page : 511 pages
File Size : 49,6 Mb
Release : 2006-04-02
Category : Medical
ISBN : 9780821362631

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Global Burden of Disease and Risk Factors by Alan D. Lopez Pdf

Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.

Author : Carlo Rossetti,Francesco Peri
Publisher : Springer Nature
Page : 180 pages
File Size : 49,9 Mb
Release : 2020-10-30
Category : Science
ISBN : 9783030563196

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The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation by Carlo Rossetti,Francesco Peri Pdf

TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade. The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer’s diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.

Author : Jean-Marc Cavaillon,Mervyn Singer
Publisher : John Wiley & Sons
Page : 1818 pages
File Size : 47,6 Mb
Release : 2018-02-20
Category : Medical
ISBN : 9783527338993

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Inflammation, 4 Volume Set by Jean-Marc Cavaillon,Mervyn Singer Pdf

The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.