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Author : Jia Yi,Liang Qiao
Publisher : Royal Society of Chemistry
Page : 361 pages
File Size : 54,7 Mb
Release : 2023-10-06
Category : Science
ISBN : 9781839167638
Author : Charles L. Wilkins,Jackson O. Lay
Publisher : John Wiley & Sons
Page : 377 pages
File Size : 47,8 Mb
Release : 2005-12-16
Category : Science
ISBN : 9780471748632
A multidisciplinary approach to understanding the fundamentals of mass spectrometry for bacterial analysis From chemotaxonomy to characterization of targeted proteins, Identification of Microorganisms by Mass Spectrometry provides an overview of both well-established and cutting-edge mass spectrometry techniques for identifying microorganisms. A vital tool for microbiologists, health professionals, and analytical chemists, the text is designed to help scientists select the most effective techniques for use in biomedical, biochemical, pharmaceutical, and bioterror defense applications. Since microbiological applications of mass spectrometry require a basic understanding of both microbiology and analytical chemistry, the editors have incorporated material from both disciplines so that readers from either field will come to understand the necessary principles of the other. Featuring contributions from some of the most recognized experts in both fields, this volume provides specific examples of fundamental methods as well as approaches developed in the last decade, including: * Metastable atom bombardment pyrolysis mass spectrometry * Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) * MALDI time-of-flight mass spectrometry (MALDI-TOF MS) of intact bacteria * High-resolution Fourier transform mass spectrometry (FTMS) * Electrospray ionization (ESI) mass spectrometry Identification of Microorganisms by Mass Spectrometry represents the most comprehensive and up-to-date work on the topic currently available. It is liberally illustrated with figures and tables and covers every aspect of spectrometric identification of microorganisms, including experimental procedures, various means of sample preparation, data analysis, and interpretation of complex mass spectral data.
Author : Haroun N. Shah,Saheer E. Gharbia,Ajit J. Shah,Erika Y. Tranfield,K. Clive Thompson
Publisher : John Wiley & Sons
Page : 565 pages
File Size : 40,7 Mb
Release : 2023-06-06
Category : Science
ISBN : 9781119814054
Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry Detailed resource presenting the capabilities of MALDI mass spectrometry (MS) to industrially and environmentally significant areas in the biosciences Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry fulfills a need to bring the key analytical technique of MALDI mass spectrometric analysis into routine practice by specialists and non-specialists, and technicians. It informs and educates established researchers on the development of techniques as applied to industrially significant areas within the biosciences. Throughout the text, the reader is presented with recognized and emerging techniques of this powerful and continually advancing field of analytical science to key areas of importance. While many scientific papers are reporting new applications of MS-based analysis in specific foci, this book is unique in that it draws together an incredibly diverse range of applications that are pushing the boundaries of MS across the broad field of biosciences. Contributed to by recognized experts in the field of MALDI MS who have been key players in promoting the advancement and dissemination of authoritative information in this field, Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry covers sample topics such as: Oil microbiology, marine and freshwater ecosystems, agricultural and food microbiology, and industrial waste microbiology Bioremediation and landfill sites microbiology, microbiology of inhospitable sites (e.g. Arctic and Antarctic, and alkaline and acidic sites, and hot temperatures) Veterinary, poultry and animals, viral applications of MS, and antibiotic resistance using tandem MS methods Recent developments which are set to transform the use of MS from its success in clinical microbiology to a wide range of commercial and environmental uses Bridging the gap between measurement and key applications, this text is an ideal resource for industrial and environmental analytical scientists, including technologists in the food industry, pharmaceuticals, and agriculture, as well as biomedical scientists, researchers, clinicians and academics and scientists in bio-resource centers.
Author : Haroun N. Shah,Saheer E. Gharbia
Publisher : John Wiley & Sons
Page : 545 pages
File Size : 55,5 Mb
Release : 2010-10-28
Category : Science
ISBN : 9781119991922
New advances in proteomics, driven largely by developments in mass spectrometry, continue to reveal the complexity and diversity of pathogenic mechanisms among microbes that underpin infectious diseases. Therefore a new era in medical microbiology is demanding a rapid transition from current procedures to high throughput analytical systems for the diagnosis of microbial pathogens. This book covers the broad microbiological applications of proteomics and mass spectrometry. It is divided into six sections that follow the general progression in which most microbiology laboratories are approaching the subject –Transition, Tools, Preparation, Profiling by Patterns, Target Proteins, and Data Analysis.
Author : A. Fox,L. Larsson,S.L. Morgan,G. Odham
Publisher : Springer
Page : 292 pages
File Size : 42,7 Mb
Release : 1990-08-31
Category : Medical
ISBN : 0306435365
Author : Goran Odham
Publisher : Springer Science & Business Media
Page : 452 pages
File Size : 44,9 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781468445268
During recent years there has been increasing interest in the value of a number of chemical and physical-chemical analytical methods for the detection and characterization of microorganisms. Furthermore, such methods are currently used in studies on microbial metabolic processes, on the role of microorganisms in the turnover of inorganic and organic compounds, and on the impact on environmental changes by microbial activity. Moreover, the introduction of some of these methods not only shortens the analytical time period compared to ·'traditional" techniques, but also improves the analytical quality. Mass spectrometry (MS) combined with chromatographic inlet systems, particularly gas chromatography (GC), belongs to those methods which during recent years have established their value for the above-mentioned purposes. The present volume starts with basic chapters on the principles for MS and common inlet systems, particulary Gc. It discusses applications of these techniques to a number of microbiological disciplines, e.g., ecologi cal and medical microbiology. Emphasis is laid on organic compound classes vii viii / PREFACE of special relevance to microbiology, e.g., volatiles, lipids, amino acids, peptides and carbohydrates. Some compound classes of a more general biochemical rather than specific microbiological importance, e.g., steroids and nucleotides, are dealt with briefly. The editors wish to thank all those who have contributed to this book. We hope it will stimulate further research in this futuristic field and will be of practical value.
Author : Plamen Demirev,Todd R. Sandrin
Publisher : Springer
Page : 336 pages
File Size : 53,9 Mb
Release : 2016-01-12
Category : Science
ISBN : 9783319260709
In the last quarter century, advances in mass spectrometry (MS) have been at the forefront of efforts to map complex biological systems including the human metabolome, proteome, and microbiome. All of these developments have allowed MS to become a well-established molecular level technology for microorganism characterization. MS has demonstrated its considerable advantage as a rapid, accurate, and cost-effective method for microorganism identification, compared to conventional phenotypic techniques. In the last several years, applications of MS for microorganism characterization in research, clinical microbiology, counter-bioterrorism, food safety, and environmental monitoring have been documented in thousands of publications. Regulatory bodies in Europe, the US, and elsewhere have approved MS-based assays for infectious disease diagnostics. As of mid-2015, more than 3300 commercial MS systems for microorganism identification have been deployed worldwide in hospitals and clinical labs. While previous work has covered broader approaches in using MS to characterize microorganisms at the species level or above, this book focuses on strain-level and subtyping applications. In twelve individual chapters, innovators, leaders and practitioners in the field from around the world have contributed to a comprehensive overview of current and next-generation approaches for MS-based microbial characterization at the subspecies and strain levels. Chapters include up-to-date reference lists as well as web-links to databases, recommended software, and other useful tools. The emergence of new, antibiotic-resistant strains of human or animal pathogens is of extraordinary concern not only to the scientific and medical communities, but to the general public as well. Developments of novel MS-based assays for rapid identification of strains of antibiotic-resistant microorganisms are reviewed in the book as well. Microbiologists, bioanalytical scientists, infectious disease specialists, clinical laboratory and public health practitioners as well as researchers in universities, hospitals, government labs, and the pharmaceutical and biotechnology industries will find this book to be a timely and valuable resource.
Author : Charles H. Wick
Publisher : CRC Press
Page : 282 pages
File Size : 48,5 Mb
Release : 2013-09-10
Category : Science
ISBN : 9781466504967
All microbes, including bacteria, viruses, and fungi, can be classified and identified by matching a few peptides known to be unique to each organism. Identifying Microbes by Mass Spectrometry Proteomics describes ways to identify microorganisms using powerful new techniques combining hardware and software and yielding highly accurate methods for detection, identification, and classification of microbes. This straightforward technology can be used to detect unknown and unsequenced microorganisms as well as microbes in complex environmental samples. This book reviews various mass analyzers used for detection and describes ionization methods frequently used for analysis of microbial constituents, a necessary step in the preparation of mass spectrometry (MS) samples. The text also discusses diverse processing methods, which are used to analyze MS files for matching mass spectral profiles, and examines protein and nucleic acid sequence-based methods capable of classification and identification of microbial agents. The book also covers sample collection methods and specific sample preparation techniques. The text addresses using computer software and bioinformatics approaches for data mining to discriminate microbes using mass spectrometry proteomics (MSP). It also discusses historical pattern recognition-based methods and other approaches such as analysis of pyrolysis products, chemical ionization (CI) of fatty acid methyl esters, and MALDI-MS. The text contains examples of the application of the MSP technique for microbe detection and includes a survey of suitable and commercially available MS-based platforms. Successful applications include the identification of unknown microbes in honey bees associated with colony collapse disorder and the analysis of virus strains from the 2009 influenza pandemic. The final chapter outlines future trends in these groundbreaking uses of MS techniques, which are fast, not limited by sample type, and show potential in answering complex environmental questions.
Author : Fernando Cobo
Publisher : Academic Press
Page : 298 pages
File Size : 49,6 Mb
Release : 2018-08-03
Category : Science
ISBN : 9780128144527
The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers
Author : Haroun N. Shah,Saheer E. Gharbia
Publisher : John Wiley & Sons
Page : 552 pages
File Size : 51,5 Mb
Release : 2017-06-12
Category : Science
ISBN : 9781118960257
This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade. This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss: Challenges of Identifying Mycobacterium to the Species level Identification of Bacteroides and Other Clinically Relevant Anaerobes Identification of Species in Mixed Microbial Populations Detection of Resistance Mechanisms Proteomics as a biomarker discovery and validation platform Determination of Antimicrobial Resistance using Tandem Mass Spectrometry
Author : Junping Peng,Yi-Wei Tang,Di Xiao
Publisher : Frontiers Media SA
Page : 169 pages
File Size : 50,9 Mb
Release : 2022-02-21
Category : Science
ISBN : 9782889744541
Author : Markus Kostrzewa,Sören Schubert
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 41,8 Mb
Release : 2016
Category : Medical
ISBN : 1910190411
Recent years have seen a phenomenal increase in the use of MALDI-TOF mass spectrometry (MALDI-TOF MS) in microbiology laboratories. The introduction of this technology to microbiology has been a major success and MALDI-TOF MS is now used for routine diagnostic or diagnostic-like purposes in clinic, veterinary, pharma and food microbiology laboratories. It has also evolved into a powerful tool for the analysis of organisms in the environment and for research into microbial communities. The throughput capabilities, accuracy and low running costs of a MALDI-TOF MS system enable analyses at a scale which was not possible until recently. In this timely and up-to-date book, experts in the field provide an overview of the application of MALDI-TOF MS in key areas of microbiology and discuss the impact this modern technology is having on laboratory practice and patient outcome. Several chapters cover applications in clinical and veterinary diagnostic laboratories, food microbiology, environmental microbiology and strain collections. Further chapters discuss the utilization of MALDI-TOF MS for the analysis of challenging microbial groups such as yeast and anaerobic bacteria. In addition, new applications such as microbial typing, DNA analysis and the detection of antibiotic resistance are also covered. The final chapter provides a valuable overview of potential future trends and developments in MALDI-TOF MS and assesses the impact of the technology in microbiology. This authoritative volume will be indispensable for all microbiology laboratories.
Author : Catherine Fenselau
Publisher : Unknown
Page : 256 pages
File Size : 54,6 Mb
Release : 1993-12-31
Category : Science
ISBN : UOM:39015032908033
Describes a high-speed, highly specific and sensitive method of detecting and identifying microorganisms in such contexts as contaminated food, polluted air or water, hospitalized immunodeficient patients, battlefield situations, and the petroleum and biotechnology industries. The 14 papers from a symposium in Washington, D. C., August 1992, include discussions of the characterization of signature lipids, the detection of biological warfare agents, and ribonucleic acid modification in microorganisms. Annotation copyright by Book News, Inc., Portland, OR
Author : Karsten Becker,Sören Schubert
Publisher : Frontiers Media SA
Page : 101 pages
File Size : 45,7 Mb
Release : 2020-12-31
Category : Science
ISBN : 9782889663132
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Mohammed Zourob,Sauna Elwary,Anthony P. F. Turner
Publisher : Springer Science & Business Media
Page : 980 pages
File Size : 48,7 Mb
Release : 2008-09-03
Category : Technology & Engineering
ISBN : 9780387751139
Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems will cover the up-to-date biosensor technologies used for the detection of bacteria. Written by the world's most renowned and learned scientists each in their own area of expertise, Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems is the first title to cover this expanding research field.