Development And Applications In Solubility

Author : Trevor M Letcher
Publisher : Royal Society of Chemistry
Page : 432 pages
File Size : 49,8 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847557681

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Developments and Applications in Solubility by Trevor M Letcher Pdf

Solubility is fundamental to most areas of chemistry and is one of the most basic of thermodynamic properties. It underlies most industrial processes. Bringing together the latest developments and ideas, Developments and Applications in Solubility covers many varied and disparate topics. The book is a collection of work from leading experts in their fields and covers the theory of solubility, modelling and simulation, industrial applications and new data and recent developments relating to solubility. Of particular interest are sections on: experimental, calculated and predicted solubilities; solubility phenomena in 'green' quaternary mixtures involving ionic liquids; molecular simulation approaches to solubility; solubility impurities in cryogenic liquids and carbon dioxide in chemical processes. The book is a definitive and comprehensive reference to what is new in solubility and is ideal for researcher scientists, industrialists and academics

Author : Rajesh Krishna,Lawrence Yu
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 52,8 Mb
Release : 2007-09-20
Category : Medical
ISBN : 9780387723792

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Biopharmaceutics Applications in Drug Development by Rajesh Krishna,Lawrence Yu Pdf

The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.

Author : Parvesh Singh
Publisher : Elsevier
Page : 650 pages
File Size : 40,9 Mb
Release : 2022-09-17
Category : Science
ISBN : 9780323914598

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Recent Developments in the Synthesis and Applications of Pyridines by Parvesh Singh Pdf

Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook for organic chemists working on innovative approaches to the synthesis of pyridines. Written by scientists in both academia and industry and designed to be a standalone reference, the book features reviews, research results and case studies on synthetic methods and applications of pyridine-based chemotypes. The book will bridge the gap between industry and academia by presenting recent innovative approaches to the synthesis of pyridines, diverse application of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry. The role of computational chemistry in the development of pyridine-based bioactive molecules is also included. This reference is essential for researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry. Includes a detailed review of recent research on the reactivity, synthesis and applications of pyridines Features concise accounts of the reactivity, synthetic and optimized protocols Discusses the medicinal, inorganic and polymer chemistry applications of pyridines

Author : Sean Ekins
Publisher : John Wiley & Sons
Page : 840 pages
File Size : 46,6 Mb
Release : 2006-07-11
Category : Medical
ISBN : 9780470037225

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Computer Applications in Pharmaceutical Research and Development by Sean Ekins Pdf

A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.

Author : Shadpour Mallakpour,Chaudhery Mustansar Hussain
Publisher : Elsevier
Page : 518 pages
File Size : 54,7 Mb
Release : 2022-06-23
Category : Technology & Engineering
ISBN : 9780128242599

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Industrial Applications of Nanocrystals by Shadpour Mallakpour,Chaudhery Mustansar Hussain Pdf

Approx.494 pages Approx.494 pages

Author : Anonim
Publisher : Elsevier
Page : 434 pages
File Size : 43,9 Mb
Release : 2022-12-02
Category : Science
ISBN : 9780323884884

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Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development by Anonim Pdf

Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development provides a valuable “go-to reference for many difficult-to-solve challenges using pertinent chromatographic theory, first-hand case studies, and examples provided from academic and industry experts. This text also enables professors teaching an analytical instrumental course to introduce and instruct students about one of the most sustainable and powerful separation methods currently available. While the text has broad applicability across industrial sectors, it focuses primarily on application in the pharmaceutical industry. The book is designed to allow readers to align current HPLC/UHPLC capabilities with SFC as an orthogonal tool for project specific methods in the pharmaceutical industry. It highlights where SFC falls on the spectrum of useful chromatographic tools for routine and challenging separative methods. Experienced HPLC users who are interested in developing knowledge in orthogonal separation techniques, as well as newcomers to the field of separation science, will find this text particularly useful. Chapters address where SFC may fit the analytical needs of the pharmaceutical industry and alert the readers as to where the technique will not fit. Readers will gain an understanding of how and where SFC may be applied and adapted more routinely across the pharmaceutical industry as a ‘green’ way of undertaking separation opportunities and challenges. Areas within the pharmaceutical industry include early drug discovery, process chemistry, and late stage development and manufacturing. Describes approaches to SFC column and mobile phase selection for method development for both analytical and preparative tasks Gives practical examples of how analytical SFC enables the monitoring of synthetic reactions including unstable intermediates, chiral and achiral polar reactants and products across small and large modalities Provides need-focused case studies for pharmaceutical analysts, process chemists, and contract chemistry facilities that can benefit from monitoring or purifying polar intermediates, mutagenic impurities, nitrosamines and other reaction by-products including excipients and metabolites

Author : Alex Avdeef
Publisher : John Wiley & Sons
Page : 741 pages
File Size : 51,8 Mb
Release : 2012-05-22
Category : Medical
ISBN : 9781118057452

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Absorption and Drug Development by Alex Avdeef Pdf

Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.

Author : Tapan K. Das
Publisher : John Wiley & Sons
Page : 380 pages
File Size : 43,6 Mb
Release : 2014-02-27
Category : Medical
ISBN : 9781118354681

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Biophysical Methods for Biotherapeutics by Tapan K. Das Pdf

With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.

Author : Hui Yao,Zhanping You,Dawei Wang,Feng Li,Yue Hou,Jie Ji
Publisher : Frontiers Media SA
Page : 214 pages
File Size : 47,7 Mb
Release : 2021-10-22
Category : Technology & Engineering
ISBN : 9782889715411

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Development and Application of Bituminous Materials for Civil Infrastructures by Hui Yao,Zhanping You,Dawei Wang,Feng Li,Yue Hou,Jie Ji Pdf

Author : Robert G. Fuller,Thomas C. Campbell,Dewey I. Dykstra,Scott M. Stevens
Publisher : IAP
Page : 345 pages
File Size : 54,6 Mb
Release : 2009-10-01
Category : Education
ISBN : 9781617352461

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College Teaching and the Development of Reasoning by Robert G. Fuller,Thomas C. Campbell,Dewey I. Dykstra,Scott M. Stevens Pdf

This book is intended to offer college faculty members the insights of the development of reasoning movement that enlighten physics educators in the late 1970s and led to a variety of college programs directed at improving the reasoning patterns used by college students. While the original materials were directed at physics concepts, they quickly expanded to include other sciences and the humanities and social sciences. On-going developments in the field will be included. The editors have introduced new topics, including discussions of Vygotsky's ideas in relation to those of Piaget, of science education research progress since 1978, of constructivist learning theory applied to educational computer games and of applications from anthropology to zoology. These materials are especially relevant for consideration by current university faculty in all subjects.

Author : Olasehinde Owoseni
Publisher : BoD – Books on Demand
Page : 168 pages
File Size : 43,7 Mb
Release : 2024-01-17
Category : Technology & Engineering
ISBN : 9781837687060

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Surfactants by Olasehinde Owoseni Pdf

This book presents detailed fundamentals of surfactant systems and links these fundamentals to emerging perspectives in the field of surfactant science. Key topics include environmentally friendly surfactants, ionic liquid-based surfactants, chemically enhanced oil recovery, synergy of surfactants with clay minerals, and reactions in microheterogeneous surfactant systems. This book is an excellent resource for students, researchers, and industry professionals.

Author : Zahid Amjad
Publisher : Springer Science & Business Media
Page : 261 pages
File Size : 43,6 Mb
Release : 2007-05-08
Category : Technology & Engineering
ISBN : 9780306469152

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Water Soluble Polymers by Zahid Amjad Pdf

This volume contains a series of papers originally presented at the symposium on Water Soluble Polymers: Solution Properties and Applications, sponsored by the Division of Colloids and Surface Chemistry of the American Chemical Society. The symposium took place in Las Vegas City, Nevada on 9 to 11th September, 1997 at the 214th American Chemical Society National Meeting. Recognized experts in their - spective fields were invited to speak. There was a strong attendance from academia, g- ernment, and industrial research centers. The purpose of the symposium was to present and discuss recent developments in the solution properties of water soluble polymers and their applications in aqueous systems. Water soluble polymers find applications in a number of fields of which the following may be worth mentioning: cosmetics, detergent, oral care, industrial water treatment, g- thermal, wastewater treatment, water purification and reuse, pulp and paper production, sugar refining, and many more. Moreover, water soluble polymers play vital role in the oil industry, especially in enhanced oil recovery. Water soluble polymers are also used in ag- culture and controlled release pharmaceutical applications. Therefore, a fundamental kno- edge of solution properties of these polymers is essential for most industrial scientists. An understanding of the basic phenomena involved in the application of these polymers, such as adsorption and interaction with different substrates (i. e. , tooth enamel, hair, reverse - mosis membrane, heat exchanger surfaces, etc. ) is of vital importance in developing high performance formulations for achieving optimum efficiency of the system.

Author : Stephen R. Byrn,George Zografi,Xiaoming (Sean) Chen
Publisher : John Wiley & Sons
Page : 420 pages
File Size : 43,5 Mb
Release : 2017-08-28
Category : Science
ISBN : 9781118145302

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Solid-State Properties of Pharmaceutical Materials by Stephen R. Byrn,George Zografi,Xiaoming (Sean) Chen Pdf

Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time

Author : Robert O. Williams III,Alan B. Watts,Dave A. Miller
Publisher : Springer Science & Business Media
Page : 656 pages
File Size : 44,9 Mb
Release : 2011-12-04
Category : Medical
ISBN : 9781461411444

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Formulating Poorly Water Soluble Drugs by Robert O. Williams III,Alan B. Watts,Dave A. Miller Pdf

This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds. Further, this book is designed to provide practical guidance for overcoming formulation challenges toward the end goal of improving drug therapies with poorly water-soluble drugs. Enhancing solubility via formulation intervention is a unique opportunity in which formulation scientists can enable drug therapies by creating viable medicines from seemingly undeliverable molecules. With the ever increasing number of poorly water-soluble compounds entering development, the role of the formulation scientist is growing in importance. Also, knowledge of the advanced analytical, formulation, and process technologies as well as specific regulatory considerations related to the formulation of these compounds is increasing in value. Ideally, this book will serve as a useful tool in the education of current and future generations of scientists, and in this context contribute toward providing patients with new and better medicines.

Author : Amit Kumar Nayak,Kalyan Kumar Sen
Publisher : Elsevier
Page : 759 pages
File Size : 43,8 Mb
Release : 2023-12-09
Category : Medical
ISBN : 9780323972468

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Dosage Forms, Formulation Developments and Regulations by Amit Kumar Nayak,Kalyan Kumar Sen Pdf

Dosage Forms, Formulation Developments and Regulations, Volume One in the Recent and Future Trends in Pharmaceutics series, explores aspects of pharmaceutics, with an original approach focused on technology, novelties and future trends in the field. The book discusses the most recent developments in pharmaceutical preformulation and formulation studies, biopharmaceutics and novel pharmaceutical formulations, regulatory affairs, and good manufacturing practices. Exciting areas such as formulation strategies, optimization techniques, the biopharmaceutical classification system, and pharmaceutical aerosols are included. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day, so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. This is an essential reference for researchers in academia and industry as well as advanced graduate students in pharmaceutics. Examines trends and recent technologies in dosage, formulation and regulation Contains contributions from leading experts in academia, research, industry and regulatory agencies Includes high-quality illustrations, flow charts and tables for easy understanding of concepts Discusses practical examples and research case studies