Drug Delivery Systems Of Phytochemicals As Therapeutic Strategies In Cancer Therapy

Author : Akhileshwar Kumar Srivastava,Divya Singh,Rajesh Kumar Singh
Publisher : Elsevier
Page : 266 pages
File Size : 40,6 Mb
Release : 2023-11-07
Category : Science
ISBN : 9780443159619

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Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy by Akhileshwar Kumar Srivastava,Divya Singh,Rajesh Kumar Singh Pdf

Phytochemicals and derivatives have become promising alternatives to increase treatment potential in cancer patients with minimal side effects. Drug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various routes/methods to deliver phytochemicals for overcoming the problems associated with delivery system in cancer treatment. Several nanotechnological methods are followed to enhance drug solubility, sustainability, bioavailability and gastrointestinal permeability of these phytochemicals. The advanced field of drug-delivery systems explains that combination therapy for cancer treatment has important benefits over mono-delivery therapeutics. Natural compounds, because of their biobased origin, have drawn higher attention than synthetic drugs. Synthesis of nano-phytomedicines has impacted the bioavailability of phytochemicals. Novel formulations have been synthesized loaded with phytochemicals and have revealed extraordinary results in treatment of various cancers. Current understanding of the relevant information presented in Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy fulfils the requirements of oncologists, molecular biologists, pharmacologist and related researchers, who want to work in the areas of drug development targeting phytochemicals for cancer therapy Explains the significance of phytochemicals in cancer therapy, along with their pharmacologic action Elucidates the importance of various phytochemicals in cancer therapy Explains the emerging need of drug-delivery system for plant metabolites Deciphers the various drug-delivery systems for phytomedicines involved in cancer treatments Describes the crucial role of nanotechnology in the development of drug-delivery systems for anticancer phytochemicals Explores the challenges associated with developing drug-delivery systems for phytochemicals to cure cancer

Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Page : 572 pages
File Size : 44,8 Mb
Release : 2021-06-24
Category : Business & Economics
ISBN : 9780323900799

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Advanced Drug Delivery Systems in the Management of Cancer by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone Pdf

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Author : Dennis M. Brown
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 44,6 Mb
Release : 2003-09-08
Category : Medical
ISBN : 9781592594276

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Drug Delivery Systems in Cancer Therapy by Dennis M. Brown Pdf

Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Author : You Han Bae,Randall J. Mrsny,Kinam Park
Publisher : Springer Science & Business Media
Page : 717 pages
File Size : 43,6 Mb
Release : 2013-08-31
Category : Medical
ISBN : 9781461478768

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Cancer Targeted Drug Delivery by You Han Bae,Randall J. Mrsny,Kinam Park Pdf

This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.

Author : PRIYANKA. KRIPLANI
Publisher : Unknown
Page : 0 pages
File Size : 45,8 Mb
Release : 2023-11-30
Category : Electronic
ISBN : 9798891131330

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Current Therapeutic Strategies for the Management of Cancer by PRIYANKA. KRIPLANI Pdf

Cancer is a leading cause of death worldwide, and the efficacy of cancer drugs is often limited due to poor bioavailability and drug resistance. Traditional treatment strategies, such as surgery, chemotherapy, radiotherapy, immunotherapy, and combinational regimens, are associated with side effects and fail to deliver an adequate amount of the drug to the target site. Chemotherapy has paved the way for novel drug delivery systems in cancer treatment, enhancing efficacy, patient compliance and reducing side effects by specifically targeting the site of action. These novel drug delivery systems employ various drug delivery systems such as nanoparticles, liposomes, niosomes, transferosomes, transdermal drug delivery systems, intranasal drug delivery systems, and others to improve drug solubility, stability, and controlled release patterns. The application of novel drug delivery systems in chemoimmunotherapy has become a hotspot in cancer treatment, and this book explores the potential of gene therapy alongside recent patents on anticancer formulations. The discussion also extends to clinical trials, which are crucial for validating these novel approaches and ensuring that effective treatments reach patients. The initial chapters provide an overview of current therapeutic approaches, while subsequent chapters focus on the role of nanotechnology in cancer treatment, emphasizing various nanoparticle-based formulations. Liposomes, transdermal drug delivery systems, microsomes, phytosomes, niosomes, intranasal drug delivery systems, and gene-drug delivery systems for cancer therapy are also discussed. Furthermore, the book addresses novel drug delivery systems, patents, and ongoing clinical trials, offering valuable insights for researchers, academicians, and scientists working towards advancements in the therapeutic management of cancer.

Author : Ho John Wing Shing
Publisher : World Scientific
Page : 172 pages
File Size : 43,9 Mb
Release : 2019-04-23
Category : Medical
ISBN : 9789814525640

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Naturally Occurring Small Molecules For Disease And Cancer Treatment: Therapeutic Benefits In Combination Therapy by Ho John Wing Shing Pdf

Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.

Author : Lesheng Teng,Zhaogang Yang,Chong Li
Publisher : Springer
Page : 0 pages
File Size : 51,9 Mb
Release : 2023-06-13
Category : Medical
ISBN : 981198929X

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Drug Delivery to Tumors by Lesheng Teng,Zhaogang Yang,Chong Li Pdf

This book summarizes emerging drug delivery strategies and new technologies for cancer treatment from the perspective of cancer pathology, including immunotherapy strategies, biomimetic drug delivery strategies, live cell drug delivery strategies, nanocrystal technology and 3D Printing technology, etc. With the development of related fields such as pharmaceutical science, materials science and nanomedicine, drug delivery systems have made significant progress in the treatment of cancer. With the in-depth study of different types of drug delivery systems, clinical transformation will be necessary. Some clinical trials have proved the obvious advantages of drug delivery vehicles in anti-cancer treatment. However, the characterization of nanomaterials, safety issues and production issues limit the application. Importantly, accurate in vitro and in vivo models are needed to predict the therapeutic effect of drug delivery systems in the clinic. The drug delivery system has been continuously innovated and improved in cancer treatment, and has broad application prospects.

Author : Hala Gali-Muhtasib,Racha Chouaib
Publisher : Unknown
Page : 0 pages
File Size : 53,7 Mb
Release : 2020-03-19
Category : Cancer
ISBN : 9814800546

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Nanoparticle Drug Delivery Systems for Cancer Treatment by Hala Gali-Muhtasib,Racha Chouaib Pdf

In recent years, nanoparticles--bionanomaterials with specific physicochemical properties--have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.

Author : Rama Rao Malla,Ganji Purnachandra Nagaraju
Publisher : Academic Press
Page : 320 pages
File Size : 45,8 Mb
Release : 2020-11-06
Category : Science
ISBN : 9780128226926

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A Theranostic and Precision Medicine Approach for Female-Specific Cancers by Rama Rao Malla,Ganji Purnachandra Nagaraju Pdf

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Author : Alexandru Grumezescu
Publisher : William Andrew
Page : 0 pages
File Size : 50,9 Mb
Release : 2016-05-30
Category : Technology & Engineering
ISBN : 9780323428637

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Nanobiomaterials in Cancer Therapy by Alexandru Grumezescu Pdf

Nanobiomaterials in Cancer Therapy

Author : Mohd Adnan,Mitesh Patel,Visweswara Rao Pasupuleti
Publisher : Frontiers Media SA
Page : 263 pages
File Size : 41,6 Mb
Release : 2023-11-24
Category : Science
ISBN : 9782832539583

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Evolution of Phytochemicals and Phytotherapies in the Treatment and Management of Cancer: Targeted Strategies in Cancer Precision Medicine by Mohd Adnan,Mitesh Patel,Visweswara Rao Pasupuleti Pdf

There is a rising recurrence of cancers in humans and related complications of chemotherapeutic agents that reduce the clinical potency of numerous anticancer agents, including those which are currently in use. Hence, there is a consistent need for the development of alternative or synergistic anticancer drugs with lower side complications. One imperative approach to develop novel anticancer agents with potent efficiency is to discover natural resource-derived bioactive compounds. Diverse phytochemical constituents (like vincristine, vinblastine, taxol analogs etc.) derived from plants have been manifested as effective therapeutics in the treatment, prevention and management of cancer. Therefore, phytochemical constituents aid as prime source and candidates for the discovery of anticancer drugs, particularly when they are screened against their molecular targets via various approaches. Plants are predicted to have innumerable functional phytochemical constituents with potent features, which can be explored via in silico, in vitro as well as in vivo approaches for targeted cancer therapy and the most suitable cascade can be identified. Therefore, this research topic aims to cover the current trends and advancements in phytotherapies with an emphasis on targeted strategies in cancer precision medicine.

Author : Chi Hin Cho,Tao Hu
Publisher : Academic Press
Page : 242 pages
File Size : 42,5 Mb
Release : 2020-05-24
Category : Science
ISBN : 9780128199381

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Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies by Chi Hin Cho,Tao Hu Pdf

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Author : Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan
Publisher : Academic Press
Page : 657 pages
File Size : 47,5 Mb
Release : 2020-04-07
Category : Business & Economics
ISBN : 9780128199183

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Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents by Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan Pdf

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives

Author : Inderbir Singh Bakshi,Rajni Bala,Reecha Madaan,Rakesh K. Sindhu
Publisher : Academic Press
Page : 495 pages
File Size : 47,9 Mb
Release : 2022-03-13
Category : Business & Economics
ISBN : 9780323859103

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Herbal Bioactive-Based Drug Delivery Systems by Inderbir Singh Bakshi,Rajni Bala,Reecha Madaan,Rakesh K. Sindhu Pdf

Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments. Explores standardization, regulation and enhancement issues in herbal bioactives Discusses novel developments, herbal cosmetics and toxicity/interaction issues Provides a comprehensive reference on all aspects of herbal bioactives

Author : Zodwa Dlamini
Publisher : Springer Nature
Page : 390 pages
File Size : 42,7 Mb
Release : 2024-06-30
Category : Electronic
ISBN : 9783031528606

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Overcoming Breast Cancer Therapy Resistance by Zodwa Dlamini Pdf