Drug Device Combinations For Chronic Diseases

Author : SuPing Lyu,Ronald Siegel
Publisher : John Wiley & Sons
Page : 280 pages
File Size : 42,9 Mb
Release : 2015-11-04
Category : Technology & Engineering
ISBN : 9781119003007

Get Book

Drug-device Combinations for Chronic Diseases by SuPing Lyu,Ronald Siegel Pdf

This book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice. The book: Discusses where drugs and devices work, where they fail, and when they need to work with each other Reviews interactions between human bodies and the drug-device combination products the measurements of these interactions Covers how a drug-device combination product is developed, tested, and regulated Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes

Author : SuPing Lyu,Ronald Alan Siegel
Publisher : Unknown
Page : 128 pages
File Size : 51,8 Mb
Release : 2016
Category : MEDICAL
ISBN : 1119002958

Get Book

Drug-device Combinations for Chronic Diseases by SuPing Lyu,Ronald Alan Siegel Pdf

Author : Institute of Medicine,Committee on Technological Innovation in Medicine
Publisher : National Academies Press
Page : 241 pages
File Size : 53,8 Mb
Release : 1990-02-01
Category : Medical
ISBN : 9780309042864

Get Book

Modern Methods of Clinical Investigation by Institute of Medicine,Committee on Technological Innovation in Medicine Pdf

The very rapid pace of advances in biomedical research promises us a wide range of new drugs, medical devices, and clinical procedures. The extent to which these discoveries will benefit the public, however, depends in large part on the methods we choose for developing and testing them. Modern Methods of Clinical Investigation focuses on strategies for clinical evaluation and their role in uncovering the actual benefits and risks of medical innovation. Essays explore differences in our current systems for evaluating drugs, medical devices, and clinical procedures; health insurance databases as a tool for assessing treatment outcomes; the role of the medical profession, the Food and Drug Administration, and industry in stimulating the use of evaluative methods; and more. This book will be of special interest to policymakers, regulators, executives in the medical industry, clinical researchers, and physicians.

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Accelerating Rare Diseases Research and Orphan Product Development
Publisher : National Academies Press
Page : 442 pages
File Size : 45,6 Mb
Release : 2011-04-03
Category : Medical
ISBN : 9780309158060

Get Book

Rare Diseases and Orphan Products by Institute of Medicine,Board on Health Sciences Policy,Committee on Accelerating Rare Diseases Research and Orphan Product Development Pdf

Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Author : Mary Beth Privitera
Publisher : Academic Press
Page : 371 pages
File Size : 44,9 Mb
Release : 2019-06-15
Category : Science
ISBN : 9780128161647

Get Book

Applied Human Factors in Medical Device Design by Mary Beth Privitera Pdf

Applied Human Factors in Medical Device Design describes the contents of a human factors toolbox with in-depth descriptions of both empirical and analytical methodologies. The book begins with an overview of the design control process, integrating human factors as directed by AAMI TIR 59 and experienced practice. It then explains each method, describing why each method is important, its potential impact, when it's ideal to use, and related challenges. Also discussed are other barriers, such as communication breakdowns between users and design teams. This book is an excellent reference for professionals working in human factors, design, engineering, marketing and regulation. Focuses on meeting agency requirements as it pertains to the application of human factors in the medical device development process in both the US and the European Union (EU) Explains technology development and the application of human factors throughout the development process Covers FDA and MHRA regulations Includes case examples with each method

Author : Jinjiang Li,Mary E. Krause,Raymond Tu
Publisher : Springer Nature
Page : 338 pages
File Size : 49,6 Mb
Release : 2021-02-12
Category : Medical
ISBN : 9783030571771

Get Book

Protein Instability at Interfaces During Drug Product Development by Jinjiang Li,Mary E. Krause,Raymond Tu Pdf

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

Author : Milica S. Prostran,Francisco R. Nieto,Sonja Maksim Vuckovic
Publisher : Frontiers Media SA
Page : 297 pages
File Size : 54,6 Mb
Release : 2020-12-03
Category : Science
ISBN : 9782889639472

Get Book

Mechanisms and New Targets for the Treatment of Chronic Pain by Milica S. Prostran,Francisco R. Nieto,Sonja Maksim Vuckovic Pdf

Acute pain has a physiological protective role in preventing tissue damage. However, pain can become chronic due to a multitude of pathophysiological states, such as: trauma, inflammation, neural injury, viral infection, cancer, autoimmune diseases and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes persistent and debilitating affecting seriously to the quality of life of patients. Chronic pain is one of the most important health problems worldwide. It has been estimated that 10% of adults are diagnosed with chronic pain each year. However, despite the high prevalence of chronic pain, its management is still no fully satisfactory probably due to the variety of chronic pain conditions with different etiologies (neuropathic, visceral and musculoskeletal pain), and because their pathophysiological mechanisms are only partially known. Therefore, there is a huge need for new effective therapies for the control and/or prevention of the different types of chronic pain. Chronic pain is associated with plastic changes in pain circuits of the peripheral and central nervous system, including changes in the expression of ion channels, neurotransmitters and receptors. In addition, there is growing consensus on non-neuronal mechanisms that can amplify or resolve chronic pain, and cells traditionally thought to act just as coordinators of the inflammatory response (such as immune and glial cells) are now accepted as real modulators of pain signaling. In this regard, animal models of persistent pain, such as models of neuropathic and visceral pain and models of arthritis, are helping to elucidate our understanding of the pathogenesis of chronic pain and make it possible to test experimental treatments.

Author : Andrew Lewis
Publisher : Elsevier
Page : 560 pages
File Size : 55,9 Mb
Release : 2009-12-15
Category : Medical
ISBN : 9781845697488

Get Book

Drug-Device Combination Products by Andrew Lewis Pdf

Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive novel product development. Advanced drug delivery devices can offer significant advantages over conventional drugs and devices alone, such as increased efficiency, improved performance and convenience. The purpose of this book is to illustrate how effective drug delivery can be achieved by means other than tablets. The book will provide a thorough analysis of the fundamentals, applications and new technologies of drug-device combination products for use throughout the human body. Part one provides readers with an introduction and background to the field. Chapters in Part two discuss areas of application such as catheter based products, drug eluting stents and beads and anti-biotic loaded cements. Part three covers the development of drug device combination products with chapters on such topics as pre-clinical testing, sterilisation, patent issues and regulation of drug device combination products. With its distinguished editor and team of international contributors, Drug-device combination products: delivery technologies and applications is an invaluable reference for product development specialists, materials scientists and engineers in the biomedical industry and academia as well as those concerned with drug delivery. Illustrates how effective drug delivery can be achieved by means other than tablets providing readers with a comprehensive introduction and background to the field Provides a thorough analysis of the fundamentals, applications and new technologies of drug device combination products Discusses areas of application such as catheter based products and reviews the development of drug device combination products including pre-clinical testing and sterilisation

Author : World Health Organization
Publisher : World Health Organization
Page : 147 pages
File Size : 53,9 Mb
Release : 2010
Category : Medical
ISBN : 9789241564045

Get Book

Medical Devices by World Health Organization Pdf

Background papers 1 to 9 published as technical documents. Available in separate records from WHO/HSS/EHT/DIM/10.1 to WHO/HSS/EHT/DIM/10.9

Author : Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Page : 4865 pages
File Size : 44,5 Mb
Release : 2017-05-18
Category : Technology & Engineering
ISBN : 9780081006924

Get Book

Comprehensive Biomaterials II by Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick Pdf

Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Author : Tapan Behl,Sukhbir Singh,Neelam Sharma
Publisher : Elsevier
Page : 524 pages
File Size : 51,6 Mb
Release : 2024-01-26
Category : Computers
ISBN : 9780443135880

Get Book

Targeting Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases by Tapan Behl,Sukhbir Singh,Neelam Sharma Pdf

Targeting Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases presents recent advances in the vivid molecular pathways targeting angiogenesis, inflammation and oxidative stress that contribute very widely to the genesis of chronic diseases. The books will also highlight the drugs from natural and synthetic origin in the management/prevention/treatment of diseases along with the drug delivery approaches. The book’s authors from various key institutions around the globe will deliver well-structured and well-designed chapters. The systematic presented information and knowledge will surely aid consistency and continuity. The multifaceted book is enriched with deep scientific contents. Each chapter will clearly define the facts, emerging role of molecular pathways and the targets and focus will be imparted on key challenges associated and the future directions that will provide torch bearer thing for the researchers to explore new targets in the domain. Focuses on the pathogenesis of the disease, along with the molecular mechanism of action Includes updates on strategic design/delivery of drugs targeting angiogenesis, inflammation, and oxidative stress Provides recent advancements in the field of pathogenesis of chronic diseases

Author : National Research Council,Division of Behavioral and Social Sciences and Education,Committee on Human-Systems Integration,Committee on the Role of Human Factors in Home Health Care
Publisher : National Academies Press
Page : 322 pages
File Size : 46,8 Mb
Release : 2010-11-14
Category : Medical
ISBN : 9780309156295

Get Book

The Role of Human Factors in Home Health Care by National Research Council,Division of Behavioral and Social Sciences and Education,Committee on Human-Systems Integration,Committee on the Role of Human Factors in Home Health Care Pdf

The rapid growth of home health care has raised many unsolved issues and will have consequences that are far too broad for any one group to analyze in their entirety. Yet a major influence on the safety, quality, and effectiveness of home health care will be the set of issues encompassed by the field of human factors research-the discipline of applying what is known about human capabilities and limitations to the design of products, processes, systems, and work environments. To address these challenges, the National Research Council began a multidisciplinary study to examine a diverse range of behavioral and human factors issues resulting from the increasing migration of medical devices, technologies, and care practices into the home. Its goal is to lay the groundwork for a thorough integration of human factors research with the design and implementation of home health care devices, technologies, and practices. On October 1 and 2, 2009, a group of human factors and other experts met to consider a diverse range of behavioral and human factors issues associated with the increasing migration of medical devices, technologies, and care practices into the home. This book is a summary of that workshop, representing the culmination of the first phase of the study.

Author : Peter G. Smith,R. H. Morrow,Richard H. Morrow,David A. Ross
Publisher : Oxford University Press, USA
Page : 479 pages
File Size : 42,6 Mb
Release : 2015
Category : Medical
ISBN : 9780198732860

Get Book

Field Trials of Health Interventions by Peter G. Smith,R. H. Morrow,Richard H. Morrow,David A. Ross Pdf

"IEA, International Epidemiological Association, Welcome Trust."

Author : Agency for Healthcare Research and Quality/AHRQ
Publisher : Government Printing Office
Page : 396 pages
File Size : 43,7 Mb
Release : 2014-04-01
Category : Medical
ISBN : 9781587634338

Get Book

Registries for Evaluating Patient Outcomes by Agency for Healthcare Research and Quality/AHRQ Pdf

This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Author : Witold Abramowicz,Sören Auer,Milena Stróżyna
Publisher : Springer Nature
Page : 389 pages
File Size : 55,7 Mb
Release : 2022-04-05
Category : Computers
ISBN : 9783031042164

Get Book

Business Information Systems Workshops by Witold Abramowicz,Sören Auer,Milena Stróżyna Pdf

This book constitutes revised papers from the eight workshops which were held during June 2021 at the 24th International Conference on Business Information Systems, BIS 2021. The conference was planned to take place in Hannover, Germany, and changed to a fully online event due to the COVID-19 pandemic. There was a total of 67 submissions to all workshops of which 31papers were accepted for publication. The workshops included in this volume are: AKTB 2021: 12th Workshop on Applications of Knowledge-Based Technologies in Business BisEd 2021: BIS Education: Trends and Challenges DigBD 2021: 1st Workshop on Digitization in the Flux of Big Data Scenarios DigEx 2021: 3rd International Workshop on transforming the Digital Customer Experience iCRM 2021: 6th International Workshop on Integrated Social CRM QOD 2021: 4th Workshop on Quality of Open Data BITA 2021: 12th Workshop on Business and IT Alignment BSCT 2021: 4th Workshop on Blockchain and Smart Contract Technologies