Drug Discovery And Traditional Chinese Medicine

Author : Yuan Lin,Joseph M. Betz,Jasjit S. Bindra,Steven C. Bobzin
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461514558

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Drug Discovery and Traditional Chinese Medicine by Yuan Lin,Joseph M. Betz,Jasjit S. Bindra,Steven C. Bobzin Pdf

The "First International Conference on Traditional Chinese Medicine: Science, Regulation and Globalization" was held from August 30 to September 2, 2000 at the University of Maryland at College Park, Maryland. There were approximately 250 participants from the Peoples Republic of China, Taiwan, Hong Kong and the United States. This objective of this conference was to promote international collaboration for the modernization of Traditional Chinese herbal medicines (TCM) and their introduction into the global health care system. It was mainly sponsored by the Ministry of Science and Technology of the People's Republic of China and the NllI National Center for Complementary and Alternative Medicine (NCCAM). It was organized by Dr. William Tai, then director of the Institute of Global Chinese Affairs at the University of Maryland and Dr. Yuan Lin, president of Marco Polo Technologies, Bethesda, MD. This conference was conceived by Dr. Tai two years earlier recognizing that this was an appropriate time and also the unique location of the University of Maryland. Today, there is a growing recognition of the of alternative medicine in modem societies and the rapid loss of importance knowledge about traditional methods for the treatment of the multitude of human illnesses found throughout the world. TCM has been in common use in China for thousands of years; and many of its formulations are well defined.

Author : James D Adams,Eric J Lien
Publisher : Royal Society of Chemistry
Page : 349 pages
File Size : 55,9 Mb
Release : 2015-10-20
Category : Science
ISBN : 9781782624936

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Traditional Chinese Medicine by James D Adams,Eric J Lien Pdf

Traditional Chinese medicine has a strong scientific basis, but the science of these important preparations is often rarely discussed. Western approaches often simplify traditional Chinese medicine to drug discovery in Chinese plants, however, the majority of traditional Chinese medications use complex mixtures of plant extracts, rather than single purified drugs. The combination of different extracts is based on yin, yang and chi theories, which are often poorly understood in the West. Yin and yang are known to be the balance of agonists and antagonists, whereas chi derives from signalling processes in the body and regulates bodily functions. Traditional Chinese medical practitioners understand that yin, yang and chi constantly interact in the body to maintain health. Western medical practitioners understand how to use agonists and antagonists and how to modify signalling processes, but generally do not accept the use of complex plant extracts to perform these functions. Aimed at medical scientists, and including detailed explanations of the theories behind the science, this text may help researchers to understand, and communicate more effectively with, Chinese medical practitioners and will lead to greater acceptance of traditional medications in the West. Presenting a clear rationale for the use of traditional Chinese medications in Western medical facilities, it enables scientists to find new directions in experimental design and encourage examination of these useful, but often poorly understood, preparations in clinical trials.

Author : Hildebert Wagner,Gudrun Ulrich-Merzenich
Publisher : Springer Science & Business Media
Page : 532 pages
File Size : 50,8 Mb
Release : 2013-02-11
Category : Medical
ISBN : 9783709104422

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Evidence and Rational Based Research on Chinese Drugs by Hildebert Wagner,Gudrun Ulrich-Merzenich Pdf

After the successful introduction of acupuncture to the West, recent advances in analytical methods in chemistry, molecular biology and systems biology – especially the development of the “omic” technologies – have again brought Chinese drugs into the focus of research on Traditional Chinese Medicine (TCM). With more than 1000 publications on the chemistry, molecular biology and pharmacology of TCM drugs in international journals over the last 10 years, Chinese drugs are gaining increasingly reputation and impact. These data offer great opportunities for the development of new pharmaceuticals for various clinical applications. International scientists have compiled relevant and trend setting research results in this book. Topics range from the latest methods of quality and safety assurance by chemical and genetic fingerprints to the development of new pharmaceuticals for a future evidence-based therapy e.g. for cancer, cardiovascular, inflammatory or infectious diseases as well as to recent experimental results on multitarget and synergy research for the preparation of multi-extract-pharmaceuticals from TCM.

Author : Xijun Wang,Aihua Zhang,Hui Sun
Publisher : Academic Press
Page : 408 pages
File Size : 50,6 Mb
Release : 2015-07-15
Category : Medical
ISBN : 9780128031186

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Chinmedomics by Xijun Wang,Aihua Zhang,Hui Sun Pdf

Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications Edited by the leading experts of research related to Chinmedomics

Author : Guoan Luo,Yiming Wang,Qionglin Liang,Qingfei Liu
Publisher : John Wiley & Sons
Page : 518 pages
File Size : 52,5 Mb
Release : 2012-07-03
Category : Science
ISBN : 9780470637975

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Systems Biology for Traditional Chinese Medicine by Guoan Luo,Yiming Wang,Qionglin Liang,Qingfei Liu Pdf

The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.

Author : Xijun Wang,Aihua Zhang,Hui Sun
Publisher : Academic Press
Page : 378 pages
File Size : 43,8 Mb
Release : 2016-12-27
Category : Medical
ISBN : 9780128111482

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Serum Pharmacochemistry of Traditional Chinese Medicine by Xijun Wang,Aihua Zhang,Hui Sun Pdf

Serum Pharmacochemistry of Traditional Chinese Medicine: Technologies, Strategies and Applications provides a valuable and indispensable guide on the latest methods, research advances, and applications in this area. Chapters offer cutting-edge information on pharmacokinetics and pharmacodynamics, analytical chemistry, traditional medicine, natural products, bioinformatics, new technologies, therapeutic applications, and more. For researchers and students in academia and industry, this book provides a hands-on description of experimental techniques, along with beneficial guidelines to help advance research in the fields of Traditional Chinese Medicine and drug development. Provides a valuable guide for practitioners of serum pharmacochemistry of Traditional Chinese Medicine, along with insights to its current use and future applications Edited and written by leading scientists at the forefront of this research Presents well written chapters that include an introduction, description of the method, and identification of chemical constituents, with applications and references to the latest research and literature

Author : Zhaohui Wu,Huajun Chen,Xiaohong Jiang
Publisher : Elsevier
Page : 253 pages
File Size : 51,5 Mb
Release : 2012-07-16
Category : Computers
ISBN : 9780123985101

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Modern Computational Approaches to Traditional Chinese Medicine by Zhaohui Wu,Huajun Chen,Xiaohong Jiang Pdf

Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM's independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists Introduces novel network technologies to Traditional Chinese Medicine informatics Provides theory and practical examples and case studies of new techniques

Author : Shao Li,Yuanjia Hu,Shi-Bing Su
Publisher : Frontiers Media SA
Page : 438 pages
File Size : 52,8 Mb
Release : 2020-10-08
Category : Medical
ISBN : 9782889660407

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Network Pharmacology and Traditional Medicine by Shao Li,Yuanjia Hu,Shi-Bing Su Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Leung Ping-chung
Publisher : World Scientific
Page : 264 pages
File Size : 46,9 Mb
Release : 2017-06-02
Category : Medical
ISBN : 9789813200357

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From Ayurveda To Chinese Medicine by Leung Ping-chung Pdf

This unique book presents the differences and similarities of the oldest system of health care. All ancient medicine has strong philosophical background and management varieties related to treatment activities. Ayurveda is one such branch of medicine that is strongly linked to Yoga and traditional Chinese medicine including activities related to Martial Arts and Acupuncture. This book successfully merges Ayurveda with Chinese medicine thereby enhancing the understanding of the two systems.

Author : Zhen'guo Wang,Ping Chen,Peiping Xie
Publisher : IOS Press
Page : 332 pages
File Size : 53,9 Mb
Release : 1999
Category : Medicine
ISBN : 7030065670

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History and Development of Traditional Chinese Medicine by Zhen'guo Wang,Ping Chen,Peiping Xie Pdf

Author : Nancy Mulford,Carol Sussman
Publisher : Unknown
Page : 356 pages
File Size : 47,8 Mb
Release : 1995
Category : Natural products
ISBN : UCSD:31822023768492

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Natural Products by Nancy Mulford,Carol Sussman Pdf

Author : David Yue-Wei Lee,Kai-Shun Bi,Ronghua Dai,Gerald T. Pollard
Publisher : Elsevier
Page : 0 pages
File Size : 50,9 Mb
Release : 2016-09-01
Category : Science
ISBN : 0128051612

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Methods and Advances in Traditional Chinese Medicine by David Yue-Wei Lee,Kai-Shun Bi,Ronghua Dai,Gerald T. Pollard Pdf

A new volume in the Emerging Issues in Analytical Chemistry series, Methods and Advances in Traditional Chinese Medicine describes analytical chemistry methods used to characterize constituents of herbal remedies, explore their mechanisms of action singly and in concert, and support the clinical trials necessary to bring Traditional Chinese Medicine (TCM) into the mainstream of therapeutics. With recent advances in analytical instruments, molecular pharmacology, and genetics, it is now possible to investigate the bioactive molecules in a complex medicine on a rational basis. This book is the first to combine TCM with analytical chemistry methods toward this goal. The book begins with a brief history of TCM, consideration of its strengths and weaknesses, and a review of the literature on application of Western analytical methods. It continues with an examination of the concept of synergistic, multi-targeted action among components, followed by an analysis of how analytical chemistry and other methods are used to assure quality and uniformity of natural products within tolerable limits. It then addresses the complexity introduced by absorption, distribution, and metabolism of an already complex drug. The last chapter advocates a system biological approach as the way forward for drug discovery and development in TCM. The Emerging Issues in Analytical Chemistry series is published in partnership with RTI International and edited by Brian F. Thomas. Please be sure to check out our other featured volumes: Thomas, Brian F. and ElSohly, Mahmoud. The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations, 9780128046463, December 2015. Hackney, Anthony C. Exercise, Sport, and Bioanalytical Chemistry: Principles and Practice, 9780128092064, March 2016. Tanna, Sangeeta and Lawson, Graham. Analytical Chemistry for Assessing Medication Adherence, 9780128054635, April 2016. Rao, Vikram, Knight, Rob, and Stoner, Brian. Sustainable Shale Oil and Gas: Analytical Chemistry, Biochemistry, and Geochemistry Methods, 9780128103890, forthcoming September 2016. Farsalinos, Konstantinos, et al. Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles, 9780128112410, forthcoming November 2016.

Author : Henry H. Sun,Jingyan Meng,Kaijing Yan
Publisher : Cambridge Scholars Publishing
Page : 700 pages
File Size : 49,9 Mb
Release : 2020-11-17
Category : Medical
ISBN : 9781527562356

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The Book of Chinese Medicine, Volume 2 by Henry H. Sun,Jingyan Meng,Kaijing Yan Pdf

This second volume offers numerous approaches to using Chinese medicine for the prevention and treatment of various diseases in medical practice. It brings the concepts and theories learned in the first volume and applies them in clinical settings with real patient examples. It goes over the four natures and five flavors of herbal drugs, and covers the different techniques of acupuncture. The book considers how the advancements in modern technology have shaped Traditional Chinese Medicine (TCM), and discusses the revolutionary innovations that are occurring in the Chinese medicine industry today and how they will shape the future.

Author : Nianping Feng,Zhijun Yang
Publisher : Springer Nature
Page : 342 pages
File Size : 55,6 Mb
Release : 2021-12-01
Category : Medical
ISBN : 9789811634444

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Novel Drug Delivery Systems for Chinese Medicines by Nianping Feng,Zhijun Yang Pdf

This book describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.

Author : Shein-Chung Chow
Publisher : CRC Press
Page : 430 pages
File Size : 46,7 Mb
Release : 2015-12-01
Category : Health & Fitness
ISBN : 9781498766883

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Quantitative Methods for Traditional Chinese Medicine Development by Shein-Chung Chow Pdf

A Western-Based Approach to Analyzing TCMs In recent years, many pharmaceutical companies and clinical research organizations have been focusing on the development of traditional Chinese (herbal) medicines (TCMs) as alternatives to treating critical or life-threatening diseases and as pathways to personalized medicine. Quantitative Methods for Traditional Chinese Medicine Development is the first book entirely devoted to the design and analysis of TCM development from a Western perspective, i.e., evidence-based clinical research and development. The book provides not only a comprehensive summary of innovative quantitative methods for developing TCMs but also a useful desk reference for principal investigators involved in personalized medicine. Written by one of the world’s most prominent biostatistics researchers, the book connects the pharmaceutical industry, regulatory agencies, and academia. It presents a state-of-the-art examination of the subject for: Scientists and researchers who are engaged in pharmaceutical/clinical research and development of TCMs Those in regulatory agencies who make decisions in the review and approval process of TCM regulatory submissions Biostatisticians who provide statistical support to assess clinical safety and effectiveness of TCMs and related issues regarding quality control and assurance as well as to test for consistency in the manufacturing processes for TCMs This book covers all of the statistical issues encountered at various stages of pharmaceutical/clinical development of a TCM. It explains regulatory requirements; product specifications and standards; and various statistical techniques for evaluation of TCMs, validation of diagnostic procedures, and testing consistency. It also contains an entire chapter of case studies and addresses critical issues in TCM development and FAQs from a regulatory perspective.