Drug Selectivity

Author : Norbert Handler
Publisher : John Wiley & Sons
Page : 538 pages
File Size : 41,5 Mb
Release : 2018-02-27
Category : Medical
ISBN : 9783527335381

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Drug Selectivity by Norbert Handler Pdf

The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

Author : Henri N. Doods
Publisher : Taylor & Francis Group
Page : 300 pages
File Size : 50,5 Mb
Release : 1991
Category : Medical
ISBN : UOM:39015024790985

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Receptor Data for Biological Experiments by Henri N. Doods Pdf

Provides comprehensive coverage of the most relevant knowledge on classification, localization and biological effects of receptor systems and/or enzymes.

Author : Adrien Albert
Publisher : Springer Science & Business Media
Page : 65 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400957343

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The Selectivity of Drugs by Adrien Albert Pdf

1. 1 What is Selectivity? purpose, and crop protective agent for the A biologically-active substance is said to be second, but there is no fundamental difference selective if it strongly affects certain cells with of principle in their mode of action. out causing any change in others, even when the Drug therapy has two, fundamentally two kinds of cells are close neighbours. In living opposed divisions. The first of these strives to organisms, there are many substances, often improve the action of one of the cell's natural quite small molecules, which have been chosen agents by modifying the molecule in order to for their specificity. This choice has been made localize or intensify its action. For instance, under the strong pressure of natural selection, the solubility can be decreased to make it form unhurried by any consideration of time. Such a deposit, or a change is made so that it becomes chemical compounds operate the metabolism a poorer fit on the naturally-occurring destruc of the cells and tissues, and ensure their health, tive enzyme. Both of these devices have proved survival, and reproduction. Important among useful in therapy, e. g. with steroid hormones. the smaller of these selective molecules are Such drugs, which seek to improve on Nature vitamins, coenzymes, hormones, neurotrans by performing more desirably, are called mitters, inorganic ions, nutritional fragments, agonists.

Author : Kim Neve
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 48,5 Mb
Release : 2009-02-27
Category : Medical
ISBN : 9781603273350

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Functional Selectivity of G Protein-Coupled Receptor Ligands by Kim Neve Pdf

Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.

Author : Svein G. Dahl,Lars F. Gram,Steven M. Paul,William Z. Potter
Publisher : Springer
Page : 0 pages
File Size : 40,6 Mb
Release : 2011-11-19
Category : Medical
ISBN : 3642712908

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Clinical Pharmacology in Psychiatry by Svein G. Dahl,Lars F. Gram,Steven M. Paul,William Z. Potter Pdf

The Fourth International Meeting on Clinical Pharmacology in Psychiatry was held in Bethesda, Maryland on 5-8 September 1985 and was dedicated to the memory of Dr. Earl Usdin. Earl was one of the organizers of the three previous meetings held in Chicago (1979), Troms0 (1980), and Odense (1982). During the organization of the fourth meeting Earl became ill and had to relinquish his role as one of the principal organizers. It is safe to conclude that there was no better, or more professional, or more efficient an organizer of scientific meetings in the field of neuropharmacology and psychiatry than Earl U sdin, and it was quite a task for the remaining organizers to fill the void left when he withdrew from this one. Those of us who have organized previous meetings with Earl were struck by how much more difficult our work became without him. This obviously speaks well for his subtle (and at times not so subtle) organizational skills. Nevertheless, in Earl's memory the organizers proceeded to invite a group of internationally renowned neuropsychopharmacologists to address the problem of selectivity in psychotropic drug action and to try to reconcile the amazing advances in basic preclinical neuropsychopharmacology with the problem of clinical specificity encountered by the psychiatrist.

Author : Svein G. Dahl,Lars F. Gram,Steven M. Paul,William Z. Potter
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 45,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642712883

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Clinical Pharmacology in Psychiatry by Svein G. Dahl,Lars F. Gram,Steven M. Paul,William Z. Potter Pdf

The Fourth International Meeting on Clinical Pharmacology in Psychiatry was held in Bethesda, Maryland on 5-8 September 1985 and was dedicated to the memory of Dr. Earl Usdin. Earl was one of the organizers of the three previous meetings held in Chicago (1979), Troms0 (1980), and Odense (1982). During the organization of the fourth meeting Earl became ill and had to relinquish his role as one of the principal organizers. It is safe to conclude that there was no better, or more professional, or more efficient an organizer of scientific meetings in the field of neuropharmacology and psychiatry than Earl U sdin, and it was quite a task for the remaining organizers to fill the void left when he withdrew from this one. Those of us who have organized previous meetings with Earl were struck by how much more difficult our work became without him. This obviously speaks well for his subtle (and at times not so subtle) organizational skills. Nevertheless, in Earl's memory the organizers proceeded to invite a group of internationally renowned neuropsychopharmacologists to address the problem of selectivity in psychotropic drug action and to try to reconcile the amazing advances in basic preclinical neuropsychopharmacology with the problem of clinical specificity encountered by the psychiatrist.

Author : Enrico Mihich
Publisher : Unknown
Page : 552 pages
File Size : 48,9 Mb
Release : 1973
Category : Medical
ISBN : UOM:39015003226142

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Drug Resistance and Selectivity: Biochemical and Cellular Basis by Enrico Mihich Pdf

Author : R.R. Levine,C.T. Walsh,Rochelle D. Schwartz-Bloom
Publisher : CRC Press
Page : 594 pages
File Size : 44,9 Mb
Release : 2000-04-15
Category : Medical
ISBN : 185070497X

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Pharmacology by R.R. Levine,C.T. Walsh,Rochelle D. Schwartz-Bloom Pdf

This is an updated, expanded new edition of Dr. Ruth Levine's renowned Pharmacology: Drug Actions and Reactions. It covers basic pharmacological principles and the general concepts of chemical-biological interactions and now includes important new material on molecular biology, updated clinical information, and added coverage of the newer drugs. For the sixth edition of this landmark book Dr. Levine is joined by co-authors Dr. Carol T. Walsh and Dr. Rochelle D. Schwartz-Bloom. Acclaimed for its exceptionally thorough coverage, superb presentation, and intelligent organization, the book guides you through the most elementary aspects of pharmacology to a sophisticated understanding of drug mechanisms. Each chapter contains a series of thought-provoking essay-type questions designed to test comprehension of the material in the chapter. In addition, a sufficient number of important, specific examples are included to illustrate the application of the principles. With the background provided by Pharmacology: Drug Actions and Reactions, Sixth Edition, you will be prepared to understand the actions of most individual drugs.

Author : Jordi Mestres
Publisher : Wiley-VCH
Page : 400 pages
File Size : 47,9 Mb
Release : 2013-07-10
Category : Medical
ISBN : 3527331069

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Drug Selectivity by Jordi Mestres Pdf

Author : Frank I. Tarazi,John A. Schetz
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 54,9 Mb
Release : 2005-01-11
Category : Medical
ISBN : 9781588293695

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Neurological and Psychiatric Disorders by Frank I. Tarazi,John A. Schetz Pdf

Neural principles of neurological and psychiatric disorders / Frank I. Tarazi and Marc J. Kaufman -- Pharmacotherapeutic principles of neurological and psychiatric disorders / John A. Schetz -- Alzheimer's disease / Mark P. Mattson -- Huntington's disease / Susan E. Browne -- Parkinson's disease / Thomas Wichmann -- Schizophrenia / Stephan Heckers and Sabina Berretta -- Autism spectrum disorders / Evdokia Anagnostou and Eric Hollander -- Tourette's syndrome / James E. Swain, Robert A. King, and James F. Leckman -- Obsessive/compulsive disorder / David S. Husted, Nathan A. Shapira, and Wayne K. Goodman -- Unipolar depression / Julie A. Blendy and Irwin Lucki -- Bipolar disorder / Leonardo Tondo ... [et al.] -- Attention deficit hyperactivity disorder / Kehong Zhang, Eugen Davids, and Ross J. Baldessarini.

Author : Francesco De Matteis,Edward A. Lock
Publisher : Springer
Page : 305 pages
File Size : 54,5 Mb
Release : 1987-06-18
Category : Medical
ISBN : 9781349087594

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Selectivity and Molecular Mechanisms of Toxicity by Francesco De Matteis,Edward A. Lock Pdf

Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Page : 572 pages
File Size : 55,9 Mb
Release : 2021-06-24
Category : Business & Economics
ISBN : 9780323900799

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Advanced Drug Delivery Systems in the Management of Cancer by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone Pdf

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Author : Sonsoles Martín-Santamaría
Publisher : Royal Society of Chemistry
Page : 392 pages
File Size : 53,5 Mb
Release : 2017-11-01
Category : Science
ISBN : 9781782627005

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Computational Tools for Chemical Biology by Sonsoles Martín-Santamaría Pdf

This book offers a fresh perspective on how computational tools can aid the chemical biology research community and drive new research.

Author : Miles Hacker,William S. Messer,Kenneth A. Bachmann
Publisher : Academic Press
Page : 608 pages
File Size : 47,9 Mb
Release : 2009-06-19
Category : Medical
ISBN : 0080919227

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Pharmacology by Miles Hacker,William S. Messer,Kenneth A. Bachmann Pdf

Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Author : Gabriel Waksman
Publisher : Springer Science & Business Media
Page : 325 pages
File Size : 48,8 Mb
Release : 2006-12-22
Category : Medical
ISBN : 9780387245324

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Proteomics and Protein-Protein Interactions by Gabriel Waksman Pdf

Gabriel Waksman Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London WC1E 7HX, United Kingdom Address for correspondence: Professor Gabriel Waksman Institute of Structural Molecular Biology Birkbeck and University College London Malet Street London WC1E 7H United Kingdom Email: g. waksman@bbk. ac. uk and g. waksman@ucl. ac. uk Phone: (+44) (0) 207 631 6833 Fax: (+44) (0) 207 631 6833 URL: http://people. cryst. bbk. ac. uk/?ubcg54a Gabriel Waksman is Professor of Structural Molecular Biology at the Institute of Structural Molecular Biology at UCL/Birkbeck, of which he is also the director. Before joining the faculty of UCL and Birkbeck, he was the Roy and Diana Vagelos Professor of Biochemistry and Molecular Biophysics at the Washington University School of Medicine in St Louis (USA). The rapidly evolving ?eld of protein science has now come to realize the ubiquity and importance of protein–protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of hi- throughput proteomics to monitor protein–protein interactions at an organism level, we can now safely state that protein–protein interactions are the norm and not the exception.