Dynamics And Regulation Of Cell Renewal In The Mammalian Heart And Brain

Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
Publisher : Springer
Page : 274 pages
File Size : 55,8 Mb
Release : 2017-10-27
Category : Medical
ISBN : 9783319561066

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Cardiac Regeneration by Masaki Ieda,Wolfram-Hubertus Zimmermann Pdf

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Author : Gert Fricker,Melanie Ott,Anne Mahringer
Publisher : Springer
Page : 163 pages
File Size : 42,5 Mb
Release : 2014-10-24
Category : Science
ISBN : 9783662437872

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The Blood Brain Barrier (BBB) by Gert Fricker,Melanie Ott,Anne Mahringer Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Author : Alexander Mauro
Publisher : Raven Press (ID)
Page : 582 pages
File Size : 53,9 Mb
Release : 1979
Category : Medical
ISBN : UOM:39015015064226

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Muscle Regeneration by Alexander Mauro Pdf

Author : José Marín-García
Publisher : Academic Press
Page : 944 pages
File Size : 42,9 Mb
Release : 2014-05-09
Category : Science
ISBN : 9780124046429

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Post-Genomic Cardiology by José Marín-García Pdf

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Author : Damir Janigro
Publisher : Springer Science & Business Media
Page : 227 pages
File Size : 44,9 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9781607612872

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Mammalian Brain Development by Damir Janigro Pdf

Denis Noble Nearly a decade after completion of the first draft of the entire Human Genome sequence we are in a better position to assess the nature and the consequences of that heroic achievement, which can be seen as the culmination of the molecular biological revolution of the second half of the twentieth century. The achievement itself was celebrated at the highest levels (President and Prime Minister) on both sides of the Atlantic, and rightly so. DNA sequencing has become sufficiently c- mon now, even to the extent of being used in law courts, that it is easy to forget how technically difficult it was and how cleverly the sequencing teams solved those problems in the exciting race to finish by the turn of the century [1, 2]. The fanfares were misplaced, however, in an important respect. The metaphors used to describe the project and its biological significance gave the impression to the public at large, and to many scientists themselves, that this sequence would reveal the secrets of life. DNA had already been likened to a computer program [3]. The “genetic program” for life was therefore to be found in those sequences: A kind of map that had simply to be unfolded during development. The even more colo- ful “book of life” metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.

Author : Nicole Le Douarin,Chaya Kalcheim
Publisher : Cambridge University Press
Page : 494 pages
File Size : 41,9 Mb
Release : 1999-11-28
Category : Medical
ISBN : 0521620104

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The Neural Crest by Nicole Le Douarin,Chaya Kalcheim Pdf

A 1999 edition of a highly successful book describing comprehensive research in the study of the neural crest.

Author : Carlos Simón,Antonio Pellicer,Renee Reijo Pera
Publisher : Cambridge University Press
Page : 199 pages
File Size : 50,8 Mb
Release : 2013-07-04
Category : Medical
ISBN : 9781107034471

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Stem Cells in Reproductive Medicine by Carlos Simón,Antonio Pellicer,Renee Reijo Pera Pdf

Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.

Author : James F. Amatruda,Corinne Houart,Koichi Kawakami,Kenneth D. Poss
Publisher : Unknown
Page : 0 pages
File Size : 46,8 Mb
Release : 2024
Category : Electronic
ISBN : 1071634038

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Zebrafish by James F. Amatruda,Corinne Houart,Koichi Kawakami,Kenneth D. Poss Pdf

This fully updated edition introduces new tools, models, and analytic insights that position the zebrafish even more strongly as an engine of discovery for developmental and disease biology. Beginning with a section exploring detailed methods for use of zebrafish to model a variety of human diseases, the book continues by illuminating the key ongoing role of the fish model in studies of the vertebrate nervous system, tools and approaches using zebrafish to study stem cell and regenerative biology, as well as techniques in genetics and genomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Zebrafish: Methods and Protocols, Third Edition serves as an invaluable guide to propel advances in developmental biology, disease modeling, and regeneration research using zebrafish and medaka as model systems.

Author : Maya Sieber-Blum
Publisher : World Scientific
Page : 169 pages
File Size : 55,9 Mb
Release : 2012
Category : Medical
ISBN : 9789814343800

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Neural Crest Stem Cells by Maya Sieber-Blum Pdf

Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.

Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publisher : Academic Press
Page : 1202 pages
File Size : 52,8 Mb
Release : 2010-12-16
Category : Science
ISBN : 0123814235

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Principles of Regenerative Medicine by Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem Pdf

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Author : Anonim
Publisher : Unknown
Page : 742 pages
File Size : 42,9 Mb
Release : 1989
Category : Medicine
ISBN : UOM:39015014022886

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Research Awards Index by Anonim Pdf

Author : Ornella Parolini,Antonietta Rosa Silini,Peter Ponsaerts
Publisher : Frontiers Media SA
Page : 240 pages
File Size : 43,6 Mb
Release : 2023-01-31
Category : Science
ISBN : 9782832512739

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Perinatal Derivatives and the Road to Clinical Translation, Volume II by Ornella Parolini,Antonietta Rosa Silini,Peter Ponsaerts Pdf

Author : Patrick P. L. Tam,W. James Nelson,Janet Rossant
Publisher : Unknown
Page : 0 pages
File Size : 55,7 Mb
Release : 2013
Category : Science
ISBN : 1936113244

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Mammalian Development by Patrick P. L. Tam,W. James Nelson,Janet Rossant Pdf

"A subject collection from Cold Spring Harbor perspectives in biology."

Author : Donald W. Pfaff,Nora D. Volkow
Publisher : Springer
Page : 0 pages
File Size : 52,5 Mb
Release : 2016-10-27
Category : Medical
ISBN : 1493934732

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Neuroscience in the 21st Century by Donald W. Pfaff,Nora D. Volkow Pdf

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

Author : Lazzaro Spallanzani
Publisher : Unknown
Page : 192 pages
File Size : 47,7 Mb
Release : 1769
Category : Regeneration (Biology)
ISBN : CORNELL:31924003080466

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An Essay on Animal Reproductions by Lazzaro Spallanzani Pdf