Early Diagnosis Of Human Genetic Defects Scientific And Ethical Considerations

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Early Diagnosis of Human Genetic Defects

Author : Maureen Harris,Maureen I. Harris
Publisher : Unknown
Page : 248 pages
File Size : 48,8 Mb
Release : 1971
Category : Abnormalities, Human
ISBN : UOM:39015053084292

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Early Diagnosis of Human Genetic Defects by Maureen Harris,Maureen I. Harris Pdf

Early Diagnosis of Human Genetic Defects

Author : National Institutes of Health
Publisher : Unknown
Page : 240 pages
File Size : 46,5 Mb
Release : 2005-01-01
Category : Medical
ISBN : 141021950X

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Early Diagnosis of Human Genetic Defects by National Institutes of Health Pdf

CONTENTS Participants Welcoming Remarks Chairman's Introduction Amniocentesis: Techniques and Complications Practical Aspects of Early Diagnosis An Overview of Problems Arising from Amniocentesis Identification of the Defective Patient: Biochemical Techniques Massachusetts Metabolic Disorders Screening Program Cytogenetic Problems in Antenatal Diagnosis Screening for Inherited Traits: Perspectives Detection of Heterozygotes Risks in Amniocentesis Use of Amniotic Fluid and Reliability of Diagnostic Procedures Control Studies in the Antenatal Diagnosis of Human Genetic-Metabolic Disorders Counseling in Genetics Administration and Ethics The Law and the Unborn Child: A Brief Review of Emerging Problems Ethical Issues Resulting from Prenatal Diagnosis

Early Diagnosis of Human Genetic Defects

Author : Maureen I. Harris
Publisher : Unknown
Page : 229 pages
File Size : 45,9 Mb
Release : 1972
Category : Abnormalities, Human
ISBN : OCLC:472936256

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Early Diagnosis of Human Genetic Defects by Maureen I. Harris Pdf

Assessing Genetic Risks

Author : Institute of Medicine,Committee on Assessing Genetic Risks
Publisher : National Academies Press
Page : 353 pages
File Size : 45,9 Mb
Release : 1994-01-01
Category : Medical
ISBN : 9780309047982

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Assessing Genetic Risks by Institute of Medicine,Committee on Assessing Genetic Risks Pdf

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Heritable Human Genome Editing

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 51,6 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Contemporary Bioethics

Author : Mohammed Ali Al-Bar,Hassan Chamsi-Pasha
Publisher : Springer
Page : 267 pages
File Size : 53,9 Mb
Release : 2015-05-27
Category : Medical
ISBN : 9783319184289

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Contemporary Bioethics by Mohammed Ali Al-Bar,Hassan Chamsi-Pasha Pdf

This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed. Whereas these natural sources are God’s special gifts to human beings, God’s revelation as given to the prophets is the supernatural source of divine guidance through which human communities have been guided at all times through history. The second part of the book concentrates on the objectives of Islamic religious practice – the maqa' sid – which include: Preservation of Faith, Preservation of Life, Preservation of Mind (intellect and reason), Preservation of Progeny (al-nasl) and Preservation of Property. Lastly, the third part of the book discusses selected topical issues, including abortion, assisted reproduction devices, genetics, organ transplantation, brain death and end-of-life aspects. For each topic, the current medical evidence is followed by a detailed discussion of the ethical issues involved.

How to Practice Academic Medicine and Publish from Developing Countries?

Author : Samiran Nundy,Atul Kakar,Zulfiqar A. Bhutta
Publisher : Springer Nature
Page : 475 pages
File Size : 52,7 Mb
Release : 2021-10-23
Category : Medical
ISBN : 9789811652486

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How to Practice Academic Medicine and Publish from Developing Countries? by Samiran Nundy,Atul Kakar,Zulfiqar A. Bhutta Pdf

This is an open access book. The book provides an overview of the state of research in developing countries – Africa, Latin America, and Asia (especially India) and why research and publications are important in these regions. It addresses budding but struggling academics in low and middle-income countries. It is written mainly by senior colleagues who have experienced and recognized the challenges with design, documentation, and publication of health research in the developing world. The book includes short chapters providing insight into planning research at the undergraduate or postgraduate level, issues related to research ethics, and conduct of clinical trials. It also serves as a guide towards establishing a research question and research methodology. It covers important concepts such as writing a paper, the submission process, dealing with rejection and revisions, and covers additional topics such as planning lectures and presentations. The book will be useful for graduates, postgraduates, teachers as well as physicians and practitioners all over the developing world who are interested in academic medicine and wish to do medical research.

Cells and Surveys

Author : National Research Council,Commission on Behavioral and Social Sciences and Education,Committee on Population
Publisher : National Academies Press
Page : 388 pages
File Size : 54,6 Mb
Release : 2001-01-19
Category : Social Science
ISBN : 9780309171434

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Cells and Surveys by National Research Council,Commission on Behavioral and Social Sciences and Education,Committee on Population Pdf

What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.

Genetic Disorders and the Fetus

Author : Aubrey Milunsky
Publisher : Springer Science & Business Media
Page : 910 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468451559

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Genetic Disorders and the Fetus by Aubrey Milunsky Pdf

About 21 years ago prenatal diagnosis became part of the physician's diagnostic armamentarium against genetic defects. My first monograph in 1973 (The Prenatal Diagnosis of Hereditary Disorders) critically assessed early progress and enunciated basic principles in the systematic approach to prenatal genetic diagnosis. Six years later and under the current title, a subsequent volume provided the first major reference source on this subject. The present second (effectively third) edition, which was urged in view of the excellent reception of the two earlier volumes, reflects the remarkable growth of this new discipline and points to significant and exciting future developments. Notwithstanding these advances, the use of the new tools and techniques for the benefit of at-risk parents has taken many more years than most anticipated. Key factors have been the lack of teaching of human genetics in medical schools in the preceding decades and the difficulty of educating practicing physicians in a new scientific disci pline. Even today the teaching of genetics in medical schools leaves much to be desired and this will further delay the introduction of newer genetic advances to the bedside.

Prenatal Diagnosis and Selective Abortion

Author : Harry Harris
Publisher : Harvard University Press
Page : 114 pages
File Size : 42,8 Mb
Release : 1975
Category : Abnormalities, Human
ISBN : 0674700805

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Prenatal Diagnosis and Selective Abortion by Harry Harris Pdf

The ability to identify and abort fetuses with certain genetic abnormalities is among the most recent and most important of medical advances. In this book, one of the world's leading medical geneticists, Harry Harris, discusses the promise and the perils of the new techniques. Dr. Harris writes with great clarity; he explains technical concepts and terms so well that a layman can follow his account with little effort. This book will serve as an excellent introduction to a large and growing literature. Dr. Harris begins by explaining methods of prenatal diagnosis and the kinds of disease that can, at present, be identified in utero. He identifies technological limitations of the procedure and also discusses certain theoretical factors that limit its future applicability. The book concludes with a long and balanced examination of ethical issues entailed by the practice of selective abortion. The author limits discussion of his own opinions in favor of evaluating the main contemporary positions and exploring the basis of controversy. He makes clear, however, his own view that there are clear advantages to the technique and clear limitations and that there will always be gray areas in which decision must be painful and individual--unaided by pat moralizing.

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies

Author : Sorin Hostiuc
Publisher : Academic Press
Page : 431 pages
File Size : 40,6 Mb
Release : 2018-08-07
Category : Medical
ISBN : 9780128137659

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Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies by Sorin Hostiuc Pdf

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource. Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics Contains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology Discusses preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues, and more

Assessing Genetic Risks

Author : Institute of Medicine,Committee on Assessing Genetic Risks
Publisher : National Academies Press
Page : 353 pages
File Size : 44,7 Mb
Release : 1994-02-01
Category : Medical
ISBN : 9780309086608

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Assessing Genetic Risks by Institute of Medicine,Committee on Assessing Genetic Risks Pdf

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

In the Name of Eugenics

Author : Daniel J. Kevles
Publisher : Knopf
Page : 698 pages
File Size : 49,6 Mb
Release : 2013-05-08
Category : Science
ISBN : 9780307831507

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In the Name of Eugenics by Daniel J. Kevles Pdf

Daniel Kevles traces the study and practice of eugenics--the science of "improving" the human species by exploiting theories of heredity--from its inception in the late nineteenth century to its most recent manifestation within the field of genetic engineering. It is rich in narrative, anecdote, attention to human detail, and stories of competition among scientists who have dominated the field.