Edhf

Author : Paul M. Vanhoutte
Publisher : CRC Press
Page : 644 pages
File Size : 49,6 Mb
Release : 2003-09-02
Category : Medical
ISBN : 9780203302835

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Edhf 2000 by Paul M. Vanhoutte Pdf

Understanding the nature and role of endothelium-derived hyperpolarizing factor appears to be crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion and other vascular disorders. EDHF 2000 comprises the proceedings of the Third International Symposium on endothelium-dependent hyperpolarizations. The first two meetings established a role for EDHF and other chemical factors involved in endothelium-dependent hyperpolarizations. These proceedings focus upon the role of gap junctions in cardiovascular responses and investigate the chemical identity of EDHF. Additional chapters on Physiology, Hormonal Modulation and Pathological Changes are also included. EDHF 2000 will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.

Author : Paul M. Vanhoutte
Publisher : CRC Press
Page : 456 pages
File Size : 46,7 Mb
Release : 2001-11-29
Category : Medical
ISBN : 9780203987360

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Edhf 2002 by Paul M. Vanhoutte Pdf

Understanding the nature and role of endothelium-derived hyperpolarizing factor is crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion, and other vascular disorders. EDHF 2002 is based on the proceedings of the Fourth International Symposium on endothelium-dependent hyperpolarizations. It will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.

Author : Louis J. Ignarro
Publisher : Academic Press
Page : 1017 pages
File Size : 44,8 Mb
Release : 2000-09-13
Category : Science
ISBN : 0080525032

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Nitric Oxide by Louis J. Ignarro Pdf

Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Author : David Shepro
Publisher : Elsevier
Page : 1353 pages
File Size : 49,5 Mb
Release : 2005-11-03
Category : Medical
ISBN : 9780126395105

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Microvascular Research: Biology and Pathology, Two-Volume Set by David Shepro Pdf

The microvasculature refers to the smallest blood vessels, arterial and venous, that nurture the tissues of each organ. Apart from transport, they also contribute to the systematic regulation of the body. In everyday terminology, the microcirculation is "where the action is." Microcirculation is directly involved in such disease states as Alzheimers, inflammation, tumor growth, diabetic retinopathy, and wound healing- plus cardiovascular fitness is directly related to the formation of new capillaries in large muscles. Microvascular Research is the first book devoted exclusively to this vital systemic component of the cardiovascular system and provides up to date mini-reviews of normal functions and clinical states. The contributing authors are senior scientists with international reputation in their given disciplines. This two-volume set is a broad, interdisciplinary work that encompasses basic research and clinical applications equally. * Broad coverage of both basic and clinical aspects of microvasculature research * Contains 167 chapters from over 300 international authors * Each chapter includes key figures and annotated references

Author : Rui Wang
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 40,8 Mb
Release : 2004-06-11
Category : Medical
ISBN : 9781592598069

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Signal Transduction and the Gasotransmitters by Rui Wang Pdf

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters. Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

Author : Tony Yaksh,Salim Hayek
Publisher : Springer Nature
Page : 829 pages
File Size : 55,6 Mb
Release : 2024-01-02
Category : Medical
ISBN : 9783031395581

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Neuraxial Therapeutics by Tony Yaksh,Salim Hayek Pdf

This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics, to be an invaluable guide to this treatment modality.

Author : J. F. Stoltz
Publisher : IOS Press
Page : 222 pages
File Size : 53,9 Mb
Release : 2007
Category : Endothelial cells
ISBN : 1586037757

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Cardiovascular Biology by J. F. Stoltz Pdf

Vascular endothelial plays a significant role in regulating blood flow, and endothelial cells (EC) have highly active metabolic functions. This volume focuses on Vascular Endothelium, NO and Hypertension and is a continuum of the volumes on Mechanobiology of Cartilage and Chondrocyte.

Author : Michel Feletou,Paul Vanhoutte
Publisher : CRC Press
Page : 320 pages
File Size : 40,8 Mb
Release : 2005-11-02
Category : Medical
ISBN : 1420023314

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EDHF by Michel Feletou,Paul Vanhoutte Pdf

The advances made in vascular biology in the last 25 years have considerably changed the perception that one could have of the endothelial cells. Once considered as a diffusion barrier preventing the access of the blood cells to the vascular matrix, the endothelium is now recognized as playing a major role in the control of blood fluidity, platelet aggregation, and vascular tone, but also in immunology, inflammation, angiogenesis, and for serving as a metabolizing and an endocrine organ. -- from the preface Cardiovascular diseases, so prevalent in the Western world during the twentieth century, could well become the scourge of the twenty-first century in emerging countries as well as the West. Endothelial dysfunction linked to an imbalance in the synthesis and/or release of contracting and relaxing factors is often evoked to explain the initiation of the cardiovascular pathology or its development and perpetuation. Two decades ago, when nitric oxide was demonstrated to mediate endothelium-dependent relaxations, the vascular world seemed convinced that nitric oxide was the ultimate and sole explanation for such relaxations. However not everyone agreed. EDHF: The Complete Story is the work of two leading researchers who did not accept that simple conclusion, but instead continued to search, along with others, for a deeper understanding of the ways in which endothelial cells communicate with the underlying smooth muscle to signal it to hyperpolarize. Now with most, if not all, of those ways, uncovered, the authors offer this summary as way of bringing closure to the quest. This monograph reports on the work of many researchers. It summarizes the significant recent discoveries concerning endothelium-dependent hyperpolarizations, which are likely to play a much more important role in cardiovascular physiology and pathology than was originally foreseen Extensively illustrated with original diagrams and schematics that summarize the different steps of endothelium-dependent hyperpolarization, the text is designed for vascular biologists, and cardiologists, as well as graduate students looking to gain an understanding of the intimate functioning of the blood vessel wall.

Author : Peter Lanzer,Eric J. Topol
Publisher : Springer
Page : 1923 pages
File Size : 52,8 Mb
Release : 2013-12-20
Category : Medical
ISBN : 9783642562259

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Pan Vascular Medicine by Peter Lanzer,Eric J. Topol Pdf

The textbook provides an interdisciplinary and integrated perspective of modern vascular cure. Written by experts the text proceeds from fundamental principles to advanced concepts. The book is divided into four parts, each focusing on different basic concepts of vascular cure. All fundamental principles of the area are clearly explained to facilitate vascular diagnostics and treatment in clinical practice. It is aimed at junior practitioners and experts.

Author : Paul M. Vanhoutte
Publisher : CRC Press
Page : 364 pages
File Size : 55,7 Mb
Release : 1996-12-13
Category : Science
ISBN : 3718659298

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Endothelium-Derived Hyperpolarizing Factor by Paul M. Vanhoutte Pdf

Author : Ichiro Wakabayashi,Klaus Groschner
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 44,6 Mb
Release : 2013-11-04
Category : Science
ISBN : 9783319010748

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Interdisciplinary Concepts in Cardiovascular Health by Ichiro Wakabayashi,Klaus Groschner Pdf

This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This third volume is focused on the most common “cardiovascular events” to provide an overview on pathogenesis and clinical aspects. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.

Author : Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas
Publisher : Academic Press
Page : 758 pages
File Size : 52,6 Mb
Release : 2018-02-03
Category : Medical
ISBN : 9780128125519

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Endothelium and Cardiovascular Diseases by Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas Pdf

Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes

Author : Jason X.-J. Yuan
Publisher : Springer Science & Business Media
Page : 584 pages
File Size : 48,6 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9781402078583

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Hypoxic Pulmonary Vasoconstriction by Jason X.-J. Yuan Pdf

Complete reference on hypoxic pulmonary vasoconstriction and hypoxia-mediated pulmonary hypertension. Can be utilized by the physician-scientist and researcher in the laboratory as both a technical manual and reference. Designed for clinicians to guide and improve clinical treatment and diagnosis of patients with hypoxia mediated pulmonary vascular disease and right heart failure.

Author : Sun I. Kim,Tae S. Suh
Publisher : Springer Science & Business Media
Page : 4361 pages
File Size : 46,9 Mb
Release : 2007-05-07
Category : Technology & Engineering
ISBN : 9783540368397

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World Congress of Medical Physics and Biomedical Engineering 2006 by Sun I. Kim,Tae S. Suh Pdf

These proceedings of the World Congress 2006, the fourteenth conference in this series, offer a strong scientific program covering a wide range of issues and challenges which are currently present in Medical physics and Biomedical Engineering. About 2,500 peer reviewed contributions are presented in a six volume book, comprising 25 tracks, joint conferences and symposia, and including invited contributions from well known researchers in this field.

Author : Dmitry Garbuzenko
Publisher : BoD – Books on Demand
Page : 160 pages
File Size : 51,8 Mb
Release : 2012-03-14
Category : Medical
ISBN : 9789535102519

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Portal Hypertension by Dmitry Garbuzenko Pdf

Portal hypertension is a clinical syndrome defined by a portal venous pressure gradient, exceeding 5 mm Hg. In this book the causes of its development and complications are described. Authors have presented personal experiences on conducting patients with various displays of portal hypertension. Moreover, the book presents modern data about molecular mechanisms of pathogenesis of portal hypertension in liver cirrhosis, the information about the original predictor of risk of bleeding from gastro-esophageal varices and new methods for their conservative treatment.