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Author : Andrea C. Gore Publisher : Springer Science & Business Media Page : 361 pages File Size : 44,7 Mb Release : 2007-06-08 Category : Medical ISBN : 9781597451079
Endocrine-Disrupting Chemicals by Andrea C. Gore Pdf
This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.
Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies by Muhammad Sajid Hamid Akash,Kanwal Rehman,Muhammad Zaffar Hashmi Pdf
This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.
Challenges in Endocrine Disruptor Toxicology and Risk Assessment by Alexandra Fucic,Alberto Mantovani Pdf
Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology - including interactions with other hormone pathways - has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer's disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.
Author : R M Harrison,R E Hester Publisher : Royal Society of Chemistry Page : 167 pages File Size : 53,9 Mb Release : 2007-10-31 Category : Science ISBN : 9781847550743
Endocrine Disrupting Chemicals by R M Harrison,R E Hester Pdf
Long-term environmental effects of chemical exposure have long been of concern and, more recently, chemicals which cause changes to the sexual development of exposed organisms have been identified. It is thought that low-level exposure to a wide range of chemicals may be affecting endocrine function, leading to a reduction in fertility and an increase in reproductive cancers. Endocrine Disrupting Chemicals reviews the scientific evidence and attempts to put the subject into context. Along with an overview of the issue, there is discussion of the specialised aspects in relation to wildlife; environmental oestrogens and male reproduction; and naturally occurring oestrogenic substances. With contributions from representatives of the Medical Research Council's Institute for Environment and Health and the US Environmental Protection Agency, the articles provide a comprehensive and detailed review of current issues. This book will be of interest to a wide readership, including industrial and environmental scientists, managers and policy makers.
Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Pharmacology series Updated release includes the latest information on Endocrine-Disrupting Chemicals
Endocrine Disrupters in Wastewater and Sludge Treatment Processes by J. W. Birkett,J. N. Lester Pdf
Endocrine Disrupting Chemicals (EDCs) have been shown to produce changes in the endocrine system of organisms that lead to increases in cancers and abnormalities in reproductive structure and function. Recent research has highlighted the existence of hormonally active compounds in sewage and industrial effluents and their potential for recycling back into the environment - including drinking water supplies- through point sources and non-point sources. Endocrine Disrupters in Wastewater and Sludge Treatment Processes presents the latest research on EDCs, covering the sources, fate, and transport of EDCs in sewage and industrial effluents, and sludge treatment and disposal options in light of effects on receiving environments. In addition, the authors review current legislation, future research needs, and potential management strategies for endocrine disrupters in the environment.
A leading voice in public health policy and top environmental medicine scientist reveals the alarming truth about how hormone-disrupting chemicals are affecting our daily lives--and what we can do to protect ourselves and fight back. Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we've turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Dr. Trasande exposes the chemicals that disrupt our hormonal systems and damage our health in irreparable ways. He shows us where these chemicals hide--in our homes, our schools, at work, in our food, and countless other places we can't control--as well as the workings of policy that protects the continued use of these chemicals in our lives. Drawing on extensive research and expertise, he outlines dramatic studies and emerging evidence about the rapid increases in neurodevelopmental, metabolic, reproductive, and immunological diseases directly related to the hundreds of thousands of chemicals that we are exposed to every day. Unfortunately, nowhere is safe. But, thanks to Dr. Trasande's work on the topic, and his commitment to effecting change, this book can help. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he shows us what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.
Endocrine Disrupting Chemicals by Sabrina Johnston Pdf
"Wide variety of pesticides and other synthetic chemicals may disrupt the normal function of the endocrine system, cause alteration and also attack the immune system of humans and wildlife at very low concentration levels. Chapter one of this book provides an overview of analytical methods, including sample preparation steps, chromatographic separation and detection of endocrine disrupting pesticides in a variety of food, environmental and biological matrices. Chapter two studies endocrine disrupting compound (EDC) exposure from recycled wastewater compared to other water related risks in developed and developing nations. Chapter three summarizes the role of EDCs on pregnancy and birth outcomes, included but not limited to fertility problems, premature birth, low birth weight, and miscarriage along with in-vitro, animal, and epidemiological studies. In the last chapter, the worst EDCs will be revealed and their related potential hazardous health risks to humans are discussed. Furthermore, suggestions to help the reader avoid such toxic chemicals are presented"--
National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Hormonally Active Agents in the Environment
Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Hormonally Active Agents in the Environment Publisher : National Academies Press Page : 453 pages File Size : 54,8 Mb Release : 2000-02-03 Category : Science ISBN : 9780309064194
Hormonally Active Agents in the Environment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Hormonally Active Agents in the Environment Pdf
Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
In today's world, everyone carries a toxic load of dozens of industrially produced chemicals in their bloodstream. Not only do these adversely affect the health of adults and children, but also, and more worryingly, they damage the development of unborn infants. The amniotic fluid of pregnant women has been found to contain a variety of chemicals, such as pesticides, plasticizers, disinfectant products, flame-retardants, surfactants and UV filters, many of which interfere with fetal physiology, especially thyroid hormone action. Thyroid hormone is vital for brain development, particularly for the fetus during pregnancy and for toddlers. In fact, children born to women who lack this thyroid hormone (or who are unwittingly exposed to thyroid-disrupting chemicals) have lower IQs and more neurodevelopmental problems. Evolution of the human brain has involved multiple changes and processes dependent on thyroid hormone. The urgent question thus arises: Is chemical pollution poisoning brain development and reversing evolution's most outstanding achievement: the human brain? And if so, as this book convincingly illuminates, what can be done about it both collectively and individually? Toxic Cocktail provides a clear view of how many environmental chemicals interfere with brain development. As a result, this book looks at how we define and test IQ, the evidence for IQ loss, and how chemical pollution and thyroid hormone disruption can be actors in this process, as well as increasing neurodevelopmental disease risk.
Environmental Health Risk by Marcelo Larramendy,Sonia Soloneski Pdf
This book, Environmental Health Risk - Hazardous Factors to Living Species, is intended to provide a set of practical discussions and relevant tools for making risky decisions that require actions to reduce environmental health risk against environmental factors that may adversely impact human health or ecological balances. We aimed to compile information from diverse sources into a single volume to give some real examples extending concepts of those hazardous factors to living species that may stimulate new research ideas and trends in the relevant fields.
Encyclopedia of Aquatic Ecotoxicology by Jean-Francois Férard,Christian Blaise Pdf
With its 104 chapters, this Encyclopedia of aquatic ecotoxicology reveals the diversity of issues, problems and challenges that have faced, and are facing today, receiving environments. It also indicates ways by which tools, strategies and future investigations can contribute to correct, minimize, solve and prevent water quality degradation. Structured homogeneously, the chapters convey salient information on historical background, features, characteristics, uses and/or applications of treated topics, often complemented by illustrations and case studies, as well as by conclusions and prospects. This work is most suitable for teaching purposes. Academics, for example, could literally deliver comprehensive lectures to students simply based on chapter outlines and contents. Meet the Authors of the Encyclopedia! Check out 'Meet the Authors' under ADDITIONAL INFORMATION (Right menu).
An award-winning scientist, in this urgent, thought-provoking and meticulously researched book, shows how chemicals in the modern environment are changing--and endangering--human sexuality and fertility on the grandest scale.
Endocrine Toxicology, Third Edition by J. Charles Eldridge,James T. Stevens Pdf
With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology’s increased importance in environmental safety issues due to legislative directives established over the past ten years. Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides: putative endocrine disruptors and mechanisms of endocrine toxicity the history and status of the regulatory process mechanisms of toxic effects in various hormonal systems comparisons of the endocrine responses in humans, livestock, and wildlife testing methods in mammalian, fish, avian, and amphibian models valuable insight into the approaches of various personnel in the field, including: government officials who make and oversee policy; scientists in charge of development and validation of testing methods; basic researchers who identify toxic mechanisms; and manufacturers responsible for environmentally benign product certification
Analysis of Endocrine Disrupting Compounds in Food by Leo M. L. Nollet Pdf
Analysis of Endocrine Disrupting Compounds in Food provides a unique and comprehensive professional reference source covering most of the recent analytical methodology of endocrine disrupting compounds in food. Editor Nollet and his broad team of international contributors address the most recent advances in analysis of endocrine disrupting chemicals in food. While covering conventional (typically lab-based) methods of analysis, the book focuses on leading-edge technologies that recently have been introduced. The book looks at areas such as food quality assurance and safety. Issues such as persistent organic pollutants, monitoring pesticide and herbicide residues in food, determining heavy and other metals in food and discussing the impacts of dioxins, PCBs, PCDFs and many other suspected chemicals are covered. The book discusses the relationship between chemical compounds and hormone activity. What are the health impacts of different chemical compounds for men and animals? How are these compounds entering in foodstuffs? Analysis of Endocrine Disrupting Compounds in Food offers the food professional what its title promises – a compendium of sample preparation and analysis techniques of possible endocrine disrupting compounds in food. Special Features: Uniquely concentrates on analysis and detection methods of EDCs in foodstuffs Extensive coverage of the main types of globally available analytical techniques and methodologies Fully detailed properties, sample procedures, and analysis steps for each EDC Renowned editor Leo Nollet leads a broad team of international experts
