Endoplasmic Reticulum Stress In Health And Disease

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Endoplasmic Reticulum Stress in Health and Disease

Patrizia Agostinis,Samali Afshin
Endoplasmic Reticulum Stress in Health and Disease Book PDF

Author : Patrizia Agostinis,Samali Afshin
Publisher : Springer Science & Business Media
Page : 448 pages
File Size : 51,7 Mb
Release : 2012-08-13
Category : Medical
ISBN : 9789400743519

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Endoplasmic Reticulum Stress in Health and Disease by Patrizia Agostinis,Samali Afshin Pdf

The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.

Endoplasmic Reticulum Stress

Cameron Wagner
Endoplasmic Reticulum Stress Book PDF

Author : Cameron Wagner
Publisher : Nova Science Publishers
Page : 153 pages
File Size : 49,8 Mb
Release : 2016
Category : Science
ISBN : 1634855817

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Endoplasmic Reticulum Stress by Cameron Wagner Pdf

This book provides current research on the regulation, function and role in health and disease of endoplasmic reticulum (ER) stress. The first chapter focuses on evidence that supports the role of endoplasmic reticulum stress, mitochondria-associated membranes (MAMs) microdomain and oxidative stress during obesity as a molecular pathway to type 2 diabetes mellitus (T2DM) development. Also, it addresses protein missfolding and mitochondria function as potential targets to improve metabolic derangements in obesity and T2DM. Chapter Two summarizes and discusses the current understanding of molecular mechanisms linking ER stress to beta cell fate. Chapter Three depicts the association between eIF2? kinase-linked pathways and diet-linked pathogenic responses (such as ones caused by microbes or nutritional abnormalities). Chapter Four reviews placental endoplasmic reticulum stress in the determination of pregnancy outcome. The last chapter discusses the role of ER stress in meditating the anticancer effects of tocotrienols.

Current Research Topics in Plant Virology

Aiming Wang,Xueping Zhou
Current Research Topics in Plant Virology Book PDF

Author : Aiming Wang,Xueping Zhou
Publisher : Springer
Page : 335 pages
File Size : 41,8 Mb
Release : 2016-07-07
Category : Science
ISBN : 9783319329192

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Current Research Topics in Plant Virology by Aiming Wang,Xueping Zhou Pdf

Topics covered in this book include RNA silencing and its suppression in plant virus infection, virus replication mechanisms, the association of cellular membranes with virus replication and movement, plant genetic resistance to viruses, viral cell-to-cell spread, long distance movement in plants, virus induced ER stress, virus diversity and evolution, virus-vector interactions, cross protection, geminiviruses, negative strand RNA viruses, viroids, and the diagnosis of plant viral diseases using next generation sequencing. This book was anticipated to help plant pathologists, scholars, professors, teachers and advanced students in the field with a comprehensive state-of-the-art knowledge of the subject.

The Unfolded Protein Response

Roberto Pérez-Torrado
The Unfolded Protein Response Book PDF

Author : Roberto Pérez-Torrado
Publisher : Humana
Page : 332 pages
File Size : 52,8 Mb
Release : 2022-01-06
Category : Science
ISBN : 1071617311

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The Unfolded Protein Response by Roberto Pérez-Torrado Pdf

This volume is divided in six section covering the most experimental approaches involved in the study of the unfolded protein response (UPR) pathway. Chapters detail determination of unfolded protein levels, methods to study UPR signal transmission, analysing the outcomes of the UPR pathway activation, UPR studies in mammalian models, UPR in alternative models, and UPR and disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Unfolded Protein Response: Methods and Protocols aims to describe key methods and approaches used in the study of the UPR pathway and its complex cellular implications. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Aging Research in Yeast

Michael Breitenbach,S. Michal Jazwinski,Peter Laun
Aging Research in Yeast Book PDF

Author : Michael Breitenbach,S. Michal Jazwinski,Peter Laun
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 51,7 Mb
Release : 2011-11-19
Category : Science
ISBN : 9789400725614

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Aging Research in Yeast by Michael Breitenbach,S. Michal Jazwinski,Peter Laun Pdf

This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

The Unfolded Protein Response in Cancer

Robert Clarke
The Unfolded Protein Response in Cancer Book PDF

Author : Robert Clarke
Publisher : Springer
Page : 220 pages
File Size : 45,8 Mb
Release : 2019-03-01
Category : Medical
ISBN : 9783030050672

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The Unfolded Protein Response in Cancer by Robert Clarke Pdf

This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

Preimplantation Embryo Development

Barry D. Bavister
Preimplantation Embryo Development Book PDF

Author : Barry D. Bavister
Publisher : Springer Science & Business Media
Page : 359 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461393177

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Preimplantation Embryo Development by Barry D. Bavister Pdf

This volume contains the Proceedings of the Serono Symposium on Pre implantation Embryo Development, held in Newton, Massachusetts, in 1991. The idea for the symposium grew out of the 1989 Serono Symposium on Fertilization in Mammals* at which preimplantation development was the predominant suggestion for a follow-up topic. This was indeed a timely subject in view of the recent resurgence of interest in this funda mental phase of embryogenesis and its relevance to basic research and applied fertility studies in humans, food-producing animals, and endangered species. The symposium brought together speakers from a broad range of disciplines in order to focus on key regulatory mechanisms in embryo development, using a wide variety of animal models, and on representative topics in human preimplantation embryogenesis. The culmination of preimplantation development is a blastocyst con taining the first differentiated embryonic tissues and capable of initiating and sustaining pregnancy. The central objective of the symposium was to throw light on the regulation of cellular and molecular events underlying blastocyst formation. It was particularly appropriate that the date of the symposium marked the 20th anniversary of the publication of the classic volume Biology of the Blastocyst, the proceedings of an international workshop held in 1970. This book, which summarized most of the information then available on this topic in mammals, was edited by the pioneer in blastocyst research, Dr. Richard B1andau, who was the guest speaker at the symposium.

Cellular Biology of the Endoplasmic Reticulum

Luis B. Agellon,Marek Michalak
Cellular Biology of the Endoplasmic Reticulum Book PDF

Author : Luis B. Agellon,Marek Michalak
Publisher : Springer Nature
Page : 329 pages
File Size : 54,9 Mb
Release : 2021-05-29
Category : Science
ISBN : 9783030676964

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Cellular Biology of the Endoplasmic Reticulum by Luis B. Agellon,Marek Michalak Pdf

This book provides a comprehensive overview of the biology of the endoplasmic reticulum (ER) and the associated ER proteins, it discusses their structure, function and signaling mechanisms in the cell and their role in disease. This book also offers insights into the practical aspects of research and demonstrates the use of non-mammalian models to study the structure and function of the ER. Written by leading experts in the field, the book enables readers to gain a thorough understanding of current ER biology. It is intended for scientists and clinical researchers working on the endoplasmic reticulum in all its various roles and facets in health and disease.

The Unfolded Protein Response and Cellular Stress

P. Michael Conn
The Unfolded Protein Response and Cellular Stress Book PDF

Author : P. Michael Conn
Publisher : Unknown
Page : 407 pages
File Size : 52,5 Mb
Release : 2011
Category : Cell physiology
ISBN : OCLC:703226106

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The Unfolded Protein Response and Cellular Stress by P. Michael Conn Pdf

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

Extracellular Matrix Degradation

William C. Parks,Robert Mecham
Extracellular Matrix Degradation Book PDF

Author : William C. Parks,Robert Mecham
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 41,7 Mb
Release : 2011-04-07
Category : Science
ISBN : 9783642168611

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Extracellular Matrix Degradation by William C. Parks,Robert Mecham Pdf

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Amino Acids in Nutrition and Health

Guoyao Wu
Amino Acids in Nutrition and Health Book PDF

Author : Guoyao Wu
Publisher : Springer Nature
Page : 227 pages
File Size : 40,6 Mb
Release : 2021-07-12
Category : Medical
ISBN : 9783030741808

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Amino Acids in Nutrition and Health by Guoyao Wu Pdf

This book explains about amino acids (AAs) which are not only building blocks of protein, but are also signaling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular-weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds, and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole-body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health, and well-being of individuals.

The Exocrine Pancreas

Stephen Pandol
The Exocrine Pancreas Book PDF

Author : Stephen Pandol
Publisher : Morgan & Claypool Publishers
Page : 66 pages
File Size : 46,6 Mb
Release : 2011
Category : Medical
ISBN : 9781615041381

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The Exocrine Pancreas by Stephen Pandol Pdf

The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

Quality Control of Cellular Protein in Neurodegenerative Disorders

Uddin, Md. Sahab,Ashraf, Ghulam Md.
Quality Control of Cellular Protein in Neurodegenerative Disorders Book PDF

Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
Publisher : IGI Global
Page : 515 pages
File Size : 42,8 Mb
Release : 2020-02-14
Category : Medical
ISBN : 9781799813187

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Quality Control of Cellular Protein in Neurodegenerative Disorders by Uddin, Md. Sahab,Ashraf, Ghulam Md. Pdf

Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.

The Serpin Family

Margarethe Geiger,Felix Wahlmüller,Margareta Furtmüller
The Serpin Family Book PDF

Author : Margarethe Geiger,Felix Wahlmüller,Margareta Furtmüller
Publisher : Springer
Page : 329 pages
File Size : 40,6 Mb
Release : 2015-11-13
Category : Science
ISBN : 9783319227115

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The Serpin Family by Margarethe Geiger,Felix Wahlmüller,Margareta Furtmüller Pdf

The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses.​

Regulation of Heat Shock Protein Responses

Alexzander A A Asea,Punit Kaur
Regulation of Heat Shock Protein Responses Book PDF

Author : Alexzander A A Asea,Punit Kaur
Publisher : Springer
Page : 472 pages
File Size : 43,7 Mb
Release : 2018-05-01
Category : Medical
ISBN : 9783319747156

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Regulation of Heat Shock Protein Responses by Alexzander A A Asea,Punit Kaur Pdf

This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.