Endotoxin Detection And Control In Pharma Limulus And Mammalian Systems

Author : Kevin L. Williams
Publisher : Springer
Page : 869 pages
File Size : 42,8 Mb
Release : 2019-07-24
Category : Medical
ISBN : 9783030171483

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Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems by Kevin L. Williams Pdf

Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.

Author : Anthony Lee Dellinger,Rachel Tinker-Kulberg,Christopher C. Chabot,Stephen Allen Smith,Siu Gin Cheung,Paul Shin,Kit Yue Kwan,Alan T. Critchley
Publisher : Frontiers Media SA
Page : 335 pages
File Size : 52,6 Mb
Release : 2022-05-23
Category : Science
ISBN : 9782889761494

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Advances in the Biology, Aquaculture, and Conservation of Threatened Marine Species and their Application in Human Health and Nutrition by Anthony Lee Dellinger,Rachel Tinker-Kulberg,Christopher C. Chabot,Stephen Allen Smith,Siu Gin Cheung,Paul Shin,Kit Yue Kwan,Alan T. Critchley Pdf

Author : Xiaoyuan Wang,Peter J. Quinn
Publisher : Springer Science & Business Media
Page : 419 pages
File Size : 55,8 Mb
Release : 2010-06-30
Category : Medical
ISBN : 9789048190782

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Endotoxins: Structure, Function and Recognition by Xiaoyuan Wang,Peter J. Quinn Pdf

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

Author : Wanda M. Haschek-Hock,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon
Publisher : Elsevier
Page : 974 pages
File Size : 47,8 Mb
Release : 2023-02-24
Category : Medical
ISBN : 9780443161544

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Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3 by Wanda M. Haschek-Hock,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon Pdf

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, this book covers the toxicologic pathology of major classes of environmental toxicants. Volumes emphasize the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. This series comprises the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately. Provides updated and revised chapters for in-depth discussions of toxicologic pathology for the protection of the environment and food supplies Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Author : Frederick C. Pearson,Marlys Weary,James H. Jorgensen
Publisher : Unknown
Page : 296 pages
File Size : 45,9 Mb
Release : 1985
Category : Medical
ISBN : UOM:39015009577365

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Pyrogens by Frederick C. Pearson,Marlys Weary,James H. Jorgensen Pdf

Author : Arvind Diwan,Sanjay N. Harke,Archana Panche
Publisher : Springer Nature
Page : 301 pages
File Size : 40,5 Mb
Release : 2023-11-13
Category : Medical
ISBN : 9789819908523

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Microbiome of Finfish and Shellfish by Arvind Diwan,Sanjay N. Harke,Archana Panche Pdf

This book helps us to understand the importance of the microbiome associated with finfish and shellfish inhabiting different locations and varied environmental and biological situations. It covers modern molecular tools for identifying microbiome composition and their precise identification at the species level. The book also covers the molecular structural composition of individual microbes, metabolite resources from microbiome species, their functional properties, and production aspects. Notable, the book covers the microbiome applications in the gut systems of finfish and shellfish to the digestion, nutrition, growth, reproduction, immune system, and vulnerability of the host to diseases. It also reviews diversity and functional properties, relationships with diseases, health status, data on species-specific metagenomics, and probiotic research. It highlights the relevance of microbial communities for the development of new and innovative bio-products to build bio and pharmaceutical industries, including aquaculture. This book is an invaluable source for researchers and professionals involved in fishery science, fisheries and aquaculture, fish biotechnology, and fish microbiology and pathology

Author : John T. Tanacredi,Mark L. Botton,David Smith
Publisher : Springer Science & Business Media
Page : 658 pages
File Size : 42,5 Mb
Release : 2009-06-04
Category : Science
ISBN : 9780387899596

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Biology and Conservation of Horseshoe Crabs by John T. Tanacredi,Mark L. Botton,David Smith Pdf

Horseshoe crabs, those mysterious ancient mariners, lured me into the sea as a child along the beaches of New Jersey. Drawn to their shiny domed shells and spiked tails, I could not resist picking them up, turning them over and watching the wondrous mechanical movement of their glistening legs, articulating with one another as smoothly as the inner working of a clock. What was it like to be a horseshoe crab, I wondered? What did they eat? Did they always move around together? Why were some so large and others much smaller? How old were they, anyway? What must it feel like to live underwater? What else was out there, down there, in the cool, green depths that gave rise to such intriguing creatures? The only way to find out, I reasoned, would be to go into the ocean and see for myself, and so I did, and more than 60 years later, I still do.

Author : Jeffrey D. Clogston
Publisher : Springer Nature
Page : 315 pages
File Size : 42,8 Mb
Release : 2024-06-30
Category : Electronic
ISBN : 9781071637869

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Characterization of Nanoparticles Intended for Drug Delivery by Jeffrey D. Clogston Pdf

Author : Gerhard Nahler
Publisher : Springer Science & Business Media
Page : 186 pages
File Size : 45,8 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783709140161

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Dictionary of Pharmaceutical Medicine by Gerhard Nahler Pdf

This dictionary is aimed primarily at the beginners entering the new discipline of Pharmaceutical Medicine, an area comprising aspects of toxicology, pharmacology, pharmaceutics, epidemiology, statistics, drug regulatory and legal affairs, medicine and marketing. But also more experienced colleagues in departments engaged in clinical development as well as researchers and marketing experts in the pharmaceutical industry will find concise and up-to-date information. The book is completed by a list of a about 1000 abbreviations encountered in pharmaceutical medicine and a compilation of important addresses of national and international health authorities.

Author : United States. Food and Drug Administration
Publisher : Unknown
Page : 62 pages
File Size : 52,7 Mb
Release : 1991
Category : Biotechnology
ISBN : UOM:39015040998778

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FDA Biotechnology Inspection Guide by United States. Food and Drug Administration Pdf

Author : Lucia Clontz
Publisher : CRC Press
Page : 344 pages
File Size : 42,5 Mb
Release : 2008-10-14
Category : Science
ISBN : 9781420053494

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Microbial Limit and Bioburden Tests by Lucia Clontz Pdf

In recent years, the field of pharmaceutical microbiology has experienced numerous technological advances, accompanied by the publication of new and harmonized compendial methods. It is therefore imperative for those who are responsible for monitoring the microbial quality of pharmaceutical/biopharmaceutical products to keep abreast of the latest c

Author : Mohammed Zourob,Sauna Elwary,Anthony P. F. Turner
Publisher : Springer Science & Business Media
Page : 980 pages
File Size : 44,7 Mb
Release : 2008-09-03
Category : Technology & Engineering
ISBN : 9780387751139

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Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems by Mohammed Zourob,Sauna Elwary,Anthony P. F. Turner Pdf

Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems will cover the up-to-date biosensor technologies used for the detection of bacteria. Written by the world's most renowned and learned scientists each in their own area of expertise, Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems is the first title to cover this expanding research field.

Author : Sandeep Nema,John D. Ludwig
Publisher : CRC Press
Page : 2756 pages
File Size : 49,6 Mb
Release : 2019-07-19
Category : Business & Economics
ISBN : 9780429574726

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Parenteral Medications, Fourth Edition by Sandeep Nema,John D. Ludwig Pdf

Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacturing of parenteral dosage forms, effectively balancing theoretical considerations with practical aspects of their development. Previously published as a three-volume set, all volumes have been combined into one comprehensive publication that addresses the plethora of changes in the science and considerable advances in the technology associated with these products and routes of administration. Key Features: Provides a comprehensive reference work on the formulation and manufacturing of parenteral dosage forms Addresses changes in the science and advances in the technology associated with parenteral medications and routes of administration Includes 13 new chapters and updated chapters throughout Contains the contributors of leading researchers in the field of parenteral medications Uses full color detailed illustrations, enhancing the learning process The fourth edition not only reflects enhanced content in all the chapters but also highlights the rapidly advancing formulation, processing, manufacturing parenteral technology including advanced delivery and cell therapies. The book is divided into seven sectionss: Section 1 - Parenteral Drug Administration and Delivery Devices; Section 2 - Formulation Design and Development; Section 3 - Specialized Drug Delivery Systems; Section 4 - Primary Packaging and Container Closure Integrity; Section 5 - Facility Design and Environmental Control; Section 6 - Sterilization and Pharmaceutical Processing; Section 7 - Quality Testing and Regulatory Requirements

Author : Ruth H. Carmichael,Mark L. Botton,Paul K.S. Shin,Siu Gin Cheung
Publisher : Springer
Page : 599 pages
File Size : 44,9 Mb
Release : 2015-11-09
Category : Science
ISBN : 9783319195421

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Changing Global Perspectives on Horseshoe Crab Biology, Conservation and Management by Ruth H. Carmichael,Mark L. Botton,Paul K.S. Shin,Siu Gin Cheung Pdf

This book reports significant progress of scientific research on horseshoe crabs, including aspects of evolution, genetics, ecology, population dynamics, general biology and physiology, within the recent 10 years. It also highlights the emerging issues related to world-wide conservation threats, status and needs. The contributions in this book represent part of an ongoing global effort to increase data and concept sharing to support basic research and advance conservation for horseshoe crabs.

Author : Helmut Brade
Publisher : CRC Press
Page : 968 pages
File Size : 42,7 Mb
Release : 2020-10-28
Category : Science
ISBN : 9781000110388

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Endotoxin in Health and Disease by Helmut Brade Pdf

Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.