Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders

Author : Michael Aschner,Lucio G. Costa
Publisher : Academic Press
Page : 450 pages
File Size : 40,7 Mb
Release : 2015-06-18
Category : Technology & Engineering
ISBN : 9780128004074

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Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders by Michael Aschner,Lucio G. Costa Pdf

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders Written by an international selection of the world’s foremost experts in the field of neurotoxicology Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience

Author : Anna Maria Lavezzi,Marco Colizzi,Pamela J. Lein
Publisher : Frontiers Media SA
Page : 182 pages
File Size : 53,6 Mb
Release : 2023-09-05
Category : Medical
ISBN : 9782832532690

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Advances in understanding the pathogenetic mechanisms of neurodevelopmental disorders and neurodegenerative disease - The environment as a putative risk factor by Anna Maria Lavezzi,Marco Colizzi,Pamela J. Lein Pdf

Neurodevelopmental disorders are generally influenced by genetic as well as intrauterine and extrauterine factors that affect the fetal-maternal environment and/or brain development that continues after birth. Specific genetic polymorphisms may increase susceptibility to environmental factors that alter the trajectory of brain development via diverse molecular mechanisms. In particular, the pre- and post-natal exposure to neurotoxic metals, pesticides, persistent organic pollutants, and other chemicals is increasingly recognized as involved in the pathogenesis of neurodevelopmental disorders, such as autism, deficiency attention/hyperactivity disorders, neurodegenerative disorders such as Parkinson's and Alzheimer's disease, chronic multiple sclerosis, and even fetal and infant death, including SIUDS (Sudden Unexplained Intrauterine Death Syndrome) and SIDS (Sudden Infant Death Syndrome).

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Board on Environmental Studies and Toxicology,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 87 pages
File Size : 47,6 Mb
Release : 2021-01-22
Category : Medical
ISBN : 9780309683098

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Environmental Neuroscience by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Board on Environmental Studies and Toxicology,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical. On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.

Author : Gustavo Pacheco-Lopez,Marcel Pérez-Morales,Kioko Rubi Guzman-Ramos,Johnny Davis Figueroa,Ute Krügel,Javier A. Bravo
Publisher : Frontiers Media SA
Page : 162 pages
File Size : 49,5 Mb
Release : 2021-09-23
Category : Science
ISBN : 9782889713486

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Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration by Gustavo Pacheco-Lopez,Marcel Pérez-Morales,Kioko Rubi Guzman-Ramos,Johnny Davis Figueroa,Ute Krügel,Javier A. Bravo Pdf

Author : Anonim
Publisher : Academic Press
Page : 312 pages
File Size : 42,5 Mb
Release : 2018-05-24
Category : Science
ISBN : 9780128155523

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Linking Environmental Exposure to Neurodevelopmental Disorders by Anonim Pdf

Advances in Neurotoxicology, Volume Two, addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Author : Anonim
Publisher : Academic Press
Page : 290 pages
File Size : 44,8 Mb
Release : 2017-09-19
Category : Science
ISBN : 9780128127650

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Environmental Factors in Neurodegenerative Diseases by Anonim Pdf

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Author : Randi Jenssen Hagerman,Robert L. Hendren
Publisher : Oxford University Press, USA
Page : 401 pages
File Size : 52,9 Mb
Release : 2014
Category : Medical
ISBN : 9780199937806

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Treatment of Neurodevelopmental Disorders by Randi Jenssen Hagerman,Robert L. Hendren Pdf

This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.

Author : Jeffrey L. Cummings,Jagan A. Pillai
Publisher : Oxford University Press
Page : 361 pages
File Size : 47,5 Mb
Release : 2016-11-14
Category : Medical
ISBN : 9780190233563

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Neurodegenerative Diseases by Jeffrey L. Cummings,Jagan A. Pillai Pdf

'Neurodegenerative Diseases' is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for this work.

Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Page : 321 pages
File Size : 49,9 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9781447166788

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Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Author : Institute of Medicine,Board on Global Health,Committee on Nervous System Disorders in Developing Countries
Publisher : National Academies Press
Page : 458 pages
File Size : 42,8 Mb
Release : 2001-01-01
Category : Medical
ISBN : 9780309170932

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Neurological, Psychiatric, and Developmental Disorders by Institute of Medicine,Board on Global Health,Committee on Nervous System Disorders in Developing Countries Pdf

Brain disordersâ€"neurological, psychiatric, and developmentalâ€"now affect at least 250 million people in the developing world, and this number is expected to rise as life expectancy increases. Yet public and private health systems in developing countries have paid relatively little attention to brain disorders. The negative attitudes, prejudice, and stigma that often surround many of these disorders have contributed to this neglect. Lacking proper diagnosis and treatment, millions of individual lives are lost to disability and death. Such conditions exact both personal and economic costs on families, communities, and nations. The report describes the causes and risk factors associated with brain disorders. It focuses on six representative brain disorders that are prevalent in developing countries: developmental disabilities, epilepsy, schizophrenia, bipolar disorder, depression, and stroke. The report makes detailed recommendations of ways to reduce the toll exacted by these six disorders. In broader strokes, the report also proposes six major strategies toward reducing the overall burden of brain disorders in the developing world.

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 358 pages
File Size : 40,8 Mb
Release : 2008-03-12
Category : Medical
ISBN : 9780309108812

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Autism and the Environment by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Autism spectrum disorders (ASD) constitute a major public health problem, affecting one in every 150 children and their families. Unfortunately, there is little understanding of the causes of ASD, and, despite their broad societal impact, many people believe that the overall research program for autism is incomplete, particularly as it relates to the role of environmental factors. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders, in response to a request from the U.S. Secretary of Health and Human Services, hosted a workshop called "Autism and the Environment: Challenges and Opportunities for Research." The focus was on improving the understanding of the ways in which environmental factors such as chemicals, infectious agents, or physiological or psychological stress can affect the development of the brain. Autism and the Environment documents the concerted effort which brought together the key public and private stakeholders to discuss potential ways to improve the understanding of the ways that environmental factors may affect ASD. The presentations and discussions from the workshop that are described in this book identify a number of promising directions for research on the possible role of different environmental agents in the etiology of autism.

Author : Uddin, Md. Sahab,Amran, Md. Shah
Publisher : IGI Global
Page : 597 pages
File Size : 48,9 Mb
Release : 2018-07-31
Category : Medical
ISBN : 9781522552833

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Handbook of Research on Critical Examinations of Neurodegenerative Disorders by Uddin, Md. Sahab,Amran, Md. Shah Pdf

Neurodegeneration is a key feature of several diseases that are referred to as neurodegenerative diseases. The process of neurodegeneration is not well-understood so the diseases that stem from it have, as yet, no cures. As such, studying the effects of these disorders can provide insight into the treatment, prevention, and future opportunities and challenges in this growing field. The Handbook of Research on Critical Examinations of Neurodegenerative Disorders is a critical scholarly resource that provides an extensive explanation of various neurodegenerative disorders based on existing studies to clarify etiology, pathological mechanisms, diagnosis, therapeutic interventions, as well as current status and future opportunities and challenges. Featuring coverage on a broad range of topics such as dementia, mitochondrial dysfunction, and risk factors, this book is geared towards neurobiologists, neuropsychologists, neurophysiologists, neuropathologists, medical professionals, academicians, and researchers seeking research on the complexity of neurodegenerative disorders.

Author : Matcheri S. Keshavan,James L. Kennedy,Robin M. Murray
Publisher : Cambridge University Press
Page : 576 pages
File Size : 44,8 Mb
Release : 2004-11-18
Category : Medical
ISBN : 0521823315

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Neurodevelopment and Schizophrenia by Matcheri S. Keshavan,James L. Kennedy,Robin M. Murray Pdf

This book was originally published in 2004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

Author : Peter Gluckman,Mark Hanson
Publisher : Cambridge University Press
Page : 542 pages
File Size : 48,9 Mb
Release : 2006-04-20
Category : Medical
ISBN : 0521847435

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Developmental Origins of Health and Disease by Peter Gluckman,Mark Hanson Pdf

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Author : Kazuhiko Sawada,Atsushi Yoshiki,Shigeyoshi Saito
Publisher : Frontiers Media SA
Page : 162 pages
File Size : 48,6 Mb
Release : 2022-08-31
Category : Science
ISBN : 9782889768769

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Brain abnormalities due to genetic alterations or developmental exposure to environmental factors by Kazuhiko Sawada,Atsushi Yoshiki,Shigeyoshi Saito Pdf