Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Molecular Biology of The Cell
Bruce Alberts
Enzyme Functionality
Enzyme Functionality Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Enzyme Functionality book. This book definitely worth reading, it is an incredibly well-written.
Enzyme Functionality
Allan Svendsen
Author : Allan Svendsen
Publisher : CRC Press
Page : 638 pages
File Size : 43,6 Mb
Release : 2003-10-28
Category : Medical
ISBN : 9780824756918
Enzyme Functionality by Allan Svendsen Pdf
Enzyme Functionality serves as a conduit for trailblazing research in enzyme engineering-relating current understanding of sequence families, the new notion of enzyme structure classes, and modern methods in protein engineering, design, and directed evolution to accelerate the development of novel enzyme functionalities. This reference gathers the diverse perspectives of nearly 80 scientists from around the globe and surveys all leading rational and random approaches to the artificial evolution of enzymes. Citing more than 1500 notable works, it outlines assays for enzyme activity, stability, and specificity and a wide variety of site-directed, redesign, and evolutionary engineering methods.
Enzyme Functionality
Allan Svendsen
Author : Allan Svendsen
Publisher : CRC Press
Page : 706 pages
File Size : 51,9 Mb
Release : 2003-10-28
Category : Medical
ISBN : 0203913043
Enzyme Functionality by Allan Svendsen Pdf
Enzyme Functionality serves as a conduit for trailblazing research in enzyme engineering-relating current understanding of sequence families, the new notion of enzyme structure classes, and modern methods in protein engineering, design, and directed evolution to accelerate the development of novel enzyme functionalities. This reference gathers the
Control of Enzyme Activity
Philip Cohen
Author : Philip Cohen
Publisher : Chapman & Hall
Page : 68 pages
File Size : 40,6 Mb
Release : 1976
Category : Science
ISBN : 0412130602
Control of Enzyme Activity by Philip Cohen Pdf
Methods to Determine Enzymatic Activity
Alane Beatriz Vermelho ,Sonia Couri
Author : Alane Beatriz Vermelho ,Sonia Couri
Publisher : Bentham Science Publishers
Page : 334 pages
File Size : 54,8 Mb
Release : 2013-11-22
Category : Science
ISBN : 9781608053001
Methods to Determine Enzymatic Activity by Alane Beatriz Vermelho ,Sonia Couri Pdf
Methods to Determine Enzymatic Activity is a textbook about industrial enzymes. The book features definitions, classifications and applications of selected enzymes important in industry and in biotechnological processes. Analytical methods for these enzymes are also included in the text. The main objective of this textbook is to provide readers information focused on the current analysis methods of enzymatic activity at qualitative and quantitative levels. Each chapter is about one specific enzyme and contains information about its substrate and some biochemical properties. The methodologies are presented as an experimental protocol allowing interested readers to reproduce the experimental methods detailed within the textbook. These protocols contain the principle of the technique, materials, methods, and all steps necessary for the determination of enzyme activity and interpretation of results. Each methodology is illustrated with photos and schemes for a better and clear understanding. This book, therefore, uniquely brings modern analysis techniques of industrial enzymes in a single easy to understand volume. This textbook is suitable for undergraduate enzymology courses and advanced industrial biotechnology and microbiology courses.
The Exocrine Pancreas
Stephen Pandol
Author : Stephen Pandol
Publisher : Morgan & Claypool Publishers
Page : 66 pages
File Size : 46,7 Mb
Release : 2011
Category : Medical
ISBN : 9781615041381
The Exocrine Pancreas by Stephen Pandol Pdf
The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.
How Enzymes Work
Haruo Suzuki
Author : Haruo Suzuki
Publisher : CRC Press
Page : 232 pages
File Size : 41,5 Mb
Release : 2015-02-05
Category : Medical
ISBN : 9789814463935
How Enzymes Work by Haruo Suzuki Pdf
For a long time, enzymes have been studied by measuring their activity, which has led to the advancement of "enzyme kinetics." In recent years, the mechanism of enzyme reaction has been explained in detail on the basis of the 3D structure. Genetic engineering and the 3D structural analysis of enzymes contribute to these advancements in enzymology.
Improving and Tailoring Enzymes for Food Quality and Functionality
Rickey Y. Yada,Derek R. Dee
Author : Rickey Y. Yada,Derek R. Dee
Publisher : Elsevier
Page : 380 pages
File Size : 46,8 Mb
Release : 2024-04-01
Category : Technology & Engineering
ISBN : 9780443154386
Improving and Tailoring Enzymes for Food Quality and Functionality by Rickey Y. Yada,Derek R. Dee Pdf
Improving and Tailoring Enzymes for Food Quality and Functionality, Second Edition covers the most relevant information demanded in the production, engineering, and application of enzymes. The title is very detailed and is in the important cross-field of academia and industry. This totally revised new edition covers a broad range of topics related to enzymes and their use in food, presenting both the fundamental theory and practical application, updated with interesting novel information on biosensors, waste, valorization, up-cycling and engineering perspectives, besides an increased focus on sustainability. Thoroughly updated revision covering a broad range of topics related to enzymes and their use in the food industry Presents both the fundamental theory and recent examples from the literature, including the fundamentals of protein folding and enzyme catalysis, the preparation of enzymes from natural and recombinant sources, immobilizing enzymes, and a range of specific food applications Covers new research directions in enzymes, thus helping those trying to solve a technical issue or develop a new product
Clinical Enzymology
John C. Griffiths
Author : John C. Griffiths
Publisher : Unknown
Page : 232 pages
File Size : 42,7 Mb
Release : 1979
Category : Medical
ISBN : UOM:39015003808634
Clinical Enzymology by John C. Griffiths Pdf
Enzyme Activity in Single Cells
Anonim
Author : Anonim
Publisher : Academic Press
Page : 326 pages
File Size : 53,8 Mb
Release : 2019-11-12
Category : Science
ISBN : 9780128170908
Enzyme Activity in Single Cells by Anonim Pdf
Enzyme Activity in Single Cells, Volume 628, the latest release in the Methods of Enzymology series, discusses groundbreaking cellular physiology research that is taking place in the biological sciences. Chapters in this new release cover Spatial and temporal resolution of caspase waves in single Xenopus eggs during apoptosis, Spatial and temporal organization of metabolic complexes in cells, Measuring cellular efflux and biomolecular delivery: synthetic approaches to imaging and engineering cells, Slide-based, single-cell enzyme assays, Single-cell assays using integrated continuous-flow microfluidics, High-throughput screening of single-cell lysates, Microfluidic capture of single cells for drug resistance assays, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on Enzyme Activity in Single Cells
Therapeutic Enzymes: Function and Clinical Implications
Nikolaos Labrou
Author : Nikolaos Labrou
Publisher : Springer Nature
Page : 388 pages
File Size : 49,6 Mb
Release : 2019-09-03
Category : Science
ISBN : 9789811377099
Therapeutic Enzymes: Function and Clinical Implications by Nikolaos Labrou Pdf
Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.
Mechanistic Principles of Enzyme Activity
Joel F. Liebman,Arthur Greenberg
Author : Joel F. Liebman,Arthur Greenberg
Publisher : Wiley-VCH
Page : 424 pages
File Size : 43,6 Mb
Release : 1988
Category : Science
ISBN : UOM:39015018153943
Mechanistic Principles of Enzyme Activity by Joel F. Liebman,Arthur Greenberg Pdf
Introduction to Enzyme Technology
Karl-Erich Jaeger
Author : Karl-Erich Jaeger
Publisher : Springer Nature
Page : 467 pages
File Size : 50,8 Mb
Release : 2024-07-02
Category : Electronic
ISBN : 9783031429996
Introduction to Enzyme Technology by Karl-Erich Jaeger Pdf
Kinetics of Enzyme-Modifier Interactions
Antonio Baici
Author : Antonio Baici
Publisher : Springer
Page : 489 pages
File Size : 53,8 Mb
Release : 2015-06-24
Category : Science
ISBN : 9783709114025
Kinetics of Enzyme-Modifier Interactions by Antonio Baici Pdf
The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
Evaluation of Enzyme Inhibitors in Drug Discovery
Robert A. Copeland
Author : Robert A. Copeland
Publisher : John Wiley & Sons
Page : 295 pages
File Size : 44,5 Mb
Release : 2005-04-01
Category : Science
ISBN : 9780471723264
Evaluation of Enzyme Inhibitors in Drug Discovery by Robert A. Copeland Pdf
Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.