Epigenetics And Proteomics Of Leukemia

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Epigenetics and Proteomics of Leukemia

R ̄uta Navakauskien ̇e,Dalius Navakauskas,Veronika Borutinskait ̇e,Dalius Matuzevi ̆cius
Epigenetics and Proteomics of Leukemia Book PDF

Author : R ̄uta Navakauskien ̇e,Dalius Navakauskas,Veronika Borutinskait ̇e,Dalius Matuzevi ̆cius
Publisher : Springer Nature
Page : 453 pages
File Size : 55,5 Mb
Release : 2021-09-14
Category : Science
ISBN : 9783030687083

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Epigenetics and Proteomics of Leukemia by R ̄uta Navakauskien ̇e,Dalius Navakauskas,Veronika Borutinskait ̇e,Dalius Matuzevi ̆cius Pdf

This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

Epigenetics and Proteomics of Leukemia

Rūta Navakauskienė,Dalius Navakauskas,Veronika Borutinskaite,Dalius Matuzevicius
Epigenetics and Proteomics of Leukemia Book PDF

Author : Rūta Navakauskienė,Dalius Navakauskas,Veronika Borutinskaite,Dalius Matuzevicius
Publisher : Springer
Page : 410 pages
File Size : 52,8 Mb
Release : 2021-06-30
Category : Science
ISBN : 3030687074

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Epigenetics and Proteomics of Leukemia by Rūta Navakauskienė,Dalius Navakauskas,Veronika Borutinskaite,Dalius Matuzevicius Pdf

This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

Handbook of Nutrition, Diet, and Epigenetics

Vinood B. Patel,Victor R. Preedy
Handbook of Nutrition Diet and Epigenetics Book PDF

Author : Vinood B. Patel,Victor R. Preedy
Publisher : Springer
Page : 0 pages
File Size : 55,8 Mb
Release : 2019-02-27
Category : Medical
ISBN : 3319555294

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Handbook of Nutrition, Diet, and Epigenetics by Vinood B. Patel,Victor R. Preedy Pdf

This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Epigenetic Mechanisms in Cancer

Sabita Saldanha
Epigenetic Mechanisms in Cancer Book PDF

Author : Sabita Saldanha
Publisher : Academic Press
Page : 0 pages
File Size : 51,6 Mb
Release : 2017-11-07
Category : Medical
ISBN : 0128095520

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Epigenetic Mechanisms in Cancer by Sabita Saldanha Pdf

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.

Proteoforms

Xianquan Zhan
Proteoforms Book PDF

Author : Xianquan Zhan
Publisher : BoD – Books on Demand
Page : 92 pages
File Size : 50,9 Mb
Release : 2020-07-15
Category : Science
ISBN : 9781838800338

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Proteoforms by Xianquan Zhan Pdf

A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia.

Evolution of Translational Omics

Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Evolution of Translational Omics Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 51,6 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185

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Evolution of Translational Omics by Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials Pdf

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Integrative Preventive Medicine

Richard H. Carmona,Mark Liponis
Integrative Preventive Medicine Book PDF

Author : Richard H. Carmona,Mark Liponis
Publisher : Oxford University Press
Page : 585 pages
File Size : 46,5 Mb
Release : 2017-12-12
Category : Medical
ISBN : 9780190241254

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Integrative Preventive Medicine by Richard H. Carmona,Mark Liponis Pdf

For most clinicians, the science and evidence for many integrative therapies is largely unknown or considered suspect. Most physicians don't have time to learn integrative approaches and aren't sure what to recommend or which approaches have merit or improved outcomes. Here, clinicians have easy access to the best practices in integrative medicine and expectations for outcomes

Epigenetic Biomarkers and Diagnostics

José Luis García-Giménez
Epigenetic Biomarkers and Diagnostics Book PDF

Author : José Luis García-Giménez
Publisher : Academic Press
Page : 696 pages
File Size : 41,7 Mb
Release : 2015-12-07
Category : Science
ISBN : 9780128019214

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Epigenetic Biomarkers and Diagnostics by José Luis García-Giménez Pdf

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Epigenetics in Human Disease

Trygve O Tollefsbol
Epigenetics in Human Disease Book PDF

Author : Trygve O Tollefsbol
Publisher : Elsevier
Page : 1362 pages
File Size : 49,8 Mb
Release : 2023-10-09
Category : Medical
ISBN : 9780443218125

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Epigenetics in Human Disease by Trygve O Tollefsbol Pdf

Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies. Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways Each chapter updated to include summaries, definitions, and vibrant imagery and figures to reinforce understanding Features step-by-step methods and disease research case studies to put book concepts into practice

Systems Biology of Cancer

Sam Thiagalingam
Systems Biology of Cancer Book PDF

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 47,8 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Prognostic Epigenetics

Anonim
Prognostic Epigenetics Book PDF

Author : Anonim
Publisher : Academic Press
Page : 442 pages
File Size : 54,9 Mb
Release : 2019-11-01
Category : Medical
ISBN : 9780128142608

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Prognostic Epigenetics by Anonim Pdf

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers

Epigenetics Methods

Trygve Tollefsbol
Epigenetics Methods Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 736 pages
File Size : 41,7 Mb
Release : 2020-07-08
Category : Medical
ISBN : 9780128194157

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Epigenetics Methods by Trygve Tollefsbol Pdf

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Personalized Medicine in Healthcare Systems

Nada Bodiroga-Vukobrat,Daniel Rukavina,Krešimir Pavelić,Gerald G. Sander
Personalized Medicine in Healthcare Systems Book PDF

Author : Nada Bodiroga-Vukobrat,Daniel Rukavina,Krešimir Pavelić,Gerald G. Sander
Publisher : Springer
Page : 405 pages
File Size : 55,6 Mb
Release : 2019-08-02
Category : Law
ISBN : 9783030164652

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Personalized Medicine in Healthcare Systems by Nada Bodiroga-Vukobrat,Daniel Rukavina,Krešimir Pavelić,Gerald G. Sander Pdf

This book gathers scientific contributions on comprehensive approaches to personalized medicine. In a systematic and clear manner, it provides extensive information on the methodological, technological, and clinical aspects of high-throughput analytics, nanotechnology approaches, microbiota/human interactions, in-vitro fertilization and preimplantation, and various diseases like cancer.Moreover, the book analyzes the social and legal aspects of social security systems, healthcare systems and EU law – e.g. the role of solidarity, regulatory possibilities and obstacles, justice and equality, privacy/disclosure of data, and the right to know – from an interdisciplinary perspective. Lastly, it explores the economical and ethical context in the fields of business models, intellectual property issues, the patient/physician relationship, and price discrimination.

Clinical Epigenetics

Luke B. Hesson,Antonia L. Pritchard
Clinical Epigenetics Book PDF

Author : Luke B. Hesson,Antonia L. Pritchard
Publisher : Springer Nature
Page : 265 pages
File Size : 52,9 Mb
Release : 2019-08-31
Category : Medical
ISBN : 9789811389580

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Clinical Epigenetics by Luke B. Hesson,Antonia L. Pritchard Pdf

In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.

Gene Regulation, Epigenetics and Hormone Signaling

Subhrangsu S. Mandal
Gene Regulation Epigenetics and Hormone Signaling Book PDF

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
Page : 678 pages
File Size : 42,7 Mb
Release : 2017-10-23
Category : Science
ISBN : 9783527322817

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Gene Regulation, Epigenetics and Hormone Signaling by Subhrangsu S. Mandal Pdf

The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.