Epigenetics And Psychiatric Disease

Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publisher : Academic Press
Page : 848 pages
File Size : 53,5 Mb
Release : 2021-08-21
Category : Science
ISBN : 9780128235782

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Epigenetics in Psychiatry by Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos Pdf

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Author : Anonim
Publisher : Academic Press
Page : 450 pages
File Size : 55,6 Mb
Release : 2018-06-22
Category : Science
ISBN : 9780128135662

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Epigenetics and Psychiatric Disease by Anonim Pdf

Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic regulation in schizophrenia, Progress in the epigenetics of depression, the epigenetics of circadian rhythms in imprinted neurodevelopmental disorders, DNA methylation mediating substance abuse, mechanisms and therapeutic opportunities, DNA methylation in animals model of psychosis, Epigenetics of early life stress, Epigenetic drugs for mood disorders, and more. Accessible to students and researchers alike, with content that appeals to a variety of readers Written by leading authorities in their respective fields of molecular biology

Author : Onoriode Edeh, M.D.,Kyle J. Rutledge, D.O., Ph.D.
Publisher : American Psychiatric Pub
Page : 192 pages
File Size : 48,8 Mb
Release : 2023-11-20
Category : Medical
ISBN : 9781615374137

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Applied Epigenetics for Mental Health Professionals by Onoriode Edeh, M.D.,Kyle J. Rutledge, D.O., Ph.D. Pdf

Author : Cunyou Zhao,Zhexing Wen,Weihua Yue
Publisher : Frontiers Media SA
Page : 127 pages
File Size : 51,8 Mb
Release : 2022-11-16
Category : Science
ISBN : 9782832506066

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Genetics and Epigenetics of Psychiatric Diseases - Volume II by Cunyou Zhao,Zhexing Wen,Weihua Yue Pdf

Author : Jacob Peedicayil,Dennis R. Grayson
Publisher : Elsevier
Page : 418 pages
File Size : 51,7 Mb
Release : 2023-09-29
Category : Science
ISBN : 9780443185175

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Neuropsychiatric Disorders and Epigenetics by Jacob Peedicayil,Dennis R. Grayson Pdf

Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding Includes chapter contributions from leading global experts

Author : Fushun Wang,Jason H. Huang,Fang Pan,Yi-Yuan Tang
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 43,5 Mb
Release : 2021-08-09
Category : Science
ISBN : 9782889711536

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Early Life Stress-Induced Epigenetic Changes Involved in Mental Disorders by Fushun Wang,Jason H. Huang,Fang Pan,Yi-Yuan Tang Pdf

Author : Elena Martín-García,Patrick E. Williams,Noèlia Fernàndez-Castillo
Publisher : Frontiers Media SA
Page : 200 pages
File Size : 45,5 Mb
Release : 2022-07-06
Category : Science
ISBN : 9782889765157

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Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders by Elena Martín-García,Patrick E. Williams,Noèlia Fernàndez-Castillo Pdf

Author : Bart P.F. Rutten
Publisher : Academic Press
Page : 343 pages
File Size : 41,9 Mb
Release : 2018-07-30
Category : Science
ISBN : 9780128125939

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Neuroepigenetics and Mental Illness by Bart P.F. Rutten Pdf

Neuroepigenetics and Mental Illness, Volume 158, the latest release in the Progress in Molecular Biology and Translational Science series, seeks to provide the most topical, informative, and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series seeks to provide readers with in-depth knowledge of important molecular biological aspects of organismal physiology and function, with this release focusing on Neuroepigenetics in mental illness, Neuroepigenetics of development and neurodevelopmental disorder, Neuroepigenetics of aging and age-related neurodegenerative disorders, Neuroepigenetics of prenatal psychological stress, Neuroepigenetics of the HPA axis, Neuroepigenetics of the serotonergic system, and more. Presents updated volumes comprising 15-20 chapters, allowing comprehensive coverage on a topic Uses tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided in each chapter

Author : Dietmar Spengler,Elisabeth Binder
Publisher : Springer
Page : 264 pages
File Size : 54,5 Mb
Release : 2016-04-02
Category : Medical
ISBN : 9783319244938

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Epigenetics and Neuroendocrinology by Dietmar Spengler,Elisabeth Binder Pdf

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

Author : Nessa Carey
Publisher : Columbia University Press
Page : 353 pages
File Size : 52,5 Mb
Release : 2012-03-06
Category : Science
ISBN : 9780231530712

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The Epigenetics Revolution by Nessa Carey Pdf

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Author : Nagy Youssef
Publisher : Academic Press
Page : 422 pages
File Size : 42,8 Mb
Release : 2022-02-18
Category : Medical
ISBN : 9780128230626

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Epigenetics of Stress and Stress Disorders by Nagy Youssef Pdf

Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or “epidrugs. Examines the epigenetics of stress, trauma, and related stress disorders Connects new research to clinical practice and highlights implications for patient care, drug discovery, and public health Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigenetic alterations Features chapter contributions from international experts in the field

Author : John I. Nurnberger,Wade Berrettini
Publisher : Cambridge University Press
Page : 415 pages
File Size : 40,8 Mb
Release : 2012-09-13
Category : Medical
ISBN : 9780521896498

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Principles of Psychiatric Genetics by John I. Nurnberger,Wade Berrettini Pdf

A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.

Author : Qing Yan
Publisher : Springer Nature
Page : 618 pages
File Size : 45,6 Mb
Release : 2022-09-06
Category : Medical
ISBN : 9781071625736

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Pharmacogenomics in Drug Discovery and Development by Qing Yan Pdf

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Author : Karin B. Michels
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 54,6 Mb
Release : 2012-01-02
Category : Medical
ISBN : 9789400724952

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Epigenetic Epidemiology by Karin B. Michels Pdf

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored.This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Author : Yogesh Dwivedi
Publisher : CRC Press
Page : 485 pages
File Size : 41,9 Mb
Release : 2012-06-25
Category : Medical
ISBN : 9781439838815

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The Neurobiological Basis of Suicide by Yogesh Dwivedi Pdf

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.