Epigenetics For Beginners And Intermediate 2 Books In 1

Author : Frank Brown
Publisher : Youcanprint
Page : 330 pages
File Size : 45,7 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9791220357999

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Epigenetics for Beginners and Intermediate (2 Books in 1) by Frank Brown Pdf

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes • The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Author : Frank Brown
Publisher : Unknown
Page : 330 pages
File Size : 49,5 Mb
Release : 2021
Category : Health & Fitness
ISBN : 9791220354912

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Epigenetics for Beginners and Intermediate (2 Books in 1) by Frank Brown Pdf

Author : Frank Brown
Publisher : Youcanprint
Page : 340 pages
File Size : 50,5 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9791220357975

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Epigenetics Explained. How Modern Biology is Changing the Concepts of Genetics and Inheritance. How the environment can affect our genes. by Frank Brown Pdf

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes •The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Author : Frank Brown
Publisher : Youcanprint
Page : 170 pages
File Size : 44,6 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9791220358002

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Epigenetics for Intermediate. The Most Comprehensive Exploration of the Practical, Social and Ethical Impact of DNA on Our Society and Our World by Frank Brown Pdf

You Are About To Develop An Insider Understanding Of Epigenetics, Including Their Relationship With The DNA, Environmental Factors, Human Development And Evolution; Their Role In Human Mental And Physical Health, Including Their Use In The Treating Of Different Conditions And Diseases Along With The Most Current Epigenetic Practices And Research! What started as a broad research focused on combining genetics and developmental biology during the mid-twentieth century has evolved into the field we currently refer to as epigenetics- the mechanism of gene control that can either promote or repress gene expression without altering the genetic coding of the organism. Today, we know that the environment factors and individual lifestyles can have a direct interaction with epigenetic change, which can be reflected at various stages throughout the life of an individual and even in the later generations. You've heard that a mother's exposure to pollution can affect her child's asthma susceptibility, haven't you? No? How about the argument that a child's mental fitness can be (epigenetically) influenced by his/her dad's diet? Epigenetic change, which has nothing to do with the changes to the underlying DNA sequence, does affect how cells read genes and this biological change is influenced by several factors which include environment, lifestyle and health state through a mechanisms including a popular one known as DNA methylation. But what is the relationship between the epigenetic change and physical and physiological conditions as regards to their onset and improvement? How are epigenetic modifications being used to understand our environment, society and increasing human adaptation? How exactly do epigenetic therapies work? How does DNA affect epigenetic changes? How can we exploit epigenetic mechanisms to understand life better and improve it? If you have these and other related questions, this book is for you. More precisely, you will learn: What epigenetics are and their role in developmental psychology The influence of epigenetics at the molecular level and the impact of DNA damage in epigenetic change How epigenetics are studied The functions and consequences of epigenetics, and their specific benefits in mindfulness training, healthy eating and physical activity How genes control the growth and division of cells The role of epigenetic therapy in diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia and many more How epigenetic modifications are used in cancer treatment, and plant and animal evolution How epigenetic mechanisms are used in processes including human adaptation, memory formation, growth and infant neuro-behavior. How epigenetic mechanisms are used in maternal care How environmental chemical exposures affect epigenetics The role of epigenetics in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more The role of environmental exposures in pathophysiology of IPF Modulation of epigenetic marks by environmental exposures How epigenetic regulation affects the immune system …And so much more! So if you've been exposed to the concept of epigenetics as a novel way of understanding disorders, inheritance and evolution and wondered what it's really all about and how it's related with environmental exposure and different therapy practices, this book is all you need! Scroll up and click Buy Now With 1-Click or Buy Now to get started!

Author : June Corder
Publisher : Unknown
Page : 51 pages
File Size : 48,5 Mb
Release : 2021-08-21
Category : Electronic
ISBN : 9798461522858

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Epigenetics for Beginners by June Corder Pdf

Your genes play an important role in your health, but so do your behaviors and environment, such as what you eat and how physically active you are. Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence. Gene expression refers to how often or when proteins are created from the instructions within your genes. While genetic changes can alter which protein is made, epigenetic changes affect gene expression to turn genes "on" and "off." Since your environment and behaviors, such as diet and exercise, can result in epigenetic changes, it is easy to see the connection between your genes and your behaviors and environment. Researchers studying the microscopic roundworm Caenorhabditis elegans recently discovered a set of mutations that extended the worms' normal 2-3 week lifespan by up to 30%. This was exciting, not least because discoveries in animals such as roundworms can sometimes help us understand processes like ageing in humans. This was not the end of the story though, as the researchers found that the descendants of the long-lived roundworms could also live longer than normal, even if they only inherited the non-mutated version of the genes from their parents. This doesn't seem to make sense at first; surely characteristics such as hair colour, height and even how long we or a microscopic worm could potentially live are carried in the DNA sequence of the genes that we inherit from our parents. So how can we solve the conundrum of how the roundworms inherited the long lived characteristic, without inheriting the DNA sequence that initially caused it? The answer is epigenetics. GET YOUR COPY TODAY BY SCROLLING UP AND CLICKING BUY NOW TO GET YOUR COPY TODAY

Author : Frank Brown
Publisher : Youcanprint
Page : 162 pages
File Size : 42,9 Mb
Release : 2022-01-31
Category : Medical
ISBN : 9791220354110

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Epigenetics for Beginners by Frank Brown Pdf

You Are A Step Away From Opening Your Eyes And Mind To The World Of Epigenetics In A Manner That Will Help You Appreciate The Complexity Of The Human Cell, Genes And Other Components And How That Knowledge Is Being Applied In Transforming Lives! In the Dutch Hunger Winter of 1944-1945, the individuals who were exposed to the famine just before birth were seen, about 60 years later, to have increased rates of coronary heart disease and obesity compared to those who weren't exposed to the famine. That must been a result of an alteration in their genetic coding, right? NO. Apparently, they were found to have less DNA methylation (addition of methyl groups to the DNA molecule to change a segment without affecting the DNA's sequence) of the imprinted Insulin-like Growth Factor 2 gene compared to their siblings who had not been exposed, which shows the role of a powerful factor that doesn't require the change of the genetic sequence in organisms in development and evolution. That factor is epigenetics, and has been singled out by experts as a very important factor in evolution, yet so much underestimated in modern biology. But how is this process organized and controlled in the human body? How is it being used to advance human health? What are some of the innovative ways we benefit from it, perhaps harness its power to improve chronic diseases and conditions? Are there any risks in epigenetic therapy? How do epigenetics work at the most basic level? If you have these questions now, or have been having them before you landed here, then you are at the right place. This book answers these and many more questions to give you an insight into a mechanism that has become of central importance in modern day genetics research in the most straightforward, simple and comprehensive way. The aim is to see how gene expression can successfully be altered without touching the DNA sequence, and what that means for the resultant expression of traits; and how this phenomenon can be tapped in understanding life, and improving it. Here's a bit of what you'll find in this concise book: • What epigenetics are and how they work • Why epigenetics are important and how they relate with our experiences • The basics of body cells, including what cells really are and how they divide • The ins and outs of DNA, genes and chromosomes • How epigenetics are conceptualized today • The existing evidence of epigenetic changes; within indirect epigenetics, across indirect epigenetics and transgenerational epigenetic inheritance • The mechanisms of epigenetics and methodological insights • How epigenetic therapy is used to treat mesothelioma • The types of epigenetic therapies available today • The risks, benefits and research on epigenetic therapy • How epigenetic control affects transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • The impact of epigenetic changes in diabetes and cardiovascular risk …And much more! Even if you are completely new to genetics or epigenetics in particular, this book will be useful and valuable to you even if everything sounds like complex/advanced science because the book takes a beginner friendly approach to the topic. Scroll up and click Buy Now With 1-Click or Buy Now to get started!

Author : Frank Brown
Publisher : Charlie Creative Lab
Page : 342 pages
File Size : 43,5 Mb
Release : 2020-10-15
Category : Electronic
ISBN : 1801123179

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Epigenetics Explained by Frank Brown Pdf

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Here is a bit of what you'll learn from this 2 in 1 book: - What epigenetics are, why they're important and how they work - How epigenetics relate with our experiences - How cells divide, and how genes control the growth and division of cells - The difference between the DNA, gene and chromosomes - The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance - The ins and outs of epigenetics mechanisms - The types of epigenetic therapies available today, including their risks, benefits and research on them - The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping - How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change - The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise - How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more - How epigenetic modifications are used in understanding plant and animal evolution - How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. - The role of epigenetic mechanisms in maternal care - The role of environmental chemicals in epigenetics - How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. - The role of environmental exposures in pathophysiology of IPF - Modulation of epigenetic marks by environmental exposures - How epigenetic regulation affects the immune system ...And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait....

Author : Roy Carroll
Publisher : Youcanprint
Page : 147 pages
File Size : 51,8 Mb
Release : 2022-01-25
Category : Medical
ISBN : 9791220372398

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Epigenetics Book by Roy Carroll Pdf

You Are About To Develop An Insider Understanding Of Epigenetics, Including Their Relationship With The DNA, Environmental Factors, Human Development And Evolution; Their Role In Human Mental And Physical Health, Including Their Use In The Treating Of Different Conditions And Diseases Along With The Most Current Epigenetic Practices And Research! What started as a broad research focused on combining genetics and developmental biology during the mid-twentieth century has evolved into the field we currently refer to as epigenetics- the mechanism of gene control that can either promote or repress gene expression without altering the genetic coding of the organism. Today, we know that the environment factors and individual lifestyles can have a direct interaction with epigenetic change, which can be reflected at various stages throughout the life of an individual and even in the later generations. You've heard that a mother's exposure to pollution can affect her child's asthma susceptibility, haven't you? No? How about the argument that a child's mental fitness can be (epigenetically) influenced by his/her dad's diet? Epigenetic change, which has nothing to do with the changes to the underlying DNA sequence, does affect how cells read genes and this biological change is influenced by several factors which include environment, lifestyle and health state through a mechanisms including a popular one known as DNA methylation. But what is the relationship between the epigenetic change and physical and physiological conditions as regards to their onset and improvement? How are epigenetic modifications being used to understand our environment, society and increasing human adaptation? How exactly do epigenetic therapies work? How does DNA affect epigenetic changes? How can we exploit epigenetic mechanisms to understand life better and improve it? If you have these and other related questions, this book is for you. More precisely, you will learn: What epigenetics are and their role in developmental psychology The influence of epigenetics at the molecular level and the impact of DNA damage in epigenetic change How epigenetics are studied The functions and consequences of epigenetics, and their specific benefits in mindfulness training, healthy eating and physical activity How genes control the growth and division of cells The role of epigenetic therapy in diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia and many more How epigenetic modifications are used in cancer treatment, and plant and animal evolution How epigenetic mechanisms are used in processes including human adaptation, memory formation, growth and infant neuro-behavior. How epigenetic mechanisms are used in maternal care How environmental chemical exposures affect epigenetics The role of epigenetics in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more The role of environmental exposures in pathophysiology of IPF Modulation of epigenetic marks by environmental exposures How epigenetic regulation affects the immune system …And so much more! So if you've been exposed to the concept of epigenetics as a novel way of understanding disorders, inheritance and evolution and wondered what it's really all about and how it's related with environmental exposure and different therapy practices, this book is all you need! Scroll up and click Buy Now With 1-Click or Buy Now to get started!

Author : Frank Brown
Publisher : Independently Published
Page : 164 pages
File Size : 40,9 Mb
Release : 2020-04-27
Category : Electronic
ISBN : 9798640672169

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Epigenetics for Beginners by Frank Brown Pdf

You Are A Step Away From Opening Your Eyes And Mind To The World Of Epigenetics In A Manner That Will Help You Appreciate The Complexity Of The Human Cell, Genes And Other Components And How That Knowledge Is Being Applied In Transforming Lives! In the Dutch Hunger Winter of 1944-1945, the individuals who were exposed to the famine just before birth were seen, about 60 years later, to have increased rates of coronary heart disease and obesity compared to those who weren't exposed to the famine. That must been a result of an alteration in their genetic coding, right? NO. Apparently, they were found to have less DNA methylation (addition of methyl groups to the DNA molecule to change a segment without affecting the DNA's sequence) of the imprinted Insulin-like Growth Factor 2 gene compared to their siblings who had not been exposed, which shows the role of a powerful factor that doesn't require the change of the genetic sequence in organisms in development and evolution. That factor is epigenetics, and has been singled out by experts as a very important factor in evolution, yet so much underestimated in modern biology. But how is this process organized and controlled in the human body? How is it being used to advance human health? What are some of the innovative ways we benefit from it, perhaps harness its power to improve chronic diseases and conditions? Are there any risks in epigenetic therapy? How do epigenetics work at the most basic level? If you have these questions now, or have been having them before you landed here, then you are at the right place. This book answers these and many more questions to give you an insight into a mechanism that has become of central importance in modern day genetics research in the most straightforward, simple and comprehensive way. The aim is to see how gene expression can successfully be altered without touching the DNA sequence, and what that means for the resultant expression of traits; and how this phenomenon can be tapped in understanding life, and improving it. Here's a bit of what you'll find in this concise book: What epigenetics are and how they work Why epigenetics are important and how they relate with our experiences The basics of body cells, including what cells really are and how they divide The ins and outs of DNA, genes and chromosomes How epigenetics are conceptualized today The existing evidence of epigenetic changes; within indirect epigenetics, across indirect epigenetics and transgenerational epigenetic inheritance The mechanisms of epigenetics and methodological insights How epigenetic therapy is used to treat mesothelioma The types of epigenetic therapies available today The risks, benefits and research on epigenetic therapy How epigenetic control affects transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping The impact of epigenetic changes in diabetes and cardiovascular risk ...And much more! Even if you are completely new to genetics or epigenetics in particular, this book will be useful and valuable to you even if everything sounds like complex/advanced science because the book takes a beginner friendly approach to the topic. Scroll up and click Buy Now With 1-Click or Buy Now to get started!

Author : Biotech LIVE
Publisher : Unknown
Page : 50 pages
File Size : 51,8 Mb
Release : 2017-11-02
Category : Electronic
ISBN : 1973207141

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Basic Concept of Epigenetic by Biotech LIVE Pdf

THIS BOOK HAS BEEN PUBLISHED TO MAKE SURE THAT MAXIMUM NUMBER OF STUDENTS CAN ACQUIRE KNOWLEDGE. IT HAS BEEN MADE AVAILABLE IN AN EXTREMELY SIMPLE LANGUAGE. SOME OF THE CONTENT MAY BE A COPY RIGHTED MATERIAL. THE COPYRIGHT HOLDER HAS BEEN CREDITED AT THE END.THIS BOOK IS OFFERED AS A RESOURCE TO THE STUDENTS WHO NEED BASIC KNOWLEDGE IN GENETICS AND EPIGENETICS.FEATURE: DETAILED INFORMATION ON EPIGENETICS FOR BEGINNERSSIMPLIFIED DIAGRAMSIT GIVES A BRIEF INTRODUCTION ABOUT THE EPIGENETICS, MECHANISM WITH THEIR ROLE IN DAILY LIFE AND THE CAUSE OF CANCER AND DRUGS AND MANY MOREHOPE THIS WILL GIVE A IDEA ABOUT THE TERM EPIGENETICS REGARDS, BIOTECHLIVE

Author : Dieter Kabelitz,Jaydeep Bhat
Publisher : Academic Press
Page : 386 pages
File Size : 53,8 Mb
Release : 2020-06-04
Category : Medical
ISBN : 9780128179659

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Epigenetics of the Immune System by Dieter Kabelitz,Jaydeep Bhat Pdf

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 49,5 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171

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Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Publisher : Springer Nature
Page : 215 pages
File Size : 53,5 Mb
Release : 2021-03-23
Category : Science
ISBN : 9783030686703

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Introduction to Epigenetics by Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz Pdf

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Author : Nessa Carey
Publisher : Columbia University Press
Page : 353 pages
File Size : 43,5 Mb
Release : 2012-03-06
Category : Science
ISBN : 9780231530712

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The Epigenetics Revolution by Nessa Carey Pdf

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Author : Yoshimasa Saito
Publisher : Frontiers E-books
Page : 80 pages
File Size : 50,7 Mb
Release : 2014-11-10
Category : Biology (General)
ISBN : 9782889193455

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Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell by Yoshimasa Saito Pdf

Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (H3K9) and tri-methylation of H3K27. MiRNAs are small non-coding RNAs that regulate expression of various target genes. Specific miRNAs are aberrantly expressed and play roles as tumor suppressors or oncogenes during carcinogenesis. Important tumor suppressor miRNAs are silenced by epigenetic alterations, resulting in activation of target oncogenes in human malignancies. Stem cells have the ability to perpetuate themselves through self-renewal and to generate mature cells of various tissues through differentiation. Accumulating evidence suggests that a subpopulation of cancer cells with distinct stem-like properties is responsible for tumor initiation, invasive growth, and metastasis formation, which is defined as cancer stem cells. Cancer stem cells are considered to be resistant to conventional chemotherapy and radiation therapy, suggesting that these cells are important targets of cancer therapy. DNA methylation, histone modification and miRNAs may be deeply involved in stem-like properties in cancer cells. Restoring the expression of tumor suppressor genes and miRNAs by chromatin modifying drugs may be a promising therapeutic approach for cancer stem cells. In this Research Topic, we discuss about alterations of epigenetics and miRNAs in cancer and cancer stem cell and understand the molecular mechanism underlying the formation of cancer stem cell, which may provide a novel insight for treatment of refractory cancer.