Essential Practical Nmr For Organic Chemistry

Author : S. A. Richards,J. C. Hollerton
Publisher : John Wiley & Sons
Page : 345 pages
File Size : 50,7 Mb
Release : 2010-12-07
Category : Science
ISBN : 9780470977224

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Essential Practical NMR for Organic Chemistry by S. A. Richards,J. C. Hollerton Pdf

This book describes the use of NMR spectroscopy for dealing with problems of small organic molecule structural elucidation. It features a significant amount of vital chemical shift and coupling information but more importantly, it presents sound principles for the selection of the techniques relevant to the solving of particular types of problem, whilst stressing the importance of extracting the maximum available information from the simple 1-D proton experiment and of using this to plan subsequent experiments. Proton NMR is covered in detail, with a description of the fundamentals of the technique, the instrumentation and the data that it provides before going on to discuss optimal solvent selection and sample preparation. This is followed by a detailed study of each of the important classes of protons, breaking the spectrum up into regions (exchangeables, aromatics, heterocyclics, alkenes etc.). This is followed by consideration of the phenomena that we know can leave chemists struggling; chiral centres, restricted rotation, anisotropy, accidental equivalence, non-first-order spectra etc. Having explained the potential pitfalls that await the unwary, the book then goes on to devote chapters to the chemical techniques and the most useful instrumental ones that can be employed to combat them. A discussion is then presented on carbon-13 NMR, detailing its pros and cons and showing how it can be used in conjunction with proton NMR via the pivotal 2-D techniques (HSQC and HMBC) to yield vital structural information. Some of the more specialist techniques available are then discussed, i.e. flow NMR, solvent suppression, Magic Angle Spinning, etc. Other important nuclei are then discussed and useful data supplied. This is followed by a discussion of the neglected use of NMR as a tool for quantification and new techniques for this explained. The book then considers the safety aspects of NMR spectroscopy, reviewing NMR software for spectral prediction and data handling and concludes with a set of worked Q&As.

Author : S. A. Richards,J. C. Hollerton
Publisher : John Wiley & Sons
Page : 293 pages
File Size : 44,7 Mb
Release : 2023-05-01
Category : Science
ISBN : 9781119844808

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Essential Practical NMR for Organic Chemistry by S. A. Richards,J. C. Hollerton Pdf

A hands-on resource advocating an ordered approach to gathering and interpreting NMR data The second edition of Essential Practical NMR for Organic Chemistry delivers a pragmatic and accessible text demonstrating an ordered approach to gathering and interpreting NMR data. In this informal guide, you’ll learn to make sense of the high density of NMR information through the authors’ problem-solving strategies and interpretations. The book also discusses critical aspects of NMR theory, as well as data acquisition and processing strategy. It explains the use of NMR spectroscopy for dealing with problems of small organic molecule structural elucidation and includes a brand-new chapter on Nitrogen-15 NMR. Readers will also find: Strategies for preparing a sample, spectrum acquisition, processing, and interpreting your spectrum Fulsome discussions of Carbon-13 NMR spectroscopy Practical treatments of quantification, safety procedures, and relevant software An ideal handbook for anyone involved in using NMR to solve structural problems, this latest edition of Essential Practical NMR for Organic Chemistry will be particularly useful for chemists running and looking at their own NMR spectra, as well as those who work in small molecule NMR. It will also earn a place in the libraries of undergraduate and post-graduate organic chemistry students.

Author : B. I. Ionin
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468417852

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NMR Spectroscopy in Organic Chemistry by B. I. Ionin Pdf

In recent years high-resolution nuclear magnetic resonance spec troscopy has found very wide application in organie chemistry in structural and physicochemical investigations and. also in the study of the characteristics of organic compounds which are re lated to the distribution of the electron cloud in the molecules. The vigorous development of this method, which may really be re garded as an independent branch of science, is the result of ex tensive progress in NMR technology, the refinement of its theory, and the accumulation of large amounts of experimental material, which has been correlated by empiricallaws and principles. The literature directly concerned with the NMR method and its applica tion has now grown to such an extent that a complete review of it is practically impossible. Therefore the authors have limited themselves to an examination of only the most important, funda mental, and general investigations. The book consists of six chapters. In the first chapter we have attempted to present the fundamentals of the NMR method in such a way that the reader with little knowledge of the subject will be able to use the method in practical work for investigating simple compounds and solving simple problems. The three subsequent chapters give a deeper analysis of the method, while the last two chapters and the appendix illustrate the various applications of NMR spectroscopy in organic chemistry.

Author : E. Breitmaier
Publisher : Unknown
Page : 265 pages
File Size : 41,8 Mb
Release : 1993
Category : Nuclear magnetic resonance spectroscopy
ISBN : OCLC:754873340

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Structure Elucidation by NMR in Organic Chemistry by E. Breitmaier Pdf

Author : Eberhard Breitmaier
Publisher : Wiley
Page : 278 pages
File Size : 41,5 Mb
Release : 1993-04-27
Category : Science
ISBN : 0471933813

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Structure Elucidation by NMR in Organic Chemistry by Eberhard Breitmaier Pdf

Structure Elucidation by NMR in Organic Chemistry A Practical Guide Eberhard Breitmaier, University of Bonn, Germany This text provides the graduate student with a systematic guide to unravelling structural information from the NMR spectra of unknown synthetic and natural products. A brief introduction gives an overview of the basic principles and elementary instrumental methods of NMR. This is followed by instructional strategy and tactical advice on how to interpret spectra into meaningful structural information. The book provides the student with 50 sets of spectra of graduated complexity. These are designed to challenge the student’s problem-solving abilities by the introduction of new concepts with each problem, followed by possible solutions and full explanations. A full list of solutions is provided at the end of the book.

Author : T. Claridge
Publisher : Elsevier
Page : 408 pages
File Size : 50,8 Mb
Release : 1999-12-24
Category : Science
ISBN : 0080427995

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High-resolution NMR Techniques in Organic Chemistry by T. Claridge Pdf

From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biology, medicine, materials science and geology. In this book, emphasis is on the more recently developed methods of solution-state NMR applicable to chemical research, which are chosen for their wide applicability and robustness. These have, in many cases, already become established techniques in NMR laboratories, in both academic and industrial establishments. A considerable amount of information and guidance is given on the implementation and execution of the techniques described in this book.

Author : Timothy D.W. Claridge
Publisher : Newnes
Page : 400 pages
File Size : 55,5 Mb
Release : 2009
Category : Mathematics
ISBN : 9780080546285

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High-Resolution NMR Techniques in Organic Chemistry by Timothy D.W. Claridge Pdf

"Nuclear Magnetic Resonance (NMR) Spectroscopy remains the foremost analytical technique for the structure elucidation of organic molecules and an indispensable tool for the synthetic, medicinal and natural product chemist. New techniques continue to emerge and the application of NMR methods continues to expand. High-Resolution NMR Techniques in Organic Chemistry is designed for use in academic and industrial NMR facilities, as a text for graduate-level NMR courses, and as an accessible reference for the chemist's or spectroscopist's desk."--BOOK JACKET.

Author : Darcy C. Burns,William F. Reynolds
Publisher : Royal Society of Chemistry
Page : 238 pages
File Size : 51,6 Mb
Release : 2018-09-26
Category : Science
ISBN : 9781782625391

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Optimizing NMR Methods for Structure Elucidation by Darcy C. Burns,William F. Reynolds Pdf

This book is aimed at informing organic chemists and natural products chemists on the use of NMR for structure elucidation to enable them to ensure they yield the most reliable possible data in the minimum possible time. It covers the latest pulse sequences, acquisition and processing methods, practical areas not covered in most texts e.g. detailed consideration of the relative advantages and disadvantages of different pulse sequences, choosing acquisition and processing parameters to get the best possible data in the least possible time, pitfalls to avoid and how to minimize the risks of getting wrong structures. Useful in industrial, pharma or research environments, this reference book is for anyone involved with organic chemistry research and, in particular, natural products research requiring advice for getting the best results from the NMR facilities.

Author : L. D. Field,H. L. Li,A. M. Magill
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 47,5 Mb
Release : 2015-03-30
Category : Science
ISBN : 9781118868935

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Organic Structures from 2D NMR Spectra by L. D. Field,H. L. Li,A. M. Magill Pdf

The derivation of structural information from spectroscopic data is now an integral part of organic chemistry courses at all Universities. Over recent years, a number of powerful two-dimensional NMR techniques (e.g. HSQC, HMBC, TOCSY, COSY and NOESY) have been developed and these have vastly expanded the amount of structural information that can be obtained by NMR spectroscopy. Improvements in NMR instrumentation now mean that 2D NMR spectra are routinely (and sometimes automatically) acquired during the identification and characterisation of organic compounds. Organic Structures from 2D NMR Spectra is a carefully chosen set of more than 60 structural problems employing 2D-NMR spectroscopy. The problems are graded to develop and consolidate a student’s understanding of 2D NMR spectroscopy. There are many easy problems at the beginning of the collection, to build confidence and demonstrate the basic principles from which structural information can be extracted using 2D NMR. The accompanying text is very descriptive and focussed on explaining the underlying theory at the most appropriate level to sufficiently tackle the problems. Organic Structures from 2D NMR Spectra Is a graded series of about 60 problems in 2D NMR spectroscopy that assumes a basic knowledge of organic chemistry and a basic knowledge of one-dimensional NMR spectroscopy Incorporates the basic theory behind 2D NMR and those common 2D NMR experiments that have proved most useful in solving structural problems in organic chemistry Focuses on the most common 2D NMR techniques – including COSY, NOESY, HMBC, TOCSY, CH-Correlation and multiplicity-edited C-H Correlation. Incorporates several examples containing the heteronuclei 31P, 15N and 19F Organic Structures from 2D NMR Spectra is a logical follow-on from the highly successful “Organic Structures from Spectra” which is now in its fifth edition. The book will be invaluable for students of Chemistry, Pharmacy, Biochemistry and those taking courses in Organic Chemistry. Also available: Instructors Guide and Solutions Manual to Organic Structures from 2D NMR Spectra

Author : L. D. Field,S. Sternhell,John R. Kalman
Publisher : John Wiley & Sons
Page : 426 pages
File Size : 53,9 Mb
Release : 2011-09-07
Category : Science
ISBN : 9781119964612

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Organic Structures from Spectra by L. D. Field,S. Sternhell,John R. Kalman Pdf

Organic Structures from Spectra, Fourth Edition consists of a carefully selected set of over 300 structural problems involving the use of all the major spectroscopic techniques. The problems are graded to develop and consolidate the student’s understanding of Organic Spectroscopy, with the accompanying text outlining the basic theoretical aspects of major spectroscopic techniques at a level sufficient to tackle the problems. Specific changes for the new edition will include A significantly expanded section on 2D NMR spectroscopy focusing on COSY, NOESY and CH-Correlation Incorporating new material into some tables to provide extra characteristic data for various classes of compounds Additional basic information on how to solve spectroscopic problems Providing new problems within the area of 10 2D NMR spectroscopy More problems at the ‘simpler’ end of the range As with previous editions, this book combines basic theory, practical advice and sensible approaches to solving spectra problems. It will therefore continue to prove invaluable to students studying organic spectroscopy across a range of disciplines.

Author : Matthias Findeisen,Stefan Berger
Publisher : John Wiley & Sons
Page : 322 pages
File Size : 40,7 Mb
Release : 2013-07-30
Category : Science
ISBN : 9783527336944

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50 and More Essential NMR Experiments by Matthias Findeisen,Stefan Berger Pdf

This book is the perfect link for learning how to perform the experiments after only having studied theory. In eight chapters more than 50 essential NMR experiments are described in detail. Special focus is put on the organic set of NMR spectra (1H, 13C-APT, COSY, NOESY, HSQC and HMBC). Different chapters deal with advanced organic NMR, selective methods, heteronuclear NMR, relaxation and diffusion measurements, organic applications and maintenance. Every experiment has a section providing the reader with the purpose and scope of the specific experiment. Every experiment is concluded with the spectrum as it is obtained under the conditions described. Questions and comments enable the reader to check their understanding. The authors are very experienced and the whole book is in full color, which enhances the reading experience and makes the spectra and other figures easier to understand. This book is strongly recommended for all students and researchers who are involved in the structural elucidation of chemical compounds both in practical education and in pursuing research, in particular if they handle an NMR spectrometer.

Author : Neil E. Jacobsen
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 52,5 Mb
Release : 2007-09-10
Category : Science
ISBN : 9780470173343

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NMR Spectroscopy Explained by Neil E. Jacobsen Pdf

NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments. Introduces students to modern NMR as applied to analysis of organic compounds. Presents material in a clear, conversational style that is appealing to students. Contains comprehensive coverage of how NMR experiments actually work. Combines basic ideas with practical implementation of the spectrometer. Provides an intermediate level theoretical basis for understanding laboratory experiments. Develops concepts gradually within the context of examples and useful experiments. Introduces the product operator formalism after introducing the simpler (but limited) vector model.

Author : Quincy Teng
Publisher : Springer Science & Business Media
Page : 295 pages
File Size : 52,9 Mb
Release : 2007-08-02
Category : Science
ISBN : 9780387243689

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Structural Biology by Quincy Teng Pdf

Over the years since NMR was first applied to solve problems in structural biology, it has undergonedramaticdevelopmentsinbothNMRinstrumenthardwareandmethodology. While it is established that NMR is one of the most powerful tools for understanding biological p- cesses at the atomic level, it has become increasingly difficult for authors and instructors to make valid decisions concerning the content and level for a graduate course of NMR in str- turalbiology. BecausemanyofthedetailsinpracticalNMRarenotdocumentedsystematically, students entering the field have to learn the experiments and methods through communication with other experienced students or experts. Often such a learning process is incomplete and unsystematic. This book is meant to be not only a textbook, but also a handbook for those who routinely use NMR to study various biological systems. Thus, the book is organized with experimentalists in mind, whether they are instructors or students. For those who have a little or no background in NMR structural biology, it is hoped that this book will provide sufficient perspective and insight. Those who are already experienced in NMR research may find new information or different methods that are useful to their research. Because understanding fundamental principles and concepts of NMR spectroscopy is essential for the application of NMR methods to research projects, the book begins with an introduction to basic NMR principles. While detailed mathematics and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR books, Chapter 1 illustrates some of the fundamental principles and concepts of NMR spectroscopy in a more descriptiveandstraightforwardmanner.

Author : Harald Günther
Publisher : Unknown
Page : 612 pages
File Size : 47,9 Mb
Release : 1995-03-15
Category : Science
ISBN : UOM:39015059080021

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NMR Spectroscopy by Harald Günther Pdf

As with its predecessor, this edition uses a practical non-mathematical approach. Features a number of recent developments in the field including two-dimensional methods, solid state NMR and an enlarged treatment of Fourier Transform methods. Contains numerous two-color diagrams.

Author : David W. Boykin
Publisher : CRC Press
Page : 332 pages
File Size : 45,5 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781000103090

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17 0 NMR Spectroscopy in Organic Chemistry by David W. Boykin Pdf

This book provides a comprehensive review of the application of 17O NMR spectroscopy to organic chemistry. Topics include the theoretical aspects of chemical shift, quadrupolar and J coupling; 17O enrichment; the effect of steric interactions on 17O chemical shifts of functional groups in flexible and rigid systems; the application of 17O NMR spectroscopy to hydrogen bonding investigations; mechanistic problems in organic and bioorganic chemistry; and 17O NMR spectroscopy of oxygen monocoordinated to carbon in alcohols, ethers, and derivatives. Recent results that show correlations between molecular geometry, determined by X-ray studies and estimated by molecular mechanics calculations, and 17O chemical shifts are also covered. 17O Spectroscopy in Organic Chemistry provides important reference information for organic chemists and other scientists interested in 17O NMR spectroscopy as a tool for obtaining new structural and chemical data about organic molecules.