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Author : Cold Spring Harbor Laboratory
Publisher : Unknown
Page : 248 pages
File Size : 44,6 Mb
Release : 1982
Category : Science
ISBN : UOM:39015000315013
Author : Yakov Gluzman
Publisher : Unknown
Page : 239 pages
File Size : 40,9 Mb
Release : 1982
Category : Electronic
ISBN : 0783764421
Author : Nicholas Muzyczka
Publisher : Springer Science & Business Media
Page : 183 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642756085
In the past ten years there has been enormous progress in the development of eukaryotic viral vectors. In general, these vectors have been developed for one of three reasons: to achieve high levels of expression of a particular gene product (poxvirus, baculovirus, and adenovirus), to clone eukaryotic genes in combination with functional assays (Epstein-Barr virus), of for use as delivery vehicles for the stable introduction of foreign genes into mammalian cells (retroviruses, Epstein-Barr virus, and adeno-associated virus). Each vector has its strengths and weaknesses that are rooted in the sometimes bewildering stra tegies that the parent viruses use for propagation. No one of these vectors is appropriate for all of the problems that a mole cular biology laboratory is likely to encounter, and few of us are knowledgeable in the molecular virology of all of these viruses. This volume represents an attempt by the authors to assem ble a review of these vectors in one place and in a form useful to laboratories that do not necessarily have experience with eukaryotic viruses. Clearly, any virus can be modified to serve as a vector for some purposes, and it was not possible to include a description of all of these. In addition, one eukaryotic vector, SV40 (the first one developed), has been reviewed so widely that we saw no reason to include it here.
Author : Yakov Gluzman,Stephen H. Hughes
Publisher : Unknown
Page : 212 pages
File Size : 53,9 Mb
Release : 1988
Category : Science
ISBN : UCAL:B4509874
Author : Ottmar Herchenröder,Brigitte Pützer
Publisher : Unknown
Page : 0 pages
File Size : 42,7 Mb
Release : 2024-03-18
Category : Science
ISBN : 372580530X
Viral vectors are gene transfer tools assembled from the backbones of naturally occurring viruses. These replication-incompetent vehicles transfer assigned payloads into eukaryotic cells. Numerous viral vector systems that influence cells or tissues have been used to perform basic and preclinical research. Some virus-derived vectors found their way into clinical practice.
Author : Michael G. Kaplitt,Arthur D. Loewy
Publisher : Academic Press
Page : 486 pages
File Size : 45,6 Mb
Release : 1995-08-14
Category : Science
ISBN : 9780080543574
Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells. Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers. This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience.
Author : Angel Cid-Arregui,Alejandro García-Carrancá
Publisher : Eaton Publishing Company/Biotechniques Books
Page : 684 pages
File Size : 55,7 Mb
Release : 2000
Category : Medical
ISBN : UOM:39015054255032
Author : Kenneth Palmer,Yuri Gleba
Publisher : Springer Science & Business Media
Page : 199 pages
File Size : 44,5 Mb
Release : 2013-12-06
Category : Medical
ISBN : 9783642408298
In this volume, the authors provide an excellent overview of how far the plant viral vector field has come. The discipline is no longer exclusively in the domain of academics—there is a small, but growing number of small biotechnology companies that exploit plant viruses as the platform for commercial innovation in crop improvement, industrial product manufacturing, and human and veterinary health care.
Author : Mary K. Collins
Publisher : Humana Press
Page : 330 pages
File Size : 45,6 Mb
Release : 1991-10-31
Category : Science
ISBN : 089603299X
Author : Otto-Wilhelm Merten,Mohamed Al-Rubeai
Publisher : Humana
Page : 0 pages
File Size : 44,7 Mb
Release : 2011-05-19
Category : Medical
ISBN : 161779094X
The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular BiologyTM series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.
Author : Patrick Arbuthnot
Publisher : Academic Press
Page : 392 pages
File Size : 50,7 Mb
Release : 2015-06-01
Category : Science
ISBN : 9780124114524
Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field
Author : John M. Coffin,Stephen H. Hughes,Harold Varmus
Publisher : CSHL Press
Page : 856 pages
File Size : 53,7 Mb
Release : 1997
Category : Electronic books
ISBN : 0879695714
For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
Author : Peter M. Howley
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 50,9 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781475705843
Author : Ambikanandan Misra
Publisher : Elsevier
Page : 686 pages
File Size : 47,7 Mb
Release : 2010-09-09
Category : Science
ISBN : 9780123849656
Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed
Author : Karl Esser,Ulrich Kück,Christine Lang-Hinrichs,Paul Lemke,Heinz D. Osiewacz,Ulf Stahl,Paul Tudzynski
Publisher : Springer Science & Business Media
Page : 131 pages
File Size : 43,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642825859
The possession of plasmids was for a long time recognized only in the bacteria. It is now evident that plasmids, or replicative forms of DNA structurally and experimentally comparable to bacterial plasmids, exist in eukaryotic organisms as well. Such plasmids are in fact common among fungi and higher plants. The present review is undertaken to provide a comprehensive account of the data available on plasmids found in eukaryotic organisms. This review will not consider plasmids of prokaryotic origin, even though certain bacterial plasmids, such as the tumor-inducing (Ti) plasmids of Agrobacterium tumefaciens, may be intimately associated with transformation of the eukaryotic host. This book, moreover, does not consider transformation experiments in eukaryotic hosts involving viral DNA as vectors, although indeed such vectors have been developed for use in plant and animal systems. After a general introduction, providing historical perspective on the nature and role of plasmids, a list of eukaryotic plasmids will be presented according to their origin. This is followed by a detailed discussion of known structure and function. In subsequent chapters the practical implications of eukaryotic plasmids for molecular cloning and biotechnology will be discussed. This latter part traces the development of interest'in biotechnical genetics and gives special consideration to the use of eukaryotic systems for gene cloning. The terminology biotechni cal genetics is introduced to the reader and is used in a general sense as equivalent to genetic engineering. Biotechnical genetics includes, but is not limited to, gene cloning through recombinant DNA technology.