Evolution Of The Molecular Biology Of Brain Tumors And The Therapeutic Implications

Author : Terry Lichtor
Publisher : BoD – Books on Demand
Page : 652 pages
File Size : 50,6 Mb
Release : 2013-02-27
Category : Medical
ISBN : 9789535109891

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Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications by Terry Lichtor Pdf

A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Author : Tom Mikkelsen
Publisher : Wiley-Liss
Page : 494 pages
File Size : 53,6 Mb
Release : 1998-05-05
Category : Medical
ISBN : UOM:39015040376223

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Brain Tumor Invasion by Tom Mikkelsen Pdf

Brain Tumor Invasion Biological, Clinical, and Therapeutic Considerations Edited by Tom Mikkelsen Rolf Bjerkvig Ole Didrik Laerum Mark L. Rosenblum Recent advances in molecular biology have given us profound new insights into the behavior of primary brain tumors. Not only are such tumors more diffuse in their infiltration of brain tissue and therefore less amenable to surgery than brain tumors originating elsewhere in the body—it now appears that the central nervous system and the normal brain itself constitute a biological environment conducive to the uncontrolled spread of primary tumors. Brain Tumor Invasion is the first comprehensive reference devoted to the invasive behavior of primary brain tumors. It examines the biological mechanisms responsible for the increased ability of gliomas to metastasize in the central nervous system, and discusses the role of chemical carcinogens, growth factors, oncogenes, and tumor suppressors in the progression of such metastases. This book surveys the latest research in the field, reviews present and future prospects of anti-invasive brain tumor therapy, and even translates preclinical trials and other research results into potential new therapies. The material is divided into five main categories: Developmental biology and molecular neuro-oncology Pathological and clinical features of malignant brain tumors Models for the study of brain tumor invasion in vivo and in vitro Mechanisms of invasion New therapeutic strategies Brain Tumor Invasion offers dozens of maps and photographs that illustrate topics under discussion. This in-depth introduction to one of the most difficult problems in the management of brain tumors is indispensable to neuro-oncologists involved in brain tumor research and therapy. It is also useful to researchers in cancer biology, neuroscience, cell biology, and molecular genetics.

Author : Bela Bodey,Stuart E. Siegel,Hans E. Kaiser
Publisher : Springer Science & Business Media
Page : 365 pages
File Size : 48,9 Mb
Release : 2006-03-06
Category : Medical
ISBN : 9781402028045

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Molecular Markers of Brain Tumor Cells by Bela Bodey,Stuart E. Siegel,Hans E. Kaiser Pdf

Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 53,8 Mb
Release : 2015
Category : Electronic
ISBN : 9535172352

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Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor by Anonim Pdf

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 48,6 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Author : Terry Lichtor
Publisher : IntechOpen
Page : 654 pages
File Size : 51,6 Mb
Release : 2013-04-10
Category : Medical
ISBN : 9535110586

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Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors by Terry Lichtor Pdf

A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.

Author : Andrew D. Norden,David A. Reardon,Patrick C. Y. Wen
Publisher : Springer Science & Business Media
Page : 568 pages
File Size : 45,7 Mb
Release : 2010-12-15
Category : Medical
ISBN : 9781607611660

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Primary Central Nervous System Tumors by Andrew D. Norden,David A. Reardon,Patrick C. Y. Wen Pdf

This comprehensive, yet practical, text is a ready collection of the most up-to-date information on primary CNS tumors. Authored by a carefully selected group of the world’s leading clinicians and scientists, the book is divided into three sections. The opening chapters cover general principles, including epidemiology, pathogenesis, tumor stem cells, supportive care, complications of therapy, and quality of life. The remaining two sections are comprised of treatment-oriented chapters covering the spectrum of gliomas and rarer tumor types. Each of these chapters presents multi-disciplinary therapeutic approaches and addresses specific disease concerns. Throughout, the authors incorporate the cutting-edge advances in molecular biology and genomics that are revolutionizing neuro-oncology. The result is an important clinical resource which provides evidence-based data and interpretation essential to intelligent therapeutic decision making.

Author : Lee Roy Morgan
Publisher : BoD – Books on Demand
Page : 274 pages
File Size : 44,9 Mb
Release : 2014-06-11
Category : Medical
ISBN : 9789535115762

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Tumors of the Central Nervous System by Lee Roy Morgan Pdf

A novel concept that is reviewed and discussed in several chapters in the book alludes to the transport of drugs bound to red blood cells into the highly vascular CNS tumors - both primary and metastatic. Such a transport mechanism is unique and of significant therapeutic potential. It is hopeful that the novel information presented in this book will result in new approaches to the treatment CNS tumors.

Author : Lauren Pecorino
Publisher : Oxford University Press
Page : 365 pages
File Size : 49,8 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780199577170

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Molecular Biology of Cancer by Lauren Pecorino Pdf

Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.

Author : Shashwat Sharad,Suman Kapur
Publisher : BoD – Books on Demand
Page : 126 pages
File Size : 45,9 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9781789845327

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Antisense Therapy by Shashwat Sharad,Suman Kapur Pdf

Antisense Therapy offers a comprehensive, state-of-the art perspective on the role of antisense therapy in the treatment of human disease, with a special focus on cancer. Use of antisense oligonucleotides is a growing field of pharmaceutical and biotech companies and research programs for treatment of several diseases. This book summarizes and presents the best updates, therapeutic principles, methods, and applications in the field and offers meaningful information to move treatment discovery forward.

Author : Lee Roy Morgan,Feyzi Birol Sarica
Publisher : BoD – Books on Demand
Page : 278 pages
File Size : 46,6 Mb
Release : 2020-01-29
Category : Medical
ISBN : 9781789841572

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Brain and Spinal Tumors by Lee Roy Morgan,Feyzi Birol Sarica Pdf

Numerous new concepts and procedures are reviewed and discussed in this book and allude to the transport of drugs to the brain. New radiation concepts are also presented, plus management of toxicities associated with both treatment modalities. It is the goal of this book to provide information and data that will be useful for both researchers and practitioners to develop new approaches for the management of CNS malignancies.

Author : Luigi Pirtoli,Giovanni Luca Gravina,Antonio Giordano
Publisher : Springer
Page : 305 pages
File Size : 49,6 Mb
Release : 2016-06-06
Category : Medical
ISBN : 9783319283050

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Radiobiology of Glioblastoma by Luigi Pirtoli,Giovanni Luca Gravina,Antonio Giordano Pdf

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Boris Rubinsky
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 50,9 Mb
Release : 2009-11-25
Category : Technology & Engineering
ISBN : 9783642054204

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Irreversible Electroporation by Boris Rubinsky Pdf

Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.

Author : Amit Agrawal
Publisher : BoD – Books on Demand
Page : 214 pages
File Size : 48,6 Mb
Release : 2022-04-20
Category : Medical
ISBN : 9781839698033

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Brain Tumors by Amit Agrawal Pdf

Brain tumors comprise a spectrum of histological patterns. Their presentation and management depend on their location, size, and grade of lesions. This book is a collection of high-quality research work from global experts on brain tumors, including meningiomas, and their treatment.