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Author : Ciba Foundation. Symposium,Gordon Ethelbert Ward Wolstenholme
Publisher : Unknown
Page : 0 pages
File Size : 45,9 Mb
Release : 1955
Category : Leprosy
ISBN : OCLC:1113072843
Author : G. E. W. Wolstenholme,Margaret P. Cameron
Publisher : John Wiley & Sons
Page : 436 pages
File Size : 52,7 Mb
Release : 2009-09-14
Category : Medical
ISBN : 9780470716380
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author : Gordon Ethelbert Ward Wolstenholme,Ciba Foundation
Publisher : Unknown
Page : 446 pages
File Size : 43,9 Mb
Release : 1955
Category : Leprosy
ISBN : NWU:35558001786116
Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 41,8 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author : W. Arber,W. Henle,P. H. Hofschneider,J. H. Humphrey,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt
Publisher : Springer
Page : 0 pages
File Size : 54,8 Mb
Release : 2011-11-11
Category : Medical
ISBN : 3642661033
The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor.
Author : Barry R. Bloom
Publisher : Unknown
Page : 664 pages
File Size : 50,7 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015035754277
The authors discuss fundamental questions about the biology, genetics, mechanisms of pathogenicity, mechanisms of resistance, and drug development strategies that are likely to provide important new knowledge about TB and new interventions to prevent and treat this disease.
Author : William R. Jacobs, Jr.,Helen McShane,Valerie Mizrahi,Ian M. Orme
Publisher : John Wiley & Sons
Page : 741 pages
File Size : 43,6 Mb
Release : 2020-07-15
Category : Medical
ISBN : 9781555819569
Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.
Author : Prashant Kesharwani
Publisher : Academic Press
Page : 284 pages
File Size : 48,5 Mb
Release : 2020-06-10
Category : Business & Economics
ISBN : 9780128226117
Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers
Author : Communicable Disease Center (U.S.),George P. Kubica
Publisher : Unknown
Page : 100 pages
File Size : 51,7 Mb
Release : 1960
Category : Tuberculosis
ISBN : UCAL:B3219858
Author : Anonim
Publisher : Unknown
Page : 92 pages
File Size : 41,8 Mb
Release : 1960
Category : Public health
ISBN : UOM:39015069599374
Author : Anonim
Publisher : Unknown
Page : 1764 pages
File Size : 48,7 Mb
Release : 2000
Category : Medicine
ISBN : OSU:32436010864831
Author : Kim Lewis
Publisher : Springer Nature
Page : 295 pages
File Size : 49,8 Mb
Release : 2019-11-13
Category : Medical
ISBN : 9783030252410
This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.
Author : Stefan H. E. Kaufmann,Paul van Helden,Eric Rubin,Warwick J. Britton
Publisher : Wiley-Blackwell
Page : 1350 pages
File Size : 50,5 Mb
Release : 2008-03-17
Category : Science
ISBN : 3527316833
Coinciding with the first TB therapies to enter clinical trials in 60 years, this is the most comprehensive account of the latest developments in clinical, therapeutic and basic research into the disease, presented by the most prolific of all researchers in the field. Divided into three clearly structured volumes, the first deals with molecular biology and biochemistry of the pathogen, including genetics and genomics, as well as drug design. The second volume covers cell biology, immunology and vaccine development, while the third is devoted to epidemiology and clinical approaches, including drug resistance, veterinary aspects and clinical field trials. With one new infection worldwide every second, this is an essential reference for bacteriologists, immunologists, pathologists and pathophysiologists, molecular and cell biologists, as well as those working in the pharmaceutical industry.
Author : U.S. Office of Experiment Stations,United States. Agricultural Research Service,United States. Office of Experiment Stations
Publisher : Unknown
Page : 1092 pages
File Size : 53,5 Mb
Release : 1934
Category : Agricultural experiment stations
ISBN : UOM:39015073349816
Author : United States. Office of Experiment Stations
Publisher : Unknown
Page : 1170 pages
File Size : 40,6 Mb
Release : 1915
Category : Agricultural experiment stations
ISBN : HARVARD:HC2BR4