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Exposure Analysis by Wayne R. Ott,Anne C. Steinemann,Lance A. Wallace Pdf
Written by experts, Exposure Analysis is the first complete resource in the emerging scientific discipline of exposure analysis. A comprehensive source on the environmental pollutants that affect human health, the book discusses human exposure through pathways including air, food, water, dermal absorption, and, for children, non-food ingesti
Public Health Risk Assessment for Human Exposure to Chemicals by K. Asante-Duah Pdf
In fact, with the control and containment of most infectious conditions and diseases of the past millennium having been achieved in most developed countries, and with the resultant increase in life expectancies, much more attention seems to have shifted to degenerative health problems. Many of the degenerative health conditions have been linked to thousands of chemicals regularly encountered in human living and occupational/work environments. It is important, therefore, that human health risk assessments are undertaken on a consistent basis - in order to determine the potential impacts of the target chemicals on public health.
Exposure Assessment of Microbiological Hazards in Food by World Health Organization Pdf
The guidelines aim to provide a practical framework and approach for undertaking exposure assessment of microbiological hazards (bacteria, fungi, viruses, protozoa and microbial toxins) in foods in the context of a risk assessment or as a stand-alone process.
Agency for Health Care Research and Quality (U.S.)
Author : Agency for Health Care Research and Quality (U.S.) Publisher : Government Printing Office Page : 204 pages File Size : 52,7 Mb Release : 2013-02-21 Category : Medical ISBN : 9781587634239
Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by Agency for Health Care Research and Quality (U.S.) Pdf
This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Exposure Assessment in Environmental Epidemiology by Mark J. Nieuwenhuijsen Pdf
This completely updated edition of Exposure Assessment in Environmental Epidemiology offers a practical introduction to exposure assessment methodologies in environmental epidemiologic studies. In addition to methods for traditional methods -- questionnaires, biomonitoring -- this new edition is expanded to include geographic information systems, modeling, personal sensoring, remote sensing, and OMICs technologies. In addition, each of these methods is contextualized within a recent epidemiology study, maximizing illustration for students and those new to these to these techniques. With clear writing and extensive illustration, this book will be useful to anyone interested in exposure assessment, regardless of background.
Residential Exposure Assessment by Jeffrey Driver,Scott R. Baker,David McCallum Pdf
Residential Exposure Assessment: A Source Book is the result of a multiyear effort known as the Residential Exposure Assessment Project (REAP) which was initiated by the Society for Risk Analysis and the International Society of Exposure Analysis. This textbook is the primary product of the REAP and it contains contributions from over 30 professionals from a variety of disciplines such as chemistry, biology, physics, engi neering, industrial hygiene, toxicology, pharmacology, and environmental law, reflecting the diverse knowledge and resources necessary to assess and manage potential exposures occurring in and around the home. Expert working groups were organized for each of the 13 chapters to address such issues as U. S. legislation relevant to products used in and around the residence, methods for measuring and modeling exposures across multiple pathways and routes, and distributional data available for key residential exposure factors. This volume is a compendium of information about predictive methods and tools, monitoring methods, data sources, and key variables that characterize exposures in the residential setting. It presents approaches for doing exposure assessments in and around all types of residences. The purpose of the Source Book is to provide a resource for use in educational programs and for "practitioners" of residential exposure assessment. Accordingly, this book is intended for risk assessors, exposure assessors, students, initi ates new to the concept of risk assessment, industrial hygienists assessing health hazards in the home, engineers, and monitoring specialists.
Occupational and Residential Exposure Assessment for Pesticides by Claire A. Franklin,John P. Worgan Pdf
This timely publication concentrates on the exposure to pesticides by agricultural workers and residential users of pesticides through inhalation and physical contact. The book discusses more recently discovered risks such as pesticides on indoor carpets and includes new trends in data interpretation. Occupational & Residential Exposure Assessment for Pesticides complements the other title on pesticide exposure in the series - Pesticide Residues in Drinking Water, by Hamilton/Crossley and is a must for all professionals in the Pesticide Industry as well as academics.
Exposure Assessment for Epidemiology and Hazard Control by Acgih Pdf
What agents should be measured? How should measurement be performed and what averaging time should be used for the measurement? What sampling strategy should be employed to characterize exposures across individuals, locations, and time? What durations of exposure should be characterized? What statistical descriptors should be used to relate exposure to effect? Exposure Assessment for Epidemiology and Hazard Control examines various approaches to answering these and other important questions. Other topics discussed include the measurement of current exposures (e.g., vapors, gases, aerosols, and complex mixtures); the application of toxicological relationships, including biological markers and sample models; an epidemiological evaluation of exposure-effect relationships, including new methods for effect evaluation and models for population exposure estimates; and strategies for exposure assessment, such as biological sampling interpretation through toxicokinetic processes. This important new volume contains essential information for industrial hygienists, epidemiologists, occupational health physicians, toxicologists, and immunologists.
Occupational Exposure Assessment for Air Contaminants by Gurumurthy Ramachandran Pdf
Over the last three decades, significant progress has been made not only in the technology of measuring air contaminants but also in the statistical descriptions of exposure distributions and exposure assessment strategies. Occupational Exposures for Air Contaminants addresses the various aspects of occupational exposure assessment for air contamin
Exposure and Risk Assessment of Pesticide Use in Agriculture by Claudio Colosio,Aristidis M. Tsatsakis,Stefan Mandic-Rajcevic,Athanasios Alegakis Pdf
Exposure and Risk Assessment of Pesticide Use in Agriculture: Approaches, Tools and Advances offers an overview of the different methods available in toxicology for pesticide exposure and risk assessment, ranging from the regulatory field, to in-field research studies. The book provides technical background on each method, describing known and grounded tools, new uses of tools and development prospects. This book is ideal for researchers in pesticide toxicology, exposure toxicology, toxicologic risk assessment, occupational hygiene and medicine, and pesticide toxicology as well as occupational health and industrial hygiene practitioners, regulatory experts of corporate and public bodies, and advanced students. Covers pesticide exposure and risk assessment, ranging from fundamentals to advanced theory Explains methods that are useful for both experts and non-experts Details the use of each method for exposure and risk assessment, also including links to additional resources and further reading
National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions
Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions Publisher : National Academies Press Page : 280 pages File Size : 50,9 Mb Release : 2014-10-29 Category : Science ISBN : 9780309310161
A Framework to Guide Selection of Chemical Alternatives by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions Pdf
Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.
Methods of Pesticide Exposure Assessment by Patricia B. Curry,Sesh Iyengar,Pamela A. Maloney,M. Maroni Pdf
This book is a summary of the presentations and discussions at the Workshop on Methods of Pesticide Exposure Assessment held in Ottawa, Canada, on October 5-8, 1993. The event was a joint effort of Health Canada and the North Atlantic Treaty Organisation and was officially supported by the United States Environmental Agency and the Organisation for Economic Co-operation and Development (OECD). The goal of the workshop was to examine current issues in the field of pesticide exposure assessment with the aim of reaching an internationally harmonized approach to methods of exposure assessment. With regulatory agencies of OECD Member countries moving towards the harmonization of data requirements, it was timely and beneficial to bring together international experts in the field of pesticide exposure assessment to discuss current issues. Approximately 60 delegates and 20 observers participated, including individuals from 15 different countries representing academia, government, industry and international organizations. A guidance document on methods of pesticide exposure assessment was presented as a means to achieving the goal of international for critique and discussion harmonization. After extensive discussion, the workshop delegates agreed in principle to procedures for revising the guidance document. Following revision and further review by a designated peer review group, the revised document will be submitted to the OECD for consideration as a draft OECD Guidance Document on pesticide exposure assessment methods. Both the revised and original documents are included in these proceedings.