Exposure Science In The 21st Century

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century
Publisher : National Academies Press
Page : 210 pages
File Size : 44,8 Mb
Release : 2012-10-28
Category : Nature
ISBN : 9780309264686

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Exposure Science in the 21st Century by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century Pdf

From the use of personal products to our consumption of food, water, and air, people are exposed to a wide array of agents each day-many with the potential to affect health. Exposure Science in the 21st Century: A Vision and A Strategy investigates the contact of humans or other organisms with those agents (that is, chemical, physical, and biologic stressors) and their fate in living systems. The concept of exposure science has been instrumental in helping us understand how stressors affect human and ecosystem health, and in efforts to prevent or reduce contact with harmful stressors. In this way exposure science has played an integral role in many areas of environmental health, and can help meet growing needs in environmental regulation, urban and ecosystem planning, and disaster management. Exposure Science in the 21st Century: A Vision and A Strategy explains that there are increasing demands for exposure science information, for example to meet needs for data on the thousands of chemicals introduced into the market each year, and to better understand the health effects of prolonged low-level exposure to stressors. Recent advances in tools and technologies-including sensor systems, analytic methods, molecular technologies, computational tools, and bioinformatics-have provided the potential for more accurate and comprehensive exposure science data than ever before. This report also provides a roadmap to take advantage of the technologic innovations and strategic collaborations to move exposure science into the future.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Incorporating 21st Century Science into Risk-Based Evaluations
Publisher : National Academies Press
Page : 201 pages
File Size : 50,8 Mb
Release : 2017-02-16
Category : Nature
ISBN : 9780309453516

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Using 21st Century Science to Improve Risk-Related Evaluations by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Incorporating 21st Century Science into Risk-Based Evaluations Pdf

Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Incorporating 21st Century Science into Risk-Based Evaluations
Publisher : National Academies Press
Page : 201 pages
File Size : 53,8 Mb
Release : 2017-03-16
Category : Nature
ISBN : 9780309453486

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Using 21st Century Science to Improve Risk-Related Evaluations by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Incorporating 21st Century Science into Risk-Based Evaluations Pdf

Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents
Publisher : National Academies Press
Page : 217 pages
File Size : 44,5 Mb
Release : 2007-11-05
Category : Nature
ISBN : 9780309151733

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Toxicity Testing in the 21st Century by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents Pdf

Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Author : Paul Lioy,Clifford Weisel
Publisher : Academic Press
Page : 116 pages
File Size : 50,6 Mb
Release : 2014-02-11
Category : Technology & Engineering
ISBN : 9780124202382

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Exposure Science by Paul Lioy,Clifford Weisel Pdf

Exposure Science: Basic Principles and Applications provides a concise overview of the field of exposure science, from its origins in sanitation and occupational health, to its exciting involvement with emerging scientific concepts. Written by world-leading experts in the field of exposure science, this book provides all the basic understanding you need to employ the best tools and methods for measurement, analysis, and modeling of exposure. Exposure Science: Basic Principles and Applications is an invaluable introduction to exposure science for anyone working in the fields of environmental health, risk assessment, toxicology, or epidemiology. Focuses on and highlights the basic fundamentals, scientific goals, theories and tools of exposure science Examines the use of the exposome and eco-exposome concepts within the field of exposure science

Author : Enrico Oddone
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 54,5 Mb
Release : 2016
Category : Occupational diseases
ISBN : 1634850734

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Occupational Exposure and Health Risks by Enrico Oddone Pdf

Despite several improvements in risk assessment and exposure prevention, the occupational environment could expose workers to a wide variety of risk factors. Beside classical risk factors, such as chemical compounds, physical agents and biological agents, a group of "new risk factors has become more and more prevalent over the last few decades; psychosocial hazards in occupational environments and exposure to nanoparticles are flawless examples of these potential issues for workers' health. This book aims to address principal classical risk factors by dealing extensively with occupational respiratory diseases, cardiovascular diseases related to work, occupational cancers, and occupational risks for hypersensitivity. Additionally, it attempts to shed light on a deepened treatise of occupational hazards related to the development of neurodegenerative diseases, psychosocial ailments, and ergonomic risk factors, which could result in cumulative trauma disorders of the upper limb. The second part of this book provides some advice regarding specific risk factors or specific occupational exposures: health issues related to exposure to mechanical vibrations, pesticides, nanomaterials, and in a hospital environment were used as examples to deepen the risk assessment and the analysis of health hazards. The authors hope to paint a global picture of the principal risk factors in occupational medicine. Given these premises, this book is not aimed to be comprehensive, but rather to provide an introductive and robust base for facing several current issues in occupational medicine.

Author : J. Austin,P. Brimblecombe,W.T. Sturges
Publisher : Elsevier
Page : 686 pages
File Size : 44,5 Mb
Release : 2002-10-31
Category : Science
ISBN : 9780080526904

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Air Pollution Science for the 21st Century by J. Austin,P. Brimblecombe,W.T. Sturges Pdf

Acid rain, photochemistry, long-range transport of pollutants, greenhouse gas emissions and aerosols have dominated tropospheric air pollution for the last 30 years of the 20th century. At the start of the 21st century, acid rain is subject to planned improvement in Europe and North America, but is still a growing problem in Asia. Tropospheric ozone is understood much better, but the problem is still with us, and desirable levels are difficult to achieve over continental Europe. The heterogeneous chemistry that is responsible for ozone depletion in the stratosphere is now reasonably clear, but there is on-going interest in the sources and sinks of CFC (chlorofluorocarbon) replacements in the troposphere. There is also increasing interest in indoor air quality, and the origin and health implications of atmospheric particles. Perhaps most important on a global perspective, intensive research has not yet determined the relationship between greenhouse gases, aerosols and surface temperature. The climactic implications of these are now more urgent than ever. This book, the first in the Developments in Environmental Science series, consists of a collection of authoritative reviews and essays on the science and application of air pollution research at the start of this new century.

Author : Anonim
Publisher : Unknown
Page : 130 pages
File Size : 46,9 Mb
Release : 2011
Category : BUSINESS & ECONOMICS
ISBN : 1536115231

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Human Exposure to Environmental Chemicals (with DVD) by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 2108 pages
File Size : 51,7 Mb
Release : 2009-07
Category : Environmental health
ISBN : NYPL:33433116726831

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Environmental Health Perspectives by Anonim Pdf

Author : Robert Pool,Institute of Medicine,Erin Rusch
Publisher : Unknown
Page : 0 pages
File Size : 41,7 Mb
Release : 2014
Category : Health & Fitness
ISBN : 0309301157

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Identifying and Reducing Environmental Health Risks of Chemicals in Our Society by Robert Pool,Institute of Medicine,Erin Rusch Pdf

"On November 7-8, 2013, the Institute of Medicine's Roundtable on Environmental Health Sciences, Research, and Medicine held a workshop to discuss approaches related to identifying and reducing potential environmental public health risks to new and existing industrial chemicals present in society. Industrial chemicals include chemicals used in industrial processes or commercial products, not including those found in food, pesticides, or pharmaceuticals. Identifying and Reducing Environmental Health Risks of Chemicals in Our Society is a summary and synthesis of the presentations and discussions that took place during the two days of the workshop. The workshop examined successes and areas for improvement within current regulatory programs for assessing industrial chemical safety, frameworks for chemical prioritization to inform targeted testing and risk management strategies, concepts of sustainability and green chemistry that support the design and use of safer alternatives, and efforts to reduce the risk of chemicals in our society."--Publisher's description.

Author : Pavlos Kanaroglou,Eric Delmelle
Publisher : Routledge
Page : 344 pages
File Size : 54,5 Mb
Release : 2016-03-09
Category : Science
ISBN : 9781317051589

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Spatial Analysis in Health Geography by Pavlos Kanaroglou,Eric Delmelle Pdf

Presenting current research on spatial epidemiology, this book covers topics such as exposure, chronic disease, infectious disease, accessibility to health care settings and new methods in Geographical Information Science and Systems. For epidemiologists, and for the management and administration of health care settings, it is critical to understand the spatial dynamics of disease. For instance, it is crucial that hospital administrators develop an understanding of the flow of patients over time, especially during an outbreak of a particular disease, so they can plan for appropriate levels of staffing and to carry out adaptive prevention measures. Furthermore, understanding where and why a disease occurs at a certain geographic location is vital for decision makers to formulate policy to increase the accessibility to health services (either by prevention, or adding new facilities). Spatial epidemiology relies increasingly on new methodologies, such as clustering algorithms, visualization and space-time modelling, the domain of Geographic Information Science. Implementation of those techniques appears at an increasing pace in commercial Geographic Information Systems, alongside more traditional techniques that are already part of such systems. This book provides the latest methods in GI Science and their use in health related problems.

Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
Publisher : Academic Press
Page : 1055 pages
File Size : 45,8 Mb
Release : 2020-05-16
Category : Medical
ISBN : 9780128137253

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Information Resources in Toxicology, Volume 1: Background, Resources, and Tools by Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes Pdf

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals Explores recent internet trends, web-based databases, and software tools in a section on the online environment Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Science for EPA's Future
Publisher : National Academies Press
Page : 188 pages
File Size : 44,6 Mb
Release : 2012-12-21
Category : Political Science
ISBN : 9780309264891

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Science for Environmental Protection by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Science for EPA's Future Pdf

In anticipation of future environmental science and engineering challenges and technologic advances, EPA asked the National Research Council (NRC) to assess the overall capabilities of the agency to develop, obtain, and use the best available scientific and technologic information and tools to meet persistent, emerging, and future mission challenges and opportunities. Although the committee cannot predict with certainty what new environmental problems EPA will face in the next 10 years or more, it worked to identify some of the common drivers and common characteristics of problems that are likely to occur. Tensions inherent to the structure of EPA's work contribute to the current and persistent challenges faced by the agency, and meeting those challenges will require development of leading-edge scientific methods, tools, and technologies, and a more deliberate approach to systems thinking and interdisciplinary science. Science for Environmental Protection: The Road Ahead outlines a framework for building science for environmental protection in the 21st century and identified key areas where enhanced leadership and capacity can strengthen the agency's abilities to address current and emerging environmental challenges as well as take advantage of new tools and technologies to address them. The foundation of EPA science is strong, but the agency needs to continue to address numerous present and future challenges if it is to maintain its science leadership and meet its expanding mandates.

Author : Mark G. Robson,William A. Toscano,Qingyu Meng,Debra A. Kaden
Publisher : CRC Press
Page : 400 pages
File Size : 42,7 Mb
Release : 2022-12-30
Category : Medical
ISBN : 9781000816099

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Risk Assessment for Environmental Health by Mark G. Robson,William A. Toscano,Qingyu Meng,Debra A. Kaden Pdf

Understanding risk to humans is one of the most important problems in environmental public health. Risk assessment is constantly changing with the advent of new exposure assessment tools, more sophisticated models, and a better understanding of disease processes. Risk assessment is also gaining greater acceptance in the developing world where major environmental problems exist. Developed in partnership with the Association of Schools of Public Health, this comprehensive text offers a thorough survey of risk assessment, management, and communications as these practices apply to public health. Key Features: Provides a practical overview of environmental risk assessment and its application by discussing the process and providing case studies and examples Focuses on tools and approaches used for humans in an environment involving potential chemical hazards Fully updated, the first part introduces the underlying principles and techniques of the field, and the second examines case studies in terms of different risk assessment scenarios Risk assessment is a core requirement for the MPH degree in environmental health Useful “stories” suitable for case studies

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on the Health Risks of Phthalates
Publisher : National Academies Press
Page : 208 pages
File Size : 46,9 Mb
Release : 2009-01-19
Category : Nature
ISBN : 9780309128414

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Phthalates and Cumulative Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on the Health Risks of Phthalates Pdf

People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals. Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.