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Factor VIII - von Willebrand Factor by M. J. Seghatchian,G. F. Savidge Pdf
Written by established investigators, this comprehensive, two-volume review explains current concepts in both scientific and clinical data related to Factor VIII and to Factor VIII deficiency states. Specific emphasis is placed on the pathophysiological relevance of Factor VIII pertaining to future trends in basic scientific and clinical research. Additionally, new methodological approaches are presented. Researchers in the haematology field will find this publication valuable.
Factor VIII - von WIllebrand Factor by M. J. Seghatchian,G. F. Savidge Pdf
In volume I (Subtitled: Biochemical, methodological and functional aspects), the purification and structure/function relationships of VIII and vWf are extensively reviewed with the relevance of advances in these areas to improved methodology and biotechnology. Emphasis is on the importance of improved interactions with plasmatic and cellular components. The issues of plasma procurement and advances in the production of therapeutic products illustrate application. An update of progress in the clinical aspects of VIII and vWf deficiency states is presented in Volume II (Subtitled: Clinical aspects of deficiency states; 6829-4). The critical issues of scientific advancement and achievement are shown to result in improved patient diagnosis and care. Annotation copyrighted by Book News, Inc., Portland, OR
Factor VIII - von WIllebrand Factor, Volume I by M. J. Seghatchian,G. F. Savidge Pdf
This book extensively reviews the purification and structure/function relationships of Factor VIII - von Willebrand Factor with the relevance of advances in the areas of biochemical, methodological and functional aspects to improved methodology and biotechnology.
Hemophilia and Von Willebrand Disease by David Green Pdf
Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis. Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology Delves into unanswered questions and future directions of this important blood-clotting complex
Congenital Bleeding Disorders by Akbar Dorgalaleh Pdf
This book describes in detail the clinical presentation, diagnosis, and management of a wide range of congenital bleeding disorders. It will assist readers in overcoming the significant challenges involved in clinical and laboratory diagnosis and in providing effective clinical care that makes optimal use of new products, including recombinant factor concentrate. The coverage ranges from hemophilia A and B and von Willebrand disease to rare bleeding disorders such as congenital factor V, factor X, factor XI, and factor XIII deficiency and inherited platelet function disorders. The exceptional attention to rarer conditions is of particular importance given the considerable risk of overlooking them during diagnosis, with potential consequences for disease-related morbidity and mortality. The authors are acknowledged specialists in the field from across the world who have particular expertise in the disorder that they discuss. The book will be of value to hematologists, oncologists, pediatricians, laboratory specialists and technicians, general physicians, and trainees.
Augusto B. Federici,Christine A. Lee,Erik E. Berntorp,David Lillicrap,Robert R. Montgomery
Author : Augusto B. Federici,Christine A. Lee,Erik E. Berntorp,David Lillicrap,Robert R. Montgomery Publisher : John Wiley & Sons Page : 569 pages File Size : 40,8 Mb Release : 2011-01-31 Category : Medical ISBN : 9781444329940
Von Willebrand Disease by Augusto B. Federici,Christine A. Lee,Erik E. Berntorp,David Lillicrap,Robert R. Montgomery Pdf
Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding. Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy. Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.
Author : Christine A. Lee,Erik E. Berntorp,W. Keith Hoots Publisher : John Wiley & Sons Page : 573 pages File Size : 43,8 Mb Release : 2014-04-22 Category : Medical ISBN : 9781118398289
Textbook of Hemophilia by Christine A. Lee,Erik E. Berntorp,W. Keith Hoots Pdf
Textbook of Hemophilia, 3rd edition Edited by Christine A. Lee, MA, MD, DSc, FRCP, FRCPath, FRCOG Emeritus Professor of Haemophilia, University of London, London, UK Erik E. Berntorp, MD, PhD Professor of Coagulation Medicine, Lund University Malmö Centre for Thrombosis and Haemostasis, Skåne University Hospital, Malmö, Sweden W. Keith Hoots, MD Director, Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute National Institutes of Health, Bethesda, MD; Professor of Pediatrics and Internal Medicine, University of Texas Medical School at Houston, Houston, TX, USA Without doubt, Textbook of Hemophilia, 3rd edition is the definitive reference source on all aspects of haemophilia including diagnosis, management and treatment. Edited by three, world-renowned experts on haemophilia, this completely revised resource features chapters written by over 60 international contributors with international expertise in caring for haemophilia patients. Textbook of Hemophilia, 3rd edition Features eight new chapters, covering individualised dosing, vCJD and haemophilia, new drugs in the pipeline, and surgery in inhibitor patients Presents new developments, such as gene therapy Highlights controversial issues and provides advice for everyday clinical questions Represents essential reading for all healthcare professionals involved in the care of those with haemophilia Titles of related interest Hemophilia and Hemostasis: A Case-Based Approach to Management, 2nd Edition Ma, ISBN: 9780470659762 Current and Future Issues in Hemophilia Care Rodriguez-Merchan, ISBN: 9780470670576 www.wiley.com/go/hematology
Louis M. Aledort,Leon W. Hoyer,Jeanne M. Lusher,Howard M. Reisner,Gilbert C. White II
Author : Louis M. Aledort,Leon W. Hoyer,Jeanne M. Lusher,Howard M. Reisner,Gilbert C. White II Publisher : Springer Science & Business Media Page : 308 pages File Size : 51,8 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461303312
Inhibitors to Coagulation Factors by Louis M. Aledort,Leon W. Hoyer,Jeanne M. Lusher,Howard M. Reisner,Gilbert C. White II Pdf
"For the blood is the life . . . . "(Deut. 12 :23) " . . . because the blood, in its value as life, makes atonement" (Lev. 17: 11) HemoPhilia is a rare disease, severe hemophilia rarer still, yet the written history of hemophilia extends back over a millennium and a half. In the ancient Middle East, blood and life were coupled. Blood was the primary substance necessary for life, given to God in sacrifice and forbidden as a food to mortals by Levitical law. Blood was essential for rites of purification and consecration. But the flow of blood during menstruation or parturition rendered a woman unclean. The circumcision of a male child required 33 days of "blood purification" by the mother. ' Circumcision, the visible reminder of the covenant of Abraham lijith Yahweh, was required of newborn Jewish males. It "connote(d) suitability for participation in what God is doing. "2 Hence, free and uncontrolled bleeding of the male child during circumcision, during the ratification of God's covenant, would be noted with awe and concern by those of the Jewish faith. It should not be surprising that the first genetic counseling offered to families with hemophilia is found in the Babylonian Talmud (compilation of Jewish law dated to about the third century AD) and concerns the necessity for circumcision in families with what we would now call hemophilia.
Author : Christine A. Lee,Erik E. Berntorp,W. Keith Hoots Publisher : John Wiley & Sons Page : 416 pages File Size : 47,5 Mb Release : 2008-04-15 Category : Medical ISBN : 9781405143868
Textbook of Hemophilia by Christine A. Lee,Erik E. Berntorp,W. Keith Hoots Pdf
The only up-to-date definitive reference source onhemophilia This book is an invaluable resource that provides an overview ofall aspects of the care of patients with haemophilia. Covering how to assess both bleeding children and adults,Haemophilia A and B, molecular basis of the disease, the role offactors in coagulation, epidemiology, pharmacokinetics, andtreatment of inhibitors. There will also be a section onmusculoskeletal aspects of haemophilia as well as newerdevelopments such as gene therapy and rare bleedingdisorders. Textbook of Hemophilia is ideal for: Trainees and residents in hematology Hematologists in practice Specialists working in thrombosis and hemostasis as well astransfusion medicine Why Buy This Book? The only up-to-date definitive reference source onhemophilia Essential for all those managing hemophilia patients Detailed guidance on assessment, diagnosis, management andtreatment Advice for everyday clinical questions Edited by three of the world’s leading experts onhemophilia
Consultative Hemostasis and Thrombosis E-Book by Craig S. Kitchens,Barbara A Konkle,Craig M. Kessler Pdf
A unique clinical focus makes Consultative Hemostasis and Thrombosis, 3rd Edition your go-to guide for quick, practical answers on managing the full range of bleeding and clotting disorders. Emphasizing real-world problems and solutions, Dr. Craig S. Kitchens, Dr. Barbara A. Konkle, and Dr. Craig M. Kessler provide all the clinical guidance you need to make optimal decisions on behalf of your patients and promote the best possible outcomes. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Efficiently look up concise descriptions of each condition, its associated symptoms, laboratory findings, diagnosis, differential diagnosis, and treatment. Get the latest information on hot topics such as Disseminated Intravascular Coagulation, Thrombophilia, Clinical and Laboratory Assessment and Management, Thrombotic -Thrombocytopenic Purpura, and Heparin-Induced Thrombocytopenia. Apply today’s newest therapies, including those that are quickly becoming standard in this fast-changing field. Meet the needs of specific patient groups with a new chapter on Bleeding and the Management of Hemorrhagic Disorders in Pregnancy and an extensively updated chapter on Thrombosis and Cancer. Zero in on key information with a new user-friendly design, and all-new full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout.
Author : Robert G. Westphal,Dennis M. Smith Publisher : American Association of Blood Banks (AABB) Page : 172 pages File Size : 43,9 Mb Release : 1989 Category : Hemophilia ISBN : PSU:000020748487
Von Willebrand Disease by Grant F. Cain,Cesar R. Massin Pdf
von Willebrand disease (VWD) is an inherited bleeding disorder that is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and also binds and stabilizes blood clotting factor VIII (FVIII) in the circulation. This book examines the need for more information on VWD prevalence and the relationship between low VWF levels of bleeding symptoms or risk and improving clinical and laboratory diagnostic tools.
