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Seattle, 1901. Professor of Electrical Engineering Benjamin Bradshaw's electrical forensic and investigative skills are put to the test. The Seattle police--and a murder-- are brought to his doorstep during the social and scientific turmoil of the early 20th century.
Drug Delivery in Oncology by Felix Kratz,Peter Senter,Henning Steinhagen Pdf
In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
The APRN and PA’s Complete Guide to Prescribing Drug Therapy 2022 by Mari J. Wirfs, PhD, MN, APRN, ANP-BC, FNP-BC, CNE Pdf
Includes 25 new diagnoses and digital updates as needed! The only prescribing guide conveniently organized by clinical diagnoses for adult and pediatric patients, this concise resource is an unrivaled reference tool for advanced health care providers (AHCPs) and students in all clinical practice settings who need guidance on prescribing drugs for patients with acute, episodic, and chronic health problems. Newly updated for 2022 with the most recent drug information and clinical guidance, this revised edition contains 25 new diagnoses including 15 additional cancer diagnoses and the novel Coronavirus (COVID-19). The APRN and PA's Complete Guide to Prescribing Drug Therapy 2022 intersperses clinically useful information throughout, such as monitored laboratory values, patient teaching points, and safety information. Section I alphabetically presents pharmacotherapy regimens for more than 600 clinical diagnoses. Each diagnosis contains drug choices alphabetically by generic name, FDA pregnancy category, OTC availability, generic availability, adult and pediatric dosing regimens, brand/trade names, available dose forms, and additive information. Section II uses a convenient table format to convey pediatric and adult immunization schedules, contraceptives, pediatric dosing tables for liquid anti infectives, and much more. An alphabetical cross reference index of drugs by generic and brand/trade names, with FDA pregnancy category and controlled drug schedule, facilitates quick identification of drugs by alternate names and relative safety during pregnancy. Key Features: Uniquely organized by clinical diagnosis! Addresses drug treatment options for over 600 specific diagnoses Guides the AHCP through drug classes, categories, and brand/trade names for primary care health issues Contains over 30 Appendices with quick access to drugs by category (e.g., antineoplastics, anticonvulsants), child and adult immunization schedules, contraceptives by form, glucocorticosteroids by potency, and much more! Index provides cross referencing of drugs by generic and brand/trade names Includes eBook and regular updates with purchase of print guide
Clinical Management of Ulcerative Colitis by Gary R. Lichtenstein, MD,Robert B. Stein, MD Pdf
Provides detailed clinical guidance on the management of ulcerative colitis by disease severity. Clinical presentation and diagnosis criteria are presented along with epidemiology, etiopathogenesis and environmental risk factors. The book contains the 2019 American College of Gastroenterology Ulcerative Colitis Treatment Guidelines. Disease management based on disease severity with separate chapters are devoted to each class of medications including aminosalicylate, corticosteroids, immunomodulators, and biologics. Comorbidities are reviewed in detail as is health maintenance for the ulcerative colitis patient.
Multigenic and Induced Systemic Resistance in Plants by Tuzun Sadik,Bent Elizabeth Pdf
Plants have developed very sophisticated mechanisms to combat pathogens and pestsusingtheleastamountofreservedorgeneratedenergypossible. Theydothis by activating major defense mechanisms after recognition of the organisms that are considered to be detrimental to their survival; therefore they have been able to exist on Earth longer than any other higher organisms. It has been known for the past century that plants carry genetic information for inherited resistance against many pathogenic organisms including fungi, bacteria, and viruses, and that the relationship between pathogenic organisms and hosts plants are rather complex and in some cases time dependent. This genetic information has been the basis for breeding for resistance that has been employed by plant breeders to develop better-yielding disease resistant varieties, some of which are still being cultivated. Single gene resistance is one type of resistance which has been extensively studied by many research groups all around the world using biotechnological methodologies that have been the subject of many books and journal articles; therefore, it is beyond the scope of this book. This type of resistance is very effective, although it can be overcome by the pressure of pathogenic organisms since it depends on interaction of a single elicitor molecule from the pathogen with a single receptor site in the host.
Hematological Malignancies in Children, Adolescents and Young Adults by Mitchell S. Cairo,Sherrie L. Perkins Pdf
Bringing together intellectual and scientific experts from pediatrics, adolescent medicine, general medicine, pathology, biology, nursing and psychology, this book is the first of its kind to cover the topics of leukemias and lymphomas in young patients ranging from infants to young adults. The content is organized and subdivided into four major sections -- under the main headings of General Considerations, Pathobiology, Clinical Manifestations and Treatment, and Supportive Care and Complications -- for ease of reference to readers. Hematological Malignancies in Children, Adolescents and Young Adults presents a comprehensive multidisciplinary review of the field of hematological malignancies and brings forth illuminating perspectives from an internationally recognized group of leading authorities in the field.
Antibody-Drug Conjugates by Kenneth J. Olivier, Jr.,Sara A. Hurvitz Pdf
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
2012 Oncology Nursing Drug Handbook by Gail M. Wilkes,Margaret Barton-Burke Pdf
Written expressly for nurses caring for patients with cancer, the 2012 Oncology Nursing Drug Handbook uniquely expresses drug therapy in terms of the nursing process: nursing diagnoses, etiologies of toxicities, and key points for nursing assessment, intervention, and evaluation. Updated annually, this essential reference provides valuable information on effective symptom management, patient education, and chemotherapy administration.Completely revised and updated, the 2012 Oncology Nursing Drug Handbook includes:* New drug entries and revisions* Specific drugs described in terms of their mechanism of action, metabolism, drug interactions, laboratory effects/interference, and special considerations* The most important and common drug side effects* Greater discussion of fundamentals of malignant transformation, new molecular targets, and drugs in the pipeline
2014 Guide to Literary Agents by Chuck Sambuchino Pdf
The best resource available for finding a literary agent! No matter what you're writing--fiction or nonfiction, books for kids or adults--you need a literary agent to secure a book deal. The 2014 Guide to Literary Agents is your essential resource for finding that literary agent--without fear of being scammed--and getting your book published. Along with listing information for more than 1,000 literary agents who represent writers and their work, this new, updated edition of GLA includes: • "New Agent Spotlights"--calling out literary reps actively building lists right now. • "How I Got My Agent" success stories from writers who describe their paths from aspiring author to published success. • Informative articles on query letters, synopsis writing, voice and craft, author platform, nonfiction book proposals, researching agents, and more. • Includes "Ask the Agent" profiles of individual literary agents who are currently seeking writers.
2013 Oncology Nursing Drug Handbook by Gail M. Wilkes,Margaret Barton-Burke Pdf
Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition. Written especially for nurses caring for patients with cancer, the 2013 Oncology Nursing Drug Handbook uniquely expresses drug therapy in terms of the nursing process: nursing diagnoses, etiologies of toxicities, and key points for nursing assessment, intervention, and evaluation. Updated annually, this essential reference provides valuable information on effective symptom management, patient education, and chemotherapy administration. Completely revised and updated, the 2013 Oncology Nursing Drug Handbook includes: * New drug entries and revisions * Specific drugs described in terms of their mechanism of action, metabolism, drug interactions, laboratory effects/interference, and special considerations * The most important and common drug side effects * Greater discussion of fundamentals of malignant transformation, new molecular targets, and drugs in the pipeline