Fine Tuning Of Rna Functions By Modification And Editing

Author : Henri Grosjean
Publisher : Springer
Page : 0 pages
File Size : 41,6 Mb
Release : 2010-02-12
Category : Science
ISBN : 3642063810

Get Book

Fine-Tuning of RNA Functions by Modification and Editing by Henri Grosjean Pdf

Naturally occurring RNA always contains numerous biochemically altered nucleotides. They are formed by enzymatic modification of the primary transcripts during the complex RNA maturation process designated RNA modification. A large number of enzymes catalyzing the formation of these modified nucleosides or converting one canonical base into another at the posttranscriptional level have been studied for many years, but only recently have systematic and comparative studies begun. The functions of individual enzymes and/or the modified/edited nucleosides in RNA, however, have remained largely ignored. This book provides advance information on RNA modification, including the associated editing machinery, while offering the reader some perspective on the significance of such modifications in fine-tuning the structure and functions of mature RNA molecules and hence the ability to influence the efficiency and accuracy of genetic expression. Outstanding scientists who are actively working on RNA modification/editing processes have provided up-to-date information on these intriguing cellular processes that have been generated over the course of millions of years in all living organisms. Each review has been written and illustrated for a large audience of readers, not only specialists in the field, but also for advanced students or researchers who want to learn more about recent progress in RNA modification and editing.

Author : Ruslan Aphasizhev
Publisher : Humana Press
Page : 0 pages
File Size : 48,9 Mb
Release : 2011-02-14
Category : Medical
ISBN : 1617790176

Get Book

RNA and DNA Editing by Ruslan Aphasizhev Pdf

The recent expansion in diversity of RNA and DNA editing types has stimulated the development of many unique genetic, molecular, biochemical, and computational approaches to biological issues. In RNA and DNA Editing: Methods and Protocols, leading experts in the field introduce methods developed over the last few years to study editing substrates, mechanisms of specificity, and functions of RNA and DNA editing enzymes and complexes. Sections of the book are dedicated to state-of-the art techniques which enable investigation of uracil insertion/deletion RNA editing in mitochondrion of Trypanosoma brucei, adenosine to inosine RNA editing, cytidine to uracil RNA and DNA editing, as well as tRNA editing and RNA modifications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNA and DNA Editing: Methods and Protocols seeks to inspire the further development of these vital and powerful techniques.

Author : Jonatha M. Gott
Publisher : Springer Science & Business Media
Page : 437 pages
File Size : 46,8 Mb
Release : 2008-02-05
Category : Science
ISBN : 9781592597758

Get Book

RNA Interference, Editing, and Modification by Jonatha M. Gott Pdf

This volume presents a comprehensive collection of cuttingedge methods for elucidating the function of new genes and altering gene expression. These readily reproducible techniques can be used either in transient and stable gene splicing applied to worms, flies, trypanosomes, mammals, and plants, or in studying RNA editing mechanisms in a wide range of organisms, including systems that involve the conversion of one base to another and insertion/deletion editing. Topics of interest include stable and transient RNA interference, gene silencing, RNA editing, bioinformatics, small noncoding RNAs, and RNomics. Special attention is given to methods for the identification and characterization of small RNAs involved in RNA interference or modification. Readily reproducible protocols for discovering new genes or altering gene expression.

Author : Anonim
Publisher : Academic Press
Page : 342 pages
File Size : 52,8 Mb
Release : 2017-06-21
Category : Science
ISBN : 9780128117781

Get Book

RNA Modification by Anonim Pdf

RNA Modification, Volume 41, examines the powerful ability to regulate the function of RNA molecules or modify the message transmitted by RNA molecules. This field has recently seen a very rapid progress in our understanding of the mechanism and enzymes involved in RNA modification. This volume presents some of the most recent advances in the identification and function of enzymes involved in modifying RNA molecules. Features authoritative expertise from recognized contributors to the field Presents the most recent advances in the rapidly evolving field of RNA modification Covers the identification and function of enzymes involved in modifying RNA molecules

Author : Henri Grosjean
Publisher : CRC Press
Page : 682 pages
File Size : 42,8 Mb
Release : 2009-06-11
Category : Science
ISBN : 9781498713153

Get Book

DNA and RNA Modification Enzymes by Henri Grosjean Pdf

This volume is a timely and comprehensive description of the many facets of DNA and RNA modification-editing processes and to some extent repair mechanisms. Each chapter offers fundamental principles as well as up to date information on recent advances in the field (up to end 2008). They ended by a short ‘conclusion and future prospect’ section and an exhaustive list of 35 to up to 257 references (in average 87). Contributors are geneticists, structural enzymologists and molecular biologists working at the forefront of this exciting, fast-moving and diverse field of researches. This book will be a major interest to PhD students and University teachers alike. It will also serve as an invaluable reference tool for new researchers in the field, as well as for specialists of RNA modification enzymes generally not well informed about what is going on in similar processes acting on DNA and vice-versa for specialists of the DNA modification-editing and repair processes usually not much acquainted with what is going on in the RNA maturation field. The book is subdivided into 41 chapters (740 pages). The common links between them are mainly the enzymatic aspects of the different modification-editing and repair machineries: structural, mechanistic, functional and evolutionary aspects. It starts with two general and historical overview of the discovery of modified nucleosides in DNA and RNA and corresponding modification-editing enzymes. Then follows eleven chapters on DNA modification and editing (mechanistic and functional aspects). Two additional chapters cover problems related to DNA/RNA repair and base editing by C-to-U deaminases, followed by three chapters on RNA editing by C-to-U and A-to-I type of deamination. Discussions about interplay between DNA and RNA modifications and the emergence of DNA are covered in two independent chapters, followed by twenty chapters on different but complementary aspects of RNA modification enzymes and their cellular implications. The last chapter concerns the description of the present state-of-the art for incorporating modified nucleosides by in vitro chemical synthesis. At the end of the book, six appendicies give useful details on modified nucleosides, modification-editing enzymes and nucleosides analogs. This information is usually difficult to obtain from current scientific literature.

Author : Harold C. Smith
Publisher : John Wiley & Sons
Page : 456 pages
File Size : 49,9 Mb
Release : 2008-04-25
Category : Science
ISBN : 0470262257

Get Book

RNA and DNA Editing by Harold C. Smith Pdf

RNA and DNA Editing assembles a team of leading experts who present the latest discoveries in the field alongside the latest models and methodology. In addition, the authors set forth the many open questions and suggest routes for further investigation. Overall, the book serves as a practical guide for professionals in the field who need to understand the interrelationship of RNA and DNA editing with other chemical and biological processes.

Author : Stefan Jurga,Volker A. Erdmann (Deceased),Jan Barciszewski
Publisher : Springer
Page : 453 pages
File Size : 55,7 Mb
Release : 2016-07-29
Category : Medical
ISBN : 9783319341750

Get Book

Modified Nucleic Acids in Biology and Medicine by Stefan Jurga,Volker A. Erdmann (Deceased),Jan Barciszewski Pdf

This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

Author : Anonim
Publisher : Academic Press
Page : 408 pages
File Size : 52,8 Mb
Release : 2015-12-11
Category : Medical
ISBN : 9780128023310

Get Book

RNA Modification by Anonim Pdf

RNA Modification provides a useful examination of the science and its role in biological regulation, the current frontier of life science research, and includes various RNA modications and their role in gene expression. It represents the most up-to-date knowledge and protocols available today. Dynamic RNA modifications and their roles in biological regulation are the current frontier of life science research This volume of Methods in Enzymology represents up to date knowledge and protocols

Author : Henri Grosjean,Rob Benne
Publisher : Unknown
Page : 0 pages
File Size : 46,7 Mb
Release : 1998
Category : RNA editing
ISBN : 1555811337

Get Book

Modification and Editing of RNA by Henri Grosjean,Rob Benne Pdf

This Comprehensive, current text explores the manifold ways in which living cells respond to genomic injury and alterations, including both spontaneous and environmentally induced DNA damage. With more than 4,000 complete references to primary research literature and over 380 color figures throughout, this book is an important text for all courses in DNA repair and mutagenesis. It will also serve as a major reference for all molecular biologists working in cancer biology, recombination, transcription and gene regulation, DNA replication, environmental studies, and biological evolution.

Author : Xiao Han,Jia Meng,Giovanni Nigita
Publisher : Frontiers Media SA
Page : 387 pages
File Size : 55,7 Mb
Release : 2022-05-05
Category : Science
ISBN : 9782889761067

Get Book

RNA Modifications and Epitranscriptomics by Xiao Han,Jia Meng,Giovanni Nigita Pdf

Author : Wayne S. Sossin
Publisher : Oxford University Press
Page : 512 pages
File Size : 49,5 Mb
Release : 2021-04-15
Category : Science
ISBN : 9780190686321

Get Book

The Oxford Handbook of Neuronal Protein Synthesis by Wayne S. Sossin Pdf

Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.

Author : Joanna Sztuba-Solinska
Publisher : Elsevier
Page : 450 pages
File Size : 48,6 Mb
Release : 2023-06-17
Category : Science
ISBN : 9780323907002

Get Book

Navigating Non-coding RNA by Joanna Sztuba-Solinska Pdf

Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications. Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA and circular RNA Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies Explores the molecular mechanisms and intermolecular interactions of ncRNA

Author : Jeffrey Laurence
Publisher : Academic Press
Page : 324 pages
File Size : 42,8 Mb
Release : 2016-12-30
Category : Medical
ISBN : 9780128006122

Get Book

Translating Epigenetics to the Clinic by Jeffrey Laurence Pdf

Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply epigenetics in the lab and clinic Features extensive pedagogical updates aiming to improve the education of translational researchers in this field Offers a transdisciplinary approach to support cross-fertilization between different sub-specialties of medicine

Author : H. Ulrich Göringer
Publisher : Springer Science & Business Media
Page : 239 pages
File Size : 53,9 Mb
Release : 2008-01-12
Category : Science
ISBN : 9783540737872

Get Book

RNA Editing by H. Ulrich Göringer Pdf

Goringer’s brilliant new work dedicates a chapter to each of the main types of RNA editing – the very first volume to do so. All of the sections here have been written by experts in the various research areas and a specific focus is put on the correlation between RNA structure and function, as well as on the complex cellular machineries that catalyze the different editing reactions. This leads to a "state of the art" compendium of our current knowledge on RNA editing.

Author : Ken J. Ishii,Shizuo Akira
Publisher : CRC Press
Page : 304 pages
File Size : 45,9 Mb
Release : 2008-05-22
Category : Medical
ISBN : 9781420068269

Get Book

Nucleic Acids in Innate Immunity by Ken J. Ishii,Shizuo Akira Pdf

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation