Fluorine In Organic Chemistry

Author : Richard D. Chambers
Publisher : CRC Press
Page : 426 pages
File Size : 53,9 Mb
Release : 2004
Category : Science
ISBN : 0849317908

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Fluorine in Organic Chemistry by Richard D. Chambers Pdf

The introduction of carbon-fluorine bonds into organic compounds can profoundly influence their chemical and physical properties when compared to their non-fluorine-containing analogues, leading to a range of man-made materials with highly desirable properties. These molecules are of interest across the wide spectrum of industrial and academic organic chemistry, from pharmaceuticals, through fine and specialty chemicals to polymers. From Prozac to Teflon, many of the most important products of the chemical and life-science industries rely on organic fluorine chemistry for their useful properties. This book covers both the preparative methodologies and chemical properties of partially and highly fluorinated organic systems.

Author : William Arthur Sheppard,Clay M. Sharts
Publisher : Unknown
Page : 636 pages
File Size : 41,5 Mb
Release : 1969
Category : Science
ISBN : UCAL:B4378648

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Organic Fluorine Chemistry by William Arthur Sheppard,Clay M. Sharts Pdf

Author : Milos Hudlicky
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 48,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461586425

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Organic Fluorine Chemistry by Milos Hudlicky Pdf

The present book is essentially based on the lectures on the chemistry of organic compounds of fluorine that I gave in 1969 at Virginia Polytechnic Institute in Blacksburg, Virginia, as a graduate course. References to material published to the end of 1969 are included. The book is primarily meant to provide the background for such a course, and, at the same time, to be a brief survey of recent knowledge in, and an introduction to deeper study of, this area of chemistry, which has been treated in a number of com prehensive monographs. I would like to thank Professor S. C. Cohen, Syracuse University, for the compilation of the data on mass spectra and nuclear magnetic res onance spectra, and my son, Tomas Hudlicky, and my daughter, Eva Hudlickci, for their help with the indexes. MILOS HUDLICKY February 13, 1970 Virginia Polytechnic Institute and State University Blacksburg, Virginia vii Contents CHAPTER 1. Introduction ......................................................... 1 Development of Fluorine Chemistry ......................................... .

Author : Milos Hudlic'ky
Publisher : Oxford University Press
Page : 145 pages
File Size : 44,5 Mb
Release : 2000-04-20
Category : Science
ISBN : 9780198030140

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Fluorine Chemistry for Organic Chemists by Milos Hudlic'ky Pdf

This book is a synthesis of two of Hudlicky's earlier books outlining the many unpredictable properties of fluorine and its compounds that are not analogous to the properties of any other halogens and their compounds. It is divided into two separate sections, the first presenting peculiar reactions as problems to be solved. Each reaction can be analyzed in the lab without the help of the second section, however if a solution is not easily reached, the second section provides discussion of the problems, outlining the products of the reactions and their mechanisms. Among the 105 reactions outlined are the introduction of fluorine into organic molecules, reduction and oxidation of fluorine compounds, reactions of fluorocompounds with halogens and their derivatives, nitration, acid catalyzed reactions, organometallic syntheses, and pyrolyses. The reactions are documented in the experimental material of the earlier volumes and will be important background knowledge for anyone working in organic chemistry.

Author : Axel Haupt
Publisher : Walter de Gruyter GmbH & Co KG
Page : 846 pages
File Size : 53,7 Mb
Release : 2021-03-22
Category : Science
ISBN : 9783110659504

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Organic and Inorganic Fluorine Chemistry by Axel Haupt Pdf

Organic and Inorganic Fluorine Chemistry provides an introduction to fluorine chemistry and an overview of the most important fluorinated compounds and general preparation techniques. The book is divided into three parts, covering general aspects, inorganic fluorides and fluoroorganic compounds. The inorganic part presents the most important element fluorides and oxyfluorides, their preparation as well as their most characteristic properties. The organic section focuses on the different types of fluorination and the corresponding reagents. The application of these techniques is discussed for many different types of substrates. The book addresses advanced students in chemistry as well as researchers in academia and industry. The readers will benefit from a large number of original references which give access to further information. In addition, study questions at the end of each chapter will help to repeat and internalise the most important aspects.

Author : R.E. Banks
Publisher : Elsevier
Page : 660 pages
File Size : 46,7 Mb
Release : 2000-12-04
Category : Science
ISBN : 0080531792

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Fluorine Chemistry at the Millennium by R.E. Banks Pdf

This volume brings together contributions by leading researchers covering a wide scope so characteristic of fluorine chemistry. It is a monograph of historical character comprising personalized accounts of progress and events in areas of particular interest. There is also much to interest and instruct chemists from other disciplines as a good proportion of the chapters contain a considerable amount of 'hard' referenced information relating to modern organic, organoelemental and inorganic chemistry. Historians of chemistry and technology will no doubt be tempted to dip into this book, and surely whoever addresses the task of commemorating Moissan's achievement at the 150-years stage will bless us all in some measure for its existence.

Author : Peer Kirsch
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 51,5 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527604197

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Modern Fluoroorganic Chemistry by Peer Kirsch Pdf

In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides. This long-awaited book represents an indispensable source of high quality information for everyone working in the field.

Author : William R. Dolbier, Jr.
Publisher : John Wiley & Sons
Page : 472 pages
File Size : 41,7 Mb
Release : 2016-08-24
Category : Science
ISBN : 9781118831090

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Guide to Fluorine NMR for Organic Chemists by William R. Dolbier, Jr. Pdf

Following its well-received predecessor, this book offers an essential guide to chemists for understanding fluorine in spectroscopy. With over 1000 compounds and 100 spectra, the second edition adds new data – featuring fluorine effects on nitrogen NMR, chemical shifts, and coupling constants. • Explains how to successfully incorporate fluorine into target molecules and utilize fluorine substituents to structurally characterize organic compounds • Includes new data on nitrogen NMR, focusing on N-15, to portray the influence of fluorine upon nitrogen NMR chemical shifts and coupling constants • Expands on each chapter from the first edition with additional data and updated discussion from recent findings • "The flawless ordering of material covered in this stand-alone volume is such that information can be found very easily." – Angewandte Chemie review of the first edition, 2010

Author : Kenji Uneyama
Publisher : John Wiley & Sons
Page : 352 pages
File Size : 41,5 Mb
Release : 2008-04-15
Category : Science
ISBN : 9781405172936

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Organofluorine Chemistry by Kenji Uneyama Pdf

The replacement of hydrogen with fluorine in organic molecules canprofoundly influence their chemical and physical properties,leading to a range of compounds with highly desirable properties.These molecules are of interest across the wide spectrum ofindustrial and academic organic chemistry, so that organofluorinechemistry is economically highly important. Organofluorine Chemistry will help chemists to develop a systematicknowledge of the chemistry of fluorine with a view towards itsapplication in the design of new reactions and syntheses, and thecreation of novel fluorinated molecules and materials. With initialchapters focusing on why fluorine creates such unique properties inorganic compounds, the book then covers general reactions offluorine. Coverage is chosen from the recent research literature,concentrating on the development of novel bioactive compounds andcatalytic ligands, and explaining, in the context of the initialchapters, how and why fluorine is so effective. With a finalchapter covering the general synthetic chemistry of organofluorinecompounds, the book is a cohesive summary of the fundamentalprincipals of organofluorine chemistry.

Author : Milos Hudlicky
Publisher : Unknown
Page : 938 pages
File Size : 47,8 Mb
Release : 1976
Category : Science
ISBN : UCAL:B4476048

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Chemistry of Organic Fluorine Compounds by Milos Hudlicky Pdf

Author : Tomoya Kitazume,Takashi Yamazaki
Publisher : Routledge
Page : 278 pages
File Size : 40,5 Mb
Release : 2019-06-14
Category : Science
ISBN : 9781351449236

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Experimental Methods in Organic Fluorine Chemistry by Tomoya Kitazume,Takashi Yamazaki Pdf

In the fields of biologically active materials and functional materials, fluorinated organic materials are becoming a focus of significant interest. Over the past decade synthetic methodologies and reagents in fluorine chemistry have been developed, especially stereocontrolled synthetic methods, enzymatic resolution to synthesize enantiomers, fluoromethylated reagents, and fluorination reagents. These methods have contributed to the opening of new pathways for fluorinated materials. However, few fluorinated materials have been put to commercial use. Furthermore, there remain problems to be solved, such as the handling of the materials, availability of reagents and selectivity (stereo-, regio-, and/or chemoselectivity). Research chemists, technical engineers, and graduate students in all branches of chemistry, pharmaceutics, and material science interested in fluorinated materials need to know detailed experimental procedures of how to synthesize the target fluorinated materials. This volume summarizes the chemical and microbial methods for obtaining functionalized fluorinated materials for use as building blocks; detailed experimental methods (reaction conditions, solvent, temperature, handling techniques, etc.); and the stereoview (possible absolute configuration) of the structures with spectral data. Mono-, di-, tri-, and polyfluorinated materials derived from fluorinating agents, fluoromethylated reagents and building blocks are summarized. A chemical name index, molecular formula index, and reagent index are also included. The publication of this monograph will provide access to the enormous possibilities in fluorine chemistry, biological material chemistry, and functionalized material chemistry.

Author : J.H. Simons
Publisher : Elsevier
Page : 255 pages
File Size : 50,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323158954

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Fluorine Chemistry V3 by J.H. Simons Pdf

Fluorine Chemistry, Volume III: Biological Effects of Organic Fluorides focuses on the biological threats of fluorine-containing compounds. The book first looks at the toxicity of fluoroacetate. Acute human poisoning, chemical factors, cause of death, pharmacological properties, evidence of fluorocitrate, and sites of inhibition are discussed. The text notes the biological effects of phosphofluoridates. Toxicity of DFP and derivatives, DFP metabolism, studies on DFP32 metabolism, and enzymes hydrolyzing DFP are described. The book also looks at the effects of acute doses of fluorine-containing organic compounds. The effects of organic fluorine compounds on enzyme systems; metabolic effects of tyrosine analogs; local anesthetics; effects of organofluorine compounds on microorganisms; and miscellaneous pharmacological effects of organic fluorides are discussed. The text underscores the acute effects of organofluorine compounds in experimental animals. Tabulated representations that show the effects of fluorine-containing compounds on humans and animals are presented. The book is a valuable source of information for readers wanting to study the biological effects of fluorine-containing compounds.

Author : Atta-ur-Rahman,Kenneth K. Laali
Publisher : Bentham Science Publishers
Page : 594 pages
File Size : 44,8 Mb
Release : 2011-01-10
Category : Science
ISBN : 9781608051984

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Advances in Organic Synthesis by Atta-ur-Rahman,Kenneth K. Laali Pdf

"The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating agents. It brings t"

Author : James H. Clark
Publisher : CRC Press
Page : 198 pages
File Size : 50,9 Mb
Release : 2018-01-10
Category : Science
ISBN : 9781351086783

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Aromatic Fluorination by James H. Clark Pdf

Academia and industry join forces in Aromatic Fluorination, as an expert from each domain contributes to this new text on fluorination of carbocyclic and heterocyclic rings. The book begins with a discussion of fluorine's unique combination of properties, including size, electronic effects, and hydrophobicity, as well as the historical development of its product applications. It explains methods for introducing fluorine into an aromatic ring, focusing on nucleophilic fluorine transfer reactions. The role of catalysts, solvents, and other variables are examined, and the scope and limitations of the methods are discussed. Of particular interest to those working in non-specialist laboratories, Aromatic Fluorination includes detailed descriptions of the new electrophilic routes to fluoroaromatics, in addition to traditional routes and alternative methods involving radical chemistry. Because one of the most important fluorine-containing substituent is CF3, the book explains routes to benzotrifluorides (ArCF3), including traditional industrial methods and modern alternatives employing C-1 halofluorocarbons and other fluoroaliphatics. An alternative to CF3 is CF3S, and several methods of synthesizing aromatic CF3S-containing molecules are described. Since the successful development and diverse applications of aromatic fluorine compounds have led to the search for new compounds and novel substituents, the incorporation of other substituents is also explored. Aromatic Fluorination concludes with discussion of the factors responsible for the successful development of pharmaceutical, agrochemical and liquid crystal applications and the potential for applications in high-performance polymers and other areas. This section also describes in detail important industrial aromatic fluorination processes and the relative merits of different process technologies and their costs.

Author : Milos Hudlicky,Stuart C. Cohen
Publisher : Unknown
Page : 193 pages
File Size : 48,7 Mb
Release : 1970
Category : Organofluorine compounds
ISBN : OCLC:4080935

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Chemistry of Organic Fluorine Compounds by Milos Hudlicky,Stuart C. Cohen Pdf