Focus On Neuropeptide Research 2007

Author : Rafael Covenãs Rodríguez
Publisher : Unknown
Page : 362 pages
File Size : 51,5 Mb
Release : 2007-01-01
Category : Neuropeptides
ISBN : 8178952912

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Focus on neuropeptide research 2007 by Rafael Covenãs Rodríguez Pdf

Neuropeptides is one of the disciplines in the field of Neuroscience that has been largely developed from the seventies and one that is foreseen to develop to possibly unimaginable heights in the near future, since neuropeptides are widespread distributed in the central and peripheral nervous systems and they are involved in many pathologies (Parkinson s disease, Alzheimer s disease, schizophrenia, depression&). Growing numbers of researches (cell biologists, biochemists, geneticists, histologists, pharmacologists, physiologists, psychiatrists, pathologists, immunologists, neurobiologists, psychologists&) are currently involved in this discipline and increasingly sophisticated methods for its study are becoming available. Our main aims in writing this book on neuropeptides were the following: a) to review the general data that exist on neuropeptides; b) to show the results found in several research works on the distribution and functions of neuropeptides; and c) to show the future perspectives on neuropeptide research. In this sense, the text has been divided in four parts. The first entitled Introduction to Neuropeptides includes the general data on neuropeptides such as: concepts of neuropeptide, neurotransmitter, neuromodulator and neurohormone, families of neuropeptides, phylogeny and ontogeny of neuropeptides, biosynthesis of neuropeptides, release and receptors of neuropeptides, enzymatic degradation of neuropeptides, methodologies used in the study of neuropeptides and distribution of neuropeptides (Chapter 1). The second part called Distribution of Neuropeptides includes the results obtained by different research groups on the distribution of neuropeptides in the cat spinal cord, brainstem, diencephalon and cerebral cortex, as well as on the distribution of neuropeptides in the dog brainstem and diencephalon and in the alpaca brainstem (Chapters 2-7). The third part deals with the Functions of the Neuropeptides and includes a review chapter on such functions (involvement of neuropeptides in pain, analgesia, thermoregulation, glucoregulation, food and water intake, immunoregulation, wakefulness and sleep, learning and memory) (Chapter 8) and a specific chapter on the implication of neuropeptides in cardiovascular control (Chapter 9). The aim of the fourth part was to show the Pathophysiology of the Neuropeptides . Thus, there is a chapter in which the involvement of neuropeptides in several pathologies such as asthma, arthritis, Alzheimer s disease, Parkinson s disease, alcoholism, schizophrenia, depression, stress and suicide is reviewed. In such chapter, the implication of neuropeptides in aging will be also reviewed (Chapter 10). Moreover, in the fourth part three specific chapters will be focused on the involvement of neuropeptides in migraine and Parkinson s and Alzheimer s disease (Chapters 11, 12), as well as on the implications of neuropeptides and NK-1 receptor antagonists in cancer research (Chapter 13). This book is directed not only to researchers interested in the field of neuropeptides, but to Life and Health Sciences Ph.D. students. For this reason, we have included three review chapters on the general concerning of neuropeptides (Chapter 1), the functional implications of neuropeptides (Chapter 8) and on the pathophysiology of the neuropeptides (Chapter 10). We hope that this text help to students to be enthusiasm in the study of neuropeptides and to introduce them in this field, since much remains to be studied on the distribution and functions of neuropeptides. Finally, we thank to Mercedes de León the help received before and during the redaction of this book.

Author : Timothy G. Geary,Aaron Maule
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 50,7 Mb
Release : 2011-01-13
Category : Medical
ISBN : 9781441969026

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Neuropeptide Systems as Targets for Parasite and Pest Control by Timothy G. Geary,Aaron Maule Pdf

The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

Author : Felix-Martin Werner,Rafael Coveñas
Publisher : Bentham Science Publishers
Page : 93 pages
File Size : 46,8 Mb
Release : 2016-02-11
Category : Medical
ISBN : 9781681082158

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Classical Neurotransmitters and Neuropeptides Involved in Schizoaffective Disorder by Felix-Martin Werner,Rafael Coveñas Pdf

Schizoaffective disorder is a psychotic disease with schizophrenic and affective i.e. depressive and/or manic symptoms. The disease can result in different patient outcomes depending upon the treatment applied. Patients suffering from the disease have in increased vulnerability towards stress and need an appropriate prophylactic medication so that they can perform social and maybe professional activities. Classical Neurotransmitters and Neuropeptides involved in Schizoaffective Disorder is a brief monograph that gives readers an overview of frequent psychotic diseases affecting patients. The contents of the monograph include details about biochemical alterations of classical neurotransmitters and neuropeptides in specific regions of the human brain, the susceptible genes and cellular mechanisms behind schizoaffective disorder, the neural networks of schizoaffective disorder and prophylactic pharmacotherapies administered to patients. Three case reports which demonstrate the alterations of classical neurotransmitters and neuropeptides in the brain are also presented. This monograph is a useful guide for medical residents and clinicians in training who wish to understand the basics about treating patients suffering from schizoaffective disorder.

Author : Bernice A. Levine
Publisher : Nova Publishers
Page : 316 pages
File Size : 45,6 Mb
Release : 2007
Category : Medical
ISBN : 1600216404

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Neuropeptide Research Trends by Bernice A. Levine Pdf

The explosion of research activity in the field of neuropeptides has led to the idenfication of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The scope of this book includes gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.

Author : Ernst Knobil
Publisher : Gulf Professional Publishing
Page : 1780 pages
File Size : 47,7 Mb
Release : 2006
Category : Science
ISBN : 0125154011

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Knobil and Neill's Physiology of Reproduction by Ernst Knobil Pdf

The 3rd edition, the first new one in ten years, includes coverage of molecular levels of detail arising from the last decade's explosion of information at this level of organismic organization. There are 5 new Associate Editors and about 2/3 of the chapters have new authors. Chapters prepared by return authors are extensively revised. Several new chapters have been added on the topic of pregnancy, reflecting the vigorous investigation of this topic during the last decade.The information covered includes both human and experimental animals; basic principels are sought, and information at the organismic and molecular levels are presented. *The leading comprehensive work on the physiology of reproduction*Edited and authored by the world's leading scientists in the field*Is a synthesis of the molecular, cellular, and organismic levels of organization*Bibliogrpahics of chapters are extensive and cover all the relevant literature

Author : S. Charles Schulz,Michael F. Green,Katharine J. Nelson
Publisher : Oxford University Press
Page : 424 pages
File Size : 50,7 Mb
Release : 2016-04-01
Category : Medical
ISBN : 9780199378074

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Schizophrenia and Psychotic Spectrum Disorders by S. Charles Schulz,Michael F. Green,Katharine J. Nelson Pdf

Schizophrenia and Psychotic Spectrum Disorders aims to engage young caregivers in psychiatry, psychology, nursing and social work so that they will be able to become well informed about this significant--and at times confusing--illness. Because schizophrenia is considered to be one of the most complicated and severe psychiatric disorders, this book has the goal of summarizing key issues of the illness, such as its presentation, frequency and age of onset, and diagnostic characteristics. It also contains informative chapters about the pathophysiology of schizophrenia, ranging from brain development issues, genetics, and likely abnormalities in neurotransmitters. This book will give young professionals and those joining the field an excellent and accessible background to treatment. In this area, Schizophrenia and Psychotic Spectrum Disorders provides a comprehensive approach to diagnosis, treatment initiation, strategies for non-response, approaches of therapy, and importantly, ways to provide family therapy and support.

Author : Yoshio Takei,Hironori Ando,Kazuyoshi Tsutsui
Publisher : Academic Press
Page : 1156 pages
File Size : 44,9 Mb
Release : 2015-08-26
Category : Science
ISBN : 9780128010679

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Handbook of Hormones by Yoshio Takei,Hironori Ando,Kazuyoshi Tsutsui Pdf

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research collates fundamental information about the structure and function of hormones from basic biology to clinical use. The handbook offers a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors and signalling pathways, and the biological activities they regulate. The evolution of hormones and gene families is also covered both in the text and in online ancillaries. Users will find simple and visual ways to learn key molecular information. Chapters and online ancillary resources integrate additional sections, providing a comparative molecular, functional, and evolutionary consideration. Provides the only single resource available with concise, yet informative descriptions of hormones in vertebrates, invertebrates, and plants Presents hormones in groups according to their origin, so that readers can easily understand their inter-relation Includes comparative information on the structures and functions of hormones enabling readers to understand both general and specific actions in and across species Ancillary website hosts additional information, including sequence data, comparative data, figures, and tables

Author : Gert Fricker,Melanie Ott,Anne Mahringer
Publisher : Springer
Page : 169 pages
File Size : 40,6 Mb
Release : 2014-10-24
Category : Science
ISBN : 9783662437872

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The Blood Brain Barrier (BBB) by Gert Fricker,Melanie Ott,Anne Mahringer Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Author : Gerald Litwack
Publisher : Academic Press
Page : 355 pages
File Size : 47,7 Mb
Release : 2019-08-13
Category : Science
ISBN : 9780128188590

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Opioid Hormones by Gerald Litwack Pdf

Vassopressin, Volume 111, the latest release in the Vitamins and Hormones series, first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics relating to hepcidin, bacterial infection, and iron overload, the role of heparan sulfates in hepcidin regulation, hepcidin CDNA and human gene sex hormones, growth factors and hepcidin, HFE gene polymorphisms and hereditary hemochromatosis, hepcidin and il-1beta, hepcidin-ferroportin axis, cardiomyocyte hepcidin, adipocyte iron, leptin and hepcidin, regulators of hepcidin expression, and much more. Focuses on the newest aspects of hormone action in connection with diseases Lays the groundwork for the focus of new chemotherapeutic targets Represents reviews on emerging areas in hormone action, cellular regulators and signaling pathways

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 42,5 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

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Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 48,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Richard E. Brown
Publisher : Cambridge University Press
Page : 434 pages
File Size : 54,7 Mb
Release : 1994-01-27
Category : Science
ISBN : 0521426650

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An Introduction to Neuroendocrinology by Richard E. Brown Pdf

This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.

Author : Elizabeth P. Farley
Publisher : Nova Publishers
Page : 308 pages
File Size : 46,7 Mb
Release : 2007
Category : Neuropeptides
ISBN : 1600216420

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Progress in Neuropeptide Research by Elizabeth P. Farley Pdf

The explosion of research activity in the field of neuropeptides has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The scope of this new and important book includes gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.

Author : Josh Dubnau
Publisher : Cambridge University Press
Page : 309 pages
File Size : 55,8 Mb
Release : 2014-06-26
Category : Medical
ISBN : 9781107009035

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Behavioral Genetics of the Fly (Drosophila Melanogaster) by Josh Dubnau Pdf

A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.

Author : John Apergis-Schoute,Geoffrey Burnstock,Michael P. Nusbaum,David Parker,Miguel A. Morales,Louis-Eric Trudeau,Erik Svensson
Publisher : Frontiers Media SA
Page : 184 pages
File Size : 44,5 Mb
Release : 2019-11-04
Category : Electronic
ISBN : 9782889459452

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Neuronal Co-transmission by John Apergis-Schoute,Geoffrey Burnstock,Michael P. Nusbaum,David Parker,Miguel A. Morales,Louis-Eric Trudeau,Erik Svensson Pdf