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Author : Anna C. Pai
Publisher : McGraw-Hill Science, Engineering & Mathematics
Page : 490 pages
File Size : 53,5 Mb
Release : 1985
Category : Genetics
ISBN : UCAL:B5018752
Author : F. A. E. Crew
Publisher : Elsevier
Page : 229 pages
File Size : 45,8 Mb
Release : 2014-06-28
Category : Science
ISBN : 9781483282657
The Foundations of Genetics describes the historical development of genetics with emphasis on the contributions to advancing genetical knowledge and the various applications of genetics. The book reviews the work of Gregor Mendel, his Law of Segregation, and of Ernst Haeckel who suggested that the nucleus is that part of the cell that is responsible for heredity. The text also describes the studies of W. Johannsen on "pure lines," and his introduction of the terms gene, genotype, and phenotype. The book explains the theory of the gene and the notion that hereditary particles are borne by the chromosomes (Sutton-Boveri hypothesis). Of the constituent parts of the nucleus only the chromatin material divides at mitosis and segregates during maturation. Following studies confirm that the chromatin material, present in the form of chromosomes with a constant and characteristic number and appearance for each species, is indeed the hereditary material. The book describes how Muller in 1927, showed that high precision energy radiation is the external cause to mutation in the gene itself if one allele can mutate without affecting its partner. The superstructure of genetics built upon the foundations of Mendelism has many applications including cytogenetics, polyploidy, human genetics, eugenics, plant breeding, radiation genetics, and the evolution theory. The book can be useful to academicians and investigators in the fields of genetics such as biochemical, biometrical, microbial, and pharmacogenetics. Students in agriculture, anthropology, botany, medicine, sociology, veterinary medicine, and zoology should add this text to their list of primary reading materials.
Author : Anthony William Fairbank Edwards
Publisher : Cambridge University Press
Page : 138 pages
File Size : 45,6 Mb
Release : 2000-01-13
Category : Science
ISBN : 0521775442
A definitive account of the origins of modern mathematical population genetics, first published in 2000.
Author : Francis Albert Eley Crew
Publisher : Unknown
Page : 128 pages
File Size : 43,5 Mb
Release : 1977
Category : Genetics
ISBN : OCLC:896188553
Author : C. A. Pai
Publisher : Unknown
Page : 128 pages
File Size : 53,8 Mb
Release : 1972
Category : Electronic
ISBN : OCLC:770261472
Author : Nan M. Laird,Christoph Lange
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 50,7 Mb
Release : 2010-12-13
Category : Medical
ISBN : 9781441973382
This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
Author : National Research Council,Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health,Forum on Drug Discovery, Development, and Translation,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Technology, and Law
Publisher : National Academies Press
Page : 106 pages
File Size : 48,9 Mb
Release : 2011-01-16
Category : Medical
ISBN : 9780309162166
Today, scores of companies, primarily in the United States and Europe, are offering whole genome scanning services directly to the public. The proliferation of these companies and the services they offer demonstrate a public appetite for this information and where the future of genetics may be headed; they also demonstrate the need for serious discussion about the regulatory environment, patient privacy, and other policy implications of direct-to-consumer (DTC) genetic testing. Rapid advances in genetic research already have begun to transform clinical practice and our understanding of disease progression. Existing research has revealed a genetic basis or component for numerous diseases, including Parkinson's disease, Alzheimer's disease, diabetes, heart disease, and several forms of cancer. The availability of the human genome sequence and the HapMap, plummeting costs of high-throughput screening, and increasingly sophisticated computational analyses have led to an explosion of discoveries of linkages between patterns of genetic variation and disease susceptibility. While this research is by no means a straight path toward better public health, improved knowledge of the genetic linkages has the potential to change fundamentally the way health professionals and public health practitioners approach the prevention and treatment of disease. Realizing this potential will require greater sophistication in the interpretation of genetic tests, new training for physicians and other diagnosticians, and new approaches to communicating findings to the public. As this rapidly growing field matures, all of these questions require attention from a variety of perspectives. To discuss some of the foregoing issues, several units of the National Academies held a workshop on August 31 and September 1, 2009, to bring together a still-developing community of professionals from a variety of relevant disciplines, to educate the public and policy-makers about this emerging field, and to identify issues for future study. The meeting featured several invited presentations and discussions on the many technical, legal, policy, and ethical questions that such DTC testing raises, including: (1) overview of the current state of knowledge and the future research trajectory; (2) shared genes and emerging issues in privacy; (3) the regulatory framework; and (4) education of the public and the medical community.
Author : Sewall Wright
Publisher : University of Chicago Press
Page : 520 pages
File Size : 52,8 Mb
Release : 1969
Category : Science
ISBN : 0226910504
"Wright's views about population genetics and evolution are so fundamental and so comprehensive that every serious student must examine these books firsthand. . . . Publication of this treatise is a major event in evolutionary biology."-Daniel L. Hartl, BioScience
Author : Peter J. Russell,Benjamin A. Pierce
Publisher : HarperCollins College
Page : 620 pages
File Size : 46,7 Mb
Release : 1994
Category : Science
ISBN : UOM:39015032735584
Gives full coverage of genetics, including the step-by-step problem-solving approach pioneered by the author. The book is suitable for students who have a limited background in biology and chemistry, or for briefer courses where there is little time to cover advanced topics.
Author : National Research Council,Board on Agriculture,Research in Agriculture,Committee on Biosciences
Publisher : National Academies Press
Page : 136 pages
File Size : 53,6 Mb
Release : 1985-01-01
Category : Technology & Engineering
ISBN : 9780309035422
Authored by an integrated committee of plant and animal scientists, this review of newer molecular genetic techniques and traditional research methods is presented as a compilation of high-reward opportunities for agricultural research. Directed to the Agricultural Research Service and the agricultural research community at large, the volume discusses biosciences research in genetic engineering, animal science, plant science, and plant diseases and insect pests. An optimal climate for productive research is discussed.
Author : Jon Adams
Publisher : Green Mountain Computing
Page : 128 pages
File Size : 50,5 Mb
Release : 2024-06-23
Category : Medical
ISBN : 8210379456XXX
Genetics Made Easy is not just a book; it's a journey into the heart of what makes us who we are. Written with the non-scientist in mind, it offers a refreshing approach to understanding the complex world of genetics. From the spirals of DNA to the marvels of gene editing, this book unfolds the mysteries of genetics with clarity, simplicity, and profound insight. Dive into the Chapters: The Alphabet of Life: DNA - Begin your journey with the basic building blocks of life, learning how DNA forms the script of our existence. Reading the Genetic Script: From DNA to Traits - Discover how genetic information is translated into the traits that define every organism. Blueprints and Architects: Genetics in Development - Explore the role of genetics in development and how it shapes organisms from conception to maturity. Genetic Editors: Mutation and Variation - Understand the mechanisms behind genetic mutations and the importance of variation for survival and evolution. Interwoven Destinies: Epigenetics and Environment - Delve into the interplay between genetics and the environment, and how external factors can influence gene expression. The Librarian's Code: Genetic Inheritance - Unravel the complexities of genetic inheritance and how traits are passed down through generations. Molecular Scissors: The Revolution of CRISPR - Get acquainted with CRISPR, the groundbreaking gene-editing technology that is reshaping the future of medicine and biology. The Future of Genetics: Ethics and Possibilities - Reflect on the ethical considerations and the vast potential that genetic research holds for humanity. Introduction to Genetics Made Easy: Embark on an enlightening expedition through the world of genetics, where complex concepts are made accessible through vivid examples, engaging analogies, and compelling explanations. This book is designed to clear the fog that often surrounds genetic science, illuminating each topic with the clarity of the morning sun. "Genetics Made Easy" is crafted for anyone eager to understand the language of life, whether you're a student, a professional in the medical or biotech fields, or simply curious about the genetic codes that write our existence. With a narrative as warm and inviting as a conversation with a friend, this book promises to open your mind and stir your sense of wonder. Why You Need This Book: For clarity: If genetics has always seemed like a dense forest of acronyms and abstract theories, this book is your path to understanding. For curiosity: Feed your curiosity about how life is written and rewritten at the molecular level. For appreciation: Gain a deeper appreciation for the intricate dance of nature's elements that weave the fabric of life. Takeaway: "Genetics Made Easy" invites you on an adventure into the genetic universe, promising not just knowledge but a profound appreciation for the beauty and complexity of life. Your journey into genetics starts now, and it promises to be as thrilling as it is enlightening. Welcome aboard.
Author : Roger N. Rosenberg,Juan M. Pascual
Publisher : Elsevier
Page : 1464 pages
File Size : 42,6 Mb
Release : 2014-10-28
Category : Medical
ISBN : 9780124105492
Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations
Author : Steven A. Frank
Publisher : Princeton University Press
Page : 284 pages
File Size : 55,8 Mb
Release : 2019-12-31
Category : Science
ISBN : 9780691206820
This is a masterly theoretical treatment of one of the central problems in evolutionary biology, the evolution of social cooperation and conflict. Steven Frank tackles the problem with a highly original combination of approaches: game theory, classical models of natural selection, quantitative genetics, and kin selection. He unites these with the best of economic thought: a clear theory of model formation and comparative statics, the development of simple methods for analyzing complex problems, and notions of information and rationality. Using this unique, multidisciplinary approach, Frank makes major advances in understanding the foundations of social evolution. Frank begins by developing the three measures of value used in biology--marginal value, reproductive value, and kin selection. He then combines these measures into a coherent framework, providing the first unified analysis of social evolution in its full ecological and demographic context. Frank also extends the theory of kin selection by showing that relatedness has two distinct meanings. The first is a measure of information about social partners, with close affinity to theories of correlated equilibrium and Bayesian rationality in economic game theory. The second is a measure of the fidelity by which characters are transmitted to future generations--an extended notion of heritability. Throughout, Frank illustrates his methods with many examples, including a complete reformulation of the theory of sex allocation. The book also provides a unique "how-to" guide for constructing models of social behavior. It is essential reading for evolutionary biologists and for economists, mathematicians, and others interested in natural selection.
Author : A. Jacquard
Publisher : Springer Science & Business Media
Page : 585 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Mathematics
ISBN : 9783642884153
It is part of the ideology of science that it is an international enterprise, carried out by a community that knows no barriers of nation or culture. But the reality is somewhat different. Despite the best intentions of scientists to form a single community, unseparated by differences of national and political viewpoint, they are, in fact, separated by language. Scientific literature in German is not generally assimilated by French workers, nor that appearing in French by those whose native language is English. The problem appears to have become more severe since the last war, because the ascendance of the United States as the preeminent economic power led, in a time of big and expensive science, to a pre dominance of American scientific production and a growing tendency (at least among English-speakers) to regard English as the international language of science. International congresses and journals of world circulation have come more and more to take English as their standard or official language. As a result, students and scientific workers in the English speaking world have become more linguistically parochial than ever before and have been cut off from a considerable scientific literature. Population genetics has been no exception to the rule. The elegant and extremely innovative theoreticaI work of Malecot, for example, is only now being properly assimilated by population biologists outside France. It was therefore with some sense of frustration that I read Prof.
Author : Ian McGonigle
Publisher : MIT Press
Page : 221 pages
File Size : 40,8 Mb
Release : 2021-08-24
Category : Science
ISBN : 9780262542944
An anthropological study based on ethnographic work in Israel and Qatar explores the relationship between science, particularly genetics, and national identity. Based on ethnographic work in Israel and Qatar, two small Middle Eastern ethnonations with significant biomedical resources, Genomic Citizenship explores the relationship between science and identity. Ian McGonigle, originally trained as a biochemist, draws on anthropological theory, STS, intellectual history, critical theory, Middle Eastern studies, cultural studies, and critical legal studies. He connects biomedical research on ethnic populations to the political, economic, legal, and historical context of the state; to global trends in genetic medicine; and to the politics of identity in the context of global biomedical research. Genomic Citizenship is more an anthropology of scientific objects than an anthropology of scientists or an ethnography of the laboratory. McGonigle bases his untraditional project on traditional anthropological methods, including participant observation. Some of the most persuasive data in the book are from public records, legal and historical sources, published scientific papers, institutional reports, websites, and brochures. McGonigle discusses biological understandings of Jewishness, especially in relation to the intellectual history of Zionism and Jewish political thought, and considers the possibility of a novel application of genetics in assigning Israeli citizenship. He also describes developments in genetic medicine in Qatar and analyzes the Qatari Biobank in the context of Qatari nationalism and state-building projects. Considering possible consequences of findings on the diverse origins of the Qatari population for tribal identities, he argues that the nation cannot be defined as either a purely natural or biological entity. Rather, it is reified, reinscribed, and refracted through genomic research and discourse.