Fragile Brain Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Fragile Brain book. This book definitely worth reading, it is an incredibly well-written.
"In this sensitive and informative account of dementia science, focusing on Alzheimer's, the neuroscientist and writer Kathleen Taylor explains what we have learnt in recent years about the condition. She looks at the strengths and weaknesses of the currently dominant view of the disease-- the amyloid cascade hypothesis-- and at the identified risk factors."-- book jacket.
Brain disease such as Alzheimer’s and Parkinson’s affect an estimated one in six Americans and are increasing in incidence as the population ages. In this eBook, Fragile Brain: Neurodegenerative Diseases, we examine these and other conditions involving the damage and loss of neurons, including other forms of dementia, amyotrophic lateral sclerosis (ALS), chronic traumatic encephalopathy (CTE) and multiple sclerosis (MS). In “The Seeds of Dementia,” the authors discuss evidence of prions and protein misfolding as a universal culprit in Alzheimer’s and other conditions. Later, two articles by Gary Stix report on ongoing research into a cluster of Columbian families that experience early onset symptoms of Alzheimer’s. Researchers studying the genes and progression of disease in these families hope that results will reveal clues about its course and possible future remedies. In “New Movement in Parkinson’s,” the authors outline abnormal cell behavior and genetic mutations that may be behind the disease. In the study of ALS, Amy Yee examines research into why eye muscles tend to last longer than other motor neurons and what this may mean for treatment. Other pieces look at new lines of inquiry in MS, including why researchers are turning to gray matter, as opposed to white matter, as the starting point for the disease. We wrap up this collection with current preventative measures and treatments that target not only disease pathology, but also lifestyle changes as well. In “A Rare Success against Alzheimer’s,” the results of a large-scale Finnish study provide evidence that choices such as diet and exercise can help prevent cognitive decline. Although this news is far from a cure, forward movement against Alzheimer’s – and neurodegenerative disease in general – is reason for optimism. As research and evidence accumulates, we get ever closer to curative therapies that can halt the debilitation and death of neurons.
Race has always been an emotional and contentious subject in America. Too often, the focus has been on one extreme or the other. Dr. Conrad provides a refreshing perspective that goes beyond news program sound bites and newspaper headlines to tackle some difficult questions, such as: Why do some people born into difficult circumstances succeed in life where others fail? What are the causes of urban violence in America? What does emotional intelligence have to do with understanding and appreciating diversity? What are the most common problems with diversity initiatives in many organizations? Dr. Conrad explores these questions based on what science tells us about our brains-their tremendous potential, and their fragility. The Fragile Mind is a valuable resource for you if you are: . A business leader or supervisor seeking to maximize the talents of your employees . An elected official or government representative seeking to understand the unique needs of your constituency . A school administrator or teacher seeking to prepare tomorrow's leaders . A non-profit leader or community worker seeking to provide the appropriate help for people in need
The Fragile X-Associated Tremor Ataxia Syndrome (FXTAS) by Flora Tassone,Elizabeth M. Berry-Kravis Pdf
In Fragile X-Associated Tremor Ataxia Syndrome (FXTAS), the editors present information on all aspects of FXTAS, including clinical features and current supportive management, radiological, psychological, and pathological findings, genotype-phenotype relationships, animal models and basic molecular mechanisms. Genetic counseling issues are also discussed. The book should serve as a resource for professionals in all fields regarding diagnosis, management, and counseling of patients with FXTAS and their families, as well as presenting the molecular basis for disease that may lead to the identification of new markers to predict disease risk and eventually lead to target treatments.
Towards Mechanism-based Treatments for Fragile X Syndrome by Daman Kumari,Inbal Gazy Pdf
It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.
The Better Brain Book by David Perlmutter,Carol Colman Pdf
From the author of the #1 New York Times bestseller Grain Brain and New York Times bestseller Brain Maker... Loss of memory is not a natural part of aging—and this book explains why. Celebrated neurologist David Perlmutter reveals how everyday memory-loss—misplacing car keys, forgetting a name, losing concentration in meetings—is actually a warning sign of a distressed brain. Here he and Carol Colman offer a simple plan for repairing those problems, clarifying misconstrued connections between memory loss and aging, and regaining and maintaining mental clarity by offering the tools for: Building a better brain through nutrition, lifestyle changes, and brain workouts Coping with specific brain disorders such as stroke, vascular dementia, Alzheimer's, Parkinson's, multiple sclerosis, and Lou Gehrig's disease Understanding risk factors and individually tailoring a diet and supplementary program Features a "Life Style Audit," quizzes, a brain fitness program with the most effective ways to exercise your brain, and a nutritional program that details the best brain food and supplements.
In The Fragile Mind, Dr. Conrad not only provides insight into what daily life is like for African Americans and individuals who are poor, he offers as innovative approach to overcoming these challenges based on what scientists have uncovered about the human brain - its brilliance, as well as its fragility. He demonstrates how conscious and subconscious actions taken by Whites have maintained their social, political, and economic dominance, while conscious and subconscious actions taken by African Americans and poor people have contributed to the perpetuation of their subordinate status in America.
A sequel to the popular Zen and the Brain further explores pivotal points of intersection in Zen Buddhism, neuroscience, and consciousness, arriving at a new synthesis of information from both neuroscience research and Zen studies. This sequel to the widely read Zen and the Brain continues James Austin's explorations into the key interrelationships between Zen Buddhism and brain research. In Zen-Brain Reflections, Austin, a clinical neurologist, researcher, and Zen practitioner, examines the evolving psychological processes and brain changes associated with the path of long-range meditative training. Austin draws not only on the latest neuroscience research and new neuroimaging studies but also on Zen literature and his personal experience with alternate states of consciousness. Zen-Brain Reflections takes up where the earlier book left off. It addresses such questions as: how do placebos and acupuncture change the brain? Can neuroimaging studies localize the sites where our notions of self arise? How can the latest brain imaging methods monitor meditators more effectively? How do long years of meditative training plus brief enlightened states produce pivotal transformations in the physiology of the brain? In many chapters testable hypotheses suggest ways to correlate normal brain functions and meditative training with the phenomena of extraordinary states of consciousness. After briefly introducing the topic of Zen and describing recent research into meditation, Austin reviews the latest studies on the amygdala, frontotemporal interactions, and paralimbic extensions of the limbic system. He then explores different states of consciousness, both the early superficial absorptions and the later, major "peak experiences." This discussion begins with the states called kensho and satori and includes a fresh analysis of their several different expressions of "oneness." He points beyond the still more advanced states toward that rare ongoing stage of enlightenment that is manifest as "sage wisdom." Finally, with reference to a delayed "moonlight" phase of kensho, Austin envisions novel links between migraines and metaphors, moonlight and mysticism. The Zen perspective on the self and consciousness is an ancient one. Readers will discover how relevant Zen is to the neurosciences, and how each field can illuminate the other.
Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease by Roger N. Rosenberg,Juan M. Pascual Pdf
Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume One, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Provides a detailed introduction on both the clinical and basic research implications of molecular and genetics surrounding the brain Includes new chapters on molecular genomics, CRISPR and the most recent updates in molecular genetics
"This is an urgently needed book that explores a number of different concepts of childhood in 21st century. The book throughout considers enduring topics and new concepts of childhood, and initiates a number of questions that students of education, childhood and early childhood studies can engage as lines of inquiries. The book offers a multidisciplinary approach of the child today, that influences practice, policy, and education, and offers diverse dimensions to provoke our thinking." - Dr. Ioanna Palaiologou, Institute of Education, University College London How we understand what ‘childhood’ means in today’s society is constantly changing, and the rate of this change is unprecedented. This new edited book explores what it really means to be a child of the 21st century, and how we as professionals, researchers, parents and adults can understand an environment seemingly in constant flux. Each chapter seeks to explore and problematise some of the different ‘labels’ that we give to children in an attempt to understand their contemporary experiences. From the Regulated Child to the Stressed Child to the Poor Child the book covers a wide array of key issues in contemporary childhood, including obesity, risk, special needs, wellbeing and poverty. The pace of change in childhood can be daunting but this book helps students, practitioners and researchers to explore and understand the variety of issues affecting children in the UK and all over the world.
Neuronal mechanisms of epileptogenesis by Roberto Di Maio Pdf
Several types of brain injuries are causes of acquired temporal lobe epilepsy (TLE). The seizure-free "latent period" that often follows the brain injury is of unknown mechanistic significance but is commonly considered as the "epileptogenic" period characterized by gradual pathogenic processes leading to the onset of clinically detectable epilepsy. Acute convulsive status epilepticus (SE) is often associated with an adverse developmental outcome characterized by learning disabilities related to the cumulative effects of seizures and development of TLE. The symptomatic manifestations of TLE appear only after a widespread irreversible damage of entorhinal cortex, and hippocampus, the brain area most affected by this disease. These pathological features of TLE reduce the possibility of successful therapeutic approaches, often rendering the disease refractory. The difficult clinical management of chronic TLE and the limited success rate of surgical approaches, increase the incapacitating nature of this specific epileptic disorder. Prevention of TLE with an appropriate intervention after a known inciting event (in the case of acquired epilepsy) might represent the most ambitious goal in the clinical treatment of this epileptic disorder, but has been largely unsuccessful to this point. Clinical trials aimed at prevention of chronic epilepsy have often produced negative, disappointing results. However, in most cases, these studies ultimately evaluated the downstream clinical manifestations, failing to monitor early, specific molecular epileptogenic events. Therefore, elucidation of the underlying mechanisms of epileptogenesis, and their time course(s) are essential. The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder.
