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Fraud in the Lab by Nicolas Chevassus-au-Louis Pdf
From manipulated results and fake data to retouched illustrations and plagiarism, cases of scientific fraud have skyrocketed in the past two decades. In a damning exposé, Nicolas Chevassus-au-Louis details the circumstances enabling the decline in scientific standards and highlights efforts to curtail future misconduct.
NATIONAL BESTSELLER • The gripping story of Elizabeth Holmes and Theranos—one of the biggest corporate frauds in history—a tale of ambition and hubris set amid the bold promises of Silicon Valley, rigorously reported by the prize-winning journalist. With a new Afterword covering her trial and sentencing, bringing the story to a close. “Chilling ... Reads like a thriller ... Carreyrou tells [the Theranos story] virtually to perfection.” —The New York Times Book Review In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the next Steve Jobs: a brilliant Stanford dropout whose startup “unicorn” promised to revolutionize the medical industry with its breakthrough device, which performed the whole range of laboratory tests from a single drop of blood. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.5 billion. There was just one problem: The technology didn’t work. Erroneous results put patients in danger, leading to misdiagnoses and unnecessary treatments. All the while, Holmes and her partner, Sunny Balwani, worked to silence anyone who voiced misgivings—from journalists to their own employees.
This is the story of wunderkind physicist Jan Hendrik Schön who faked the discovery of a new superconductor made from plastic. A star researcher at the world-renowned Bell Laboratories in New Jersey, he claimed to have stumbled across a powerful method for making carbon-based crystals into transistors, the switches found on computer chips. Had his experiments worked, they would have paved the way for huge advances in technology--computer chips that we could stick on a dress or eyewear, or even use to make electronic screens as thin and easy-to-fold as sheets of paper. But as other researchers tried to recreate Schön's experiments, the scientific community learned that it had been duped. Why did so many top experts, including Nobel prize-winners, support Schön? What led the major scientific journals to publish his work, and promote it with press releases? And what drove Schön, by all accounts a mild-mannered, modest and obliging young man, to tell such outrageous lies?
National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Committee on Responsible Science
Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Committee on Responsible Science Publisher : National Academies Press Page : 327 pages File Size : 51,5 Mb Release : 2018-01-13 Category : Science ISBN : 9780309391252
Fostering Integrity in Research by National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Committee on Responsible Science Pdf
The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support â€" or distort â€" practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices.
An in-depth look at scientific fraud Fraud in science is not as easy to identify as one might think. When accusations of scientific misconduct occur, truth can often be elusive, and the cause of a scientist's ethical misstep isn't always clear. On Fact and Fraud looks at actual cases in which fraud was committed or alleged, explaining what constitutes scientific misconduct and what doesn't, and providing readers with the ethical foundations needed to discern and avoid fraud wherever it may arise. In David Goodstein's varied experience—as a physicist and educator, and as vice provost at Caltech, a job in which he was responsible for investigating all allegations of scientific misconduct—a deceptively simple question has come up time and again: what constitutes fraud in science? Here, Goodstein takes us on a tour of real controversies from the front lines of science and helps readers determine for themselves whether or not fraud occurred. Cases include, among others, those of Robert A. Millikan, whose historic measurement of the electron's charge has been maligned by accusations of fraud; Martin Fleischmann and Stanley Pons and their "discovery" of cold fusion; Victor Ninov and the supposed discovery of element 118; Jan Hendrik Schön from Bell Labs and his work in semiconductors; and J. Georg Bednorz and Karl Müller's discovery of high-temperature superconductivity, a seemingly impossible accomplishment that turned out to be real. On Fact and Fraud provides a user's guide to identifying, avoiding, and preventing fraud in science, along the way offering valuable insights into how modern science is practiced.
Author : Daniel J. Kevles Publisher : W. W. Norton & Company Page : 512 pages File Size : 52,5 Mb Release : 2000-01-17 Category : Science ISBN : 9780393254860
The Baltimore Case: A Trial of Politics, Science, and Character by Daniel J. Kevles Pdf
"You read with a rising sense of despair and outrage, and you finish it as if awakening from a nightmare only Kafka could have conceived."--Christopher Lehmann-Haupt, New York Times David Baltimore won the Nobel Prize in medicine in 1975. Known as a wunderkind in the field of immunology, he rose quickly through the ranks of the scientific community to become the president of the distinguished Rockefeller University. Less than a year and a half later, Baltimore resigned from his presidency, citing the personal toll of fighting a long battle over an allegedly fraudulent paper he had collaborated on in 1986 while at MIT. From the beginning, the Baltimore case provided a moveable feast for those eager to hold science more accountable to the public that subsidizes its research. Did Baltimore stonewall a legitimate government inquiry? Or was he the victim of witch hunters? The Baltimore Case tells the complete story of this complex affair, reminding us how important the issues of government oversight and scientific integrity have become in a culture in which increasingly complicated technology widens the divide between scientists and society.
Forensic Fraud is the culmination of 12 years of research by author Brent E. Turvey. A practicing forensic scientist since 1996, Turvey has rendered this first of its kind study into the widespread problem of forensic fraud in the United States. It defines the nature and scope of the problem, the cultural attitudes and beliefs of those involved, and establishes clear systemic contributors. Backed up by scrupulous research and hard data, community reforms are proposed and discussed in light of the recently published National Academy of Sciences report on forensic science. An adaptation of Dr. Turvey’s doctoral dissertation, this volume relentlessly cites chapter and verse in support of its conclusions that law enforcement cultural and scientific values are incompatible, and that the problem of forensic fraud is systemic in nature. It begins with an overview of forensic fraud as a sub-type of occupational fraud, it explores the extent of fraud in both law enforcement and scientific employment settings, it establishes and then contrasts the core values of law enforcement and scientific cultures and then it provides a comprehensive review of the scientific literature regarding forensic fraud. The final chapters present data from Dr. Turvey’s original research into more than 100 fraudulent examiners between 2000 and 2010, consideration of significant findings, and a review of proposed reforms to the forensic science community based on what was learned. It closes with a chapter on the numerous crime lab scandals, and closures that occurred between 2010 and 2012 – an update on the deteriorating state of the forensic science community in the United States subsequent to data collection efforts in the present research. Forensic Fraud is intended for use as a professional reference manual by those working in the criminal system who encounter the phenomenon and want to understand its context and origins. It is intended to help forensic scientist and their supervisors to recognize, manage and expel it; to provide policy makers with the necessary understaffing for acknowledging and mitigating it; and to provide agents of the courts with the knowledge, and confidence, to adjudicate it. It is also useful for those at the university level seeking a strong secondary text for courses on forensic science, law and evidence, or miscarriages of justice. First of its kind overview of the cultural instigators of forensic fraud First of its kind research into the nature and impact of forensic fraud, with data (2000-2010) First of its kind typology of forensic fraud, for use in future case examination in research Numerous profiles of forensic fraudsters Review of major crime lab scandals between 2010 and 2012
A Lab of One's Own by Rita Colwell,Sharon Bertsch McGrayne Pdf
A “beautifully written” (Kirkus Reviews, starred review) memoir-manifesto from the first female director of the National Science Foundation about the entrenched sexism in science, the elaborate detours women have take to bypass the problem, and how to fix the system. If you think sexism thrives only on Wall Street or Hollywood, you haven’t visited a lab, a science department, a research foundation, or a biotech firm. Rita Colwell is one of the top scientists in America: the groundbreaking microbiologist who discovered how cholera survives between epidemics and the former head of the National Science Foundation. But when she first applied for a graduate fellowship in bacteriology, she was told, “We don’t waste fellowships on women.” A lack of support from some male superiors would lead her to change her area of study six times before completing her PhD. A Lab of One’s Own is an “engaging” (Booklist) book that documents all Colwell has seen and heard over her six decades in science, from sexual harassment in the lab to obscure systems blocking women from leading professional organizations or publishing their work. Along the way, she encounters other women pushing back against the status quo, including a group at MIT who revolt when they discover their labs are a fraction of the size of their male colleagues. Resistance gave female scientists special gifts: forced to change specialties so many times, they came to see things in a more interdisciplinary way, which turned out to be key to making new discoveries in the 20th and 21st centuries. Colwell would also witness the advances that could be made when men and women worked together—often under her direction, such as when she headed a team that helped to uncover the source of anthrax used in the 2001 letter attacks. A Lab of One’s Own is “an inspiring read for women embarking on a career or experiencing career challenges” (Library Journal, starred review) that shares the sheer joy a scientist feels when moving toward a breakthrough, and the thrill of uncovering a whole new generation of female pioneers. It is the science book for the #MeToo era, offering an astute diagnosis of how to fix the problem of sexism in science—and a celebration of women pushing back.
The Lab explains the idea of the “culture lab,” Edwards’ concept for experimental art and design centers like those he recently founded in Paris and at Harvard. He presents the lab as a new kind of educational art studio based on a contemporary science lab model, and he shows how students learn by translating ideas alongside experienced creators by exhibiting risky experimental processes in gallery settings.
National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science
Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science Publisher : National Academies Press Page : 257 pages File Size : 51,8 Mb Release : 2019-10-20 Category : Science ISBN : 9780309486163
Reproducibility and Replicability in Science by National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science Pdf
One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science.
Strictly off limits to the public, Plum Island is home to virginal beaches, cliffs, forests, ponds -- and the deadliest germs that have ever roamed the planet. Lab 257 blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore. Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, Lab 257 takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism. Lab 257 is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.
From a New York Times bestselling author comes the gripping, untold history of science's darkest secrets, "a fascinating book [that] deserves a wide audience" (Publishers Weekly, starred review). Science is a force for good in the world—at least usually. But sometimes, when obsession gets the better of scientists, they twist a noble pursuit into something sinister. Under this spell, knowledge isn’t everything, it’s the only thing—no matter the cost. Bestselling author Sam Kean tells the true story of what happens when unfettered ambition pushes otherwise rational men and women to cross the line in the name of science, trampling ethical boundaries and often committing crimes in the process. The Icepick Surgeon masterfully guides the reader across two thousand years of history, beginning with Cleopatra’s dark deeds in ancient Egypt. The book reveals the origins of much of modern science in the transatlantic slave trade of the 1700s, as well as Thomas Edison’s mercenary support of the electric chair and the warped logic of the spies who infiltrated the Manhattan Project. But the sins of science aren’t all safely buried in the past. Many of them, Kean reminds us, still affect us today. We can draw direct lines from the medical abuses of Tuskegee and Nazi Germany to current vaccine hesitancy, and connect icepick lobotomies from the 1950s to the contemporary failings of mental-health care. Kean even takes us into the future, when advanced computers and genetic engineering could unleash whole new ways to do one another wrong. Unflinching, and exhilarating to the last page, The Icepick Surgeon fuses the drama of scientific discovery with the illicit thrill of a true-crime tale. With his trademark wit and precision, Kean shows that, while science has done more good than harm in the world, rogue scientists do exist, and when we sacrifice morals for progress, we often end up with neither.
This highly original work presents laboratory science in a deliberately skeptical way: as an anthropological approach to the culture of the scientist. Drawing on recent work in literary criticism, the authors study how the social world of the laboratory produces papers and other "texts,"' and how the scientific vision of reality becomes that set of statements considered, for the time being, too expensive to change. The book is based on field work done by Bruno Latour in Roger Guillemin's laboratory at the Salk Institute and provides an important link between the sociology of modern sciences and laboratory studies in the history of science.