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Author : Edward S. Ruthazer,Takao K. Hensch
Publisher : Frontiers Media SA
Page : 192 pages
File Size : 55,8 Mb
Release : 2021-11-16
Category : Science
ISBN : 9782889716432
Author : Mariano Soiza-Reilly,Peter Saggau ,Benjamin R. Arenkiel
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 47,9 Mb
Release : 2015-09-14
Category : Neural circuitry
ISBN : 9782889195619
Deciphering anatomical and functional maps in the nervous system is a main challenge for both clinical and basic neuroscience. Modern approaches to mark and manipulate neurons are bringing us closer than ever to better understand nervous system wiring diagrams. Here we present both original research and review material on current work in this area. Together, this eBook aims to provide a comprehensive snapshot of some of the tools and technologies currently available to investigate brain wiring and function, as well as discuss ongoing challenges the field will be confronted with in the future.
Author : Steve M Potter,Eberhard E Fetz,Ahmed El Hady
Publisher : Frontiers Media SA
Page : 424 pages
File Size : 41,7 Mb
Release : 2014-12-03
Category : Neurophysiology
ISBN : 9782889193561
Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.
Author : Jean Decety,Yves Christen
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 52,6 Mb
Release : 2013-12-11
Category : Medical
ISBN : 9783319029047
Traditionally, neuroscience has considered the nervous system as an isolated entity and largely ignored influences of the social environments in which humans and many animal species live. However, there is mounting evidence that the social environment affects behavior across species, from microbes to humans. This volume brings together scholars who work with animal and human models of social behavior to discuss the challenges and opportunities in this interdisciplinary academic field.
Author : Federico Bermudez-Rattoni
Publisher : CRC Press
Page : 368 pages
File Size : 44,7 Mb
Release : 2007-04-17
Category : Science
ISBN : 1420008412
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniques have been used to investigate how cellular and brain circuits may be modified by experience. In each chapter, researchers present findings and explain their innovative methodologies. The book begins by introducing key issues and providing a historical overview of the field of memory consolidation. The following chapters review the putative genetic and molecular mechanisms of cell plasticity, elaborating on how experience could induce gene and protein expression and describing their role in synaptic plasticity underlying memory formation. They explore how putative modifications of brain circuits and synaptic elements through experience can become relatively permanent and hence improve brain function. Interdisciplinary reviews focus on how nerve cell circuitry, molecular expression, neurotransmitter release, and electrical activity are modified during the acquisition and consolidation of long-term memory. The book also covers receptor activation/deactivation by different neurotransmitters that enable the intracellular activation of second messengers during memory formation. It concludes with a summary of current research on the modulation and regulation that different neurotransmitters and stress hormones have on formation and consolidation of memory.
Author : Lisa Federer
Publisher : Rowman & Littlefield
Page : 243 pages
File Size : 47,7 Mb
Release : 2016-09-15
Category : Language Arts & Disciplines
ISBN : 9781442264281
Technological advances and the rise of collaborative, interdisciplinary approaches have changed the practice of research. The 21st century researcher not only faces the challenge of managing increasingly complex datasets, but also new data sharing requirements from funders and journals. Success in today’s research enterprise requires an understanding of how to work effectively with data, yet most researchers have never had any formal training in data management. Libraries have begun developing services and programs to help researchers meet the demands of the data-driven research enterprise, giving librarians exciting new opportunities to use their expertise and skills. The Medical Library Association Guide to Data Management for Librarians highlights the many ways that librarians are addressing researchers’ changing needs at a variety of institutions, including academic, hospital, and government libraries. Each chapter ends with “pearls of wisdom,” a bulleted list of 5-10 takeaway messages from the chapter that will help readers quickly put the ideas from the chapter into practice. From theoretical foundations to practical applications, this book provides a background for librarians who are new to data management as well as new ideas and approaches for experienced data librarians.
Author : Sten Grillner,Ann M. Graybiel
Publisher : MIT Press
Page : 471 pages
File Size : 54,7 Mb
Release : 2006
Category : Anatomy
ISBN : 9780262072786
Leading neuroscientists discuss the function of microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior. Microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior, could provide the link between neurons and global brain function. Microcircuits are designed to serve particular functions; examples of these functional modules include the cortical columns in sensory cortici, glomeruli in the olfactory systems of insects and vertebrates, and networks generating different aspects of motor behavior. In this Dahlem Workshop volume, leading neuroscientists discuss how microcircuits work to bridge the single cell and systems levels and compare the intrinsic function of microcircuits with their ion channel subtypes, connectivity, and receptors, in order to understand the design principles and function of the microcircuits. The chapters cover the four major areas of microcircuit research: motor systems, including locomotion, respiration, and the saccadic eye movements; the striatum, the largest input station of the basal ganglia; olfactory systems and the neural organization of the glomeruli; and the neocortex. Each chapter is followed by a group report, a collaborative discussion among senior scientists. Contributors Lidia Alonso-Nanclares, Hagai Bergman, Maria Blatow, J. Paul Bolam, Ansgar Büschges, Antonio Caputi, Jean-Pierre Changeux, Javier DeFelipe, Carsten Duch, Paul Feinstein, Stuart Firestein, Yves Frégnac, Rainer W. Friedrich, C. Giovanni Galizia, Ann M. Graybiel, Charles A. Greer, Sten Grillner, Tadashi Isa, Ole Kiehn, Minoru Kimura, Anders Lanser, Gilles Laurent, Pierre-Marie Lledo, Wolfgang Maass, Henry Markram, David A. McCormick, Christoph M. Michel, Peter Mombaerts, Hannah Monyer, Hans-Joachim Pflüger, Dietmar Plenz, Diethelm W. Richter, Silke Sachse, H. Sebastian Seung, Keith T. Sillar, Jeffrey C. Smith, David L. Sparks, D. James Surmeier, Eörs Szathmáry, James M. Tepper, Jeff R. Wickens, Rafael Yuste
Author : Adrian C. Michael,Laura Borland
Publisher : CRC Press
Page : 544 pages
File Size : 41,9 Mb
Release : 2006-12-13
Category : Science
ISBN : 9781420005868
Since the first implant of a carbon microelectrode in a rat 35 years ago, there have been substantial advances in the sensitivity, selectivity and temporal resolution of electrochemical techniques. Today, these methods provide neurochemical information that is not accessible by other means. The growing recognition of the versatility of electrochemical techniques indicates a need for a greater understanding of the scientific foundation and use of these powerful tools. Electrochemical Methods for Neuroscience provides an updated summary of the current, albeit evolving, state of the art and lays the scientific foundation for incorporating electrochemical techniques into on-going or newly emerging research programs in the neuroscience disciplines. With contributions from pioneers in the field, the text outlines the applications and benefits of a wide range of electrochemical techniques. It explores the methodology behind the acquisition of neurochemical and neurobiological data through continuous amperometry, fast scan cyclic voltammetry, high-speed chronoamperometry, ion-selective microelectrodes, enzyme based microelectrodes, and in vivo voltammetry with telemetry. The text also introduces emerging concepts in the field such as the correlation of electrochemical recordings with information obtained from patch clamp, electrophysiological, and behavioral techniques. By presenting up-to-date information on the growing collection of electrochemical methods, microsensors, and research techniques, Electrochemical Methods for Neuroscience assists seasoned researchers and newcomers to the field in making sound decisions about adopting the most appropriate of these tools for their future research objectives.
Author : Michela Chiappalone,Valentina Pasquale,Monica Frega
Publisher : Springer
Page : 387 pages
File Size : 45,7 Mb
Release : 2019-05-09
Category : Medical
ISBN : 9783030111359
This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.
Author : Anonim
Publisher : Academic Press
Page : 600 pages
File Size : 44,5 Mb
Release : 2018-11-16
Category : Science
ISBN : 9780128120149
Handbook of Object Novelty Recognition, Volume 26, synthesizes the empirical and theoretical advances in the field of object recognition and memory that have occurred since the development of the spontaneous object recognition task. The book is divided into four sections, covering vision and perception of object features and attributions, definitions of concepts that are associated with object recognition, the influence of brain lesions and drugs on various memory functions and processes, and models of neuropsychiatric disorders based on spontaneous object recognition tasks. A final section covers genetic and developmental studies and gender and hormone studies. Details the brain structures and the neural circuits that underlie memory of objects, including vision and olfaction Provides a thorough description of the object novelty recognition task, variations on the basic task, and methods and techniques to help researchers avoid common pitfalls Assists researchers in understanding all aspects of object memory, conducting object novelty recognition tests, and producing reliable, reproducible results
Author : Eilif Muller,James A. Bednar,Markus Diesmann,Marc-Oliver Gewaltig,Michael Hines,Andrew P. Davison
Publisher : Frontiers Media SA
Page : 275 pages
File Size : 54,9 Mb
Release : 2015-07-23
Category : Electronic book
ISBN : 9782889196081
Python is rapidly becoming the de facto standard language for systems integration. Python has a large user and developer-base external to theneuroscience community, and a vast module library that facilitates rapid and maintainable development of complex and intricate systems. In this Research Topic, we highlight recent efforts to develop Python modules for the domain of neuroscience software and neuroinformatics: - simulators and simulator interfaces - data collection and analysis - sharing, re-use, storage and databasing of models and data - stimulus generation - parameter search and optimization - visualization - VLSI hardware interfacing. Moreover, we seek to provide a representative overview of existing mature Python modules for neuroscience and neuroinformatics, to demonstrate a critical mass and show that Python is an appropriate choice of interpreter interface for future neuroscience software development.
Author : Andreas Schmidt-Rhaesa,Steffen Harzsch,Günter Purschke
Publisher : Oxford University Press
Page : 776 pages
File Size : 52,6 Mb
Release : 2015-12-17
Category : Science
ISBN : 9780191504747
The nervous system is particularly fascinating for many biologists because it controls animal characteristics such as movement, behavior, and coordinated thinking. Invertebrate neurobiology has traditionally been studied in specific model organisms, whilst knowledge of the broad diversity of nervous system architecture and its evolution among metazoan animals has received less attention. This is the first major reference work in the field for 50 years, bringing together many leading evolutionary neurobiologists to review the most recent research on the structure of invertebrate nervous systems and provide a comprehensive and authoritative overview for a new generation of researchers. Presented in full colour throughout, Structure and Evolution of Invertebrate Nervous Systems synthesizes and illustrates the numerous new findings that have been made possible with light and electron microscopy. These include the recent introduction of new molecular and optical techniques such as immunohistochemical staining of neuron-specific antigens and fluorescence in-situ-hybridization, combined with visualization by confocal laser scanning microscopy. New approaches to analysing the structure of the nervous system are also included such as micro-computational tomography, cryo-soft X-ray tomography, and various 3-D visualization techniques. The book follows a systematic and phylogenetic structure, covering a broad range of taxa, interspersed with chapters focusing on selected topics in nervous system functioning which are presented as research highlights and perspectives. This comprehensive reference work will be an essential companion for graduate students and researchers alike in the fields of metazoan neurobiology, morphology, zoology, phylogeny and evolution.
Author : Ioan Opris,Mikhail Lebedev,Ruxandra Vidu,Victor Manuel Pulgar,Marius Enachescu,Manuel Fernando Casanova
Publisher : Frontiers Media SA
Page : 328 pages
File Size : 45,9 Mb
Release : 2020-05-05
Category : Electronic
ISBN : 9782889636754
Author : Jean-Claude Dreher,Leon Tremblay
Publisher : Academic Press
Page : 440 pages
File Size : 41,7 Mb
Release : 2016-09-27
Category : Medical
ISBN : 9780128053317
Decision Neuroscience addresses fundamental questions about how the brain makes perceptual, value-based, and more complex decisions in non-social and social contexts. This book presents compelling neuroimaging, electrophysiological, lesional, and neurocomputational models in combination with hormonal and genetic approaches, which have led to a clearer understanding of the neural mechanisms behind how the brain makes decisions. The five parts of the book address distinct but inter-related topics and are designed to serve both as classroom introductions to major subareas in decision neuroscience and as advanced syntheses of all that has been accomplished in the last decade. Part I is devoted to anatomical, neurophysiological, pharmacological, and optogenetics animal studies on reinforcement-guided decision making, such as the representation of instructions, expectations, and outcomes; the updating of action values; and the evaluation process guiding choices between prospective rewards. Part II covers the topic of the neural representations of motivation, perceptual decision making, and value-based decision making in humans, combining neurcomputational models and brain imaging studies. Part III focuses on the rapidly developing field of social decision neuroscience, integrating recent mechanistic understanding of social decisions in both non-human primates and humans. Part IV covers clinical aspects involving disorders of decision making that link together basic research areas including systems, cognitive, and clinical neuroscience; this part examines dysfunctions of decision making in neurological and psychiatric disorders, such as Parkinson’s disease, schizophrenia, behavioral addictions, and focal brain lesions. Part V focuses on the roles of various hormones (cortisol, oxytocin, ghrelin/leptine) and genes that underlie inter-individual differences observed with stress, food choices, and social decision-making processes. The volume is essential reading for anyone interested in decision making neuroscience. With contributions that are forward-looking assessments of the current and future issues faced by researchers, Decision Neuroscience is essential reading for anyone interested in decision-making neuroscience. Provides comprehensive coverage of approaches to studying individual and social decision neuroscience, including primate neurophysiology, brain imaging in healthy humans and in various disorders, and genetic and hormonal influences on decision making Covers multiple levels of analysis, from molecular mechanisms to neural-systems dynamics and computational models of how we make choices Discusses clinical implications of process dysfunctions, including schizophrenia, Parkinson’s disease, eating disorders, drug addiction, and pathological gambling Features chapters from top international researchers in the field and full-color presentation throughout with numerous illustrations to highlight key concepts
Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Publisher : National Academies Press
Page : 610 pages
File Size : 42,8 Mb
Release : 2000-11-13
Category : Social Science
ISBN : 9780309069885
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.