Gene Therapy And Gene Delivery Systems

Author : Yashwant Pathak
Publisher : CRC Press
Page : 317 pages
File Size : 47,8 Mb
Release : 2022-07-01
Category : Medical
ISBN : 9781000580297

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Gene Delivery Systems by Yashwant Pathak Pdf

This unique volume in our Drugs and Pharmaceutical Sciences series covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases. Key Features: Overview of the development of gene therapy Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing Presents CRISPR gene therapy recent trends and applications Discusses siRNA, mRNA, and DNA plasmids

Author : Yashwant Pathak
Publisher : CRC Press
Page : 0 pages
File Size : 54,8 Mb
Release : 2022
Category : Medical
ISBN : 1003186068

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Gene Delivery Systems by Yashwant Pathak Pdf

Gene therapy is a technique that modifies a person's genes to treat or cure disease and can be used as an alternative to using drugs or surgery. Here the authors discuss the development of gene therapy today, from the technology involved to gene correction and the advances in genome editing. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases. Key Features: Overview of the development of gene therapy Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing Presents CRISPR gene therapy recent trends and applications Discusses siRNA, mRNA, and DNA plasmids A collection of 15 chapters containing recent research, this volume covers the development of gene therapy, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of CRISPR/Cas9 gene-editing technique, an approach that has recently been given the Nobel Prize in Chemistry, 2020.

Author : Yashwant Pathak
Publisher : Unknown
Page : 128 pages
File Size : 52,5 Mb
Release : 2022
Category : Gene therapy
ISBN : 1032029722

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Gene Delivery Systems by Yashwant Pathak Pdf

"Gene therapy involves altering the genes inside your body's cells in an effort to treat or stop disease, instead of using drugs or surgery. This book discusses the development of gene therapy today, from the technology involved to gene correction and the advances in genome editing"--

Author : David V. Schaffer,Weichang Zhou
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 54,5 Mb
Release : 2005-12-20
Category : Medical
ISBN : 3540284044

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Gene Therapy and Gene Delivery Systems by David V. Schaffer,Weichang Zhou Pdf

1 D.V. Schaffer, W. Zhou: Gene Therapy as Future Human Therapeutics.- 2 J. Heidel, S. Mishra, M.E. Davis: Molecular Conjugates.- 3 M. Manthorpe, P. Hobart, G. Hermanson, M. Ferrari, A. Geall, B. Goff, A. Rolland: Plasmid Vaccines and Therapeutics: From Design to Applications.- 4 S.R. Little, R. Langer: Non-Viral Delivery of Cancer Genetic Vaccines.- 5 J.C. Grieger, R.J. Samulski: Adeno-Associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications.- 6 J.H. Yu, D.V. Schaffer: Advanced Targeting Strategies for Murine Retroviral and Adeno-Associated Viral Vectors.- 7 N. Loewen, E.M. Poeschla: Lentiviral Vectors.- 8 N.E. Altaras, J.G. Aunins, R.K. Evans, A. Kamen, J.O. Konz, J.J. Wolf: Production and Formulation of Adenovirus Vectors.-

Author : Alain Rolland
Publisher : CRC Press
Page : 442 pages
File Size : 40,8 Mb
Release : 2003-04-11
Category : Medical
ISBN : 9780824748586

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Pharmaceutical Gene Delivery Systems by Alain Rolland Pdf

This volume examines the advantages and limitations of the major gene delivery systems and offers guidelines to select the most appropriate viral or synthetic delivery system for specific therapeutic applications. It discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancerous, cardiovascular, pulmonary, genetic, and infectious diseases.

Author : Yashwant Pathak
Publisher : CRC Press
Page : 307 pages
File Size : 55,8 Mb
Release : 2022-07-01
Category : Medical
ISBN : 9781000580310

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Gene Delivery Systems by Yashwant Pathak Pdf

This unique volume in our Drugs and Pharmaceutical Sciences series covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases. Key Features: Overview of the development of gene therapy Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing Presents CRISPR gene therapy recent trends and applications Discusses siRNA, mRNA, and DNA plasmids

Author : Nancy Smyth Templeton,D. D. Lasic
Publisher : CRC Press
Page : 616 pages
File Size : 42,5 Mb
Release : 2000-06-15
Category : Medical
ISBN : UOM:39015050321036

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Gene Therapy by Nancy Smyth Templeton,D. D. Lasic Pdf

This text covers all aspects of gene therapy, including basic principles, viral and nonviral delivery systems, targeted diseases, regulatory issues, and FDA requirements. It investigates genetic bullets to block HIV-1 replication and genetic guns to deliver antiviral agents.

Author : Alain Rolland
Publisher : CRC Press
Page : 300 pages
File Size : 45,7 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303818

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Advanced Gene Delivery by Alain Rolland Pdf

A practical resource for everyone involved in the gene therapy field and in the design of effective gene delivery systems, this volume presents an overview and update of recent advances in the field of non-viral methods for the in vivo transfer of therapeutic genes to biological targets using conventional routes of administration. Methods to control the spatial and temporal modulation of gene function in vivo as well as the level, duration, specificity, and fidelity of gene expression are described. The rational design and the applications of a variety of non-viral gene delivery systems, such as cationic lipid-, polymer-, and (poly) peptide-based systems, are exemplified for the control of location of therapeutic genes administered by various routes. Current and potential clinical applications of gene-based medicines are presented for the prevention, correction or modulation of diseases. Examples of current applications of plasmid-based systems for genetic vaccination, treatment of genetic disorders such as cystic fibrosis, and treatment of acquired diseases such as cancer are also provided.

Author : Mansoor M. Amiji
Publisher : CRC Press
Page : 707 pages
File Size : 50,5 Mb
Release : 2004-09-29
Category : Medical
ISBN : 9780203500477

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Polymeric Gene Delivery by Mansoor M. Amiji Pdf

To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry

Author : Ravin Narain
Publisher : Woodhead Publishing
Page : 302 pages
File Size : 55,5 Mb
Release : 2016-01-09
Category : Science
ISBN : 9780081005217

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Polymers and Nanomaterials for Gene Therapy by Ravin Narain Pdf

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

Author : Anonim
Publisher : OECD
Page : 456 pages
File Size : 53,6 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015038027028

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Gene Delivery Systems by Anonim Pdf

Author : Kazunari Taira,Kazunori Kataoka,Takuro Niidome
Publisher : Springer Science & Business Media
Page : 494 pages
File Size : 41,6 Mb
Release : 2006-03-20
Category : Science
ISBN : 9784431278795

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Non-viral Gene Therapy by Kazunari Taira,Kazunori Kataoka,Takuro Niidome Pdf

Presents information on non-viral gene-delivery techniques, covering a spectrum of disciplines that include chemistry, molecular biology, cell biology, and pharmacokinetics. This work is useful to researchers and engineers in genetic engineering, molecular medicine, biochemical engineering, and biotechnology.

Author : Vanessa Zimmer
Publisher : Unknown
Page : 0 pages
File Size : 41,8 Mb
Release : 2019
Category : Gene therapy
ISBN : 153616268X

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Gene Delivery by Vanessa Zimmer Pdf

Gene Delivery: Methods and Applications provides a comprehensive overview on viral and non-viral methods used to genetically engineer human mesenchymal stromal cells. In addition, an update on ongoing and completed clinical studies with engineered mesenchymal stromal cells will be provided, as well as a snapshot of the advances and technical challenges yet to be addressed.Next, a variety of gene delivery systems including physical transfection techniques, virus-based delivery vectors, chemically engineered delivery systems and bio-inspired vehicles are reviewed and their strengths, shortcomings and biomedical applications are discussed.Selfish DNA called transposons capable of cutting out and pasting into the host genome are active throughout the phylogenetic kingdoms. Researchers have repurposed natural transposons for use in delivering a gene-of-interest, enabling for the study of a large and growing list of preclinical gene therapy applications. As such, the authors discuss the past achievements and future challenges of this early-stage technology.The closing chapter introduces cell-penetrating peptides as an efficient tool for DNA transfection. HR9, a designed cell-penetrating peptides, containing nona-arginine flanked by cysteine and penta-histidine displayed a high penetrating ability in mammalian cells.

Author : Yashwant Pathak
Publisher : CRC Press
Page : 377 pages
File Size : 42,5 Mb
Release : 2022-06-29
Category : Medical
ISBN : 9781000594799

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Gene Delivery by Yashwant Pathak Pdf

Gene delivery is a transport of genes of therapeutic values into the chromosomes of the cells or tissues which can be targeted to replace the faulty genes. In last two decades lot of research efforts are dedicated to gene delivery for therapeutic applications. Today gene therapy is promising approach in treatment of genetic diseases including mitochondrial related diseases like blindness, muscular dystrophy, cystic fibrosis, and some cancers. Gene Delivery Systems: Nano Delivery Technologies observes the exploration of nanotechnology for gene therapy and gene delivery. Written by prominent authors in the field, this book covers various aspects of gene delivery including challenges in delivering gene therapy, advances in genome editing, RNA-based gene therapy, Green nanoparticles for oligonucleotide delivery. Additional features include" Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing. Includes knowledge of the current application of CRISPR/Cas9 gene-editing technique; an approach that has recently been given the Noble Prize. Examines the development of mRNA vaccines for Covid -19 in challenging pandemic scenario Discusses siRNA, mRNA, and DNA plasmids.

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 52,7 Mb
Release : 2012-10-31
Category : Medical
ISBN : 9789535108108

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Recent Advances in Novel Drug Carrier Systems by Ali Demir Sezer Pdf

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.