Gene Therapy For Hiv Infection

Author : Clay Smith
Publisher : Springer Science & Business Media
Page : 178 pages
File Size : 43,8 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9783662118214

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Gene Therapy for HIV Infection by Clay Smith Pdf

ince the early 1980s, the HIV epidemic has been raging within the S 1 United States and around the world. Drug therapy for HIV infection has not been curative, prompting the search for alternative strategies to control HIV infection within infected persons. One potential alterna tive to drug therapy is a developing medical technology termed gene therapy. 2 Gene therapy involves introducing genetic elements into popu lations of cells in order to correct or prevent a pathologic process. A large number of gene therapy strategies have been developed in an at tempt to inhibit HIV expression and spread. These strategies fall into two general categories, genetic modification of cells in order to elicit an immune response against HIV and genetic modification of the target cells of HIV infection in order to block HIV expression and reproduction. In the first strategy, termed genetic immunotherapy by some, genetic material encoding HIV proteins is introduced into patient's cells in order to stimulate a cellular immune response above and beyond 3 5 that stimulated by the viral infection itself. - Two general genetic im munotherapy strategies have been developed. Genes encoding HIV pro teins have been directly injected into the dermis or muscle tissue of patients. These genes have been encoded in plasmids or viral DNA and have been injected either in the form of naked DNA or complexed with lipids.

Author : Gerhard Bauer,Joseph S. Anderson
Publisher : Springer Science & Business Media
Page : 72 pages
File Size : 47,9 Mb
Release : 2014-02-07
Category : Medical
ISBN : 9781493904341

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Gene Therapy for HIV by Gerhard Bauer,Joseph S. Anderson Pdf

This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV. Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients. In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices.

Author : Ben Berkhout,Hildegund C.J. Ertl,Marc S. Weinberg
Publisher : Springer
Page : 236 pages
File Size : 40,5 Mb
Release : 2015-03-10
Category : Medical
ISBN : 9781493924325

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Gene Therapy for HIV and Chronic Infections by Ben Berkhout,Hildegund C.J. Ertl,Marc S. Weinberg Pdf

This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990’s. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.

Author : Clay Smith
Publisher : Springer
Page : 200 pages
File Size : 54,9 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 366211822X

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Gene Therapy for HIV Infection by Clay Smith Pdf

This book focuses primarily on the development of effective gene therapy approaches for HIV infection, including the improvement of gene transfer vectors, procedures for the ex-vivo manipulation and transduction of T-lymphocytes and hematopoietic stem cells, and preclinical testing of HIV inhibition strategies. It provides a balanced perspective of the many accomplishments in this field as well as the problems which need to be solved in order to develop safe and effective therapies which benefit persons with HIV infection.

Author : Ulrich R Hengge
Publisher : Unknown
Page : 128 pages
File Size : 40,5 Mb
Release : 2024-06-15
Category : Electronic
ISBN : 1848151047

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Immunotreatment and Gene Therapy of HIV Infection by Ulrich R Hengge Pdf

Author : Ulrich R. Hengge,Marylyn M. Addo
Publisher : Unknown
Page : 144 pages
File Size : 40,7 Mb
Release : 2004
Category : Electronic
ISBN : 3895997021

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Immunotreatment and Gene Therapy of HIV Infection by Ulrich R. Hengge,Marylyn M. Addo Pdf

Tremendous progress in the understanding of the immune pathogenesis of HIV disease has been made in the last two decades like in no other field of science ever before. Besides the inhibition of viral replication with highly active antiretroviral therapy (HAART) immunoreconstitution remains an important mainstay to be achieved in the battle against HIV. Intensive research has led to worldwide phase-III studies of immunotreatment of HIV infection such as the SILCAAT and ESPRIT trials to boost existing immune responses and to restore the immune system leading to the control of viral replication. The science and practical management of immunotherapy of HIV patients is described by famous experts from immunology, virology, gene therapy, dermatology, and clinical medicine.

Author : Yi-Wei Tang
Publisher : BoD – Books on Demand
Page : 582 pages
File Size : 49,5 Mb
Release : 2011-11-02
Category : Medical
ISBN : 9789533077192

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Recent Translational Research in HIV/AIDS by Yi-Wei Tang Pdf

The collective efforts of HIV/AIDS research scientists from over 16 countries in the world are included in the book. This 27-chapter Open Access book well covers HIV/AIDS translational researches on pathogenesis, diagnosis, treatment, prevention, and also those beyond conventional fields. These are by no means inclusive, but they do offer a good foundation for the development of clinical patient care. The translational model forms the basis for progressing HIV/AIDS clinical research. When linked to the care of the patients, translational researches should result in a direct benefit for HIV/AIDS patients.

Author : Seth C. Kalichman
Publisher : Springer Science & Business Media
Page : 218 pages
File Size : 44,8 Mb
Release : 2009-01-16
Category : Medical
ISBN : 9780387794761

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Denying AIDS by Seth C. Kalichman Pdf

Paralleling the discovery of HIV and the rise of the AIDS pandemic, a flock of naysayers has dedicated itself to replacing genuine knowledge with destructive misinformation—and spreading from the fringe to the mainstream media and the think tank. Now from the editor of the journal AIDS and Behavior comes a bold exposé of the scientific and sociopolitical forces involved in this toxic evasion. Denying AIDS traces the origins of AIDS dissidents disclaimers during the earliest days of the epidemic and delves into the psychology and politics of the current denial movement in its various incarnations. Seth Kalichman focuses not on the “difficult” or doubting patient, but on organized, widespread forms of denial (including the idea that HIV itself is a myth and HIV treatments are poison) and the junk science, faulty logic, conspiracy theories, and larger forces of homophobia and racism that fuel them. The malignant results of AIDS denial can be seen in those individuals who refuse to be tested, ignore their diagnoses, or reject the treatments that could save their lives. Instead of ignoring these currents, asserts Kalichman, science has a duty to counter them. Among the topics covered: Why AIDS denialism endures, and why science must understand it. Pioneer virus HIV researcher Peter Duesberg’s role in AIDS denialism. Flawed immunological, virological, and pharmacological pseudoscience studies that are central to texts of denialism. The social conservative agenda and the politics of AIDS denial, from the courts to the White House. The impact of HIV misinformation on public health in South Africa. Fighting fiction with reality: anti-denialism and the scientific community. For anyone affected by, interested in, or working with researchers in HIV/AIDS, and public health professionals in general, the insight and vision of Denying AIDS will inspire outrage, discussion, and ultimately action. See http://denyingaids.blogspot.com/ for more information.

Author : Patrick Arbuthnot
Publisher : Academic Press
Page : 392 pages
File Size : 50,8 Mb
Release : 2015-06-01
Category : Science
ISBN : 9780124114524

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Gene Therapy for Viral Infections by Patrick Arbuthnot Pdf

Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field

Author : Christopher Baum
Publisher : Humana Press
Page : 0 pages
File Size : 48,5 Mb
Release : 2009-03-13
Category : Science
ISBN : 1607611171

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Genetic Modification of Hematopoietic Stem Cells by Christopher Baum Pdf

Gene Transfer into Hematopoietic Cells: From Basic Science to Clinical Application Christopher Baum 1. The Potential of Gene Transfer into Hematopoietic Vectors with the potential for stable transgene integration are Cells widely used in basic hematology and clinical trials of gene me- cine. In basic research, both gain-of-function and loss-of-fu- tion situations of individual genes can be created by gene transfer, leading to a wide range of applications in developmental biology, stem cell biology, immunology, leukemia research, and human genetics. With the first evidence of successful modification of murine hematopoietic cells using retroviral gene vectors (1, 2), researchers have also explored the therapeutic potential of this approach. To date, the emerging discipline of gene therapy is a highly diversified field that offers entirely novel approaches to treat a great variety of human diseases (3). All hematopoietic cell types are of major interest in this context, since the modification of the hematopoietic stem cell population may potentially give rise to a completely transgenic hematopoiesis with the potential to cure genetic disorders or fight severe chronic infections, and the targeting of mature cells such as lymphocytes or antigen-p- senting dendritic cells offers all types of transient and semiper- nent modifications of the immune system. The unifying principle of gene medicine is the need to transfer complex nucleic acids cells that do not contribute to the germline (somatic cells).

Author : Bartholomew Ibeh
Publisher : BoD – Books on Demand
Page : 264 pages
File Size : 47,6 Mb
Release : 2015-09-02
Category : Medical
ISBN : 9789535121572

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Trends in Basic and Therapeutic Options in HIV Infection by Bartholomew Ibeh Pdf

The past decade has seen several changes in HIV prevention, transmission and therapeutic interventions to end the scourge. This book is a collection of expert assays on various aspects of HIV prevention, bioresource deployment, microbicides, host antiviral proteins, antiviral drug responses and novel treatment strategies for which there is evident need for scientific focus and review of the current trend. A visible objective of the book is to provide a wider readership of scientist, clinicians, social workers/HIV caregivers, immunologist, postgraduate students, trainers and vaccine developers an informative and multidisciplinary approach to HIV treatment and intervention strategy by presenting current trends in the development of therapeutic options and its attendant challenges. Practical and informative, the book provides state-of-the-art information on dynamics of HIV distribution, transmission, therapeutic measures and functional cure.

Author : World Health Organization
Publisher : Unknown
Page : 0 pages
File Size : 45,9 Mb
Release : 2022
Category : Electronic
ISBN : OCLC:1396937430

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ANTIRETROVIRAL THERAPY FOR HIV INFECTION IN INFANTS AND CHILDREN: TOWARDS UNIVERSAL ACCESS: Recommendations for a Public Health Approach by World Health Organization Pdf

Author : Houria Bachtarzi
Publisher : BoD – Books on Demand
Page : 200 pages
File Size : 42,7 Mb
Release : 2019-03-13
Category : Medical
ISBN : 9781789857177

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In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders by Houria Bachtarzi Pdf

Ongoing advances in pharmaceutical biotechnology have paved the way to ground-breaking new biological therapeutic modalities, offering the possibility of a durable curative approach for a number of life-threatening diseases, for which the medical need is as yet unmet. Over the past decades, gene therapy has seen a massive transformation from a proof-of-concept approach to a clinical reality culminating in the regulatory approval of state-of-the-art products in the European Union and in the United States. This book captures some of the scientific progresses notably in gene transfer technologies and translational development of in vivo and ex vivo gene therapy interventions in the treatment of a broad range of complex and debilitating non-inherited and inherited disorders such as: human immunodeficiency virus 1 (HIV-1) infection, cancer, cystic fibrosis, hereditary retinopathies, haemophilia B, cardiac diseases, and chronic liver fibrosis.

Author : Carolina Garrido,Alberto Bosque,Maria Salgado
Publisher : Frontiers Media SA
Page : 153 pages
File Size : 54,5 Mb
Release : 2021-07-08
Category : Science
ISBN : 9782889669813

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Immunotherapies Towards HIV Cure by Carolina Garrido,Alberto Bosque,Maria Salgado Pdf

Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 55,8 Mb
Release : 2008-12-19
Category : Medical
ISBN : 9780387779768

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Immunopharmacology by Manzoor M. Khan Pdf

During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.