Genes Germs And Medicine The Life Of Joshua Lederberg

Author : Jan Sapp
Publisher : World Scientific
Page : 424 pages
File Size : 52,5 Mb
Release : 2021-02-23
Category : Science
ISBN : 9789811225499

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Genes, Germs And Medicine: The Life Of Joshua Lederberg by Jan Sapp Pdf

Genes, Germs and Medicine explores the development of modern biomedical science in the United States through the life of one of the Twentieth Century's most influential scientists.Joshua Lederberg was a scientific renaissance man. He and his collaborators founded the field of bacterial genetics, and he was awarded the Nobel Prize at the age of 33 (the second youngest in history). He helped to lay the foundations for genetic engineering, made fundamental revisions to immunological and evolutionary theory, and developed medical genetics. He initiated the search for extraterrestrial microbial life, developed artificial intelligence, and was a visionary of the Digital Age. Lederberg coined some of the central terms of modern biology: plasmid, transduction, exobiology, euphenics and microbiome.A complex humanist who spoke out for social justice, Lederberg confronted racism, and denied a gene-centered view of humans. Pondering our social evolution outside of nature, he forewarned of the complex ethical issues arising from bioengineering. He sounded the alarm about coming pandemics at a time when few would listen, and warned of the peril of biowarfare and strove to prevent it. Lederberg was a man with a deep sense of social and intellectual responsibility, a trusted advisor to eight presidential administrations.

Author : Thomas E. Schindler
Publisher : Oxford University Press
Page : 177 pages
File Size : 41,8 Mb
Release : 2021
Category : Biography & Autobiography
ISBN : 9780197531679

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A Hidden Legacy by Thomas E. Schindler Pdf

"Esther Zimmer Lederberg's research revealed the unique features of bacterial sex. In the decade leading up to the discovery of the DNA double helix, she collaborated with her husband, Joshua Lederberg, to establish the new field of bacterial genetics. The impressive series of achievements by team Lederberg included: the discovery of [lambda] bacteriophage; the discovery of the first plasmid known as the F-factor; the demonstration that viruses carry bacterial genes between bacteria, and fundamental properties of bacterial sex. The Lederbergs' successful collaboration earned Joshua the 1958 Nobel Prize, which he shared with two of Esther's mentors, George Beadle and Edward Tatum. Esther Lederberg's contributions, however, were overlooked by the Nobel committee, an example of institutional discrimination known as The Matilda Effect. Esther Lederberg should have been recognized for inventing Replica Plating, an elegant technique that she originated by re-purposing her compact makeup pad as a kind of ink stamp for conveniently transferring bacterial colonies from one Petri dish to another. Instead, the credit for the invention -still in use today, 70 years later-is given to her famous husband, or, at best, to Dr. and Mrs. Lederberg"--

Author : Andrew S. Lea
Publisher : JHU Press
Page : 255 pages
File Size : 51,5 Mb
Release : 2023-07-25
Category : Medical
ISBN : 9781421446813

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Digitizing Diagnosis by Andrew S. Lea Pdf

"This is the first book-length account of early efforts to computerize medical diagnosis. It explores how these efforts produced and interacted with certain professional tensions, disease constructions, personal identities, cultural ideals, economic interests, and material practices. The book offers a historical account that raises pressing questions, problems, and challenges that must be addressed as we work to harness artificial intelligence for the benefit of the medical profession and its patients"--

Author : Eric Cohen,William Kristol
Publisher : Rowman & Littlefield
Page : 390 pages
File Size : 41,5 Mb
Release : 2002
Category : Business & Economics
ISBN : 0742521966

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The Future is Now by Eric Cohen,William Kristol Pdf

This book looks at both the past and the future of the debate over whether there are moral limits to scientific progress and what life will look like in the genetic age.

Author : Nathan Crowe
Publisher : University of Pittsburgh Press
Page : 295 pages
File Size : 48,6 Mb
Release : 2021-12-07
Category : Science
ISBN : 9780822987680

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Forgotten Clones by Nathan Crowe Pdf

Long before scientists at the Roslin Institute in Scotland cloned Dolly the sheep in 1996, American embryologist and aspiring cancer researcher Robert Briggs successfully developed the technique of nuclear transplantation using frogs in 1952. Although the history of cloning is often associated with contemporary ethical controversies, Forgotten Clones revisits the influential work of scientists like Briggs, Thomas King, and Marie DiBerardino, before the possibility of human cloning and its ethical implications first registered as a concern in public consciousness, and when many thought the very idea of cloning was experimentally impossible. By focusing instead on new laboratory techniques and practices and their place in Anglo-American science and society in the mid-twentieth century, Nathan Crowe demonstrates how embryos constructed in the lab were only later reconstructed as ethical problems in the 1960s and 1970s with the emergence of what was then referred to as the Biological Revolution. His book illuminates the importance of the early history of cloning for the biosciences and their institutional, disciplinary, and intellectual contexts, as well as providing new insights into the changing cultural perceptions of the biological sciences after Second World War.

Author : Joseph A. November
Publisher : JHU Press
Page : 361 pages
File Size : 43,6 Mb
Release : 2012-06-01
Category : Technology & Engineering
ISBN : 9781421406657

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Biomedical Computing by Joseph A. November Pdf

Winner of the Computer History Museum Prize of the Special Interest Group: Computers, Information, and Society Imagine biology and medicine today without computers. What would laboratory work be like if electronic databases and statistical software did not exist? Would disciplines like genomics even be feasible if we lacked the means to manage and manipulate huge volumes of digital data? How would patients fare in a world absent CT scans, programmable pacemakers, and computerized medical records? Today, computers are a critical component of almost all research in biology and medicine. Yet, just fifty years ago, the study of life was by far the least digitized field of science, its living subject matter thought too complex and dynamic to be meaningfully analyzed by logic-driven computers. In this long-overdue study, historian Joseph November explores the early attempts, in the 1950s and 1960s, to computerize biomedical research in the United States. Computers and biomedical research are now so intimately connected that it is difficult to imagine when such critical work was offline. Biomedical Computing transports readers back to such a time and investigates how computers first appeared in the research lab and doctor's office. November examines the conditions that made possible the computerization of biology—including strong technological, institutional, and political support from the National Institutes of Health—and shows not only how digital technology transformed the life sciences but also how the intersection of the two led to important developments in computer architecture and software design. The history of this phenomenon has been only vaguely understood. November's thoroughly researched and lively study makes clear for readers the motives behind computerizing the study of life and how that technology profoundly affects biomedical research today.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 330 pages
File Size : 51,8 Mb
Release : 2009-05-10
Category : Science
ISBN : 9780309131216

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Microbial Evolution and Co-Adaptation by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.

Author : Kathy Wilson Peacock
Publisher : Infobase Publishing
Page : 369 pages
File Size : 44,7 Mb
Release : 2010
Category : Science
ISBN : 9781438130606

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Biotechnology and Genetic Engineering by Kathy Wilson Peacock Pdf

Explains why biotechnology is a relevant and volatile issues. Begins with a history of biotechnology and its effect on agriculture, medicine, and the environment. Equal space is devoted to discussing the efforts of human-rights advocates, animal-rights advocates, and environmentalists to create definitive governmental regulations for this budding industry.

Author : Bill Sullivan
Publisher : National Geographic Books
Page : 340 pages
File Size : 47,6 Mb
Release : 2019-08-06
Category : Science
ISBN : 9781426220562

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Pleased to Meet Me by Bill Sullivan Pdf

Why are you attracted to a certain "type?" Why are you a morning person? Why do you vote the way you do? From a witty new voice in popular science comes a clever, life-changing look at what makes you you. "I can't believe I just said that." "What possessed me to do that?" "What's wrong with me?" We're constantly seeking answers to these fundamental human questions, and now, science has the answers. The foods we enjoy, the people we love, the emotions we feel, and the beliefs we hold can all be traced back to our DNA, germs, and environment. This witty, colloquial book is popular science at its best, describing in everyday language how genetics, epigenetics, microbiology, and psychology work together to influence our personality and actions. Mixing cutting-edge research and relatable humor, Pleased to Meet Me is filled with fascinating insights that shine a light on who we really are--and how we might become our best selves.

Author : Bruno J. Strasser
Publisher : University of Chicago Press
Page : 421 pages
File Size : 48,6 Mb
Release : 2019-06-04
Category : Science
ISBN : 9780226635040

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Collecting Experiments by Bruno J. Strasser Pdf

Databases have revolutionized nearly every aspect of our lives. Information of all sorts is being collected on a massive scale, from Google to Facebook and well beyond. But as the amount of information in databases explodes, we are forced to reassess our ideas about what knowledge is, how it is produced, to whom it belongs, and who can be credited for producing it. Every scientist working today draws on databases to produce scientific knowledge. Databases have become more common than microscopes, voltmeters, and test tubes, and the increasing amount of data has led to major changes in research practices and profound reflections on the proper professional roles of data producers, collectors, curators, and analysts. Collecting Experiments traces the development and use of data collections, especially in the experimental life sciences, from the early twentieth century to the present. It shows that the current revolution is best understood as the coming together of two older ways of knowing—collecting and experimenting, the museum and the laboratory. Ultimately, Bruno J. Strasser argues that by serving as knowledge repositories, as well as indispensable tools for producing new knowledge, these databases function as digital museums for the twenty-first century.

Author : Chung King-thom,Liu Jong-kang
Publisher : World Scientific
Page : 600 pages
File Size : 48,5 Mb
Release : 2017-08-23
Category : Biography & Autobiography
ISBN : 9789813200388

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Pioneers In Microbiology: The Human Side Of Science by Chung King-thom,Liu Jong-kang Pdf

Pasteurization, penicillin, Koch's postulates, and gene coding. These discoveries and inventions are vital yet commonplace in modern life, but were radical when first introduced to the public and academia. In this book, the life and times of leading pioneers in microbiology are discussed in vivid detail, focusing on the background of each discovery and the process in which they were developed — sometimes by accident or sheer providence.

Author : Roy Porter
Publisher : Cambridge University Press
Page : 11 pages
File Size : 42,5 Mb
Release : 2006-06-05
Category : Medical
ISBN : 9780521864268

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The Cambridge History of Medicine by Roy Porter Pdf

Against the backdrop of unprecedented concern for the future of health care, 'The Cambridge History of Medicine' surveys the rise of medicine in the West from classical times to the present. Covering both the social and scientific history of medicine, this volume traces the chronology of key developments and events.

Author : Tina M. Henkin,Joseph E. Peters
Publisher : John Wiley & Sons
Page : 642 pages
File Size : 50,6 Mb
Release : 2020-10-27
Category : Science
ISBN : 9781555819750

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Snyder and Champness Molecular Genetics of Bacteria by Tina M. Henkin,Joseph E. Peters Pdf

The single most comprehensive and authoritative textbook on bacterial molecular genetics Snyder & Champness Molecular Genetics of Bacteria is a new edition of a classic text, updated to address the massive advances in the field of bacterial molecular genetics and retitled as homage to the founding authors. In an era experiencing an avalanche of new genetic sequence information, this updated edition presents important experiments and advanced material relevant to current applications of molecular genetics, including conclusions from and applications of genomics; the relationships among recombination, replication, and repair and the importance of organizing sequences in DNA; the mechanisms of regulation of gene expression; the newest advances in bacterial cell biology; and the coordination of cellular processes during the bacterial cell cycle. The topics are integrated throughout with biochemical, genomic, and structural information, allowing readers to gain a deeper understanding of modern bacterial molecular genetics and its relationship to other fields of modern biology. Although the text is centered on the most-studied bacteria, Escherichia coli and Bacillus subtilis, many examples are drawn from other bacteria of experimental, medical, ecological, and biotechnological importance. The book's many useful features include Text boxes to help students make connections to relevant topics related to other organisms, including humans A summary of main points at the end of each chapter Questions for discussion and independent thought A list of suggested readings for background and further investigation in each chapter Fully illustrated with detailed diagrams and photos in full color A glossary of terms highlighted in the text While intended as an undergraduate or beginning graduate textbook, Molecular Genetics of Bacteria is an invaluable reference for anyone working in the fields of microbiology, genetics, biochemistry, bioengineering, medicine, molecular biology, and biotechnology. "This is a marvelous textbook that is completely up-to-date and comprehensive, but not overwhelming. The clear prose and excellent figures make it ideal for use in teaching bacterial molecular genetics." —Caroline Harwood, University of Washington

Author : Stuart Hogg
Publisher : John Wiley & Sons
Page : 534 pages
File Size : 46,6 Mb
Release : 2013-06-10
Category : Science
ISBN : 9781119978916

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Essential Microbiology by Stuart Hogg Pdf

Essential Microbiology 2nd Edition is a fully revised comprehensive introductory text aimed at students taking a first course in the subject. It provides an ideal entry into the world of microorganisms, considering all aspects of their biology (structure, metabolism, genetics), and illustrates the remarkable diversity of microbial life by devoting a chapter to each of the main taxonomic groupings. The second part of the book introduces the reader to aspects of applied microbiology, exploring the involvement of microorganisms in areas as diverse as food and drink production, genetic engineering, global recycling systems and infectious disease. Essential Microbiology explains the key points of each topic but avoids overburdening the student with unnecessary detail. Now in full colour it makes extensive use of clear line diagrams to clarify sometimes difficult concepts or mechanisms. A companion web site includes further material including MCQs, enabling the student to assess their understanding of the main concepts that have been covered. This edition has been fully revised and updated to reflect the developments that have occurred in recent years and includes a completely new section devoted to medical microbiology. Students of any life science degree course will find this a concise and valuable introduction to microbiology.

Author : Anonim
Publisher : Unknown
Page : 736 pages
File Size : 53,9 Mb
Release : 1977
Category : Electronic
ISBN : IND:32000013015971

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To the Point International by Anonim Pdf