Genetic Predisposition To Cancer 2ed

Author : Ros Eng,Douglas Easton,Bruce Ponder,Charis Eng
Publisher : CRC Press
Page : 468 pages
File Size : 47,5 Mb
Release : 2004-08-27
Category : Medical
ISBN : 9780340762547

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Genetic Predisposition to Cancer, 2Ed by Ros Eng,Douglas Easton,Bruce Ponder,Charis Eng Pdf

Over the last 20 years it has become increasingly apparent that the occurrence of many cancers can have an inherited basis. This book examines the principles underlying genetic predisposition to cancer and will be relevant to practising oncologists, geneticists and other professionals interested in this rapidly expanding field. Coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the identification and characterisation of predisposition genes, to a consideration of heritable cancer syndromes, and encompasses both rare and common cancers. The text also features a discussion of cancer risk assessment, genetic counselling issues, genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues. Building on the reputation of the previous edition, and to reflect the rapid advances in the field since its publication, the contents of the second edition have been thoroughly updated and include discussion of many newly identified cancer genes. In particular, the book features new chapters added on the biological basis of cancer predisposition, population-based studies of susceptibility, and evaluation of management strategies for individuals at increased cancer risk.

Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401106771

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The Genetics of Cancer by B.A. Ponder,M.J. Waring Pdf

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Author : Paolo Peterlongo,Nandita Mitra,Luis G. Carvajal-Carmona
Publisher : Frontiers Media SA
Page : 141 pages
File Size : 52,9 Mb
Release : 2019-10-16
Category : Electronic
ISBN : 9782889631322

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Accomplishments, Collaborative Projects and Future Initiatives in Breast Cancer Genetic Predisposition by Paolo Peterlongo,Nandita Mitra,Luis G. Carvajal-Carmona Pdf

In this eBook, we described the accomplishments, collaborative projects and future initiatives in the field of breast cancer genetic predisposition. More specifically, the articles included focused on aspects such as mutation screening in unexplored populations, identification and characterization of novel predisposing genes and mutations, and population screening.

Author : Rosalind A. Eeles
Publisher : Springer
Page : 423 pages
File Size : 45,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489945013

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Genetic Predisposition to Cancer by Rosalind A. Eeles Pdf

Author : William D. Foulkes,Shirley V. Hodgson
Publisher : Cambridge University Press
Page : 480 pages
File Size : 42,9 Mb
Release : 1998-06-28
Category : Medical
ISBN : 0521563402

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Inherited Susceptibility to Cancer by William D. Foulkes,Shirley V. Hodgson Pdf

Many cancers, both common and rare, are known to have a hereditary predisposition and advances in genetics have clarified the risks and in some cases the mechanisms of cancer developing in an individual. First published in 1998, this important contribution to the literature of cancer genetics covers all the key issues, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses. It is divided into two parts. The first deals with ethical, legal and social issues. The second systematically outlines current knowledge of the inheritance patterns of many different cancer types, both from a site-by-site perspective and for special groups. This authoritative volume will be of interest to oncologists, physicians and surgeons in other specialities and to health professionals in the areas of primary care, counselling and cancer risk assessment.

Author : Kenneth Offit
Publisher : Clinics: Internal Medicine
Page : 0 pages
File Size : 52,7 Mb
Release : 2010
Category : Medical
ISBN : 1437722040

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Genetic Predisposition to Cancer by Kenneth Offit Pdf

This issue serves as a timely review of both the genetic and genomic factors resulting in a predisposition to human cancer. There is now strong evidence to support the use of genetic testing for cancer predisposition in the practice of preventive medicine, and at the same time, there is emerging new literature defining the role of genomic approaches to assessment of cancer predisposition. Articles address predisposition syndromes in the areas of breast cancer, lower GI cancer, genitourinary cancer, pediatric cancer, endocrine cancer, and hematologic malignancy.

Author : Chris Jacobs,Lorraine Robinson,Patricia Webb
Publisher : OUP Oxford
Page : 384 pages
File Size : 49,9 Mb
Release : 2014-08-14
Category : Medical
ISBN : 9780191653490

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Genetics for Health Professionals in Cancer Care by Chris Jacobs,Lorraine Robinson,Patricia Webb Pdf

The role of genetics is becoming increasingly important in all aspects of healthcare and particularly in the field of cancer care. Genetics for Health Professionals in Cancer Care: From Principles to Practice equips health professionals with the knowledge and skills required for all aspects of managing cancer family history. This includes taking an accurate cancer family history and drawing a family tree; understanding cancer biology, basic cancer genetics and the genes involved in hereditary breast, ovarian, prostate, colorectal, gastric and related gynaecological cancers and rare cancer predisposing syndromes; assessing cancer risk and communicating risk information; early detection and risk reducing measures available for those at increased risk and managing individuals with hereditary cancer. Drawing on experiences of health professionals, Genetics for Health Professionals in Cancer Care discusses the challenges raised and provides practical advice and insight into what happens when a patient is referred for genetic counselling and genetic testing, including the psychological, social and ethical issues faced by individuals and families with and at risk of hereditary cancer. The book also provides practical guidance on setting up a cancer family history clinic in primary and secondary care. Genetics for Health Professionals in Cancer Care is essential reading for healthcare professionals working with cancer patients and their families, and is an ideal reference text for non-specialists working in cancer genetics.

Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine
Publisher : National Academies Press
Page : 160 pages
File Size : 40,6 Mb
Release : 2002-08-01
Category : Science
ISBN : 9780309169240

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Cancer and the Environment by Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine Pdf

The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Author : Anonim
Publisher : Unknown
Page : 93 pages
File Size : 40,9 Mb
Release : 2008
Category : Cancer
ISBN : 0199558396

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Concise Handbook of Familial Cancer Susceptibility Syndromes by Anonim Pdf

Author : Fred Bunz
Publisher : Springer
Page : 343 pages
File Size : 52,5 Mb
Release : 2016-03-01
Category : Medical
ISBN : 9789401774840

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Principles of Cancer Genetics by Fred Bunz Pdf

This is the second edition of a widely used textbook that consolidates the basic concepts of the cancer gene theory and provides a framework for understanding the genetic basis of cancer. Particular attention is devoted to the origins of the mutations that cause cancer, and the application of evolutionary theory to explain how the cell clones that harbor cancer genes tend to expand. Focused on the altered genes and pathways that cause the growth of the most common tumors, Principles of Cancer Genetics is aimed at advanced undergraduates who have completed introductory coursework in genetics, biology and biochemistry, medical students and medical house staff. For students with a general interest in cancer, this book provides a highly accessible and readable overview. For more advanced students contemplating future study in the field of oncology and cancer research, this concise book will be useful as a primer.

Author : S. V. Hodgson,E. R. Maher
Publisher : Cambridge University Press
Page : 258 pages
File Size : 51,5 Mb
Release : 1993-02-25
Category : Medical
ISBN : 0521409519

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A Practical Guide to Human Cancer Genetics by S. V. Hodgson,E. R. Maher Pdf

This extensively up-dated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics - an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section then deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. Up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers are also provided. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.

Author : Shirley V. Hodgson,Eamonn R. Maher
Publisher : Cambridge University Press
Page : 354 pages
File Size : 42,5 Mb
Release : 1999-07-22
Category : Medical
ISBN : 0521649617

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A Practical Guide to Human Cancer Genetics by Shirley V. Hodgson,Eamonn R. Maher Pdf

This extensively updated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics--an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. The authors also provide up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.

Author : Hansjakob Müller,R. J. Scott,Walter Weber
Publisher : S. Karger AG (Switzerland)
Page : 256 pages
File Size : 48,7 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015038151893

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Hereditary Cancer by Hansjakob Müller,R. J. Scott,Walter Weber Pdf

Molecular genetics has revolutionized our understanding of the susceptibility to and pathogenesis of cancer and is heralding the era of 'molecular oncology'. This progress is well illustrated by the gain in knowledge accumulated since the release of 'Familial Cancer' in 1985 - known among experts as the 'yellow book'. Cancer genes can now be identified, mapped and sequenced, and this technology has resulted in presymptomatic testing of persons at risk and the development of preventive therapeutic measures. This book provides an update of the latest advances by international experts in the field of hereditary cancer, with special emphasis on the needs of medical practice. The first part is devoted to a discussion of the mechanisms by which predispositions lead to breast and ovarian cancer, intestinal cancer, neoplasia of endocrine glands, and tumors in rare cancer syndromes. Attention is also given to epidemiological aspects of familial cancer occurrence. The second part covers genetic counseling and testing of members of high-risk families, as well as the prevention and treatment of hereditary cancer. Clearly written and well-organized, this book provides essential information not only for molecular geneticists and epidemiologists, but also for genetic counselors and oncologists.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 53,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : David T. Curiel,Joanne T. Douglas
Publisher : Springer Science & Business Media
Page : 490 pages
File Size : 42,7 Mb
Release : 2007-11-03
Category : Medical
ISBN : 9781592597857

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Cancer Gene Therapy by David T. Curiel,Joanne T. Douglas Pdf

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.