Genetic Toxicology Of Complex Mixtures

Author : Michael D. Waters,F.Bernhard Daniel,Joellen Lewtas,Martha M. Moore,Stephen Nesnow
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 55,9 Mb
Release : 2013-03-13
Category : Medical
ISBN : 9781468458503

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Genetic Toxicology of Complex Mixtures by Michael D. Waters,F.Bernhard Daniel,Joellen Lewtas,Martha M. Moore,Stephen Nesnow Pdf

Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source character ization and source apportionment were discussed as an aid to understand ing the origin and relative contribution of various kinds of complex mix tures to the ambient environment. Similarly, investigations of genotoxi cants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures
Publisher : National Academies Press
Page : 240 pages
File Size : 54,9 Mb
Release : 1988-02-01
Category : Science
ISBN : 9780309037785

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Complex Mixtures by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures Pdf

In the laboratory, testing the toxic effects for a single compound is a straightforward process. However, many common harmful substances occur naturally as mixtures and can interact to exhibit greater toxic effects as a mixture than the individual components exhibit separately. Complex Mixtures addresses the problem of identifying and classifying complex mixtures, investigating the effect of exposure, and the research problems inherent in testing their toxicity to human beings. A complete series of case studies is presented, including one that examines the cofactors of alcohol consumption and cigarette smoke.

Author : Albert P. Li
Publisher : CRC Press
Page : 508 pages
File Size : 45,6 Mb
Release : 1991-03-27
Category : Medical
ISBN : 0849388155

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Genetic Toxicology by Albert P. Li Pdf

Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents.

Author : Cornelis A. M. van Gestel,Martijs Jonker,Jan E. Kammenga,Ryszard Laskowski,Claus Svendsen
Publisher : CRC Press
Page : 312 pages
File Size : 40,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439830093

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Mixture Toxicity by Cornelis A. M. van Gestel,Martijs Jonker,Jan E. Kammenga,Ryszard Laskowski,Claus Svendsen Pdf

In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
Publisher : National Academies Press
Page : 300 pages
File Size : 40,7 Mb
Release : 2007-11-19
Category : Science
ISBN : 9780309178891

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology Pdf

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Author : Melanie Bergmann,Lars Gutow,Michael Klages
Publisher : Springer
Page : 447 pages
File Size : 55,8 Mb
Release : 2015-06-01
Category : Science
ISBN : 9783319165103

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Marine Anthropogenic Litter by Melanie Bergmann,Lars Gutow,Michael Klages Pdf

This book describes how man-made litter, primarily plastic, has spread into the remotest parts of the oceans and covers all aspects of this pollution problem from the impacts on wildlife and human health to socio-economic and political issues. Marine litter is a prime threat to marine wildlife, habitats and food webs worldwide. The book illustrates how advanced technologies from deep-sea research, microbiology and mathematic modelling as well as classic beach litter counts by volunteers contributed to the broad awareness of marine litter as a problem of global significance. The authors summarise more than five decades of marine litter research, which receives growing attention after the recent discovery of great oceanic garbage patches and the ubiquity of microscopic plastic particles in marine organisms and habitats. In 16 chapters, authors from all over the world have created a universal view on the diverse field of marine litter pollution, the biological impacts, dedicated research activities, and the various national and international legislative efforts to combat this environmental problem. They recommend future research directions necessary for a comprehensive understanding of this environmental issue and the development of efficient management strategies. This book addresses scientists, and it provides a solid knowledge base for policy makers, NGOs, and the broader public.

Author : Ray Proudlock
Publisher : Academic Press
Page : 460 pages
File Size : 43,7 Mb
Release : 2016-05-28
Category : Medical
ISBN : 9780128010068

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Genetic Toxicology Testing by Ray Proudlock Pdf

Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab

Author : Raymond S.H. Yang
Publisher : Elsevier
Page : 745 pages
File Size : 46,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483289403

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Toxicology of Chemical Mixtures by Raymond S.H. Yang Pdf

Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content. Emphasis is on low-level, long-term exposure. Some of the issues addressed include Target organ toxicities in response to chemical mixture exposures Risk assessment and experimental approaches Case studies and special pollution problems Special pollution problems

Author : Geoffrey I. Sunahara,Agnès Y. Renoux,Claude Thellen,Connie L. Gaudet,Adrien Pilon
Publisher : John Wiley & Sons
Page : 494 pages
File Size : 41,8 Mb
Release : 2002-03-12
Category : Science
ISBN : 0471986690

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Environmental Analysis of Contaminated Sites by Geoffrey I. Sunahara,Agnès Y. Renoux,Claude Thellen,Connie L. Gaudet,Adrien Pilon Pdf

Bioremediation is a process applied to restore contaminated sites using biological tools. The success or failure of this process usually depends on an understanding of the biotechnological process as well as the strengths and weaknesses of the ecotoxicological tools used for its evaluation. This useful book offers a unique treatment of the subject, linking soil ecotoxicity tests, bioremediation and environmental risk assessment. It also, describes the inter-relationships between the laboratory and field ecotoxicologist, the biotechnology consultant and different international environmental regulatory agencies and explains how they seek to achieve a successful evaluation of contaminated site restoration.

Author : United States. Environmental Protection Agency
Publisher : Unknown
Page : 542 pages
File Size : 52,5 Mb
Release : 1991
Category : Environmental protection
ISBN : UOM:39015026563018

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EPA Publications Bibliography by United States. Environmental Protection Agency Pdf

Author : Anonim
Publisher : Unknown
Page : 646 pages
File Size : 49,7 Mb
Release : 2000
Category : Environmental health
ISBN : MINN:31951P006992595

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Environmental Health Perspectives by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 232 pages
File Size : 54,5 Mb
Release : 1994
Category : Air
ISBN : NWU:35556032008989

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Risk Assessment of Urban Air by Anonim Pdf

Author : Marcelo L Larramendy
Publisher : Royal Society of Chemistry
Page : 461 pages
File Size : 48,8 Mb
Release : 2017-07-05
Category : Science
ISBN : 9781788011792

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Ecotoxicology and Genotoxicology by Marcelo L Larramendy Pdf

The potential impact of anthropogenic pollutants such as agrochemicals on the environment is of global concern. Increasing use of certain compounds can result in contamination of food, water and atmospheric systems and in order to combat this pollution it is important to be able to accurately monitor the short and long term effects. This book describes the latest aquatic species models used as indicators of the toxic effects of environmental pollutants, including models that have not routinely been used. The book enables understanding of the effects of pollutants in non-target species, and therefore enables analysis of the effects on ecosystems. This book will be of interest to anyone interested in developing new biomarker species with high degrees of ecological relevance. It will serve as a useful resource for regulatory and research toxicologists, particularly those studying freshwater, marine water and sediment environments.

Author : Michael D. Waters
Publisher : Springer Science & Business Media
Page : 580 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461336112

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Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III by Michael D. Waters Pdf

In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate.

Author : David Brusick
Publisher : CRC Press
Page : 274 pages
File Size : 54,8 Mb
Release : 1994-01-11
Category : Science
ISBN : 1566700396

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Methods for Genetic Risk Assessment by David Brusick Pdf

Genetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well. Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms. Topics considered include: