Genetics Of Bone Biology And Skeletal Disease

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Genetics of Bone Biology and Skeletal Disease

Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Genetics of Bone Biology and Skeletal Disease Book PDF

Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publisher : Academic Press
Page : 878 pages
File Size : 43,6 Mb
Release : 2017-10-31
Category : Medical
ISBN : 9780128041987

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Genetics of Bone Biology and Skeletal Disease by Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi Pdf

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

The Genetics of Osteoporosis and Metabolic Bone Disease

Michael J. Econs
The Genetics of Osteoporosis and Metabolic Bone Disease Book PDF

Author : Michael J. Econs
Publisher : Springer Science & Business Media
Page : 465 pages
File Size : 51,7 Mb
Release : 2000-05-12
Category : Medical
ISBN : 9781592590339

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The Genetics of Osteoporosis and Metabolic Bone Disease by Michael J. Econs Pdf

The explosive growth in the field of molecular biology over the last two decades has started to make a great impact on clinical medicine. Genes have been cloned for diseases that were poorly understood only a decade ago. Additionally, investigators are increasingly aware that there are strong genetic components to complex disorders, such as osteoporosis, that are not classically thought of as genetic disorders. New insights into the pathogenesis of metabolic bone diseases have been obtained from investigations into the molecular biology of these diseases and new therapies will become available based on these new insights. In The Genefies of Osteoporosis and Metabolie Bane Disease, I have assembled an internationally renowned group of experts to write the various chapters. Each of the authors is an expert in his/her field who is currently performing research on the content of their chapter and have made important contributions to the understanding of the clinical fea tures and pathophysiology of metabolic bone disease and genetics. The first part of The Genefies of Osteoporosis and Metabolie Bane Disease addresses issues related to genetic contributions to the development of osteoporosis and the many factors that must be considered when searching for genesthat predispose to osteoporosis. The second sec tion addresses recent advances in the clinical and molecular biological aspects of inherited metabolic bone disorders. The last section reviews the latest techniques for finding genes that predispose to metabolic bone diseases.

Pediatric Bone

Francis H. Glorieux,John M. Pettifor,Harald Jüppner
Pediatric Bone Book PDF

Author : Francis H. Glorieux,John M. Pettifor,Harald Jüppner
Publisher : Academic Press
Page : 885 pages
File Size : 47,6 Mb
Release : 2011-09-28
Category : Medical
ISBN : 9780123820402

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Pediatric Bone by Francis H. Glorieux,John M. Pettifor,Harald Jüppner Pdf

Pediatric osteology, a medical specialty that has come of age, has contributed to the understanding of adult bone diseases as well. This second edition reference updates the 2003 edition with more emphasis on management as well as new and revised contributions. Thirty chapters present basic information regarding bone development, tools and techniques for evaluation (including a new chapter on radiographic imaging), and the specifics of various diseases. The three editors are affiliated as follows: Francis H. Glorieux (McGill U., Canada), John M. Pettifor (Chir Hani Baragwanath Hospital, South Africa), and Harald Juppner (Harvard Medical School, US). Academic Press is an imprint of Elsevier. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com).

Principles of Bone Biology

John P. Bilezikian,T. John Martin,Thomas L. Clemens,Clifford Rosen
Principles of Bone Biology Book PDF

Author : John P. Bilezikian,T. John Martin,Thomas L. Clemens,Clifford Rosen
Publisher : Academic Press
Page : 2024 pages
File Size : 50,6 Mb
Release : 2019-08-22
Category : Science
ISBN : 9780128148426

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Principles of Bone Biology by John P. Bilezikian,T. John Martin,Thomas L. Clemens,Clifford Rosen Pdf

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science. This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology. Provides a "one-stop" shopping paradise. Anything you want to find about bone biology is here and written by the world’s experts THE essential resource for anyone involved in the study of the skeleton and metabolic bone diseases Covers everything from the basic scientific concepts to the underlying principles of therapeutics and management Allows readers to easily search and locate information quickly in the online format Volumes include: Basic Principles; Molecular Mechanisms of Metabolic Bone Disease; Pharmacological Mechanisms of Therapeutics; Methods in Bone Research

Clinical and Biochemical Disorders of the Skeleton

Roger Smith (M.D.),B. Paul Wordsworth
Clinical and Biochemical Disorders of the Skeleton Book PDF

Author : Roger Smith (M.D.),B. Paul Wordsworth
Publisher : Oxford University Press, USA
Page : 471 pages
File Size : 55,8 Mb
Release : 2005
Category : Medical
ISBN : 0192617400

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Clinical and Biochemical Disorders of the Skeleton by Roger Smith (M.D.),B. Paul Wordsworth Pdf

This book is the definitive guide on the subject. It comprehensively covers common polygenic and rare monogenic disorders and emphasizes the new advances which have been made in bone cell biology and in human skeletal disease, particularly as a result of molecular medicine. This accessible and well-illustrated book is written for postgraduates and clinicians who find disorders of the skeleton mysterious, and for whom an understandable explanation has been hard to find. It will be of particular interest to those who look after patients with a wide variety of metabolic bone diseases, including general physicians, rheumatologists, endocrinologists and orthopaedic surgeons, and contains new information of interest to paediatricians and geneticists.

Bone Dysplasias

Jürgen W. Spranger,Andrea Superti-Furga,Sheila Unger
Bone Dysplasias Book PDF

Author : Jürgen W. Spranger,Andrea Superti-Furga,Sheila Unger
Publisher : Oxford University Press, USA
Page : 929 pages
File Size : 42,9 Mb
Release : 2018
Category : Medical
ISBN : 9780190626655

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Bone Dysplasias by Jürgen W. Spranger,Andrea Superti-Furga,Sheila Unger Pdf

The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs.This updated and expanded fourth edition of Bone Dysplasias presents age-related radiographs, photographs and clinical guidelines for more than 250 rare constitutional skeletal diseases. Focusing on diagnostically essential imaging and clinical features, each chapter is supplemented with prognosticand therapeutic information, a guide to differential diagnoses, and a short list of the most relevant publications.Organized in accordance with the most recent International Nosology and Classification of Genetic Skeletal Disorders, this new Bone Dysplasias distills the insights of a small, world-class author team on diagnosis and clinical approaches to this most difficult class of disorders.

Bone Dysplasias

Jürgen W. Spranger,Paula W. Brill,Christine Hall,Gen Nishimura,Andrea Superti-Furga,Sheila Unger
Bone Dysplasias Book PDF

Author : Jürgen W. Spranger,Paula W. Brill,Christine Hall,Gen Nishimura,Andrea Superti-Furga,Sheila Unger
Publisher : Oxford University Press
Page : 976 pages
File Size : 40,6 Mb
Release : 2018-10-25
Category : Medical
ISBN : 9780190626662

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Bone Dysplasias by Jürgen W. Spranger,Paula W. Brill,Christine Hall,Gen Nishimura,Andrea Superti-Furga,Sheila Unger Pdf

The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs "Brilliantly written and produced and deserves to be on the shelves of all pediatric radiologists. It should also be available to geneticists, counselors, and pediatricians." --Radiology This updated and expanded fourth edition of Bone Dysplasias presents age-related radiographs, photographs and clinical guidelines for more than 250 rare constitutional skeletal diseases. Focusing on diagnostically essential imaging and clinical features, each chapter is supplemented with prognostic and therapeutic information, a guide to differential diagnoses, and a short list of the most relevant publications. Organized in accordance with the most recent International Nosology and Classification of Genetic Skeletal Disorders, this new Bone Dysplasias distills the insights of a small, world-class author team on diagnosis and clinical approaches to this most difficult class of disorders.

Principles of Bone Biology

John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Principles of Bone Biology Book PDF

Author : John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Publisher : Academic Press
Page : 2074 pages
File Size : 48,8 Mb
Release : 2008-09-29
Category : Medical
ISBN : 9780080568751

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Principles of Bone Biology by John P. Bilezikian,Lawrence G. Raisz,T. John Martin Pdf

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Juliet E. Compston,Jane B. Lian
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Book PDF

Author : Juliet E. Compston,Jane B. Lian
Publisher : John Wiley & Sons
Page : 559 pages
File Size : 44,9 Mb
Release : 2009-12-22
Category : Science
ISBN : 9780470623985

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Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism by Juliet E. Compston,Jane B. Lian Pdf

EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.

Current Topics In Bone Biology

Hong-wen Deng,Yao-zhong Liu,Chun-yuan Guo,Di Chen
Current Topics In Bone Biology Book PDF

Author : Hong-wen Deng,Yao-zhong Liu,Chun-yuan Guo,Di Chen
Publisher : World Scientific
Page : 540 pages
File Size : 53,8 Mb
Release : 2005-05-09
Category : Science
ISBN : 9789814480727

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Current Topics In Bone Biology by Hong-wen Deng,Yao-zhong Liu,Chun-yuan Guo,Di Chen Pdf

This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic of bone mechanics, which include a brief overview of the mechanostat hypothesis, a more detailed review on mechanotransduction and bone adaptation, and a chapter illustrating the basic principles of bone mechanical testing. New emerging fields such as skeletal stem cells, bone tissue engineering, phytoestrogens applications, and bone genetics study using mouse models, are also covered in detail. The book closes with a special chapter dedicated to state-of-the-art advances in bone biology research.

Bone Health and Osteoporosis

United States Public Health Service,Surgeon General of the United States
Bone Health and Osteoporosis Book PDF

Author : United States Public Health Service,Surgeon General of the United States
Publisher : Unknown
Page : 0 pages
File Size : 43,9 Mb
Release : 2004-12
Category : Health & Fitness
ISBN : 1410219275

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Bone Health and Osteoporosis by United States Public Health Service,Surgeon General of the United States Pdf

This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Murray J. Favus
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Book PDF

Author : Murray J. Favus
Publisher : Unknown
Page : 536 pages
File Size : 49,9 Mb
Release : 1999
Category : Bones
ISBN : UOM:39015048826849

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Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism by Murray J. Favus Pdf

Anatomy and biology of bone matrix and cellular elements; Skeletal physiology; Mineral homeostasis; Clinical evaluation of bone and mineral disorders; Disorders of serum minerals; Metabolic bone diseases; Genetic, developmenal, and dysplastic skeletal disorders; Acquired disorders of cartilage and bone; Paget's disease; Extraskeletal (ectopic) calcification and ossification; Nephrolithiasis; Dentistry.

Basic and Applied Bone Biology

David B. Burr,Matthew R. Allen
Basic and Applied Bone Biology Book PDF

Author : David B. Burr,Matthew R. Allen
Publisher : Academic Press
Page : 390 pages
File Size : 43,6 Mb
Release : 2013-06-11
Category : Science
ISBN : 9780123914590

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Basic and Applied Bone Biology by David B. Burr,Matthew R. Allen Pdf

This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. Presents an in-depth overview of skeletal biology from the molecular to the organ level Offers "refresher" level content for clinicians or researchers outside their areas of expertise Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology

Bone Pathology

Jasvir S. Khurana
Bone Pathology Book PDF

Author : Jasvir S. Khurana
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 49,7 Mb
Release : 2009-12-02
Category : Medical
ISBN : 9781597453479

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Bone Pathology by Jasvir S. Khurana Pdf

Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.

Encyclopedia of Bone Biology

Anonim
Encyclopedia of Bone Biology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 2390 pages
File Size : 45,6 Mb
Release : 2020-06-26
Category : Science
ISBN : 9780128140826

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Encyclopedia of Bone Biology by Anonim Pdf

Encyclopedia of Bone Biology, Three Volume Set covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understanding of both bone physiology and its relation to other organs and pathophysiology. This encyclopedia will serve as a vital resource for those involved in bone research, research in other fields that cross link with bone, such as metabolism and immunology, and physicians who treat bone diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from advanced undergraduate students to research professionals. Chapters also explore the latest advances and hot topics that have emerged in recent years, including the Hematopoietic Niche and Nuclear Receptors. In the electronic edition, each chapter will include hyperlinked references and further readings as well as cross-references to related articles. Incorporates perspectives from experts working within the domains of biomedicine, including physiology, pathobiology, pharmacology, immunology, endocrinology, orthopedics and metabolism Provides an authoritative introduction for non-specialists and readers from undergraduate level upwards, as well as up-to-date foundational content for those familiar with the field Includes multimedia features, cross-references and color images/videos