Genetics Of Cardiomyopathy And Heart Failure An Issue Of Heart Failure Clinics
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Genetics of Cardiomyopathy and Heart Failure, An Issue of Heart Failure Clinics by Calum MacRae Pdf
This issue explores the genetic basis of specific cardiomyopathies and phenotypic components of heart failure with an eye to the clinical implications of this genetic knowledge. An understanding of the genetic causes of disease can aid in development of effective prevention and management strategies.
Clinical and Molecular Aspects of Cardiomyopathies: On the road from gene to therapy, An Issue of Heart Failure Clinics, E-Book by Giuseppe Limongelli Pdf
This issue of Heart Failure Clinics--edited by Drs. Giuseppe Limongelli, Sharlene Day, and Perry Elliott--will cover Clinical and Molecular Aspects of Cardiomyopathies: On the Road from Gene to Therapy. Topics include, but are not limited to, Epidemiology and Clinical aspects of Genetic Cardiomyopathies, Existing and New therapies, Gene editing and gene-based therapeutics, Controversies surrounding exercise in genetic cardiomyopathies, Genetic infiltrative cardiomyopathies, LV Noncompaction, Clinical presentation and natural history of hypertrophic cardiomyopathy in Rasopathies, and Moelcular basis and new treatments of cardiac diseases in Rasopathies.
Acute Heart Failure by Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo Pdf
For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.
Inherited Cardiac Disease by Perry Elliott,Pier D. Lambiase,Dhavendra Kumar Pdf
Containing summaries of inherited cardiovascular disorders with a focus on aetiology, presentation and management, this handbook covers the fundamentals of molecular biology and genetic testing, and the detailed clinical information relevant to patient management.
Mohan K. Raizada,Julian F. R. Paton,Michael J. Katovich,Sergey Kasparov
Author : Mohan K. Raizada,Julian F. R. Paton,Michael J. Katovich,Sergey Kasparov Publisher : Springer Science & Business Media Page : 367 pages File Size : 42,7 Mb Release : 2008-02-24 Category : Medical ISBN : 9781592598830
Cardiovascular Genomics by Mohan K. Raizada,Julian F. R. Paton,Michael J. Katovich,Sergey Kasparov Pdf
Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.
Genetics of Cardiomyopathy and Heart Failure, An Issue of Heart Failure Clinics by Calum MacRae Pdf
This issue explores the genetic basis of specific cardiomyopathies and phenotypic components of heart failure with an eye to the clinical implications of this genetic knowledge. An understanding of the genetic causes of disease can aid in development of effective prevention and management strategies.
Clinical Cardiogenetics by H.F. Baars,P.A.F.M. Doevendans,J.J. van der Smagt Pdf
Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?
Dilated Cardiomyopathy by Gianfranco Sinagra,Marco Merlo,Bruno Pinamonti Pdf
This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Author : Barry J. Maron Publisher : John Wiley & Sons Page : 527 pages File Size : 50,6 Mb Release : 2008-04-15 Category : Medical ISBN : 9781405146159
Diagnosis and Management of Hypertrophic Cardiomyopathy by Barry J. Maron Pdf
Diagnosis and Management of Hypertrophic Cardiomyopathy is aunique, multi-authored compendium of information regarding thecomplexities of clinical and genetic diagnosis, natural history,and management of hypertrophic cardiomyopathy (HCM)—the mostcommon and important of the genetic cardiovasculardiseases—as well as related issues impacting the health oftrained athletes. Edited by Dr. Barry J. Maron, a world authority on HCM, and withmajor contributions from all of the international experts in thisfield, this book provides a single comprehensive source ofinformation concerning HCM. Recent advances in the field arediscussed, including the importance of left ventricular outflowtract obstruction, the use of implantable defibrillators for theprevention of sudden death in young people, definition of thegenetic basis for HCM and its role in clinical diagnosis and riskstratification, the development of more precise strategies forassessing the level of risk for sudden death among all patientswith HCM, and the evolution of invasive interventions for heartfailure symptoms, such as surgical management and its alternatives(alcohol septal ablation and dual-chamber pacing). Key Features: Contributions from all experts in the field,representing diverse viewpoints regarding this heterogeneousdisease and related issues in athletes Information to dispel misunderstandings regarding issuesassociated with HCM and cardiovascular disease in athletes The only comprehensive source of information available on thetopic
Disease Control Priorities, Third Edition (Volume 5) by Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent Pdf
Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.
Hubert F. Baars,Pieter A. F. M. Doevendans,Arjan C. Houweling,J. Peter van Tintelen
Author : Hubert F. Baars,Pieter A. F. M. Doevendans,Arjan C. Houweling,J. Peter van Tintelen Publisher : Springer Page : 405 pages File Size : 40,6 Mb Release : 2016-11-30 Category : Medical ISBN : 9783319442037
Clinical Cardiogenetics by Hubert F. Baars,Pieter A. F. M. Doevendans,Arjan C. Houweling,J. Peter van Tintelen Pdf
Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?
Rare Cardiovascular Diseases, An Issue of Heart Failure Clinics, E-Book by Giuseppe Limongelli,Eduardo Bossone Pdf
In this issue of Heart Failure Clinics, Guest Editors Giuseppe Limongelli and Eduardo Bossone bring their considerable expertise to the topic of rare cardiovascular diseases. Top experts in the field cover key topics such as coronary artery dissection, genetics in congenital heart disease, HCM in Rasopathies, and more. Provides in-depth, clinical reviews on Rare Cardiovascular Diseases, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 17 relevant, practice-oriented topics including The influence of genotype on the phenotype, clinical course, and risk of adverse events in children with Hypertrophic cardiomyopathy; Unravelling the genetic background in heritable and non-heritable BAV: a long roadmap; The risk of sudden unexpected cardiac death in children: epidemiology, clinical causes, and prevention; The renal involvement in patients with storage and infiltrative cardiomyopathies; and more.
The Breathless Heart by Michele Emdin,Alberto Giannoni,Claudio Passino Pdf
This book systematically focuses on central sleep apneas, analyzing their relationship especially with heart failure and discussing recent research results and emerging treatment strategies based on feedback modulation. The opening chapters present historical background information on Cheyne-Stokes respiration (CSR), clarify terminology, and explain the mechanics and chemistry of respiration. Following a description of the physiology of respiration, the pathophysiology underlying central apneas in different disorders and particularly in heart failure is discussed. The similarities and differences of obstructive and central apneas are then considered. The book looks beyond the concept of sleep apnea to daytime CSR and periodic breathing during effort and contrasts the opposing views of CSR as a compensatory phenomenon or as detrimental to the failing heart. The diagnostic tools currently in use for the detection of CSR are thoroughly reviewed, with guidance on interpretation of findings. The book concludes by describing the various forms of treatment that are available for CSR and by explaining how to select patients for treatment.
Takotsubo Syndrome, An Issue of Heart Failure Clinics, by Eduardo Bossone,Raimund Erbel Pdf
This issue of the Heart Failure Clinics, edited by Drs. Eduardo Bossone and Raimund Erbel, will cover the current consensus on Takotsubo (Stress) Cardiomyopathy. Topics covered will include the influence of age and gender on TTS; current concepts in pathophysiology; the clinician’s approach to TTS; imaging; genetics; and international perspectives, among other topics.
Hypertension and Hypertensive Heart Disease, An Issue of Cardiology Clinics - E-Book by George A. Mensah Pdf
Hypertensive heart disease, the number one cause of death associated with hypertension, refers to coronary artery disease, heart failure, and enlargement of the heart that occurs because of high blood pressure. This issue summarizes the current state-of-the-art in diagnosing, treating, and preventing this potentially fatal disease so that cardiologists can offer the best current treatment to their patients.