Genetics Of Human Infertility

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Genetics of Human Infertility

P.H. Vogt
Genetics of Human Infertility Book PDF

Author : P.H. Vogt
Publisher : Karger Medical and Scientific Publishers
Page : 178 pages
File Size : 53,5 Mb
Release : 2017-09-12
Category : Medical
ISBN : 9783318060980

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Genetics of Human Infertility by P.H. Vogt Pdf

Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

The Genetics of Male Infertility

Douglas T. Carrell
The Genetics of Male Infertility Book PDF

Author : Douglas T. Carrell
Publisher : Springer Science & Business Media
Page : 337 pages
File Size : 50,7 Mb
Release : 2007-11-08
Category : Medical
ISBN : 9781597451765

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The Genetics of Male Infertility by Douglas T. Carrell Pdf

In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Towards Reproductive Certainty: Fertility and Genetics Beyond 1999: The Plenary Proceedings of the 11th World Congress

R. Jansen,D. Mortimer
Towards Reproductive Certainty Fertility and Genetics Beyond 1999 The Plenary Proceedings of the 11th World Congress Book PDF

Author : R. Jansen,D. Mortimer
Publisher : CRC Press
Page : 556 pages
File Size : 52,6 Mb
Release : 1999-04-15
Category : Medical
ISBN : 1850700842

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Towards Reproductive Certainty: Fertility and Genetics Beyond 1999: The Plenary Proceedings of the 11th World Congress by R. Jansen,D. Mortimer Pdf

This is a forward-looking clinical reference of definitive authority on today's headline controversies surrounding in vitro fertilization (IVF) and reproductive genetics. Written by leading experts from medicine, education, psychology, ethics, counseling, and other disciplines studying fertility and genetics, the book contains nearly 70 chapters in seven sections. The introductory section deals with biology, business, morality and society in IVF and reproductive genetics; other sections focus on IVF outcomes, personal ethics and business, biology of the egg, sperm and embryo, implantation, IVF and society, and such 21st century topics as space travel and human reproduction, the disappearing male,and the future of motherhood. Includes bibliographic references and index.

The Genetic Basis of Male Infertility

Ken McElreavey
The Genetic Basis of Male Infertility Book PDF

Author : Ken McElreavey
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 45,8 Mb
Release : 2012-11-03
Category : Medical
ISBN : 9783540484615

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The Genetic Basis of Male Infertility by Ken McElreavey Pdf

Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic sterility, and comparative genetics of human spermatogenesis from the perspective of yeast, Drosophila and mice provide a global overview of the field.

Reproductomics

José A. Horcajadas,Jaime Gosálvez
Reproductomics Book PDF

Author : José A. Horcajadas,Jaime Gosálvez
Publisher : Academic Press
Page : 425 pages
File Size : 40,7 Mb
Release : 2018-07-23
Category : Medical
ISBN : 9780128126769

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Reproductomics by José A. Horcajadas,Jaime Gosálvez Pdf

Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data Features chapter contributions by leading international experts

Textbook of Human Reproductive Genetics

Stéphane Viville,Karen D. Sermon
Textbook of Human Reproductive Genetics Book PDF

Author : Stéphane Viville,Karen D. Sermon
Publisher : Cambridge University Press
Page : 255 pages
File Size : 47,9 Mb
Release : 2022-12-31
Category : Medical
ISBN : 9781009197694

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Textbook of Human Reproductive Genetics by Stéphane Viville,Karen D. Sermon Pdf

A basic understanding of human genetics is vital for all those working in the field of assisted human reproduction. Genetic makeup can hamper reproduction and insight into this is making genetic diagnosis and counselling increasingly important. This fully updated textbook continues the clear structure of the original edition, beginning with a chapter on the basics of genetics and cytogenetics. Genetic causes of infertility and the effect of epigenetics and transposons on fertility are discussed in detail. Several new chapters are included in this edition, reflecting the advances of the field, including preconception genetic analysis and screening in IVF and mitochondrial genetics. Combining genetics, reproductive biology and medicine, this is an essential text for practitioners in reproductive medicine and geneticists involved in the field looking to improve their knowledge of the subject and provide outstanding patient care.

Genetics of Male Infertility

Mohamed Arafa,Haitham Elbardisi,Ahmad Majzoub,Ashok Agarwal
Genetics of Male Infertility Book PDF

Author : Mohamed Arafa,Haitham Elbardisi,Ahmad Majzoub,Ashok Agarwal
Publisher : Springer Nature
Page : 374 pages
File Size : 44,7 Mb
Release : 2020-03-14
Category : Health & Fitness
ISBN : 9783030379728

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Genetics of Male Infertility by Mohamed Arafa,Haitham Elbardisi,Ahmad Majzoub,Ashok Agarwal Pdf

This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

Heritable Human Genome Editing

The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Heritable Human Genome Editing Book PDF

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 43,6 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Genetic Damage in Human Spermatozoa

Elisabetta Baldi,Monica Muratori
Genetic Damage in Human Spermatozoa Book PDF

Author : Elisabetta Baldi,Monica Muratori
Publisher : Springer Science & Business Media
Page : 195 pages
File Size : 53,8 Mb
Release : 2013-08-16
Category : Medical
ISBN : 9781461477839

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Genetic Damage in Human Spermatozoa by Elisabetta Baldi,Monica Muratori Pdf

There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Human Reproductive and Prenatal Genetics

Peter C.K. Leung,Jie Qiao
Human Reproductive and Prenatal Genetics Book PDF

Author : Peter C.K. Leung,Jie Qiao
Publisher : Elsevier
Page : 930 pages
File Size : 54,5 Mb
Release : 2023-03-22
Category : Science
ISBN : 9780323913812

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Human Reproductive and Prenatal Genetics by Peter C.K. Leung,Jie Qiao Pdf

Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. Features chapter contributions from leading international scientists and clinicians Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

Reproductive Endocrinology and Infertility

Douglas T. Carrell,C. Matthew Peterson
Reproductive Endocrinology and Infertility Book PDF

Author : Douglas T. Carrell,C. Matthew Peterson
Publisher : Springer Science & Business Media
Page : 812 pages
File Size : 44,7 Mb
Release : 2010-03-23
Category : Medical
ISBN : 9781441914361

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Reproductive Endocrinology and Infertility by Douglas T. Carrell,C. Matthew Peterson Pdf

Management of the modern reproductive endocrinology and infertility clinic has become very complex. In addition to the medical and scientific aspects, it is crucial that the modern director be aware of of incongruent fields such as marketing, accounting, management, and regulatory issues. Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice was developed to assist the practicing reproductive endocrinologist and/or laboratory director by providing an overview of relevant scientific, medical, and management issues in a single volume. Experts in all pertinent areas present concise, practical, evidence-based summaries of relevant topics, producing a key resource for physicians and scientists engaged in this exciting field of medicine. As novel technologies continue to amplify, Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice offers insight into development, and imparts extra confidence to practitioners in handling the many demands presented by their work.

WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction

World Health Organisation
WHO Laboratory Manual for the Examination of Human Semen and Sperm Cervical Mucus Interaction Book PDF

Author : World Health Organisation
Publisher : Cambridge University Press
Page : 150 pages
File Size : 53,9 Mb
Release : 1999-05-13
Category : Medical
ISBN : 0521645999

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WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction by World Health Organisation Pdf

The definitive and essential source of reference for all laboratories involved in the analysis of human semen.

Clinical Management of Male Infertility

Giorgio Cavallini,Giovanni Beretta
Clinical Management of Male Infertility Book PDF

Author : Giorgio Cavallini,Giovanni Beretta
Publisher : Springer
Page : 187 pages
File Size : 41,7 Mb
Release : 2014-10-20
Category : Health & Fitness
ISBN : 9783319085036

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Clinical Management of Male Infertility by Giorgio Cavallini,Giovanni Beretta Pdf

This book provides andrologists and other practitioners with reliable, up-to-date information on all aspects of male infertility and is designed to assist in the clinical management of patients. Clear guidance is offered on classification of infertility, sperm analysis interpretation and diagnosis. The full range of types and causes of male infertility are then discussed in depth. Particular attention is devoted to poorly understood conditions such as unexplained couple infertility and idiopathic male infertility, but the roles of diverse disorders, health and lifestyle factors and environmental pollution are also fully explored. Research considered stimulating for the reader is highlighted, reflecting the fascinating and controversial nature of the field. International treatment guidelines are presented and the role of diet and dietary supplements is discussed in view of their increasing importance. Clinicians will find that the book’s straightforward approach ensures that it can be easily and rapidly consulted.

Male Infertility: Understanding, Causes and Treatment

RAJENDER SINGH,Kiran Singh
Male Infertility Understanding Causes and Treatment Book PDF

Author : RAJENDER SINGH,Kiran Singh
Publisher : Springer
Page : 497 pages
File Size : 51,6 Mb
Release : 2017-06-17
Category : Medical
ISBN : 9789811040177

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Male Infertility: Understanding, Causes and Treatment by RAJENDER SINGH,Kiran Singh Pdf

This book covers the latest research on male infertility. The topics discussed range from understanding the genetic basis of infertility, to its causes and treatment. Since infertility is also of great interest to the general public, the book also includes a detailed description of what infertility is and how one can understand the different types. Given the complex etiology of infertility, the book includes a number of chapters defining the known and probable causes of male infertility. Providing detailed information suitable for patients and clinicians alike, it also features a separate section on treatment, the ultimate goal.

Infertility in the Male

Larry I. Lipshultz,Stuart S. Howards,Craig S. Niederberger
Infertility in the Male Book PDF

Author : Larry I. Lipshultz,Stuart S. Howards,Craig S. Niederberger
Publisher : Cambridge University Press
Page : 128 pages
File Size : 55,7 Mb
Release : 2009-09-24
Category : Medical
ISBN : 1139483242

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Infertility in the Male by Larry I. Lipshultz,Stuart S. Howards,Craig S. Niederberger Pdf

The new edition of this canonical text on male reproductive medicine will cement the book's market-leading position. Practitioners across many specialties - including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice – will see men with suboptimal fertility and reproductive problems. The book provides an excellent source of timely, well-considered information for those training in this young and rapidly evolving field. While several recent books provide targeted 'cookbooks' for those in a male reproductive laboratory, or quick reference for practising generalists, the modern, comprehensive reference providing both a background for male reproductive medicine as well as clinical practice information based on that foundation has been lacking until now. The book has been extensively revised with a particular focus on modern molecular medicine. Appropriate therapeutic interventions are highlighted throughout.