Genetics Of The Mouse

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Genetics of the Mouse

Author : Jean Louis Guénet,Fernando Benavides,Jean-Jacques Panthier,Xavier Montagutelli
Publisher : Springer
Page : 417 pages
File Size : 52,9 Mb
Release : 2014-11-29
Category : Science
ISBN : 9783662442876

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Genetics of the Mouse by Jean Louis Guénet,Fernando Benavides,Jean-Jacques Panthier,Xavier Montagutelli Pdf

This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

Mouse Genetics

Author : Professor of Molecular Biology Lee M Silver, Professor Dr,Lee M. Silver
Publisher : Oxford University Press on Demand
Page : 362 pages
File Size : 49,6 Mb
Release : 1995
Category : Medical
ISBN : 0195075544

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Mouse Genetics by Professor of Molecular Biology Lee M Silver, Professor Dr,Lee M. Silver Pdf

Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.

Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes

Author : Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo
Publisher : Cambridge University Press
Page : 361 pages
File Size : 55,6 Mb
Release : 2013-04-25
Category : Science
ISBN : 9781107355576

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Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes by Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo Pdf

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Mouse Genetics

Author : Shree Ram Singh,Robert M. Hoffman,Amit Singh
Publisher : Humana
Page : 217 pages
File Size : 53,7 Mb
Release : 2021-02-20
Category : Science
ISBN : 1071610074

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Mouse Genetics by Shree Ram Singh,Robert M. Hoffman,Amit Singh Pdf

This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.

The Mouse In Animal Genetics And Breeding Research

Author : Eugene J Eisen
Publisher : World Scientific
Page : 376 pages
File Size : 53,8 Mb
Release : 2005-06-27
Category : Science
ISBN : 9781783260263

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The Mouse In Animal Genetics And Breeding Research by Eugene J Eisen Pdf

The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields.

The BALB/c Mouse

Author : Michael Potter
Publisher : Springer Science & Business Media
Page : 261 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642707407

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The BALB/c Mouse by Michael Potter Pdf

The mouse was first used in immunological research by Paul Ehrlich in 1891 in an extraordinary series of experiments on the maternal transfer of antitoxic immunity. A short 22 years later in 1913 Halsey Bagg acquired a stock of albino mice from a commercial dealer and used them in a series of experiments on learning. Because he was interested in the genetics of intelligence, Halsey Bagg began breeding a pedigreed line of these mice that were subsequently named for him - Bagg Albino. Though Halsey Bagg is not credited with initiating the inbred strains of mice, his stock curiously has played an indisputably important role. Bagg Albinos were progenitors of the present day BALB/c family of sublines - the subject of this book. They were also used as one of the parents in the development of inbred strains A, CBA and C3H, three other very famous strains. Today the BALB/c mouse is among the five most widely used inbred strains in biomedical research and a particular favorite in immunology and infectious disease research. The hallmark of the BALB/c response to so many kinds of infections is susceptibility and sometimes an exaggerated susceptibility, but this paradoxically is not associated with immunodeficiency as BALB/c is an excellent responder to immuni zation. These characteristics have made the BALB/c mouse a model for identifying genes that determine susceptibility to infectious and neoplastic diseases. In 1985 the laboratory BALB/c mouse became 72 years old. The current filial generations are somewhere around 350 generations [MURPHY].

The Genetics of the Mouse

Author : Hans Grüneberg
Publisher : CUP Archive
Page : 462 pages
File Size : 40,5 Mb
Release : 1952
Category : Animal genetics
ISBN : 8210379456XXX

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The Genetics of the Mouse by Hans Grüneberg Pdf

Contributions to Behavior-genetic Analysis

Author : Gardner Lindzey,Delbert D. Thiessen
Publisher : Ardent Media
Page : 362 pages
File Size : 44,6 Mb
Release : 1970
Category : Science
ISBN : 0390562750

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Contributions to Behavior-genetic Analysis by Gardner Lindzey,Delbert D. Thiessen Pdf

Mouse Genetics

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 47,9 Mb
Release : 2001
Category : Mice
ISBN : OCLC:48998578

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Mouse Genetics by Anonim Pdf

Microbial and Phenotypic Definition of Rats and Mice

Author : National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research
Publisher : National Academies Press
Page : 113 pages
File Size : 44,6 Mb
Release : 1999-07-26
Category : Science
ISBN : 9780309172820

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Microbial and Phenotypic Definition of Rats and Mice by National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research Pdf

US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

Genetic Variants and Strains of the Laboratory Mouse

Author : Mary F. Lyon,Sohaila Rastan
Publisher : Unknown
Page : 980 pages
File Size : 52,6 Mb
Release : 1996
Category : Mice
ISBN : UOM:39015037415232

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Genetic Variants and Strains of the Laboratory Mouse by Mary F. Lyon,Sohaila Rastan Pdf

Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes

Author : Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo
Publisher : Cambridge University Press
Page : 361 pages
File Size : 40,8 Mb
Release : 2013-04-25
Category : Medical
ISBN : 9781107034815

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Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes by Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo Pdf

A comprehensive review of the current state of our knowledge on the inheritance of normal behaviour in the laboratory mouse.

Mouse Genetics

Author : Shree Ram Singh,Robert M. Hoffman,Amit Singh
Publisher : Unknown
Page : 217 pages
File Size : 55,9 Mb
Release : 2021
Category : Animal models in research
ISBN : 1071610082

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Mouse Genetics by Shree Ram Singh,Robert M. Hoffman,Amit Singh Pdf

This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.

Cells and Surveys

Author : National Research Council,Commission on Behavioral and Social Sciences and Education,Committee on Population
Publisher : National Academies Press
Page : 388 pages
File Size : 55,7 Mb
Release : 2001-01-19
Category : Social Science
ISBN : 9780309171434

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Cells and Surveys by National Research Council,Commission on Behavioral and Social Sciences and Education,Committee on Population Pdf

What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.

The Mouse in Biomedical Research

Author : Henry Foster
Publisher : Elsevier
Page : 321 pages
File Size : 49,6 Mb
Release : 1981-01-01
Category : Science
ISBN : 9780323156066

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The Mouse in Biomedical Research by Henry Foster Pdf

The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.