Genome And Genomics

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Ecological Genomics

Christian R. Landry,Nadia Aubin-Horth
Ecological Genomics Book PDF

Author : Christian R. Landry,Nadia Aubin-Horth
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 51,9 Mb
Release : 2013-11-25
Category : Science
ISBN : 9789400773479

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Ecological Genomics by Christian R. Landry,Nadia Aubin-Horth Pdf

Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation.

Genome

Matt Ridley
Genome Book PDF

Author : Matt Ridley
Publisher : Harper Collins
Page : 370 pages
File Size : 42,5 Mb
Release : 2013-03-26
Category : Science
ISBN : 9780062253460

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Genome by Matt Ridley Pdf

“Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker The genome's been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it all: what it is, how it works, and what it portends for the future Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

Mapping and Sequencing the Human Genome

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Mapping and Sequencing the Human Genome Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Page : 128 pages
File Size : 45,8 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309038409

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Mapping and Sequencing the Human Genome by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome Pdf

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Sequence — Evolution — Function

Eugene V. Koonin,Michael Galperin
Sequence Evolution Function Book PDF

Author : Eugene V. Koonin,Michael Galperin
Publisher : Springer Science & Business Media
Page : 482 pages
File Size : 49,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475737837

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Sequence — Evolution — Function by Eugene V. Koonin,Michael Galperin Pdf

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Principles of Genome Analysis and Genomics

Sandy B. Primrose,Richard Twyman
Principles of Genome Analysis and Genomics Book PDF

Author : Sandy B. Primrose,Richard Twyman
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 47,5 Mb
Release : 2009-04-01
Category : Science
ISBN : 9781444311280

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Principles of Genome Analysis and Genomics by Sandy B. Primrose,Richard Twyman Pdf

With the first draft of the human genome project in the publicdomain and full analyses of model genomes now available, thesubject matter of 'Principles of Genome Analysis and Genomics' iseven 'hotter' now than when the first two editions were publishedin 1995 and 1998. In the new edition of this very practical guideto the different techniques and theory behind genomes and genomeanalysis, Sandy Primrose and new author Richard Twyman provide afresh look at this topic. In the light of recent excitingadvancements in the field, the authors have completely revised andrewritten many parts of the new edition with the addition of fivenew chapters. Aimed at upper level students, it is essential thatin this extremely fast moving topic area the text is up to date andrelevant. Completely revised new edition of an establishedtextbook. Features new chapters and examples from exciting new researchin genomics, including the human genome project. Excellent new co-author in Richard Twyman, also co-author ofthe new edition of hugely popular Principles of GeneManipulation. Accompanying web-page to help students deal with this difficulttopic at www.blackwellpublishing.com/primrose

Genomics

Charles R. Cantor,Cassandra L. Smith
Genomics Book PDF

Author : Charles R. Cantor,Cassandra L. Smith
Publisher : John Wiley & Sons
Page : 621 pages
File Size : 55,7 Mb
Release : 2004-01-06
Category : Science
ISBN : 9780471461869

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Genomics by Charles R. Cantor,Cassandra L. Smith Pdf

A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchers In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features: * Topical organization within chapters for easy reference * A discussion of the developing methods of sequencing, such as sequencing by hybridization (SBH) in which data is read through words instead of letters * Detailed explanations and critical evaluations of the many different types of DNA maps that can be generated-including cytogenic and restriction maps as well as interspecies cell hybrids * Informed predictions for the future of DNA sequencing

Comparative Genomics

Nicholas H. Bergman
Comparative Genomics Book PDF

Author : Nicholas H. Bergman
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 41,7 Mb
Release : 2007-11-29
Category : Medical
ISBN : 9781934115374

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Comparative Genomics by Nicholas H. Bergman Pdf

This volume provides a collection of robust protocols for molecular biologists studying comparative genomics. Given the tremendous increase in available biosequence data over the past ten years, this volume is timely, comprehensive, and novel. The volume is intended for molecular biologists, biochemists and geneticists.

Genetics and Genomics of the Brassicaceae

Renate Schmidt,Ian Bancroft
Genetics and Genomics of the Brassicaceae Book PDF

Author : Renate Schmidt,Ian Bancroft
Publisher : Springer Science & Business Media
Page : 675 pages
File Size : 47,9 Mb
Release : 2010-12-03
Category : Science
ISBN : 9781441971180

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Genetics and Genomics of the Brassicaceae by Renate Schmidt,Ian Bancroft Pdf

The Genetics and Genomics of the Brassicaceae provides a review of this important family (commonly termed the mustard family, or Cruciferae). The family contains several cultivated species, including radish, rocket, watercress, wasabi and horseradish, in addition to the vegetable and oil crops of the Brassica genus. There are numerous further species with great potential for exploitation in 21st century agriculture, particularly as sources of bioactive chemicals. These opportunities are reviewed, in the context of the Brassicaceae in agriculture. More detailed descriptions are provided of the genetics of the cultivated Brassica crops, including both the species producing most of the brassica vegetable crops (B. rapa and B. oleracea) and the principal species producing oilseed crops (B. napus and B. juncea). The Brassicaceae also include important “model” plant species. Most prominent is Arabidopsis thaliana, the first plant species to have its genome sequenced. Natural genetic variation is reviewed for A. thaliana, as are the genetics of the closely related A. lyrata and of the genus Capsella. Self incompatibility is widespread in the Brassicaceae, and this subject is reviewed. Interest arising from both the commercial value of crop species of the Brassicaceae and the importance of Arabidopsis thaliana as a model species, has led to the development of numerous resources to support research. These are reviewed, including germplasm and genomic library resources, and resources for reverse genetics, metabolomics, bioinformatics and transformation. Molecular studies of the genomes of species of the Brassicaceae revealed extensive genome duplication, indicative of multiple polyploidy events during evolution. In some species, such as Brassica napus, there is evidence of multiple rounds of polyploidy during its relatively recent evolution, thus the Brassicaceae represent an excellent model system for the study of the impacts of polyploidy and the subsequent process of diploidisation, whereby the genome stabilises. Sequence-level characterization of the genomes of Arabidopsis thaliana and Brassica rapa are presented, along with summaries of comparative studies conducted at both linkage map and sequence level, and analysis of the structural and functional evolution of resynthesised polyploids, along with a description of the phylogeny and karyotype evolution of the Brassicaceae. Finally, some perspectives of the editors are presented. These focus upon the Brassicaceae species as models for studying genome evolution following polyploidy, the impact of advances in genome sequencing technology, prospects for future transcriptome analysis and upcoming model systems.

Computational Genomics with R

Altuna Akalin
Computational Genomics with R Book PDF

Author : Altuna Akalin
Publisher : CRC Press
Page : 462 pages
File Size : 44,6 Mb
Release : 2020-12-16
Category : Mathematics
ISBN : 9781498781862

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Computational Genomics with R by Altuna Akalin Pdf

Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.

Genomics

John M. Archibald
Genomics Book PDF

Author : John M. Archibald
Publisher : Oxford University Press
Page : 161 pages
File Size : 51,9 Mb
Release : 2018
Category : SCIENCE
ISBN : 9780198786207

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Genomics by John M. Archibald Pdf

In the years since the Human Genome Project, genomics has grown into a big and rapidly developing field driven by bioinformatics technology. The implications for our health and privacy, and our understanding of ecological systems and evolution are profound. This book provides an account of this exciting new science, its impact and its potential.

Genetics and Genomics of Cotton

Andrew H. Paterson
Genetics and Genomics of Cotton Book PDF

Author : Andrew H. Paterson
Publisher : Springer Science & Business Media
Page : 515 pages
File Size : 49,8 Mb
Release : 2009-03-11
Category : Science
ISBN : 9780387708102

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Genetics and Genomics of Cotton by Andrew H. Paterson Pdf

The Gossypium (cotton) genus presents novel opportunities to advance our understanding of the natural world and its organic evolution. In this book, advances of the past decade are summarized and synthesized to elucidate the current state of knowledge of the structure, function, and evolution of the Gossypium genome, and progress in the application of this knowledge to cotton improvement. This book provides the first comprehensive reference on cotton genomics.

Genomics: Concepts and Applications

Caleb Elliot
Genomics Concepts and Applications Book PDF

Author : Caleb Elliot
Publisher : Unknown
Page : 205 pages
File Size : 40,8 Mb
Release : 2021-12-07
Category : Science
ISBN : 1647400929

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Genomics: Concepts and Applications by Caleb Elliot Pdf

Genomics is a field of biology that studies the genome. It involves the analysis and sequencing of genes to analyze the function and structure of the complete genome. A revolutionary development in genomics has been the Human Genome Project under which the complete genome sequencing of the human body was achieved. This was possible due to an amalgamation of efficient sequencing technologies and utilization of bioinformatics resources. The genome analysis of an organism usually consists of three stages- DNA sequencing, representation of the original chromosome using knowledge of the assembly of the DNA sequence, and the analysis and annotation of that representation. Some of the areas of research in genomics are functional genomics, structural genomics, metagenomics, epigenomics, etc. Such studies contribute to the advancement of biotechnology, medicine, bioengineering and conservation. The objective of this book is to give a general view of the different areas of genomics and its applications. The various studies that are constantly contributing towards advancing technologies and evolution of this field are examined in detail. This book is a collective contribution of a renowned group of international experts.

Genome and Genomics

K. V. Chaitanya
Genome and Genomics Book PDF

Author : K. V. Chaitanya
Publisher : Springer Nature
Page : 319 pages
File Size : 50,8 Mb
Release : 2019-11-17
Category : Medical
ISBN : 9789811507021

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Genome and Genomics by K. V. Chaitanya Pdf

This book provides a detailed and up-to-dated information on the genomes belonging to three major life forms on Earth – archaea, prokaryotes and eukaryotes. Each section describes about the genome of a specific group of organisms, such as viruses, archaea, bacteria, eukaryotes and organellar genomes. Individual chapters provide details of their organization, structure, evolution, sequencing strategies and functions. Further, this book discusses the technologies that are applied for genome sequencing; assembly, annotation and gene prediction. Other topics include the genomes of important model organisms, mitochondria genome of Neanderthal fossil, etc. This book also examines the evolution of chloroplast and mitochondria genomes by comparing with bacteria, addresses the diseases that occur in humans due to the mutations in mitochondrial genome, gene therapy and engineering of chloroplast and mitochondrial genomes. Lastly, it features an overview of the role of proteomics, exposomics, connectomics, metabolomics, and microbiomics. This book is a fascinating read for students, lecturers and researchers in the field of genetics, genomics, microbiology and life sciences.

Genetics and Genomics of Papaya

Ray Ming,Paul H. Moore
Genetics and Genomics of Papaya Book PDF

Author : Ray Ming,Paul H. Moore
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 43,7 Mb
Release : 2013-08-13
Category : Science
ISBN : 9781461480877

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Genetics and Genomics of Papaya by Ray Ming,Paul H. Moore Pdf

This book reviews various aspects of papaya genomics, including existing genetic and genomic resources, recent progress on structural and functional genomics, and their applications in papaya improvement. Organized into four sections, the volume explores the origin and domestication of papaya, classic genetics and breeding, recent progress on molecular genetics, and current and future applications of genomic resources for papaya improvement. Bolstered by contributions from authorities in the field, Genetics and Genomics of Papaya is a valuable resource that provides the most up to date information for papaya researchers and plant biologists.

Population Genomics

Om P. Rajora
Population Genomics Book PDF

Author : Om P. Rajora
Publisher : Springer
Page : 822 pages
File Size : 40,5 Mb
Release : 2019-01-07
Category : Science
ISBN : 9783030045890

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Population Genomics by Om P. Rajora Pdf

Population genomics has revolutionized various disciplines of biology including population, evolutionary, ecological and conservation genetics, plant and animal breeding, human health, medicine and pharmacology by allowing to address novel and long-standing questions with unprecedented power and accuracy. It employs large-scale or genome-wide genetic information and bioinformatics to address various fundamental and applied aspects in biology and related disciplines, and provides a comprehensive genome-wide perspective and new insights that were not possible before. These advances have become possible due to the development of new and low-cost sequencing and genotyping technologies and novel statistical approaches and software, bioinformatics tools, and models. Population genomics is tremendously advancing our understanding the roles of evolutionary processes, such as mutation, genetic drift, gene flow, and natural selection, in shaping up genetic variation at individual loci and across the genome and populations; improving the assessment of population genetic parameters or processes such as adaptive evolution, effective population size, gene flow, admixture, inbreeding and outbreeding depression, demography, and biogeography; resolving evolutionary histories and phylogenetic relationships of extant, ancient and extinct species; understanding the genomic basis of fitness, adaptation, speciation, complex ecological and economically important traits, and disease and insect resistance; facilitating forensics, genetic medicine and pharmacology; delineating conservation genetic units; and understanding the genetic effects of resource management practices, and assisting conservation and sustainable management of genetic resources. This Population Genomics book discusses the concepts, approaches, applications and promises of population genomics in addressing most of the above fundamental and applied crucial aspects in a variety of organisms from microorganisms to humans. The book provides insights into a range of emerging population genomics topics including population epigenomics, landscape genomics, seascape genomics, paleogenomics, ecological and evolutionary genomics, biogeography, demography, speciation, admixture, colonization and invasion, genomic selection, and plant and animal domestication. This book fills a vacuum in the field and is expected to become a primary reference in Population Genomics world-wide.