Genomic Messages

Author : George Annas,Sherman Elias
Publisher : HarperCollins
Page : 173 pages
File Size : 46,8 Mb
Release : 2015-06-23
Category : Health & Fitness
ISBN : 9780062228277

Get Book

Genomic Messages by George Annas,Sherman Elias Pdf

Two leaders in the field of genetics—a bioethicist-health lawyer and an obstetrician-gynecologist geneticist—answer the most pressing questions about the application of new genetics to our universal medicine and what personalized medicine means for individual healthcare. Breakthroughs in genetic research are changing modern medicine and pharmaceuticals. But what are these changes and how do they affect our individual care? Genomic Messages examines these groundbreaking changes and the questions they raise: What kind of specific medical innovation do we have to look forward to now and tomorrow? How will this “flood” of genetic messages change our lives, our interaction with our physicians and our healthcare system? Groundbreaking and provocative, Genomic Messages fuses the often conflicting worlds of medicine and law to provide information and insight that will impact the health choices of every one of us, from how medicine is practiced to concepts of privacy, confidentiality, and informed consent. Ultimately, it reveals how genetic information is changing how we think about ourselves, our health, and our future.

Author : Cédric Gaucherel,Pierre-Henri Gouyon,Jean-Louis Dessalles
Publisher : John Wiley & Sons
Page : 212 pages
File Size : 53,6 Mb
Release : 2019-01-03
Category : Computers
ISBN : 9781119579328

Get Book

Information, The Hidden Side of Life by Cédric Gaucherel,Pierre-Henri Gouyon,Jean-Louis Dessalles Pdf

This book explores the unity of life. It proposes that the concept of information is the inner essence of what we today call life. The importance of information for our species is obvious. Human beings are highly dependent on information, constantly exchanging with conspecifics. In a less apparent way, we are the product of genetic and epigenetic information which determines our development in a given environment from a fertilized egg to the adult stage. Even less apparent is that information plays a determining role in ecosystems. This observation may include the prebiotic systems in which life emerged. Our claim is that Nature processes information continuously. This means that even beyond living entities, we can see messages and decoding procedures. Nature can be said to send messages to its own future and then to decode them. Nature “talks” to itself! The systematic organization of messages suggests that, in some respects, we should even speak of the “languages” of Nature.

Author : M. Potter,F. Melchers,M. Weigert
Publisher : Springer Science & Business Media
Page : 281 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642698606

Get Book

Oncogenes in B-Cell Neoplasia by M. Potter,F. Melchers,M. Weigert Pdf

Author : Gerard Battail
Publisher : Springer Nature
Page : 191 pages
File Size : 55,8 Mb
Release : 2022-06-01
Category : Technology & Engineering
ISBN : 9783031016295

Get Book

An Outline of Informational Genetics by Gerard Battail Pdf

Heredity performs literal communication of immensely long genomes through immensely long time intervals. Genomes nevertheless incur sporadic errors referred to as mutations which have significant and often dramatic effects, after a time interval as short as a human life. How can faithfulness at a very large timescale and unfaithfulness at a very short one be conciliated? The engineering problem of literal communication has been completely solved during the second half of the XX-th century. Originating in 1948 from Claude Shannon's seminal work, information theory provided means to measure information quantities and proved that communication is possible through an unreliable channel (by means left unspecified) up to a sharp limit referred to as its capacity, beyond which communication becomes impossible. The quest for engineering means of reliable communication, named error-correcting codes, did not succeed in closely approaching capacity until 1993 when Claude Berrou and Alain Glavieux invented turbocodes. By now, the electronic devices which invaded our daily lives (e.g., CD, DVD, mobile phone, digital television) could not work without highly efficient error-correcting codes. Reliable communication through unreliable channels up to the limit of what is theoretically possible has become a practical reality: an outstanding achievement, however little publicized. As an engineering problem that nature solved aeons ago, heredity is relevant to information theory. The capacity of DNA is easily shown to vanish exponentially fast, which entails that error-correcting codes must be used to regenerate genomes so as to faithfully transmit the hereditary message. Moreover, assuming that such codes exist explains basic and conspicuous features of the living world, e.g., the existence of discrete species and their hierarchical taxonomy, the necessity of successive generations and even the trend of evolution towards increasingly complex beings. Providing geneticists with an introduction to information theory and error-correcting codes as necessary tools of hereditary communication is the primary goal of this book. Some biological consequences of their use are also discussed, and guesses about hypothesized genomic codes are presented. Another goal is prompting communication engineers to get interested in genetics and biology, thereby broadening their horizon far beyond the technological field, and learning from the most outstanding engineer: Nature. Table of Contents: Foreword / Introduction / A Brief Overview of Molecular Genetics / An Overview of Information Theory / More on Molecular Genetics / More on Information Theory / An Outline of Error-Correcting Codes / DNA is an Ephemeral Memory / A Toy Living World / Subsidiary Hypothesis, Nested System / Soft Codes / Biological Reality Conforms to the Hypotheses / Identification of Genomic Codes / Conclusion and Perspectives

Author : Jorge L. Contreras
Publisher : Algonquin Books
Page : 573 pages
File Size : 41,8 Mb
Release : 2021-10-26
Category : Law
ISBN : 9781643752150

Get Book

The Genome Defense by Jorge L. Contreras Pdf

In this riveting, behind-the-scenes courtroom drama, a brilliant legal team battles corporate greed and government overreach for our fundamental right to control our genes. When attorney Chris Hansen learned that the U.S. government was issuing patents for human genes to biotech companies, his first thought was, How can a corporation own what makes us who we are? Then he discovered that women were being charged exorbitant fees to test for hereditary breast and ovarian cancers, tests they desperately needed—all because Myriad Genetics had patented the famous BRCA genes. So he sued them. Jorge L. Contreras, one of the nation’s foremost authorities on human genetics law, has devoted years to investigating the groundbreaking civil rights case known as AMP v. Myriad. In The Genome Defense Contreras gives us the view from inside as Hansen and his team of ACLU lawyers, along with a committed group of activists, scientists, and physicians, take their one-in-a-million case all the way to the U.S. Supreme Court. Contreras interviewed more than a hundred key players involved in all aspects of the case—from judges and policy makers to ethicists and genetic counselors, as well as cancer survivors and those whose lives would be impacted by the decision—expertly weaving together their stories into a fascinating narrative of this pivotal moment in history. The Genome Defense is a powerful and compelling story about how society must balance scientific discovery with corporate profits and the rights of all people.

Author : Anonim
Publisher : Academic Press
Page : 1350 pages
File Size : 41,7 Mb
Release : 2012-10-30
Category : Science
ISBN : 9780123822284

Get Book

Genomic and Personalized Medicine by Anonim Pdf

Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Author : Dianne M. Bartels,Bonnie S. LeRoy,Arthur L. Caplan
Publisher : Routledge
Page : 206 pages
File Size : 41,9 Mb
Release : 2017-07-12
Category : Medical
ISBN : 9781351517959

Get Book

Genetic Counseling by Dianne M. Bartels,Bonnie S. LeRoy,Arthur L. Caplan Pdf

Genetic counseling is fairly new. The fact that the field is an accepted professional enterprise in universities, clinics, and hospitals throughout the United States is remarkable. The contributors argue that genetics and medicine rest on beliefs widely held in American society. Scientific progress is good, and highly sophisticated technologies are appropriate means to solving medical problems. The better understanding they gain about the nature and evolution of disease, the more prepared clinicians will be to treat and prevent future occurrence of disease. A belief that medicine, including genetic medicine, is clear, factually based, and objective undergirds the strategies and norms of genetic counseling. This collection of original papers explores the history, values, and norms of that process, with focus on the value of non-directiveness in counseling practice. The contributors' examination of genetic counseling issues serves as a foundation from which to address the ethical, legal, and policy considerations of clinical genetics.

Author : Sandrine Dudoit,Mark J. van der Laan
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 54,8 Mb
Release : 2007-12-18
Category : Science
ISBN : 9780387493176

Get Book

Multiple Testing Procedures with Applications to Genomics by Sandrine Dudoit,Mark J. van der Laan Pdf

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.

Author : Dana C. Crawford,Jessica Nicole Cooke Bailey,William Scott Bush
Publisher : Frontiers Media SA
Page : 98 pages
File Size : 51,5 Mb
Release : 2020-10-30
Category : Science
ISBN : 9782889660995

Get Book

The Importance of Diversity in Precision Medicine Research by Dana C. Crawford,Jessica Nicole Cooke Bailey,William Scott Bush Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Kostas Kampourakis
Publisher : Cambridge University Press
Page : 319 pages
File Size : 40,5 Mb
Release : 2017-03-30
Category : Science
ISBN : 9781107567498

Get Book

Making Sense of Genes by Kostas Kampourakis Pdf

What are genes? What do genes do? These seemingly simple questions are in fact challenging to answer accurately. As a result, there are widespread misunderstandings and over-simplistic answers, which lead to common conceptions widely portrayed in the media, such as the existence of a gene 'for' a particular characteristic or disease. In reality, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning of our life story. This comprehensive book analyses and explains the gene concept, combining philosophical, historical, psychological and educational perspectives with current research in genetics and genomics. It summarises what we currently know and do not know about genes and the potential impact of genetics on all our lives. Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals.

Author : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health
Publisher : Unknown
Page : 56 pages
File Size : 50,7 Mb
Release : 2003
Category : Science
ISBN : UOM:39015089026416

Get Book

The National Institutes of Health-decoding our federal investment in genomic research by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health Pdf

Author : George Jabboure Netto,Karen L. Kaul
Publisher : Springer
Page : 638 pages
File Size : 53,7 Mb
Release : 2018-12-10
Category : Medical
ISBN : 9783319968308

Get Book

Genomic Applications in Pathology by George Jabboure Netto,Karen L. Kaul Pdf

​The recent advances in genomics are continuing to reshape our approach to diagnostics, prognostics and therapeutics in oncologic and other disorders. A paradigm shift in pharmacogenomics and in the diagnosis of genetic inherited diseases and infectious diseases is unfolding as the result of implementation of next generation genomic technologies. With rapidly growing knowledge and applications driving this revolution, along with significant technologic and cost changes, genomic approaches are becoming the primary methods in many laboratories and for many diseases. As a result, a plethora of clinical genomic applications have been implemented in diagnostic pathology laboratories, and the applications and demands continue to evolve rapidly. This has created a tremendous need for a comprehensive resource on genomic applications in clinical and anatomic pathology. We believe that our current textbook provides such a resource to practicing molecular pathologists, hematopathologists and other subspecialized pathologists, general pathologists, pathology and other trainees, oncologists, geneticists and a growing spectrum of other clinicians. With periodic updates and a sufficiently rapid time from submission to publication, this textbook will be the resource of choice for many professionals and teaching programs. Its focus on genomics parallels the evolution of these technologies as primary methods in the clinical lab. The rapid evolution of genomics and its applications in medicine necessitates the (frequent) updating of this publication. This text will provide a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays will be discussed together with issues related to reporting and the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms will be detailed. Genomic applications in pharmacogenomics, inherited genetic diseases and infectious diseases will also be discussed. The latest iteration of practice recommendations or guidelines in genomic testing put forth by stakeholder professional organizations such as the College of American Pathology and the Association for Molecular Pathology, will be discussed as well as regulatory issues and laboratory accreditation related to genomic testing. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Author : Great Britain: Parliament: House of Lords: Science and Technology Committee
Publisher : The Stationery Office
Page : 652 pages
File Size : 41,5 Mb
Release : 2009-07-07
Category : Political Science
ISBN : 0108444503

Get Book

Genomic medicine by Great Britain: Parliament: House of Lords: Science and Technology Committee Pdf

Volume 1 Report also available (ISBN 9780108444517). Genomic medicine has developed from the sequencing of the human genome

Author : Yoshihito Yawata
Publisher : John Wiley & Sons
Page : 454 pages
File Size : 49,8 Mb
Release : 2006-01-24
Category : Science
ISBN : 9783527605323

Get Book

Cell Membrane by Yoshihito Yawata Pdf

This publication presents the structure and function of biological membranes to improve the understanding of cells in both normal and pathogenic states. Recently, vast amounts of new information have been accumulated, especially about pathological conditions, and there is now much evidence correlating genotypes and phenotypes in normal and disease states. This book surveys the most recent findings in research on the molecular biology, biochemistry, and genetics of the membranes of human red blood cells.

Author : Sir John Kendrew
Publisher : John Wiley & Sons
Page : 1201 pages
File Size : 43,6 Mb
Release : 2009-07-06
Category : Science
ISBN : 9781444313840

Get Book

The Encylopedia of Molecular Biology by Sir John Kendrew Pdf

The Encylopaedia of Molecular Biology is a truly unique work of reference. 6000 definitions cover the entire spectrum of molecular life science The complete one-volume guide to understanding the way molecular biology is transforming medicine and agriculture Long and short entries written by over 300 of the world's finest researchers For rapid research or detailed study ... this is the A to Z of the New Biology