Glial Neurobiology In Mental Illness

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Glial Neurobiology in Mental Illness

Jaxon Blakeley
Glial Neurobiology in Mental Illness Book PDF

Author : Jaxon Blakeley
Publisher : American Medical Publishers
Page : 0 pages
File Size : 41,5 Mb
Release : 2023-09-26
Category : Medical
ISBN : 9798887401348

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Glial Neurobiology in Mental Illness by Jaxon Blakeley Pdf

Mental illness refers to a mental or behavioral pattern which causes significant interference with the functioning of a person. The behavioral patterns can be remitting, relapsing or persistent, and can occur in isolated episodes. Glial cells are important for proper functioning of neurons and dysfunction in glial cells can result in various mental illnesses, like psychiatric disorders, autism, glioblastoma and multiple sclerosis. They do not produce electrical impulses and are found in the peripheral nervous system and the central nervous system. They help homeostasis, produce myelin in the peripheral nervous system, while providing protection and support to the neurons. Glial cells comprise ependymal cells, oligodendrocytes, microglia and astrocytes in the central nervous system. They are made up of satellite cells and schwann cells in the peripheral nervous system. This book strives to provide a fair idea about glial neurobiology in mental illness and to help develop a better understanding of the latest advances in their clinical management. Those with an interest in this field would find it helpful.

Minding Glial Cells in the Novel Understandings of Mental Illness

Takahiro A. Kato,Aye M. Myint,Johann Steiner
Minding Glial Cells in the Novel Understandings of Mental Illness Book PDF

Author : Takahiro A. Kato,Aye M. Myint,Johann Steiner
Publisher : Frontiers Media SA
Page : 277 pages
File Size : 45,6 Mb
Release : 2017-05-03
Category : Electronic book
ISBN : 9782889451579

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Minding Glial Cells in the Novel Understandings of Mental Illness by Takahiro A. Kato,Aye M. Myint,Johann Steiner Pdf

Traditionally, abnormalities of neurons and neuronal networks including synaptic abnormalities and disturbance of neurotransmitters have dominantly been believed to be the main causes of psychiatric disorders. Recent cellular neuroscience has revealed various unknown roles of glial cells such as astrocytes, oligodendrocytes and microglia. These glial cells have proved to continuously contact with neurons /synapses, and have been shown to play important roles in brain development, homeostasis and various brain functions. Beyond the classic neuronal doctrine, accumulating evidence has suggested that abnormalities and disturbances of neuron-glia crosstalk may induce psychiatric disorders, while these mechanisms have not been well understood. This Research Topic of the Frontiers in Cellular Neuroscience will focus on the most recent developments and ideas in the study of glial cells (astrocytes, oligodendrocytes and microglia) focusing on psychiatric disorders such as schizophrenia, mood disorders and autism. Not only molecular, cellular and pharmacological approaches using in vitro / in vivo experimental methods but also translational research approaches are welcome. Novel translational research approaches, for example, using novel techniques such as induced pluripotent stem (iPS) cells, may lead to novel solutions. We believe that investigations to clarify the correlation between glial cells and psychiatric disorders contribute to a novel understanding of the pathophysiology of these disorders and the development of effective treatment strategies.

Neurobiology of Mental Illness

Dennis S. Charney,Joseph D. Buxbaum,Pamela Sklar,Eric J. Nestler
Neurobiology of Mental Illness Book PDF

Author : Dennis S. Charney,Joseph D. Buxbaum,Pamela Sklar,Eric J. Nestler
Publisher : Oxford University Press
Page : 1259 pages
File Size : 48,5 Mb
Release : 2013-07-04
Category : Medical
ISBN : 9780199934959

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Neurobiology of Mental Illness by Dennis S. Charney,Joseph D. Buxbaum,Pamela Sklar,Eric J. Nestler Pdf

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Neurobiology of Psychiatric Disorders

Thomas E Schlaepfer,Charles B. Nemeroff
Neurobiology of Psychiatric Disorders Book PDF

Author : Thomas E Schlaepfer,Charles B. Nemeroff
Publisher : Elsevier
Page : 781 pages
File Size : 50,7 Mb
Release : 2012-07-09
Category : Medical
ISBN : 9780444520029

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Neurobiology of Psychiatric Disorders by Thomas E Schlaepfer,Charles B. Nemeroff Pdf

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

The Neurobiological Basis of Suicide

Yogesh Dwivedi
The Neurobiological Basis of Suicide Book PDF

Author : Yogesh Dwivedi
Publisher : CRC Press
Page : 485 pages
File Size : 52,6 Mb
Release : 2012-06-25
Category : Medical
ISBN : 9781439838815

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The Neurobiological Basis of Suicide by Yogesh Dwivedi Pdf

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Neurobiology of Mental Illness

Eric J. Nestler
Neurobiology of Mental Illness Book PDF

Author : Eric J. Nestler
Publisher : Oxford University Press
Page : 1267 pages
File Size : 45,6 Mb
Release : 2004-01-15
Category : Medical
ISBN : 9780199725250

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Neurobiology of Mental Illness by Eric J. Nestler Pdf

The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics. For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.

Astrocytes in Psychiatric Disorders

Baoman Li,Vladimir Parpura,Alexei Verkhratsky,Caterina Scuderi
Astrocytes in Psychiatric Disorders Book PDF

Author : Baoman Li,Vladimir Parpura,Alexei Verkhratsky,Caterina Scuderi
Publisher : Springer Nature
Page : 368 pages
File Size : 54,6 Mb
Release : 2021-12-09
Category : Medical
ISBN : 9783030773755

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Astrocytes in Psychiatric Disorders by Baoman Li,Vladimir Parpura,Alexei Verkhratsky,Caterina Scuderi Pdf

This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.

Charney & Nestler's Neurobiology of Mental Illness

Dennis S. Charney,Pamela B. Sklar,Eric J. Nestler,Joseph D. Buxbaum
Charney Nestler s Neurobiology of Mental Illness Book PDF

Author : Dennis S. Charney,Pamela B. Sklar,Eric J. Nestler,Joseph D. Buxbaum
Publisher : Oxford University Press
Page : 1025 pages
File Size : 51,8 Mb
Release : 2018
Category : Medical
ISBN : 9780190681425

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Charney & Nestler's Neurobiology of Mental Illness by Dennis S. Charney,Pamela B. Sklar,Eric J. Nestler,Joseph D. Buxbaum Pdf

Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Glial Plasticity in Depression

João F. Oliveira,Catarina A. Gomes,Sandra H. Vaz,Nuno Sousa,Luisa Pinto
Glial Plasticity in Depression Book PDF

Author : João F. Oliveira,Catarina A. Gomes,Sandra H. Vaz,Nuno Sousa,Luisa Pinto
Publisher : Frontiers Media SA
Page : 101 pages
File Size : 42,6 Mb
Release : 2016-10-24
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889199990

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Glial Plasticity in Depression by João F. Oliveira,Catarina A. Gomes,Sandra H. Vaz,Nuno Sousa,Luisa Pinto Pdf

Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment.

Neuroglia

Helmut Kettenmann,Bruce R. Ransom
Neuroglia Book PDF

Author : Helmut Kettenmann,Bruce R. Ransom
Publisher : Oxford University Press, USA
Page : 955 pages
File Size : 46,7 Mb
Release : 2013
Category : Medical
ISBN : 9780199794591

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Neuroglia by Helmut Kettenmann,Bruce R. Ransom Pdf

Neuroglia, the third edition, is the long-awaited revision of the most highly regarded reference volume on glial cells. This indispensable edition has been completely revised, greatly enlarged, and enhanced with four-color figures throughout, all in response to the tremendous amount of new information that has accumulated since the previous edition seven years ago. Glial cells are, without doubt, the new stars in the neuroscience and neurology communities. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anatomy, physiology, biochemistry and function, and consider the central roles of these cells in neurological diseases including stroke, Alzheimer disease, multiple sclerosis, Parkinson's disease, neuropathy, and psychiatric conditions. More than 20 new chapters have been added to accommodate the unprecedented growth of knowledge about the basic biology of glia and the sophisticated manner in which they partner with neurons in the course of normal brain function. Lavishly illustrated and meticulously edited, the third edition remains the most convenient and maximally useful reference available. This new edition is an essential reference for both newcomers to the field as well as established investigators. Neuroglia belongs on every neuroscientist's bookshelf and will be a great asset for educators and neurological clinicians as well.

Neurobiology of Bipolar Disorder

Joao Quevedo,Andre Ferrer Carvalho,Eduard Vieta
Neurobiology of Bipolar Disorder Book PDF

Author : Joao Quevedo,Andre Ferrer Carvalho,Eduard Vieta
Publisher : Academic Press
Page : 472 pages
File Size : 40,9 Mb
Release : 2020-11-25
Category : Medical
ISBN : 9780128191835

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Neurobiology of Bipolar Disorder by Joao Quevedo,Andre Ferrer Carvalho,Eduard Vieta Pdf

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Child and Adolescent Behavioral Health

Edilma L. Yearwood,Geraldine S. Pearson,Jamesetta A. Newland
Child and Adolescent Behavioral Health Book PDF

Author : Edilma L. Yearwood,Geraldine S. Pearson,Jamesetta A. Newland
Publisher : John Wiley & Sons
Page : 608 pages
File Size : 47,6 Mb
Release : 2021-02-23
Category : Medical
ISBN : 9781119487586

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Child and Adolescent Behavioral Health by Edilma L. Yearwood,Geraldine S. Pearson,Jamesetta A. Newland Pdf

Research has shown that a range of adult psychiatric disorders and mental health problems originate at an early age, yet the psychiatric symptoms of an increasing number of children and adolescents are going unrecognized and untreated—there are simply not enough child psychiatric providers to meet this steadily rising demand. It is vital that advanced practice registered nurses (APRNs) and primary care practitioners take active roles in assessing behavioral health presentations and work collaboratively with families and other healthcare professionals to ensure that all children and adolescents receive appropriate treatment. Child and Adolescent Behavioral Health helps APRNs address the mental health needs of this vulnerable population, providing practical guidance on assessment guidelines, intervention and treatment strategies, indications for consultation, collaboration, referral, and more. Now in its second edition, this comprehensive and timely resource has been fully updated to include DSM-5 criteria and the latest guidance on assessing, diagnosing, and treating the most common behavioral health issues facing young people. New and expanded chapters cover topics including eating disorders, bullying and victimization, LGBTQ identity issues, and conducting research with high-risk children and adolescents. Edited and written by a team of accomplished child psychiatric and primary care practitioners, this authoritative volume: Provides state-of-the-art knowledge about specific psychiatric and behavioral health issues in multiple care settings Reviews the clinical manifestation and etiology of behavioral disorders, risk and management issues, and implications for practice, research, and education Offers approaches for interviewing children and adolescents, and strategies for integrating physical and psychiatric screening Discusses special topics such as legal and ethical issues, cultural influences, the needs of immigrant children, and child and adolescent mental health policy Features a new companion website containing clinical case studies to apply concepts from the chapters Designed to specifically address the issues faced by APRNs, Child and Adolescent Behavioral Health is essential reading for nurse practitioners and clinical nurse specialists, particularly those working in family, pediatric, community health, psychiatric, and mental health settings.

Psychotherapy in an Age of Neuroscience

Joel Paris
Psychotherapy in an Age of Neuroscience Book PDF

Author : Joel Paris
Publisher : Oxford University Press
Page : 217 pages
File Size : 51,6 Mb
Release : 2017
Category : Psychology
ISBN : 9780190601010

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Psychotherapy in an Age of Neuroscience by Joel Paris Pdf

Psychiatry, once proud of its biopsychosocial model, has now adopted a neuroscience-based approach that strongly favors psychopharmacological treatments and downplays the role of psychotherapies (or social interventions). This kind of practice can be sufficient for the psychoses, but it is neither evidence-based nor beneficial for patients with common mental disorders such as depression, anxiety, substance use, and personality disorders. Current practice derives from a theoretical model in which psychiatry is viewed primarily as an application of neuroscience, with little reference to the vast literature on psychology, social sciences, and psychotherapy. This work reviews research bearing on these issues, and it shows why existing data support a different set of conclusions from those held by many experts and most practitioners

From Neurons to Neighborhoods

National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
From Neurons to Neighborhoods Book PDF

Author : National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
Publisher : National Academies Press
Page : 610 pages
File Size : 51,6 Mb
Release : 2000-11-13
Category : Social Science
ISBN : 9780309069885

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From Neurons to Neighborhoods by National Research Council,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development Pdf

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.