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Author : D. Häussinger,H. Sies
Publisher : Springer Science & Business Media
Page : 301 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642697548
Author : Helmut Sies
Publisher : Unknown
Page : 20 pages
File Size : 48,7 Mb
Release : 1983
Category : Electronic
ISBN : OCLC:917506831
Author : Elling Kvamme
Publisher : CRC Press
Page : 280 pages
File Size : 42,9 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351080743
Based on the joint effort of a great many top scientists, this book covers most aspects of the metabolism and function of glutamine and glutamate in mammals.
Author : Jaime Mora
Publisher : Elsevier
Page : 355 pages
File Size : 53,8 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323154543
Glutamine: Metabolism, Enzymology, and Regulation presents significant contributions on the metabolism, enzymology, and regulation of glutamine of microorganisms to higher animals. The book is a collection of papers presented during the scientific symposium of the fiftieth anniversary of the granting of the autonomy of the University of Mexico, held in Hacienda Galindo, Queretaro, Mexico in November 1979. The monograph covers glutamine metabolism centered mainly in enzymatic studies on glutamine synthetase and the enzymes that utilize glutamine; the model of cascade control of glutamine synthetase in Escherichia coli; the mechanisms that control gene expression of glutamine synthetase and its relation to nitrogen metabolism in prokaryotes; the relationship between the structure and function of glutamine synthetase in eukaryotic microorganisms; nitrogen and glutamine metabolism in plants; the role of glutamine in the animal body; and the synthesis of glutamine in animal tissues. Biologists, botanists, and zoologists will find the compendium very insightful.
Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 47,6 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author : John Conrad Waterlow,Peter J. Garlick,D. J. Millward
Publisher : North-Holland
Page : 824 pages
File Size : 50,5 Mb
Release : 1978
Category : Nature
ISBN : UOM:39015000287105
Author : Hamish Nisbet Munro,James Boyd Allison
Publisher : Unknown
Page : 600 pages
File Size : 47,6 Mb
Release : 1964
Category : Mammals
ISBN : UOM:39015003789453
A general survey of mechanisms regulating protein metabolism in mammals; Hormonal regulation of synthesis of liver enzymes; Regulation of protein degradation in mammalian tissues; Sites of hormonal regulation of protein metabolism; Free amino acid pools and their role in regulation; The regulation of intermediary amino acid metabolism in animal tissues; Diurnal rhythms in mammalian protein metabolism; The role of the gastrointestinal tract in the regulation of protein metabolism; The role of the liver in regulation of amino acid and protein metabolism; The role of the kidney in the regulation of protein metabolism; The role of skeletal and cardiac muscle in the regulation of protein metabolism.
Author : Lubiniecki
Publisher : Routledge
Page : 656 pages
File Size : 42,6 Mb
Release : 2018-05-02
Category : Medical
ISBN : 9781351435710
An interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. The volume offers a biological perspective of large-scale animal cell culture and examines diverse processing strategies, process management, regulator
Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 722 pages
File Size : 41,8 Mb
Release : 1999-05-13
Category : Medical
ISBN : 9780309173186
Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Author : Hitoshi Endou
Publisher : Karger Medical and Scientific Publishers
Page : 240 pages
File Size : 53,5 Mb
Release : 1991-01-01
Category : Medical
ISBN : 3805553684
Author : Vicente Felipo,Santiago Grisolía
Publisher : Springer Science & Business Media
Page : 215 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461519898
This volume contains the papers presented at the International Symposium on "Cirrhosis, Hyperammonemia and Hepatic Encephalopathy", held in Valencia, Spain, January 24th-27th, 1994. Liver cirrhosis and other hepatic dysfunctions such as fulminant hepatic failure and congenital defects of urea cycle enzymes can lead to hepatic encephalopathy, coma and death. Hepatic encephalopathy is one of the main causes of death in western countries. The ability to detoxify ammonia by its incorporation into urea is diminished by impaired liver function, resulting in increased ammonia levels in blood and brain. Hyperammonemia is considered one of the main factors in the mediation of hepatic encephalopathy and the classical clinical treatments are directed towards reducing blood ammonia levels. However, the molecular bases of the pathogenesis of hepatic encephalopathy and the role of hyperammonemia in this process remain unclear and several hypotheses have been proposed. To clarify the mechanisms involved in hepatic encephalopathy and hyperammonemia suitable animal models are necessary. The animal models available and the ideal features of an animal model are presented in the initial part of the book.
Author : Ernst Petzinger,Rolf K.H. Kinne,Helmut Sies
Publisher : Springer Science & Business Media
Page : 440 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642742477
Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.
Author : Santiago Grisolía,Vicente Felipo,Maria-Dolores Miñana
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 45,9 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9781468458268
Proceedings of an international symposium held in Valencia, Spain, November 27--29, 1989
Author : Thorsten Cramer,Clemens A. Schmitt
Publisher : Springer
Page : 272 pages
File Size : 54,9 Mb
Release : 2016-08-24
Category : Medical
ISBN : 9783319421186
This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 448 pages
File Size : 46,8 Mb
Release : 1999-09-15
Category : Technology & Engineering
ISBN : 9780309172813
It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
