Growth Hormones And Short Stature

Author : Paul Kaplowitz,Jeffrey Baron
Publisher : Hachette+ORM
Page : 152 pages
File Size : 50,6 Mb
Release : 2008-06-06
Category : Health & Fitness
ISBN : 9780446543798

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The Short Child by Paul Kaplowitz,Jeffrey Baron Pdf

For the millions of parents concerned about their child's height, there is now an authoritative resource of comprehensive information to reassure and guide them in seeking help. This groundbreaking book by two of America's leading pediatric endocrinologists offers reliable guidance on the diagnosis and treatment of growth disorders, from helping parents determine whether their child's height is normal to understanding when it's necessary to seek the advice of a specialist. Parents will also learn about: The role of genetics, nutrition, and hormones in their child's growth The social and psychological impact of short stature Methods for estimating the height a child will be as an adult Important topics of concern to discuss with their child's doctors Medical conditions that cause short stature The most up-to-date research on treatment, including the controversial use of growth hormone-so you and your physician can decide what's right for your child.

Author : Jens O. L. Jørgensen,Jens Sandahl Christiansen
Publisher : Karger Medical and Scientific Publishers
Page : 241 pages
File Size : 42,7 Mb
Release : 2005-01-01
Category : Science
ISBN : 9783805579926

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Growth Hormone Deficiency in Adults by Jens O. L. Jørgensen,Jens Sandahl Christiansen Pdf

It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Author : Gianluca Tornese,Annalisa Deodati,Lukas Plachy
Publisher : Frontiers Media SA
Page : 111 pages
File Size : 46,5 Mb
Release : 2024-04-08
Category : Medical
ISBN : 9782832547427

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Short Stature: Beyond Growth Hormone by Gianluca Tornese,Annalisa Deodati,Lukas Plachy Pdf

Short stature refers to a height less than two standard deviations below the mean for a given age and gender. The effective investigation of short stature pathology in children combines clinical assessment, to view symptoms and bodily dysfunctions; endocrine assessment, to determine hormone levels and sensitivity; and increasingly advanced genetic analysis. Many children of short stature do not have an identified underlying pathology, thus assigned as having idiopathic short stature (ISS). Consequently, the ISS population can be subdivided into those with ‘normal variants’ of growth, termed familial short stature (FSS) and non-familial short stature (NFSS), including constitutional delay of growth and puberty (CDGP). These categories can then separate from that of children with ISS who show a different etiology.

Author : Peter C. Hindmarsh
Publisher : Karger Medical and Scientific Publishers
Page : 170 pages
File Size : 55,9 Mb
Release : 1999
Category : Medical
ISBN : 9783805567572

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Current Indications for Growth Hormone Therapy by Peter C. Hindmarsh Pdf

Breaking new ground in terms of scientific analysis, this book addresses the question of who benefits most from treatment with recombinant human growth hormone. Outlined at the beginning of this book are the principles of evidence-based medicine along with a critical appraisal of the statistical issues that lie at the center of growth hormone trials. Each chapter reviews the current state of knowledge on the use of growth hormone in conditions ranging from Turner syndrome through other syndromes of intrauterine growth retardation to the short normal child, also highlighting issues that remain to be addressed in further research. Evaluating therapies in terms of efficacy and safety or the health benefit for the individual or society as a whole are rarely approached in pediatric endocrinology and for this reason a special chapter on health economic evaluation is included. This book is of interest and offers practical help to pediatricians and endocrinologists.

Author : Michael B. Ranke,David Anthony Price,Edward O. Reiter
Publisher : Karger Medical and Scientific Publishers
Page : 534 pages
File Size : 45,5 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9783805582568

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Growth Hormone Therapy in Pediatrics by Michael B. Ranke,David Anthony Price,Edward O. Reiter Pdf

For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.

Author : Susan Cohen,Christine Cosgrove
Publisher : Penguin
Page : 420 pages
File Size : 43,9 Mb
Release : 2009
Category : Body image
ISBN : 1585426830

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Normal at Any Cost by Susan Cohen,Christine Cosgrove Pdf

Cohen and Cosgrove present a fascinating story of medical experimentation, parental love, and the extreme measures taken to make children fit within the normal height range.

Author : Constantine A. Stratakis
Publisher : Academic Press
Page : 312 pages
File Size : 48,7 Mb
Release : 2021-06-01
Category : Medical
ISBN : 9780128145388

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Gigantism and Acromegaly by Constantine A. Stratakis Pdf

Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism

Author : Alan David Rogol,Laurie E. Cohen,Edward Reiter
Publisher : Frontiers Media SA
Page : 52 pages
File Size : 49,9 Mb
Release : 2022-01-04
Category : Medical
ISBN : 9782889719365

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History of Growth Hormone: Animal to Human by Alan David Rogol,Laurie E. Cohen,Edward Reiter Pdf

Author : National Institute of Arthritis, Metabolism, and Digestive Diseases (U.S.)
Publisher : Unknown
Page : 12 pages
File Size : 44,7 Mb
Release : 1979
Category : Dwarfism, Pituitary
ISBN : MINN:31951D03569209X

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Human Growth Hormone by National Institute of Arthritis, Metabolism, and Digestive Diseases (U.S.) Pdf

Author : S. Raiti,R.A. Tolman
Publisher : Springer Science & Business Media
Page : 642 pages
File Size : 51,6 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9781461572015

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Human Growth Hormone by S. Raiti,R.A. Tolman Pdf

It has been ten years since the National Hormone and Pituitary Program (then called the National Pituitary Agency) sponsored a symposium on human growth hormone (hGH). Numerous advances have occurred during this period. This book does not attempt to summarize past achievements. Rather, it deals with the contemporary issues in hGH research. A discussion of the present state of the art, of necessity, includes a review of the past. Some of the topics herein discussed include the following: 1. Growth hormone releasing factor (GRF). In 1973, the growth hormone inhibitory factor (somatostatin) had recently been discovered. The search for a releasing factor in humans led to its discovery not in the pituitary but in a pancreatic tumor that secreted growth hormone. The advances are discussed in this book. The current hope is that GRF will eventually become an effective therapeutic agent for idiopathic hypopituitarism in childhood and adolescence. 2. Biosynthesis of hGR by recombinant DNA technology. Current advances are discussed. Although hGH is not yet an approved drug, it will eventually become one. This will broaden our horizons in terms of hGH effectiveness in disorders other than hypopituitary dwarfism. The current experience with this type of hGH in both the Vnited States and Europe is reviewed by several authors.

Author : John A.H. Wass,Paul M. Stewart
Publisher : Oxford University Press, USA
Page : 2158 pages
File Size : 40,9 Mb
Release : 2011-07-28
Category : Medical
ISBN : 9780199235292

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Oxford Textbook of Endocrinology and Diabetes by John A.H. Wass,Paul M. Stewart Pdf

Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.

Author : Terence J Wilkin
Publisher : Routledge
Page : 140 pages
File Size : 44,7 Mb
Release : 2021-09-17
Category : Medical
ISBN : 9781134338337

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Growth In Childhood by Terence J Wilkin Pdf

First Published in 1989 this is a collection of essays based on a series of lectures given at a symposium held at the University of Southampton Medical School from eight experts in the field of growth failure. Interest in growth hormone, its regulation and its therapeutic use has grown enormously since the introduction of genetically engineered growth hormone in 1985. The very pratcial probelms of measuring growth, the physiology of growth failure and its epidemiology are followed by a richly illustrated chapter on the spectrum of diseases assciated with short stature and an expert with extensive experience in the field looks at the application of growth hormone therapy.

Author : Robert Rapaport,Martin Oswald Savage
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 54,9 Mb
Release : 2022-10-25
Category : Medical
ISBN : 9782832503225

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Controversies in Growth Hormone Treatment and Diagnosis by Robert Rapaport,Martin Oswald Savage Pdf

Author : Shlomo Melmed
Publisher : Academic Press
Page : 744 pages
File Size : 46,6 Mb
Release : 2010-12-09
Category : Medical
ISBN : 0123809274

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The Pituitary by Shlomo Melmed Pdf

The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches

Author : Laurie E. Cohen
Publisher : Springer
Page : 228 pages
File Size : 49,7 Mb
Release : 2016-07-04
Category : Medical
ISBN : 9783319280387

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Growth Hormone Deficiency by Laurie E. Cohen Pdf

Providing the most current information on the function of human growth hormone (GH) and the consequences of its deficiency, this practical yet comprehensive text is divided into three sections. Part one describes the mechanisms of GH secretion and action, including the physiology of GH and its regulation by sex steroids and thyroid hormones, the effects of both under nutrition and obesity on GH secretion, and the metabolic effects of human recombinant GH therapy. The second section covers diagnostic strategies and tests for GH deficiency in both children and adults, including MRI of the pituitary. The final section describes the different etiologies of GH deficiency, from molecular mechanisms and gene abnormalities to cranial radiation and traumatic brain injury, along with syndromes related to this deficiency. Presenting underlying mechanisms and pathologies, as well as diagnostic methods, Growth Hormone Deficiency will provide the most up-to-date essential information and evidence on this condition for the clinical endocrinologist.