Handbook Of Glycomics

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Handbook of Glycomics

Richard D. Cummings,J. Michael Pierce
Handbook of Glycomics Book PDF

Author : Richard D. Cummings,J. Michael Pierce
Publisher : Academic Press
Page : 512 pages
File Size : 54,5 Mb
Release : 2009-10-19
Category : Science
ISBN : 0080920055

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Handbook of Glycomics by Richard D. Cummings,J. Michael Pierce Pdf

The Handbook of Glycomics provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans. Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches

A Practical Guide to Using Glycomics Databases

Kiyoko F. Aoki-Kinoshita
A Practical Guide to Using Glycomics Databases Book PDF

Author : Kiyoko F. Aoki-Kinoshita
Publisher : Springer
Page : 370 pages
File Size : 48,8 Mb
Release : 2016-12-06
Category : Science
ISBN : 9784431564546

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A Practical Guide to Using Glycomics Databases by Kiyoko F. Aoki-Kinoshita Pdf

This book provides glycoscientists with a handbook of useful databases that can be applied to glycoscience research. Although many databases are now publicly available, one of the hurdles for their users is the learning curve required to effectively utilize those databases. Therefore, this book not only describes the existing databases, but also provides tips on how to obtain the target data. That is, because many databases provide a variety of data that could be obtained from different perspectives, each chapter provides users with potential biological questions that can be answered by a particular database and step-by-step instructions, with figures, on how to obtain that data. Troubleshooting tips are also provided to aid users encountering problems that can be predicted when using these databases. Moreover, contact information for each database is provided in case unexpected issues arise.

Glycomics

Nicolle H. Packer,Niclas G. Karlsson
Glycomics Book PDF

Author : Nicolle H. Packer,Niclas G. Karlsson
Publisher : Humana Press
Page : 0 pages
File Size : 41,8 Mb
Release : 2010-11-19
Category : Science
ISBN : 1617377694

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Glycomics by Nicolle H. Packer,Niclas G. Karlsson Pdf

Due to the significant contributions of carbohydrates to the functional diversity of the cell, the challenging study of the glycome has expanded beyond the research of carbohydrate experts and into the wider scope of the life sciences. To aid all scientists now delving into this vital subject area, Glycomics: Methods and Protocols collects a compendium of detailed laboratory protocols reflecting the increasing availability of sample preparation, chromatographic, electrophoretic, mass spectrometric, and bioinformatic tools specifically designed for the analysis of glycosylation. Leading researchers in the field address subjects such as glycoprotein and proteoglycan analysis, glycosylation structure determination, as well as various approaches to investigate the interaction between glycans and a variety of carbohydrate-recognizing proteins in order to aid exploration into the functional significance of the oligosaccharides. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glycomics: Methods and Protocols serves as a valuable guide for experimenters facing the challenges of glycan analysis in hope of providing further insights into the biology of cell-cell communication and interaction.

Functional Glycomics

Jianjun Li
Functional Glycomics Book PDF

Author : Jianjun Li
Publisher : Humana
Page : 284 pages
File Size : 44,6 Mb
Release : 2016-08-23
Category : Science
ISBN : 1493956973

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Functional Glycomics by Jianjun Li Pdf

The study of functional glycomics requires the continuous development of rapid and sensitive methods for the identification of glycan structures and integration to structure-function relationships. In Functional Glycomics: Methods and Protocols, a panel of world-renowned experts provide new developments and emerging glycomics techniques in the form of detailed protocols exploring the fundamental challenges and most cutting-edge novel applications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters in this volume present brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes sections, highlighting key tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Functional Glycomics: Methods and Protocols serves as an ideal reference for scientists working in biochemistry, molecular biology, cell biology, immunology, microbiology, and virology and a guide to appropriate techniques and the design of achievable research plans in this vital field.

Handbook of Glycosyltransferases and Related Genes

Naoyuki Taniguchi,Koichi Honke,Minoru Fukuda
Handbook of Glycosyltransferases and Related Genes Book PDF

Author : Naoyuki Taniguchi,Koichi Honke,Minoru Fukuda
Publisher : Springer Science & Business Media
Page : 668 pages
File Size : 50,8 Mb
Release : 2011-06-28
Category : Science
ISBN : 9784431678779

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Handbook of Glycosyltransferases and Related Genes by Naoyuki Taniguchi,Koichi Honke,Minoru Fukuda Pdf

The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations.

Essentials of Glycobiology

Ajit Varki,Maarten J. Chrispeels
Essentials of Glycobiology Book PDF

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 55,8 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

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Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Glycomics

Anonim
Glycomics Book PDF

Author : Anonim
Publisher : Academic Press
Page : 664 pages
File Size : 47,7 Mb
Release : 2010-10-25
Category : Science
ISBN : 0123810027

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Glycomics by Anonim Pdf

In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers’ own research efforts Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry

The Glycome

Adeel Malik,Tanveer A. Dar
The Glycome Book PDF

Author : Adeel Malik,Tanveer A. Dar
Publisher : CRC Press
Page : 305 pages
File Size : 49,9 Mb
Release : 2021-07-07
Category : Science
ISBN : 9781000344325

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The Glycome by Adeel Malik,Tanveer A. Dar Pdf

This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker. The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture. The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.

Handbook on Immunosenescence

Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
Handbook on Immunosenescence Book PDF

Author : Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
Publisher : Springer Science & Business Media
Page : 1693 pages
File Size : 41,8 Mb
Release : 2009-02-27
Category : Medical
ISBN : 9781402090639

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Handbook on Immunosenescence by Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec Pdf

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Handbook of Biomarkers and Precision Medicine

Claudio Carini,Mark Fidock,Alain van Gool
Handbook of Biomarkers and Precision Medicine Book PDF

Author : Claudio Carini,Mark Fidock,Alain van Gool
Publisher : CRC Press
Page : 631 pages
File Size : 45,7 Mb
Release : 2019-04-16
Category : Mathematics
ISBN : 9780429576737

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Handbook of Biomarkers and Precision Medicine by Claudio Carini,Mark Fidock,Alain van Gool Pdf

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

The Handbook of Biomarkers

Kewal K. Jain
The Handbook of Biomarkers Book PDF

Author : Kewal K. Jain
Publisher : Humana Press
Page : 760 pages
File Size : 48,6 Mb
Release : 2017-09-16
Category : Science
ISBN : 9781493974313

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The Handbook of Biomarkers by Kewal K. Jain Pdf

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today.

Handbook of Biomarkers and Precision Medicine

Claudio Carini,Mark Fidock,Alain van Gool
Handbook of Biomarkers and Precision Medicine Book PDF

Author : Claudio Carini,Mark Fidock,Alain van Gool
Publisher : CRC Press
Page : 1025 pages
File Size : 48,9 Mb
Release : 2019-04-16
Category : Mathematics
ISBN : 9780429574627

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Handbook of Biomarkers and Precision Medicine by Claudio Carini,Mark Fidock,Alain van Gool Pdf

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

The Art of Carbohydrate Analysis

Gerrit J. Gerwig
The Art of Carbohydrate Analysis Book PDF

Author : Gerrit J. Gerwig
Publisher : Springer Nature
Page : 362 pages
File Size : 50,6 Mb
Release : 2021-10-23
Category : Medical
ISBN : 9783030777913

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The Art of Carbohydrate Analysis by Gerrit J. Gerwig Pdf

The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.

Sustainable Nanosystems Development, Properties, and Applications

Putz, Mihai V.,Mirica, Marius Constantin
Sustainable Nanosystems Development Properties and Applications Book PDF

Author : Putz, Mihai V.,Mirica, Marius Constantin
Publisher : IGI Global
Page : 794 pages
File Size : 45,7 Mb
Release : 2016-08-01
Category : Technology & Engineering
ISBN : 9781522504931

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Sustainable Nanosystems Development, Properties, and Applications by Putz, Mihai V.,Mirica, Marius Constantin Pdf

Global economic demands and population surges have led to dwindling resources and problematic environmental issues. As the climate and its natural resources continue to struggle, it has become necessary to research and employ new forms of sustainable technology to help meet the growing demand. Sustainable Nanosystems Development, Properties, and Applications features emergent research and theoretical concepts in the areas of nanotechnology, photovoltaics, electrochemistry, and materials science, as well as within the physical and environmental sciences. Highlighting progressive approaches and utilization techniques, this publication is a critical reference source for researchers, engineers, students, scientists, and academicians interested in the application of sustainable nanotechnology.

Molecular Biomethods Handbook

John M. Walker,Ralph Rapley
Molecular Biomethods Handbook Book PDF

Author : John M. Walker,Ralph Rapley
Publisher : Springer Science & Business Media
Page : 1105 pages
File Size : 52,6 Mb
Release : 2008-11-04
Category : Science
ISBN : 9781603273756

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Molecular Biomethods Handbook by John M. Walker,Ralph Rapley Pdf

Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. This book expands upon the techniques included in the first edition, providing theory, outlines of practical procedures, and applications for a range of techniques. Written by a well-established panel of research scientists, the book provides an up-to-date collection of methods used regularly in the authors’ own research programs.