Handbook Of Pharmacokinetic Pharmacodynamic Correlation

Author : Hartmut Derendorf,Guenther Hochhaus
Publisher : CRC Press
Page : 496 pages
File Size : 47,9 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000005905

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Handbook of Pharmacokinetic/Pharmacodynamic Correlation by Hartmut Derendorf,Guenther Hochhaus Pdf

First published in 1995: Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time.

Author : Rajesh Krishna
Publisher : Springer Science & Business Media
Page : 576 pages
File Size : 50,9 Mb
Release : 2004
Category : Medical
ISBN : 0306477661

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Applications of Pharmacokinetic Principles in Drug Development by Rajesh Krishna Pdf

This book presents a collection of articles that representindividual and expert perspectives in both preclinical and clinicaldevelopment, including case studies on real-life examples ofsuccessful drugs that add value to the pharmacokinetic principleslearned and applied. Unlike existing books that focus onpharmacokinetic theory, the current book emphasizes application ofpharmacokinetic principles in new drug development.

Author : Ronald D. Schoenwald
Publisher : CRC Press
Page : 430 pages
File Size : 49,7 Mb
Release : 2002-03-06
Category : Medical
ISBN : 9781420010084

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Pharmacokinetics in Drug Discovery and Development by Ronald D. Schoenwald Pdf

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existi

Author : Wolfgang A. Ritschel,Gregory L. Kearns
Publisher : American Pharmacists Association (APhA)
Page : 590 pages
File Size : 51,5 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015043764953

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Handbook of Basic Pharmacokinetics-- Including Clinical Applications by Wolfgang A. Ritschel,Gregory L. Kearns Pdf

First published in 1976, this handbook is a consolidation of principles and techniques for practitioners, researchers and students involved in the various applications of pharmacokinetics. Twenty-six of the previous edition's 37 chapters have been revised. A new chapter entitled Extracorporeal Methods of Drug Removal addresses the clinical pharmacokinetic challenges that accompany renal replacement therapy. Pharmacokinetic data profiles for an additional 128 drugs have been added to the appendix, which now provides accessible information on 426 drugs.

Author : Younggil Kwon
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 46,5 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306468209

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Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by Younggil Kwon Pdf

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Author : Peter L. Bonate
Publisher : Springer Science & Business Media
Page : 634 pages
File Size : 41,9 Mb
Release : 2011-07-01
Category : Medical
ISBN : 9781441994851

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Pharmacokinetic-Pharmacodynamic Modeling and Simulation by Peter L. Bonate Pdf

This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.

Author : Anonim
Publisher : Unknown
Page : 730 pages
File Size : 53,7 Mb
Release : 2003
Category : Biopharmaceutics
ISBN : IND:30000121643542

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International Journal of Clinical Pharmacology and Therapeutics by Anonim Pdf

Author : Johan Gabrielsson,Daniel Weiner
Publisher : CRC Press
Page : 926 pages
File Size : 52,6 Mb
Release : 2001-11-30
Category : Medical
ISBN : 9186274929

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Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition by Johan Gabrielsson,Daniel Weiner Pdf

This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Author : Edythe D. London
Publisher : Routledge
Page : 454 pages
File Size : 45,9 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9781351439336

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Imaging Drug Action in the Brain by Edythe D. London Pdf

Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Author : Joseph I. Boullata,Vincent T. Armenti
Publisher : Springer Science & Business Media
Page : 824 pages
File Size : 49,6 Mb
Release : 2010-03-17
Category : Science
ISBN : 9781603273626

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Handbook of Drug-Nutrient Interactions by Joseph I. Boullata,Vincent T. Armenti Pdf

Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.

Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 40,6 Mb
Release : 2007-10-23
Category : Medical
ISBN : 9781588297808

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Handbook of Drug Monitoring Methods by Amitava Dasgupta Pdf

Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Author : Edith Mathiowitz
Publisher : Unknown
Page : 584 pages
File Size : 42,7 Mb
Release : 1999
Category : Drug carriers (Pharmacy)
ISBN : UOM:39015047710275

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Encyclopedia of Controlled Drug Delivery: M-Z by Edith Mathiowitz Pdf

Author : Peter G. Welling
Publisher : Unknown
Page : 416 pages
File Size : 45,6 Mb
Release : 1997
Category : Drugs
ISBN : STANFORD:36105110341216

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Pharmacokinetics by Peter G. Welling Pdf

Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of drugs in humans. This book, written by an internationally known researcher, teaches the basic principles, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, and metabolism. Extensively revised, this edition presents the mathematics of pharmacokinetics with various single- and multi-compartment models including detailed descriptions of metabolite and nonlinear pharmacokinetics. It also describes renal and hepatic drug clearance, and the influence of kidney and liver impairment on these functions. Taking a tutorial approach throughout, the author provides both a clear introduction to pharmacokinetics and a critical look at how this science affects drug discovery and development.

Author : Derek Chadwick,Jamie Goode
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 54,8 Mb
Release : 1997-06-19
Category : Medical
ISBN : UOM:39015041371462

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Antibiotic Resistance by Derek Chadwick,Jamie Goode Pdf

Antibiotic Resistance: Origins, Evolution, Selection and Spread Chairman: Stuart B. Levy, 1997 Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.

Author : Leland G. Alkire,Cheryl Westerman-Alkire
Publisher : Gale Cengage
Page : 1638 pages
File Size : 54,9 Mb
Release : 2006
Category : Periodicals
ISBN : UCSC:32106018187085

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Periodical Title and Abbreviation by Abbreviation by Leland G. Alkire,Cheryl Westerman-Alkire Pdf

Volume 1 is a comprehensive dictionary with more than 230,000 entries. It covers periodicals from a wide variety of subjects, including: science, social sciences, humanities, law, medicine, religion, library science, engineering, education, business, and art. Volume 1lists, in a single in letter-by-letter sequence, abbreviations commonly used for periodicals together with their full titles.