Hiv 1 Molecular Biology And Pathogenesis Viral Mechanisms
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HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms by Anonim Pdf
This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells. Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting.
HIV: Molecular Biology and Pathogenesis: Viral Mechanisms by Anonim Pdf
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Detailed insights into viral packaging, expression, and assembly Mechanistic understanding of how HIV interacts with receptors and infects cells Delineation of virally encoded regulatory processes unique to HIV Clinical Applications: An updated review of current chemotherapeutics for HIV New concepts in the discovery and design of novel anti-HIV drugs The latest developments in HIV-vaccine research
HIV I: Molecular Biology and Pathogenesis: Clinical Applications by Anonim Pdf
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines. The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Detailed insights into viral packaging, expression, and assembly Mechanistic understanding of how HIV interacts with receptors and infects cells Delineation of virally encoded regulatory processes unique to HIV Clinical Applications: An updated review of current chemotherapeutics for HIV New concepts in the discovery and design of novel anti-HIV drugs The latest developments in HIV-vaccine research
The Molecular Biology of HIV/AIDS by A. M. L. Lever Pdf
This study, based on both clinical and molecular trials, outlines the principles of the molecular biology of HIV and AIDS. Topics such as the origins of the virus, viral interactions with the immune system, antiviral intervention and vaccine prospects are covered.
HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms by Anonim Pdf
This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells. Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting.
The Biology of Dendritic Cells and HIV Infection by Sandra Gessani,Filippo Belardelli Pdf
Dendritic cells play the most vital part in inducing anti-viral immune responses in HIV and AIDS among many other viruses. Research on dendritic cells (DCs) is emerging as a fundamental aspect for the comprehension of the mechanisms underlying the pathogenesis of viral diseases. This volume focuses on the role of DCs in the pathogenesis and immunity of HIV-1 infection. It is the only comprehensive volume on pathogenesis and immunity of Dendritic Cells that also focuses on HIV.
Author : Nelson Michael,Jerome H. Kim Publisher : Springer Science & Business Media Page : 402 pages File Size : 41,8 Mb Release : 2008-02-01 Category : Medical ISBN : 9781592596010
The worldwide impact of infection with human immunodeficiency virus type 1 (HIV- is reflected in the cumulative number ofHIV- 1 infections, which is now predicted to exceed 40 million by the year 2000---equivalent to the n- ber of humans who perished in World War II. The medical and scientific - sponse to the HIV-1 pandemic has steadily grown since its recognition in 1981. The outlay by the United States alone for HIV research funded by the National Institutes of Health in 1997 was $1. 4 billion. Laboratory-based HIV research has brought together academic clinicians, retrovirologists, molecular biologists, and immunologists in the formation of research teams attempting to dissect the viral and host factors contributing to disease pathogenesis. Increasing focus is being placed on those aspects of viral biology and host immune responses that bear on the development of vaccines to prevent HIV infection. HIVProtocols reflects the state of HIV research in several ways. First, chapters are organized into four sections: Virology, Molecular Biology, Humoral Immunology, and Cellular Immunology. This organization is a natural consequence of the diverse scientific disciplines that have been attracted to HIV research. Second, the chapters reflect such diverse research directions as viral coreceptor usage, quantitation of viral genomes, HIV promoter function, B-cell epitope mapping, and measurements of T-cell function, each of which bears on the goal of understanding the viral and host immune responses that will be critical to the design of effective preventive vaccines.
HIV-1 Latency by Guido Silvestri,Mathias Lichterfeld Pdf
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
HIV Protocols by Vinayaka R. Prasad,Ganjam V. Kalpana Pdf
This third edition volume expands upon the previous editions with new research topics and numerous leading-edge HIV protocols. This book contains chapters that cover various aspects of HIV-1 replication and are helpful for investigating the mechanisms of HIV-1 replication or pathogenesis. The chapters are grouped into six sections: HIV early events; HIV-1 RNA structure and RNA-protein interactions; HIV-1 post-integration events; HIV-1 pathogenesis in animal models; tools to study HIV-1 latency; and NeuroAIDS. Chapters are written by research experts who have diligently developed techniques, improved them, simplified them, or applied them to their own HIV research. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, HIV Protocols, Third Edition is a great resource for HIV research, and contains many significant tips and tricks rarely mentioned in standard protocols.
Author : Raymond P. Roos Publisher : Springer Science & Business Media Page : 599 pages File Size : 42,9 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461204077
Neurovirology, the study of viral infection of the ner vous system, has evolved at the interface of three of the most rapidly unfolding fields of investigation-neurobiology, vi rology, and immunology. In all three, increasing knowledge about the molecular structure of surface receptors, how in tracellular messages are transmitted, and how diversity is regulated genetically is provided, along with the techniques of molecular biology. This promises to give us knowledge not only about the process of infection and the complex host and viral determinants of neuroinvasiveness and neurovirulence, but eventually it will provide the background from which to engineer vaccines and to devise novel therapeutic agents. Animal virology and molecular biology developed quite independently from different origins. Animal virology was originally the province of the pathologists, and by clinical observation and histological preparations, they tried to ex plain the incubation period, the pathways of virus spread, and the mechanisms of disease. Molecular virology grew out of biochemistry, particularly through studies of bacterio phage, with emphasis on the physical and chemical structure of viruses and the sequences of biochemical events during the replicative cycle in cells.
HIV and the Pathogenesis of AIDS by Jay A. Levy Pdf
The second edition of HIV and the Pathogenesis of AIDS updates this important, well–annotated text on HIV pathogenesis. with valuable insights and written with clarity and succinctness, the history and background of human immunodeficiency virus (HIV) and the steps involved in its infection of cells and the development of AIDS are discussed. Aspects of HIV epidemiology and transmission and the HIV–associated cancers that are prominent in infection are also covered. Regarding treatment, Dr Levy discusses the most recent approaches for antiviral therapy that have shown promise in controling infection and presents the challenges faced in developing a vaccine for blocking the transmission of this deadly virus. This book, which was extremely well–received by the scientific community in its initial volume four years ago, provides the most current information on HIV and AIDS and captures the spirit of this virologic and immunologic disease. It defines the future directions that must be taken to find a solution to this devastating illness.
Viral Pathogenesis and Immunity by Neal Nathanson,Rafi Ahmed Pdf
This text provides a coherent and concise introduction to the field of viral pathogenesis and immunity. The text is divided into four sections which highlight the fundamental principles within this field of study. Section 1, Essentials of Viral Pathogenesis, describes the sequential events in viral infection, the localization of viral infections and the variety of virus-cell interactions. Section 2, Host Responses to Viral Infection, examines immune responses including virus-induced immunopathology and immunosuppression. Section 3, Virus-Host Interactions, covers virulence, viral persistence, virus-induced oncogenesis and host susceptibility. Section 4, Prevention of Viral Infections, explains the key principles of vaccine development.
